Jinil Han
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View article: Plasma-based digital PCR assay for early detection of gastric cancer using multiple methylation biomarkers
Plasma-based digital PCR assay for early detection of gastric cancer using multiple methylation biomarkers Open
Endoscopy is the gold standard for diagnosing gastric cancer (GC), but its invasiveness limits widespread participation and has not substantially reduced GC-related mortality. This study developed and validated a blood-based digital PCR as…
View article: Predicting the Response of Neoadjuvant Chemotherapy in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer With Axillary Lymph Node Metastasis by Multigene Assay
Predicting the Response of Neoadjuvant Chemotherapy in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer With Axillary Lymph Node Metastasis by Multigene Assay Open
We demonstrated that the BCT score predicts NACT responsiveness in HR+/HER2- BC with LN metastasis and might help determine whether NACT should be performed. Further studies are required to validate these results.
View article: Predicting the response of neoadjuvant chemotherapy in hormone receptor- positive and HER2-negative breast cancer with axillary lymph node metastasis by a multigene assay (GenesWell™ BCT)
Predicting the response of neoadjuvant chemotherapy in hormone receptor- positive and HER2-negative breast cancer with axillary lymph node metastasis by a multigene assay (GenesWell™ BCT) Open
The GenesWell™ BCT (BCT score) is a recently developed multigene assay that predicts the risk of distant recurrence in patients with hormone receptor-positive (HR+) and HER2 negative (HER2-) early breast cancer (BC). The ability of the ass…
View article: Validation of the GenesWell BCT Score in Young Asian Women With HR+/HER2− Early Breast Cancer
Validation of the GenesWell BCT Score in Young Asian Women With HR+/HER2− Early Breast Cancer Open
Background The prognostic or predictive value of commonly used multigene assays in young patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) early breast cancer is unclear. In this study…
View article: UBE2C Overexpression Aggravates Patient Outcome by Promoting Estrogen-Dependent/Independent Cell Proliferation in Early Hormone Receptor-Positive and HER2-Negative Breast Cancer
UBE2C Overexpression Aggravates Patient Outcome by Promoting Estrogen-Dependent/Independent Cell Proliferation in Early Hormone Receptor-Positive and HER2-Negative Breast Cancer Open
We previously showed that UBE2C mRNA expression is significantly associated with poor prognosis only in patients with hormone receptor (HR)+/human epidermal growth factor receptor 2 (HER2)– breast cancer. In this study, we further reanalyz…
View article: DKK1 Induced by 1,25D3 Is Required for the Mineralization of Osteoblasts
DKK1 Induced by 1,25D3 Is Required for the Mineralization of Osteoblasts Open
1α,25-dihydroxyvitamin D3 (1,25D3), the most popular drug for osteoporosis treatment, drives osteoblast differentiation and bone mineralization. Wnt/β-catenin signaling is involved in commitment and differentiation of osteoblasts, but the …
View article: Optimizing the Operation of Animal Shelters to Minimize Unnecessary Euthanasia: A Case Study in the Seoul Capital Area
Optimizing the Operation of Animal Shelters to Minimize Unnecessary Euthanasia: A Case Study in the Seoul Capital Area Open
To build a sustainable social system in the future, the promotion of animal welfare, as well as human welfare, is essential. In this study, we address the issues related to animal euthanasia that are commonly encountered in animal shelters…
View article: Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2
Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2 Open
Silent information regulator 2 (Sirtuin2 / SIRT2) is a NAD+-dependent deacetylase that regulates the cellular oxidative stress response. It modulates transcriptional silencing and protein stability through deacetylation of target proteins …
View article: Comparison of GenesWell BCT Score With Oncotype DX Recurrence Score for Risk Classification in Asian Women With Hormone Receptor-Positive, HER2-Negative Early Breast Cancer
Comparison of GenesWell BCT Score With Oncotype DX Recurrence Score for Risk Classification in Asian Women With Hormone Receptor-Positive, HER2-Negative Early Breast Cancer Open
Introduction: The GenesWell Breast Cancer Test (BCT) is a recently developed multigene assay that predicts the risk of distant recurrence in patients with early breast cancer. Here, we analyzed the concordance of the BCT score with the Onc…
View article: CCAAT/enhancer-binding protein beta (C/EBPβ) is an important mediator of 1,25 dihydroxyvitamin D3 (1,25D3)-induced receptor activator of nuclear factor kappa-B ligand (RANKL) expression in osteoblasts
CCAAT/enhancer-binding protein beta (C/EBPβ) is an important mediator of 1,25 dihydroxyvitamin D3 (1,25D3)-induced receptor activator of nuclear factor kappa-B ligand (RANKL) expression in osteoblasts Open
Receptor activator of nuclear factor kappa B ligand (RANKL) expression in osteoblasts is regulated by 1,25-dihydroxyvitamin D3 (1,25D3). CCAAT/enhancer-binding protein beta (C/EBPβ) has been proposed to function as a transcription factor a…
View article: Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors
Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors Open
Significance Transient receptor potential melastatin type 2 (TRPM2) is an oxidative stress-sensing calcium-permeable channel that is thought to contribute to the calcium influx associated with neurodegenerative diseases. Here we show that …
View article: BCT score predicts chemotherapy benefit in Asian patients with hormone receptor-positive, HER2-negative, lymph node-negative breast cancer
BCT score predicts chemotherapy benefit in Asian patients with hormone receptor-positive, HER2-negative, lymph node-negative breast cancer Open
The Breast Cancer Test (BCT) score has been validated for its ability to predict the risk of distant metastasis in hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer. This study aimed to…
View article: Erratum: ESRP1 is overexpressed in ovarian cancer and promotes switching from mesenchymal to epithelial phenotype in ovarian cancer cells
Erratum: ESRP1 is overexpressed in ovarian cancer and promotes switching from mesenchymal to epithelial phenotype in ovarian cancer cells Open
Correction to: Oncogenesis (2017) 6, e389; doi:10.1038/oncsis.2017.87; Published online 9 October 2017 The legend of Figure 5 was published incorrectly. The correct legend should read as follows: Figure 5. Association between ESRP1 gene ex…
View article: ESRP1 is overexpressed in ovarian cancer and promotes switching from mesenchymal to epithelial phenotype in ovarian cancer cellsThis article has been corrected since Advance Online Publication and an erratum is also printed in this issue
ESRP1 is overexpressed in ovarian cancer and promotes switching from mesenchymal to epithelial phenotype in ovarian cancer cellsThis article has been corrected since Advance Online Publication and an erratum is also printed in this issue Open
Epithelial splicing regulatory protein 1 (ESRP1) and 2 (ESRP2), epithelial cell-specific regulators of alternative splicing, are downregulated during the epithelial–mesenchymal transition (EMT). These factors have roles in tumor progressio…
View article: Genes co-amplified with <i>ERBB2</i> or <i>MET</i> as novel potential cancer-promoting genes in gastric cancer
Genes co-amplified with <i>ERBB2</i> or <i>MET</i> as novel potential cancer-promoting genes in gastric cancer Open
Gastric cancer (GC), one of the most common cancers worldwide, has a high mortality rate due to limited treatment options. Identifying novel and promising molecular targets is a major challenge that must be overcome if treatment of advance…
View article: An Analytical Validation of the GenesWell<sup>TM</sup> BCT Multigene Prognostic Test in Patients with Early Breast Cancer
An Analytical Validation of the GenesWell<sup>TM</sup> BCT Multigene Prognostic Test in Patients with Early Breast Cancer Open
Jee-Eun Kim, Byeong-il Kang, Seung-Min Bae, Saebom Han, Areum Jun, Jinil Han, Min-ah Cho, Yoon-La Choi, Jong-Heun Lee, and Young-Ho Moon. Korean J Clin Lab Sci. 2017;49:79-87. https://doi.org/10.15324/kjcls.2017.49.2.79
View article: Targeted exome sequencing of Korean triple-negative breast cancer reveals homozygous deletions associated with poor prognosis of adjuvant chemotherapy-treated patients
Targeted exome sequencing of Korean triple-negative breast cancer reveals homozygous deletions associated with poor prognosis of adjuvant chemotherapy-treated patients Open
Triple-negative breast cancer is characterized by the absence of estrogen and progesterone receptors and human epidermal growth factor receptor 2, and is associated with a poorer outcome than other subtypes of breast cancer. Moreover, ther…
View article: CD24 Overexpression Is Associated with Poor Prognosis in Luminal A and Triple-Negative Breast Cancer
CD24 Overexpression Is Associated with Poor Prognosis in Luminal A and Triple-Negative Breast Cancer Open
CD24 is associated with unfavourable prognoses in various cancers, but the prevalence of CD24 expression and its influence on clinical outcome in subtypes of breast cancers remain unclear. CD24 expression was analyzed by immunohistochemist…