Jingzhong Zhang
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View article: Non-monotonic response of macrophages to mechanical stretch impacts skin wound healing
Non-monotonic response of macrophages to mechanical stretch impacts skin wound healing Open
Our observation of the non-monotonic macrophage response to MS provides a foundation for elucidating how macrophages may translate mechanical cues into paracrine signals that influence skin function and wound healing dynamics.
View article: Neural Organoids Protect Engineered Heart Tissues From Glucolipotoxicity by Transferring Versican in a Co‐Culture System
Neural Organoids Protect Engineered Heart Tissues From Glucolipotoxicity by Transferring Versican in a Co‐Culture System Open
Metabolic disorders could cause dysregulated glucose and lipid at the systemic level, but how inter‐tissue/organ communications contribute to glucolipotoxicity is difficult to dissect in animal models. To solve this problem, myocardium and…
View article: Neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican in a co-culture system
Neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican in a co-culture system Open
Metabolic disorders could cause dysregulated glucose and lipid at the systemic level, but how inter-tissue/organ communications contribute to glucolipotoxicity is difficult to dissect in animal models. To solve this problem, myocardium and…
View article: Mesenchymal Stem Cells Restore Endothelial Integrity and Alleviate Emotional Impairments in a Diabetic Mouse Model via Inhibition of MMP-9 Activity
Mesenchymal Stem Cells Restore Endothelial Integrity and Alleviate Emotional Impairments in a Diabetic Mouse Model via Inhibition of MMP-9 Activity Open
Diabetes mellitus (DM) has reached pandemic prevalence, significantly impacting global health. Accumulating evidence has highlighted a bidirectional relationship between diabetes and depression, with blood–brain barrier (BBB) disruption pl…
View article: Activation of angiopoietin-1 signaling with engineering mesenchymal stem cells promoted efficient angiogenesis in diabetic wound healing
Activation of angiopoietin-1 signaling with engineering mesenchymal stem cells promoted efficient angiogenesis in diabetic wound healing Open
Treatment with MSCs alone promotes angiogenesis and DFU healing, while the engineering of MSCs with ANG1 provides substantial additional benefits to this therapeutic process. The engineering of MSCs with ANG1 presents a promising avenue fo…
View article: Advances in engineered organoid models of skin for biomedical research
Advances in engineered organoid models of skin for biomedical research Open
In recent years, significant progress has been made in the development of organoids, which offer promising opportunities for developmental and translational research. With advances in cell biology and bioengineering techniques, skin models…
View article: The Effect of Conditioned Medium from Angiopoietin-1 Gene-Modified Mesenchymal Stem Cells on Wound Healing in a Diabetic Mouse Model
The Effect of Conditioned Medium from Angiopoietin-1 Gene-Modified Mesenchymal Stem Cells on Wound Healing in a Diabetic Mouse Model Open
Introduction: Mesenchymal stem cells (MSCs) have been introduced as a promising treatment for diabetic wounds. The effects of stem cell therapy are thought to be caused by bioactive molecules secreted by stem cells. Stem cell-based gene th…
View article: Adipose-Derived Stem-Cell-Membrane-Coated PLGA-PEI Nanoparticles Promote Wound Healing via Efficient Delivery of miR-21
Adipose-Derived Stem-Cell-Membrane-Coated PLGA-PEI Nanoparticles Promote Wound Healing via Efficient Delivery of miR-21 Open
miRNAs have been shown to be involved in the regulation of a variety of physiological and pathological processes, but their use in the treatment of diseases is still limited due to their instability. Biomimetic nanomaterials combine nanoma…
View article: Standard: human intestine-on-a-chip
Standard: human intestine-on-a-chip Open
Organs-on-chips are microphysiological systems that allow to replicate the key functions of human organs and accelerate the innovation in life sciences including disease modeling, drug development, and precision medicine. However, due to t…
View article: The composite biomatrix SC/CM improved the therapeutic effects of xenogeneic MSC on wound healing in immune-competent mice via immune niche reprogramming
The composite biomatrix SC/CM improved the therapeutic effects of xenogeneic MSC on wound healing in immune-competent mice via immune niche reprogramming Open
Allogenic mesenchymal stem cell (allo-MSC) transplantation has shown great potential in the field of tissue repair. Increasing evidence has shown that allo-MSC are not completely immune-privileged; the immunogenic response after transplant…
View article: Causes and Hazards of Perimeter Rock Cavities behind Shield Tunnels
Causes and Hazards of Perimeter Rock Cavities behind Shield Tunnels Open
The purpose of this paper is to discuss the reasons for the generation of voids in the surrounding rock behind water transmission shield tunnels and the potential hazards they bring. Firstly, it analyzes in detail the possible causes of ca…
View article: Study on Preparation Technology of Novel Fluorosilicone Rubber Composite Insulator
Study on Preparation Technology of Novel Fluorosilicone Rubber Composite Insulator Open
Currently, commonly used external insulation materials for power products lack operational stability compared to high-temperature vulcanized silicone rubber. The excellent hydrophobicity of PTFE provides a direction for further enhancing h…
View article: Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model
Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model Open
Epigenetic dysregulation that leads to alterations in gene expression and is suggested to be one of the key pathophysiological factors of Parkinson’s disease (PD). Here, we found that α-synuclein preformed fibrils (PFFs) induced histone H3…
View article: High-Voltage Electrostatic Field Hydrogel Microsphere 3D Culture System Improves Viability and Liver-like Properties of HepG2 Cells
High-Voltage Electrostatic Field Hydrogel Microsphere 3D Culture System Improves Viability and Liver-like Properties of HepG2 Cells Open
Three-dimensional (3D) hepatocyte models have become a research hotspot for evaluating drug metabolism and hepatotoxicity. Compared to two-dimensional (2D) cultures, 3D cultures are better at mimicking the morphology and microenvironment o…
View article: CXCL10 and Nrf2-upregulated mesenchymal stem cells reinvigorate T lymphocytes for combating glioblastoma
CXCL10 and Nrf2-upregulated mesenchymal stem cells reinvigorate T lymphocytes for combating glioblastoma Open
Background Lack of tumor-infiltrating T lymphocytes and concurrent T-cell dysfunction have been identified as major contributors to glioblastoma (GBM) immunotherapy resistance. Upregulating CXCL10 in the tumor microenvironment (TME) is a p…
View article: Research on the Influence of Heavy Pollution Environment on Hydrophobic Substances in Silicone Rubber Materials
Research on the Influence of Heavy Pollution Environment on Hydrophobic Substances in Silicone Rubber Materials Open
Power load forecasting is very important for power dispatching. Accurate load forecasting is of great significance for saving energy, reducing generating costs, and improving social and economic benefits. In order to accurately predict the…
View article: General requirements for the production of extracellular vesicles derived from human stem cells
General requirements for the production of extracellular vesicles derived from human stem cells Open
‘General requirements for the production of extracellular vesicles derived from human stem cells’ is the first guideline for stem cells derived extracellular vesicles in China, jointly drafted and agreed upon by experts from the Chinese So…
View article: Cerebral-Organoid-Derived Exosomes Alleviate Oxidative Stress and Promote LMX1A-Dependent Dopaminergic Differentiation
Cerebral-Organoid-Derived Exosomes Alleviate Oxidative Stress and Promote LMX1A-Dependent Dopaminergic Differentiation Open
The remarkable advancements related to cerebral organoids have provided unprecedented opportunities to model human brain development and diseases. However, despite their potential significance in neurodegenerative diseases such as Parkinso…
View article: MRI-Guided Mesenchymal Stem Cell Therapy Reinvigorates T Lymphocytes in Glioblastoma
MRI-Guided Mesenchymal Stem Cell Therapy Reinvigorates T Lymphocytes in Glioblastoma Open
View article: <i>In Situ</i>-Formed Fibrin Hydrogel Scaffold Loaded With Human Umbilical Cord Mesenchymal Stem Cells Promotes Skin Wound Healing
<i>In Situ</i>-Formed Fibrin Hydrogel Scaffold Loaded With Human Umbilical Cord Mesenchymal Stem Cells Promotes Skin Wound Healing Open
Healing of full-thickness skin wounds remains a major challenge. Recently, human umbilical cord mesenchymal stem cells (hUC-MSCs) were shown to possess an extraordinary potential to promote skin repair in clinical settings. However, their …
View article: Linear-Nonlinear Switching Active Disturbance Rejection Speed Controller for Permanent Magnet Synchronous Motors
Linear-Nonlinear Switching Active Disturbance Rejection Speed Controller for Permanent Magnet Synchronous Motors Open
To combine the advantages of linear active disturbance rejection control (LADRC) and nonlinear active disturbance rejection control (NLADRC) and improve the contradiction between the response speed and control precision caused by the limit…
View article: Improved One-Stage Detectors with Neck Attention Block for Object Detection in Remote Sensing
Improved One-Stage Detectors with Neck Attention Block for Object Detection in Remote Sensing Open
Object detection in remote sensing is becoming a conspicuous challenge with the rapidly increasing quantity and quality of remote sensing images. Although the application of Deep Learning has obtained remarkable performance in Computer Vis…
View article: Corrigendum to“Application of fluorescent nano-biosensor for the detection of cancer bio-macromolecular markers” [Polym. Test. 115 (2022) 107746]
Corrigendum to“Application of fluorescent nano-biosensor for the detection of cancer bio-macromolecular markers” [Polym. Test. 115 (2022) 107746] Open
View article: Design of Compact Mid-Infrared Cooled Echelle Spectrometer Based on Toroidal Uniform-Line-Spaced (TULS) Grating
Design of Compact Mid-Infrared Cooled Echelle Spectrometer Based on Toroidal Uniform-Line-Spaced (TULS) Grating Open
A traditional flat-panel spectrometer does not allow high-resolution observation and miniaturization simultaneously. In this study, a compact, high-resolution cross-dispersion spectrometer was designed based on the theoretical basis of ech…
View article: Optimal Compensation of MEMS Gyroscope Noise Kalman Filter Based on Conv-DAE and MultiTCN-Attention Model in Static Base Environment
Optimal Compensation of MEMS Gyroscope Noise Kalman Filter Based on Conv-DAE and MultiTCN-Attention Model in Static Base Environment Open
Errors in microelectromechanical systems (MEMS) inertial measurement units (IMUs) are large, complex, nonlinear, and time varying. The traditional noise reduction and compensation methods based on traditional models are not applicable. Thi…
View article: Application of fluorescent nano-biosensor for the detection of cancer bio-macromolecular markers
Application of fluorescent nano-biosensor for the detection of cancer bio-macromolecular markers Open
Fluorescent sensors developed based on nano-materials have penetrated into cancer medical sensing research due to their unique properties, such as high sensitivity, high specificity. The number of cancer patients has continued to rise in r…
View article: Active shim coils design for Halbach magnet based on inverse boundary element method
Active shim coils design for Halbach magnet based on inverse boundary element method Open
With advantages of small volume, high field strength, and compact stray field, the Halbach array magnet is of great potential in desktop NMR applications. However, field inhomogeneity poses a main obstacle to its applications. Active shimm…
View article: Rate and Equilibrium Constants for Bupivacaine’s Binding to Isolated Alpha-1-Acid Glycoprotein: An In vitro study.
Rate and Equilibrium Constants for Bupivacaine’s Binding to Isolated Alpha-1-Acid Glycoprotein: An In vitro study. Open
Binding of local anesthetics to plasma proteins has been presented as an important determinant of their bioavailability. Local anesthetics with a high potential for systemic toxicity, e.g. bupivacaine (BUP), are bound strongly by alpha1-ac…
View article: The Different Molecular Code in Generation of Dopaminergic Neurons from Astrocytes and Mesenchymal Stem Cells
The Different Molecular Code in Generation of Dopaminergic Neurons from Astrocytes and Mesenchymal Stem Cells Open
Transplantation of exogenous dopaminergic (DA) neurons is an alternative strategy to replenish DA neurons that have lost along the course of Parkinson’s disease (PD). From the perspective of ethical acceptation, the source limitations, and…
View article: Multimodal Magnetic Resonance and Fluorescence Imaging of the Induced Pluripotent Stem Cell Transplantation in the Brain
Multimodal Magnetic Resonance and Fluorescence Imaging of the Induced Pluripotent Stem Cell Transplantation in the Brain Open
BackgroundThe understanding of the engrafted cell behaviors such as the survival, growth and distribution is the prerequisite to optimize cell therapy, and a multimodal imaging at both anatomical and molecular levels is designed to achieve…