Jin‐Ha Choi
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View article: Multiplexed Optical Nanobiosensing Technologies for Disease Biomarker Detection
Multiplexed Optical Nanobiosensing Technologies for Disease Biomarker Detection Open
Most biomarkers exhibit abnormal expression in more than one disease, making conventional single-biomarker detection strategies prone to false-negative results. Detecting multiple biomarkers associated with a single disease can therefore s…
View article: Biohybrid motor neuron spheroid composed of graphene/HUVEC/neural cell for 3D biosensing system to evaluate drug of amyotrophic lateral sclerosis
Biohybrid motor neuron spheroid composed of graphene/HUVEC/neural cell for 3D biosensing system to evaluate drug of amyotrophic lateral sclerosis Open
A 3D motor neuron (MN) spheroid has been developed to investigate neurodegenerative and neuromuscular junction (NMJ) disease. However, core necrosis and reduced neurogenesis, impairing neural network formation, were observed as the MN sphe…
View article: Electrochemical Microneedles for Real-Time Monitoring in Interstitial Fluid: Emerging Technologies and Future Directions
Electrochemical Microneedles for Real-Time Monitoring in Interstitial Fluid: Emerging Technologies and Future Directions Open
Conventional blood-based detection methods for biomarkers and analytes face significant limitations, including complex processing, variability in blood components, and the inability to provide continuous monitoring. These challenges hinder…
View article: Colorimetric Biosensors: Advancements in Nanomaterials and Cutting-Edge Detection Strategies
Colorimetric Biosensors: Advancements in Nanomaterials and Cutting-Edge Detection Strategies Open
Colorimetric-based biosensors are practical detection devices that can detect the presence and concentration of biomarkers through simple color changes. Conventional laboratory-based tests are highly sensitive but require long processing t…
View article: CRISPR/Cas-Based Nanobiosensor Using Plasmonic Nanomaterials to Detect Disease Biomarkers
CRISPR/Cas-Based Nanobiosensor Using Plasmonic Nanomaterials to Detect Disease Biomarkers Open
The development of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein (Cas) technology (CRISPR/Cas) as a gene-editing tool has the potential to revolutionize nucleic acid analysis. Recently, CR…
View article: Recent advances in two-dimensional materials for the diagnosis and treatment of neurodegenerative diseases
Recent advances in two-dimensional materials for the diagnosis and treatment of neurodegenerative diseases Open
With the size of the aging population increasing worldwide, the effective diagnosis and treatment of neurodegenerative diseases (NDDs) has become more important. Two-dimensional (2D) materials offer specific advantages for the diagnosis an…
View article: Recent Strategies for MicroRNA Detection: A Comprehensive Review of SERS-Based Nanobiosensors
Recent Strategies for MicroRNA Detection: A Comprehensive Review of SERS-Based Nanobiosensors Open
With advances in technology, diagnostic techniques have become more sophisticated and efficient at detecting biomarkers rapidly. Biomarkers such as microRNA (miRNA), which exhibit exceptional specificity and sensitivity compared with other…
View article: Recent Advances in Lateral Flow Assays for Viral Protein Detection with Nanomaterial-Based Optical Sensors
Recent Advances in Lateral Flow Assays for Viral Protein Detection with Nanomaterial-Based Optical Sensors Open
Controlling the progression of contagious diseases is crucial for public health management, emphasizing the importance of early viral infection diagnosis. In response, lateral flow assays (LFAs) have been successfully utilized in point-of-…
View article: One-Pot CRISPR-Cas12a-Based Viral DNA Detection via HRP-Enriched Extended ssDNA-Modified Au@Fe3O4 Nanoparticles
One-Pot CRISPR-Cas12a-Based Viral DNA Detection via HRP-Enriched Extended ssDNA-Modified Au@Fe3O4 Nanoparticles Open
In the context of virus outbreaks, the need for early and accurate diagnosis has become increasingly urgent. In addition to being crucial for effective disease control, timely and precise detection of viral infections is also necessary for…
View article: Human Motor System‐Based Biohybrid Robot‐On‐a‐Chip for Drug Evaluation of Neurodegenerative Disease
Human Motor System‐Based Biohybrid Robot‐On‐a‐Chip for Drug Evaluation of Neurodegenerative Disease Open
Biohybrid robots have been developed for biomedical applications and industrial robotics. However, the biohybrid robots have limitations to be applied in neurodegenerative disease research due to the absence of a central nervous system. In…
View article: An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection
An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection Open
Neurotransmitters are chemical compounds released by nerve cells, including neurons, astrocytes, and oligodendrocytes, that play an essential role in the transmission of signals in living organisms, particularly in the central nervous syst…
View article: In Situ Detection of Neuroinflammation Using Multicellular 3D Neurovascular‐Unit‐on‐a‐Chip
In Situ Detection of Neuroinflammation Using Multicellular 3D Neurovascular‐Unit‐on‐a‐Chip Open
The human neurovascular system is a complex network of blood vessels and brain cells that is essential to the proper functioning of the brain. Researchers have become increasingly interested in the system for developing drugs to treat neur…
View article: Horseradish Peroxidase-Encapsulated Fluorescent Bio-Nanoparticle for Ultra-Sensitive and Easy Detection of Hydrogen Peroxide
Horseradish Peroxidase-Encapsulated Fluorescent Bio-Nanoparticle for Ultra-Sensitive and Easy Detection of Hydrogen Peroxide Open
Hydrogen peroxide (H2O2) has been a fascinating target in various chemical, biological, clinical, and industrial fields. Several types of fluorescent protein-stabilized gold nanoclusters (protein-AuNCs) have been developed for sensitive an…
View article: Proteolytic Biosensors with Functional Nanomaterials: Current Approaches and Future Challenges
Proteolytic Biosensors with Functional Nanomaterials: Current Approaches and Future Challenges Open
Proteolytic enzymes are one of the important biomarkers that enable the early diagnosis of several diseases, such as cancers. A specific proteolytic enzyme selectively degrades a certain sequence of a polypeptide. Therefore, a particular p…
View article: Recent Development in Plasmonic Nanobiosensors for Viral DNA/RNA Biomarkers
Recent Development in Plasmonic Nanobiosensors for Viral DNA/RNA Biomarkers Open
Recently, due to the coronavirus pandemic, the need for early diagnosis of infectious diseases, including viruses, is emerging. Though early diagnosis is essential to prevent infection and progression to severe illness, there are few techn…
View article: Electroactive nano-Biohybrid actuator composed of gold nanoparticle-embedded muscle bundle on molybdenum disulfide nanosheet-modified electrode for motion enhancement of biohybrid robot
Electroactive nano-Biohybrid actuator composed of gold nanoparticle-embedded muscle bundle on molybdenum disulfide nanosheet-modified electrode for motion enhancement of biohybrid robot Open
View article: Fabrication of Hollow Nanocones Membrane with an Extraordinary Surface Area as CO2 Sucker
Fabrication of Hollow Nanocones Membrane with an Extraordinary Surface Area as CO2 Sucker Open
Recently, more and more attention has been paid to the development of eco-friendly solid sorbents that are cost-effective, noncorrosive, have a high gas capacity, and have low renewable energy for CO2 capture. Here, we claimed the fabricat…
View article: Biosensing System for Drug Evaluation of Amyotrophic Lateral Sclerosis Based on Muscle Bundle and Nano-Biohybrid Hydrogel Composed of Multiple Motor Neuron Spheroids and Carbon Nanotubes
Biosensing System for Drug Evaluation of Amyotrophic Lateral Sclerosis Based on Muscle Bundle and Nano-Biohybrid Hydrogel Composed of Multiple Motor Neuron Spheroids and Carbon Nanotubes Open
View article: Nanomaterial-Based Fluorescence Resonance Energy Transfer (FRET) and Metal-Enhanced Fluorescence (MEF) to Detect Nucleic Acid in Cancer Diagnosis
Nanomaterial-Based Fluorescence Resonance Energy Transfer (FRET) and Metal-Enhanced Fluorescence (MEF) to Detect Nucleic Acid in Cancer Diagnosis Open
Nucleic acids, including DNA and RNA, have received prodigious attention as potential biomarkers for precise and early diagnosis of cancers. However, due to their small quantity and instability in body fluids, precise and sensitive detecti…
View article: Microfluidic Chip-Based Cancer Diagnosis and Prediction of Relapse by Detecting Circulating Tumor Cells and Circulating Cancer Stem Cells
Microfluidic Chip-Based Cancer Diagnosis and Prediction of Relapse by Detecting Circulating Tumor Cells and Circulating Cancer Stem Cells Open
Detecting circulating tumor cells (CTCs) has been considered one of the best biomarkers in liquid biopsy for early diagnosis and prognosis monitoring in cancer. A major challenge of using CTCs is detecting extremely low-concentrated target…
View article: Microfluidic System to Analyze the Effects of Interleukin 6 on Lymphatic Breast Cancer Metastasis
Microfluidic System to Analyze the Effects of Interleukin 6 on Lymphatic Breast Cancer Metastasis Open
Metastasis is the primary cause of a large number of cancer-associated deaths. By portraying the precise environment of the metastasis process in vitro , the microfluidic system provides useful insights on the mechanisms underlying cancer …
View article: Electrochemical H2O2 biosensor based on horseradish peroxidase encapsulated protein nanoparticles with reduced graphene oxide-modified gold electrode
Electrochemical H2O2 biosensor based on horseradish peroxidase encapsulated protein nanoparticles with reduced graphene oxide-modified gold electrode Open
In this study, an electrochemical biosensor composed of a horseradish peroxidase (HRP)-encapsulated protein nanoparticles (HEPNP) was fabricated for the sensitive and selective detection of H 2 O 2 . The HEPNP has a three-dimensional struc…
View article: <i>In Situ</i> Detection of Neurotransmitters from Stem Cell-Derived Neural Interface at the Single-Cell Level via Graphene-Hybrid SERS Nanobiosensing
<i>In Situ</i> Detection of Neurotransmitters from Stem Cell-Derived Neural Interface at the Single-Cell Level via Graphene-Hybrid SERS Nanobiosensing Open
In situ quantitative measurements of neurotransmitter activities can provide useful insights into the underlying mechanisms of stem cell differentiation, the formation of neuronal networks, and neurodegenerative diseases. Currently,…
View article: Applications of Bionano Sensor for Extracellular Vesicles Analysis
Applications of Bionano Sensor for Extracellular Vesicles Analysis Open
Recently, extracellular vesicles (EVs) and their contents have been revealed to play crucial roles in the intrinsic intercellular communications and have received extensive attention as next-generation biomarkers for diagnosis of diseases …
View article: Noble Metal-Assisted Surface Plasmon Resonance Immunosensors
Noble Metal-Assisted Surface Plasmon Resonance Immunosensors Open
For the early diagnosis of several diseases, various biomarkers have been discovered and utilized through the measurement of concentrations in body fluids such as blood, urine, and saliva. The most representative analytical method for biom…
View article: Application of Conducting Polymer Nanostructures to Electrochemical Biosensors
Application of Conducting Polymer Nanostructures to Electrochemical Biosensors Open
Over the past few decades, nanostructured conducting polymers have received great attention in several application fields, including biosensors, microelectronics, polymer batteries, actuators, energy conversion, and biological applications…
View article: Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals
Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals Open
The biosensing platform is noteworthy for high sensitivity and precise detection of target analytes, which are related to the status of cells or specific diseases. The modification of the transducers with metallic nanoparticles (MNPs) has …
View article: In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device
In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device Open
The blood–brain barrier (BBB) plays critical role in the human physiological system such as protection of the central nervous system (CNS) from external materials in the blood vessel, including toxicants and drugs for several neurological …
View article: Magnetic-Assisted Cell Alignment within a Magnetic Nanoparticle-Decorated Reduced Graphene Oxide/Collagen 3D Nanocomposite Hydrogel
Magnetic-Assisted Cell Alignment within a Magnetic Nanoparticle-Decorated Reduced Graphene Oxide/Collagen 3D Nanocomposite Hydrogel Open
Hydrogel scaffolds are particularly interesting for applications in tissue engineering because of their ability to create a favorable environment which mimics in vivo conditions. However, the hierarchically ordered anisotropic structure wh…
View article: Magnetic assisted cell alignment within magnetic nanoparticle decorated reduced graphene oxide/ collagen 3D nanocomposite hydrogel
Magnetic assisted cell alignment within magnetic nanoparticle decorated reduced graphene oxide/ collagen 3D nanocomposite hydrogel Open
Video S1: Calcium image propagation of aligned SH-SY5Y cells within 3D construct Video S2: Calcium image propagation of un-aligned SH-SY5Y cells within 3D construct