Jun Wu
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View article: Pre-clinical evaluation of a potent and effective Pin1-degrading agent in pancreatic cancer
Pre-clinical evaluation of a potent and effective Pin1-degrading agent in pancreatic cancer Open
View article: Coinhibition of the MEK/RTK pathway has high therapeutic efficacy in KRAS-mutant non-small cell lung cancer
Coinhibition of the MEK/RTK pathway has high therapeutic efficacy in KRAS-mutant non-small cell lung cancer Open
Oncogenic KRAS mutations are frequently detected in NSCLC. It remains a major challenge to target all KRAS mutants. MEK inhibitors are considered candidates for treating KRAS-mutant NSCLC; however, their easy adaptive resistance precludes …
View article: Uncovering stromal cell fate genes and a novel risk stratification in UCEC by integrating single-cell RNA sequencing and multi-omics analysis
Uncovering stromal cell fate genes and a novel risk stratification in UCEC by integrating single-cell RNA sequencing and multi-omics analysis Open
View article: VirulentHunter: deep learning-based virulence factor predictor illuminates pathogenicity in diverse microbial contexts
VirulentHunter: deep learning-based virulence factor predictor illuminates pathogenicity in diverse microbial contexts Open
Virulence factors (VFs) are critical determinants of bacterial pathogenicity, but current homology-based identification methods often miss novel or divergent VFs, and many machine learning approaches neglect functional classification. Here…
View article: EMitool: Explainable Multi-Omics Integration for Disease Subtyping
EMitool: Explainable Multi-Omics Integration for Disease Subtyping Open
Disease subtyping is essential for personalized medicine, enabling tailored treatment strategies based on disease heterogeneity. Advances in high-throughput technologies have led to the rapid accumulation of multi-omics data, driving the d…
View article: Case report: post COVID-19 encephalopathy and oral cenesthopathy
Case report: post COVID-19 encephalopathy and oral cenesthopathy Open
View article: Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells
Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells Open
Natural products have long been a viable source of therapeutic agents, providing unique structures and mechanisms that may be beneficial for cancer treatment. Herein we first report on the anticancer activity OST-01, a natural product from…
View article: A novel signature predicts prognosis in pancreatic cancer based on tumor membrane-associated genes
A novel signature predicts prognosis in pancreatic cancer based on tumor membrane-associated genes Open
View article: Pan-cancer analysis of CLDN18.2 shed new insights on the targeted therapy of upper gastrointestinal tract cancers
Pan-cancer analysis of CLDN18.2 shed new insights on the targeted therapy of upper gastrointestinal tract cancers Open
Background CLDN18.2 is a widely researched drug target. However, previous research has primarily been based on immunohistochemistry results and focused on gastric cancer. Methods To analyze the potential cancer-targeting effect of CLDN18.2…
View article: 6-Phosphogluconate dehydrogenase promotes glycolysis and fatty acid synthesis by inhibiting the AMPK pathway in lung adenocarcinoma cells
6-Phosphogluconate dehydrogenase promotes glycolysis and fatty acid synthesis by inhibiting the AMPK pathway in lung adenocarcinoma cells Open
Abnormal metabolism has emerged as a prominent hallmark of cancer and plays a pivotal role in carcinogenesis and progression of lung adenocarcinoma (LUAD). In this study, single-cell sequencing revealed that the metabolic enzyme 6-phosphog…
View article: Landscape of global urban environmental resistome and its association with local socioeconomic and medical status
Landscape of global urban environmental resistome and its association with local socioeconomic and medical status Open
View article: Enhanced Photocatalytic Degradation of Polycyclic Aromatic Hydrocarbons (Pahs) in Biochar Using Nano-Tio2 Under Ultraviolet Light Irradiation: Effect and Mechanisms
Enhanced Photocatalytic Degradation of Polycyclic Aromatic Hydrocarbons (Pahs) in Biochar Using Nano-Tio2 Under Ultraviolet Light Irradiation: Effect and Mechanisms Open
View article: PLM-ARG: antibiotic resistance gene identification using a pretrained protein language model
PLM-ARG: antibiotic resistance gene identification using a pretrained protein language model Open
Motivation Antibiotic resistance presents a formidable global challenge to public health and the environment. While considerable endeavors have been dedicated to identify antibiotic resistance genes (ARGs) for assessing the threat of antib…
View article: Identification of a two metastasis-related prognostic signature in the process of predicting the survival of laryngeal squamous cell carcinoma
Identification of a two metastasis-related prognostic signature in the process of predicting the survival of laryngeal squamous cell carcinoma Open
View article: Data and code for: <b>Urbanization Ages Linked to Differences in Microbial Community Composition and Diversity</b>
Data and code for: <b>Urbanization Ages Linked to Differences in Microbial Community Composition and Diversity</b> Open
Data and code in this study.
View article: Urban Governance Information Classification Method Based on BERT-TextCNN
Urban Governance Information Classification Method Based on BERT-TextCNN Open
In view of the existing Word2Vec traditional word vector model cannot solve the problem of text context semantics, this paper proposes a network model BERT-TextCNN for text classification of urban governance information based on the combin…
View article: An Enriched Environment Improves the Motor Function of Cerebral Infarction Mice by Promoting mTOR-Dependent Autophagy in the Contralateral Dentate Nucleus
An Enriched Environment Improves the Motor Function of Cerebral Infarction Mice by Promoting mTOR-Dependent Autophagy in the Contralateral Dentate Nucleus Open
View article: Identification of Differentially Expressed Genes Related to the Lipid Metabolism of Esophageal Squamous Cell Carcinoma by Integrated Bioinformatics Analysis
Identification of Differentially Expressed Genes Related to the Lipid Metabolism of Esophageal Squamous Cell Carcinoma by Integrated Bioinformatics Analysis Open
Purpose: In recent years, lipid metabolism has been reprogrammed to meet the energy and substrate needs of tumorigenesis and development and is a potential new target for cancer treatment. However, the regulatory mechanism of lipid metabol…
View article: 2cChIP-seq and 2cMeDIP-seq: The Carrier-Assisted Methods for Epigenomic Profiling of Small Cell Numbers or Single Cells
2cChIP-seq and 2cMeDIP-seq: The Carrier-Assisted Methods for Epigenomic Profiling of Small Cell Numbers or Single Cells Open
Chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq) can profile genome-wide epigenetic marks associated with regulatory genomic elements. However, conventional ChIP-seq is challenging when examining limited num…
View article: Investigation of small lung lesion detection for lung cancer screening in low dose FDG PET imaging by deep neural networks
Investigation of small lung lesion detection for lung cancer screening in low dose FDG PET imaging by deep neural networks Open
Purpose FDG PET imaging is often recommended for the diagnosis of pulmonary nodules after indeterminate low dose CT lung cancer screening. Lowering FDG injecting is desirable for PET imaging. In this work, we aimed to investigate the perfo…
View article: Blood-based tumour mutation index act as prognostic predictor for immunotherapy and chemotherapy in non-small cell lung cancer patients
Blood-based tumour mutation index act as prognostic predictor for immunotherapy and chemotherapy in non-small cell lung cancer patients Open
Background Circulating tumour DNA (ctDNA)-based sequencing might provide a simple test for the stratified model of non-small cell lung cancer (NSCLC). Here, we aimed to assess the ctDNA sequencing-based tumour mutation index (TMI) model fo…
View article: The Role of Lipid Metabolism in Gastric Cancer
The Role of Lipid Metabolism in Gastric Cancer Open
Gastric cancer has been one of the most common cancers worldwide with extensive metastasis and high mortality. Chemotherapy has been found as a main treatment for metastatic gastric cancer, whereas drug resistance limits the effectiveness …
View article: Comparative transcriptome analysis of resistant and susceptible wheat in response to Rhizoctonia cerealis
Comparative transcriptome analysis of resistant and susceptible wheat in response to Rhizoctonia cerealis Open
View article: Effects of Thoracic Paravertebral Block on Inflammatory Response, Stress Response,Hemodynamics and Anesthesia Resuscitation in Gallbladder Carcinoma
Effects of Thoracic Paravertebral Block on Inflammatory Response, Stress Response,Hemodynamics and Anesthesia Resuscitation in Gallbladder Carcinoma Open
The study aimed to explore the effects of the ultrasound-guided thoracic paravertebral block (TPVB) on the inflammatory response, stress response, hemodynamics and anesthesia resuscitation in gallbladder carcinoma. Eighty gallbladder carci…
View article: Proteomic Quantification of Lysine Acetylation and Succinylation Profile Alterations in Lung Adenocarcinomas of Non-Smoking Females
Proteomic Quantification of Lysine Acetylation and Succinylation Profile Alterations in Lung Adenocarcinomas of Non-Smoking Females Open
This study provides insight into lung adenocarcinomas acetylation and succinylation profile alterations in carcinoma pathogenesis and provides a potential therapeutic target for lung adenocarcinomas.
View article: Propofol suppresses proliferation, migration, invasion, and tumor growth of liver cancer cells via suppressing cancer susceptibility candidate 9/phosphatase and tensin homolog/AKT serine/threonine kinase/mechanistic target of rapamycin kinase axis
Propofol suppresses proliferation, migration, invasion, and tumor growth of liver cancer cells via suppressing cancer susceptibility candidate 9/phosphatase and tensin homolog/AKT serine/threonine kinase/mechanistic target of rapamycin kinase axis Open
Propofol is a commonly used drug for sedation and general anesthesia during cancer surgery. Previous studies indicate that propofol exerts anti-tumor effect in various cancers. The aim of this study was to investigate the underlying molecu…
View article: A Novel Risk-Score Model With Eight MiRNA Signatures for Overall Survival of Patients With Lung Adenocarcinoma
A Novel Risk-Score Model With Eight MiRNA Signatures for Overall Survival of Patients With Lung Adenocarcinoma Open
Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer with heterogeneous outcomes and diverse therapeutic responses. To classify patients into different groups and facilitate the suitable therapeutic strategy, we first selec…
View article: Annotating unknown species of urban microorganisms on a global scale unveils novel functional diversity and local environment association
Annotating unknown species of urban microorganisms on a global scale unveils novel functional diversity and local environment association Open
View article: Aberrant lipid metabolism reprogramming and immune microenvironment for gastric cancer: a literature review
Aberrant lipid metabolism reprogramming and immune microenvironment for gastric cancer: a literature review Open
Recent research suggests that targeting metabolism is an emerging and potentially promising treatment strategy for gastric cancer patients. We need to explore it further.
View article: Effects of low lead exposure on sperm quality and sperm DNA methylation in adult men
Effects of low lead exposure on sperm quality and sperm DNA methylation in adult men Open