Jianwen Wang
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View article: Effect of Supplemental Bamboo Leaf Extract on Milk Production, Composition, Biochemical Indices, and Fecal Microbiota Diversity in Grazing Yili Mares
Effect of Supplemental Bamboo Leaf Extract on Milk Production, Composition, Biochemical Indices, and Fecal Microbiota Diversity in Grazing Yili Mares Open
Purpose: This study investigated the effects of dietary bamboo leaf extract (BLE) on milk parameters and intestinal microbiota in lactating Yili mares. Methods: Twenty-four Yili mares of similar age (10 ± 2 years), weight (360.62 ± 15.23 k…
View article: Dietary Proline Supplementation Promotes Growth and Development in Weaned Foals by Modulating Gut Microbial Amino Acid Metabolism
Dietary Proline Supplementation Promotes Growth and Development in Weaned Foals by Modulating Gut Microbial Amino Acid Metabolism Open
This study investigated the effects of varying proline supplementation doses in weaned foals. Twenty-eight weaned foals (approximately 5 months of age; body weight: 54.45 ± 11.33 kg; with an equal number of males and females) were randomly…
View article: Multidimensional assessment of meat quality across anatomical regions of Kazakh horses: an integrative evaluation of meat quality traits, amino acid profiles, and fatty acid composition
Multidimensional assessment of meat quality across anatomical regions of Kazakh horses: an integrative evaluation of meat quality traits, amino acid profiles, and fatty acid composition Open
This study employed HE staining, LC-MS/MS, and related analytical techniques to assess meat quality, muscle fiber characteristics, and nutritional composition in five anatomical regions—longissimus dorsi (LD), diaphragm (DI), psoas major (…
View article: The characterization of adipose tissue in distinct anatomical regions of the Kazakh horse: a comprehensive analysis of the morphology, fatty acid profile, and lipidomic profile
The characterization of adipose tissue in distinct anatomical regions of the Kazakh horse: a comprehensive analysis of the morphology, fatty acid profile, and lipidomic profile Open
The Kazakh horse is one of the important horse breeds in China. The distribution of its adipose tissue and the characteristics of lipid metabolism play a crucial role in the horse’s fat utilization efficiency, meat quality, and energy stor…
View article: Molecular Mechanisms Underlying Differences in Athletic Ability in Racehorses Based on Whole Transcriptome Sequencing
Molecular Mechanisms Underlying Differences in Athletic Ability in Racehorses Based on Whole Transcriptome Sequencing Open
This study aimed to compare blood samples from Yili horses with outstanding and average performance in 5000 m races through transcriptome sequencing, identify key differentially expressed genes, lncRNAs, and circRNAs, as well as related en…
View article: Comparative analysis of miRNA expression in Yili horses pre- and post-5000-m race
Comparative analysis of miRNA expression in Yili horses pre- and post-5000-m race Open
Equine athletic performance is modulated by both genetic and epigenetic mechanisms. As dynamic regulators of gene expression, MicroRNAs (miRNAs) play a central role in the physiological response to exercise-induced stress18. This study foc…
View article: Single-Cell Transcriptomic Profiling of Longissimus Dorsi and Biceps Femoris Muscles in Kazakh Horses Reveals Cellular Heterogeneity and Myogenic Regulation
Single-Cell Transcriptomic Profiling of Longissimus Dorsi and Biceps Femoris Muscles in Kazakh Horses Reveals Cellular Heterogeneity and Myogenic Regulation Open
Kazakh horses are renowned for their endurance and adaptability, with distinct muscle groups such as the longissimus dorsi (LD) and biceps femoris (BF) muscles serving specialized functions. However, the molecular mechanisms underlying the…
View article: Bridging Breeds: Transcriptomic Insights into Immune Traits of Yili, Thoroughbred, and Kazakh Horses
Bridging Breeds: Transcriptomic Insights into Immune Traits of Yili, Thoroughbred, and Kazakh Horses Open
Background: Studying the genetic characteristics and molecular mechanisms of immune regulation in horses is of great significance for protecting their genetic resources, improving breeding strategies, and enhancing their disease resistance…
View article: Mechanisms of Variation in Abdominal Adipose Color Among Male Kazakh Horses Through Non-Coding RNA Sequencing
Mechanisms of Variation in Abdominal Adipose Color Among Male Kazakh Horses Through Non-Coding RNA Sequencing Open
The Kazakh horse is a highly valuable indigenous Chinese breed known for its use in both milk and meat production. However, the mechanisms underlying color variation in the abdominal adipose tissue of this breed remain poorly understood. I…
View article: Whole Transcriptome Sequencing and Differential Analysis of Testes in Pre- and Post-Sexual Maturity Bactrian Camels (Camelus bactrianus)
Whole Transcriptome Sequencing and Differential Analysis of Testes in Pre- and Post-Sexual Maturity Bactrian Camels (Camelus bactrianus) Open
Testicular development in male animals is a conserved and highly regulated biological process. Investigating the molecular mechanisms underlying testicular development in Junggar Bactrian camels is essential for gaining a deeper understand…
View article: Transcriptome Analysis of Muscle Tissue from Three Anatomical Locations in Male and Female Kazakh Horses
Transcriptome Analysis of Muscle Tissue from Three Anatomical Locations in Male and Female Kazakh Horses Open
The Kazakh horse, a versatile breed, is renowned for stable genetic performance and strong tolerance to coarse feed. Sex is a key factor influencing skeletal muscle development. However, the mechanisms underlying sex-specific regulation of…
View article: Comparative analysis of blood whole transcriptome profiles in Yili horses pre- and post-5000-meter racing
Comparative analysis of blood whole transcriptome profiles in Yili horses pre- and post-5000-meter racing Open
This study employed Yili horses participating in a 5000-meter race as a model to investigate exercise-induced gene expression alterations in peripheral blood using whole transcriptome sequencing. Jugular vein blood samples from the three l…
View article: Metagenomic Analysis Reveals the Anti-Inflammatory Properties of Mare Milk
Metagenomic Analysis Reveals the Anti-Inflammatory Properties of Mare Milk Open
This study aimed to assess the anti-inflammatory properties of mare milk by analyzing immune markers in mice following gavage of mare milk. Metagenomic sequencing was employed to examine variations in the composition and functional profile…
View article: Transcriptome Sequencing and Differential Analysis of Ovaries Across Diverse States (Follicular and Non-Follicular Phases)
Transcriptome Sequencing and Differential Analysis of Ovaries Across Diverse States (Follicular and Non-Follicular Phases) Open
The Kazakh horse, one of China’s indigenous primitive breeds, is renowned for its remarkable adaptability and distinctive physiological traits. The ovary is a vital reproductive organ in female animals, responsible for oocyte production an…
View article: Influence of Pregnancy on Whole-Transcriptome Sequencing in the Mammary Gland of Kazakh Mares
Influence of Pregnancy on Whole-Transcriptome Sequencing in the Mammary Gland of Kazakh Mares Open
Kazakh mares have drawn significant attention for their outstanding lactation traits. Lactation, a complex physiological activity, is modulated by multiple factors. This study utilized high-throughput sequencing to conduct whole-transcript…
View article: Whole-Transcriptome Sequencing and Differential Expression Analysis of the Epididymis in Junggar Bactrian Camels Before and After Sexual Maturity
Whole-Transcriptome Sequencing and Differential Expression Analysis of the Epididymis in Junggar Bactrian Camels Before and After Sexual Maturity Open
The Junggar Bactrian camel, a primitive indigenous breed in China, exhibits low reproductive efficiency under natural grazing conditions. This is partly attributed to the development of the epididymis and the quality of semen, both of whic…
View article: F.7 Chromosome 1p loss and 1q gain are highly prognostic and can inform WHO grading of meningioma
F.7 Chromosome 1p loss and 1q gain are highly prognostic and can inform WHO grading of meningioma Open
Background: The WHO grade of meningioma was updated in 2021 to include homozygous deletions of CDKN2A/B and TERT promotor mutations. Previous work including the recent cIMPACT-NOW statement have discussed the potential value of including c…
View article: Effects of Different Stages of Training on the Intestinal Microbes of Yili Horses Analyzed Using Metagenomics
Effects of Different Stages of Training on the Intestinal Microbes of Yili Horses Analyzed Using Metagenomics Open
Objectives: The aim of this study was to investigate the effects of different stages of training on the intestinal microbial abundance of Yili horses. Methods: Ten Yili horses, all aged 2 years old and weighing 305 ± 20 kg, were selected a…
View article: Plasma Lipidomics and Proteomics Analyses Pre- and Post-5000 m Race in Yili Horses
Plasma Lipidomics and Proteomics Analyses Pre- and Post-5000 m Race in Yili Horses Open
The impact of exercise on human metabolism has been extensively studied, yet limited research exists on the effects of high-intensity racing on equine metabolism. The aim of this study was to screen the effect of a 5000 m race on lipids an…
View article: Absolute Quantitative Lipidomics Reveals Differences in Lipid Compounds in the Blood of Trained and Untrained Yili Horses
Absolute Quantitative Lipidomics Reveals Differences in Lipid Compounds in the Blood of Trained and Untrained Yili Horses Open
The purpose of this study was to explore the relationship between blood lipid levels and the differences in cardiac structure and function of trained and untrained Yili horses as related to exercise performance. We utilized quantitative li…
View article: Regulatory Mechanisms of Yili Horses During an 80 km Race Based on Transcriptomics and Metabolomics Analyses
Regulatory Mechanisms of Yili Horses During an 80 km Race Based on Transcriptomics and Metabolomics Analyses Open
Equine endurance exercise induces physiological changes that alter metabolism and molecular pathways to maintain balance after intense physical activity. However, the specific regulatory mechanisms remain under debate. Identifying differen…
View article: The Impact of the Competition on miRNA, Proteins, and Metabolites in the Blood Exosomes of the Yili Horse
The Impact of the Competition on miRNA, Proteins, and Metabolites in the Blood Exosomes of the Yili Horse Open
Purpose: Horse racing may cause stress-induced physiological changes and tissue damage in horses, but the changes in miRNA expression, protein expression, and metabolic substances in the plasma exosomes of the Yili horse after racing are s…
View article: Effects of Combined Transcriptome and Metabolome Analysis Training on Athletic Performance of 2-Year-Old Trot-Type Yili Horses
Effects of Combined Transcriptome and Metabolome Analysis Training on Athletic Performance of 2-Year-Old Trot-Type Yili Horses Open
Objectives: Training is essential for enhancing equine athletic performance, but the genetic mechanisms that regulate athletic performance are unknown. Therefore, this paper aims to identify candidate genes and metabolic pathways for the e…
View article: Integrated traditional Chinese and western nursing care of an elderly patient with toxic epidermal necrolysis complicated by malignant tumors of the prostate
Integrated traditional Chinese and western nursing care of an elderly patient with toxic epidermal necrolysis complicated by malignant tumors of the prostate Open
To summarize the experience of integrated traditional Chinese and western nursing care of an elderly patient with toxic epidermal necrolysis complicated by malignant tumors of the prostate. The patient was treated using a combination of tr…
View article: Strategies for Constructing Osteosarcoma 3D Culture Models and Progress in Their Applications
Strategies for Constructing Osteosarcoma 3D Culture Models and Progress in Their Applications Open
Osteosarcoma is a highly malignant primary bone tumor, and traditional two-dimensional (2D) culture methods cannot accurately simulate the tumor microenvironment. Three-dimensional (3D) culture better simulates the in vivo tumor microenvir…
View article: Discordance Between Angiographic Assessment and Fractional Flow Reserve or Intravascular Ultrasound in Intermediate Coronary Lesions: A Post-hoc Analysis of the FLAVOUR Trial
Discordance Between Angiographic Assessment and Fractional Flow Reserve or Intravascular Ultrasound in Intermediate Coronary Lesions: A Post-hoc Analysis of the FLAVOUR Trial Open
ClinicalTrials.gov Identifier: NCT02673424.
View article: [Impact of nonsteroidal anti-inflammatory drugs on efficacy of anti-PD-1 therapy for primary liver cancer].
[Impact of nonsteroidal anti-inflammatory drugs on efficacy of anti-PD-1 therapy for primary liver cancer]. Open
Our results show no favorable effect of NSAIDs on the efficacy of immunotherapy in patients with advanced primary liver cancer, but this finding still needs to be verified by future prospective studies of large cohorts.
View article: Real-time and Multi-physics Fiber Optic Monitoring of Landslides in Three Gorges Reservoir Area
Real-time and Multi-physics Fiber Optic Monitoring of Landslides in Three Gorges Reservoir Area Open
Accurate and real-time measurement of the evolution of landslides has become a great concern in recent years. Fiber Bragg grating (FBG), as a popular quasi-distributed fiber optic sensing technology, has been successfully applied to geotec…
View article: [Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by blocking spike protein-mediated membrane fusion].
[Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by blocking spike protein-mediated membrane fusion]. Open
Sal-B and its magnesium salt ZDDY can inhibit the entry of SARS-CoV-2 in Vero-E6 cells in vitro by blocking SARS-CoV-2 spike protein-mediated virus-cell membrane fusion.
View article: Inflammatory Cytokines Alter Mesenchymal Stem Cell Mechanosensing and Adhesion on Stiffened Infarct Heart Tissue After Myocardial Infarction
Inflammatory Cytokines Alter Mesenchymal Stem Cell Mechanosensing and Adhesion on Stiffened Infarct Heart Tissue After Myocardial Infarction Open
Mesenchymal stem cell (MSC) transplantation has demonstrated its potential in repairing infarct heart tissue and recovering heart function after myocardial infarction (MI). However, its therapeutic effect is still limited due to poor MSC e…