Jinjun Dang
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View article: CBFA2T3-GLIS2 mediates transcriptional regulation of developmental pathways through a gene regulatory network
CBFA2T3-GLIS2 mediates transcriptional regulation of developmental pathways through a gene regulatory network Open
CBFA2T3-GLIS2 is a fusion oncogene found in pediatric acute megakaryoblastic leukemia that is associated with a poor prognosis. We establish a model of CBFA2T3-GLIS2 driven acute megakaryoblastic leukemia that allows the distinction of fus…
View article: Supplementary Tables 1-5 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma
Supplementary Tables 1-5 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma Open
Supplementary Table 1. Validated Tier 1-3 Mutation CallsSupplementary Table 2. Genes Upregulated in CIC-NUTM2ASupplementary Table 3. CIC-NUTM2A Gene Set Enrichment Analysis in Pediatric Hematologic MalignanciesSupplementary Table 4. ssGSEA…
View article: Supplementary Figures 1-7 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma
Supplementary Figures 1-7 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma Open
Supplementary Methods and FiguresSupplementary Figure 1. A newborn with isolated myeloid sarcoma.Supplementary Figure 2. Myeloid Sarcoma Histology.Supplementary Figure 3. Bone Marrow.Supplementary Figure 4. Genes Upregulated in CIC-NUTM2A.…
View article: Data from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma
Data from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma Open
Myeloid sarcoma is a rare condition consisting of extramedullary myeloid blasts found in association with acute myeloid leukemia or, in the absence of bone marrow involvement. We identified an infant with isolated myeloid sarcoma whose bon…
View article: Supplementary Figures 1-7 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma
Supplementary Figures 1-7 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma Open
Supplementary Methods and FiguresSupplementary Figure 1. A newborn with isolated myeloid sarcoma.Supplementary Figure 2. Myeloid Sarcoma Histology.Supplementary Figure 3. Bone Marrow.Supplementary Figure 4. Genes Upregulated in CIC-NUTM2A.…
View article: Supplementary Tables 1-5 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma
Supplementary Tables 1-5 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma Open
Supplementary Table 1. Validated Tier 1-3 Mutation CallsSupplementary Table 2. Genes Upregulated in CIC-NUTM2ASupplementary Table 3. CIC-NUTM2A Gene Set Enrichment Analysis in Pediatric Hematologic MalignanciesSupplementary Table 4. ssGSEA…
View article: Data from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma
Data from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma Open
Myeloid sarcoma is a rare condition consisting of extramedullary myeloid blasts found in association with acute myeloid leukemia or, in the absence of bone marrow involvement. We identified an infant with isolated myeloid sarcoma whose bon…
View article: Therapy‐related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature
Therapy‐related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature Open
Therapy‐related myeloid neoplasms (t‐MN) are a distinct subgroup of myeloid malignancies with a poor prognosis that include cases of therapy‐related myelodysplastic syndrome (t‐MDS), therapy‐related myeloproliferative neoplasms (t‐MPN) and…
View article: Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia
Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia Open
IGH@ proto-oncogene translocation is a common oncogenic event in lymphoid lineage cancers such as B-ALL, lymphoma and multiple myeloma. Here, to investigate the interplay between IGH@ proto-oncogene translocation and IGH allelic exclusion,…
View article: Immunophenotyping of Murine Precursor B-Cell Leukemia/Lymphoma: A Comparison of Immunohistochemistry and Flow Cytometry
Immunophenotyping of Murine Precursor B-Cell Leukemia/Lymphoma: A Comparison of Immunohistochemistry and Flow Cytometry Open
In humans and in mouse models, precursor B-cell lymphoblastic leukemia (B-ALL)/lymphoblastic lymphoma (B-LBL) can be classified as either the pro-B or pre-B subtype. This is based on the expression of antigens associated with the pro-B and…
View article: A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML
A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML Open
Improvement in survival has been achieved for children and adolescents with AML but is largely attributed to enhanced supportive care as opposed to the development of better treatment regimens. High risk subtypes continue to have poor outc…
View article: Pediatric non–Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes
Pediatric non–Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes Open
View article: The genomic landscape of core-binding factor acute myeloid leukemias
The genomic landscape of core-binding factor acute myeloid leukemias Open
View article: PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia
PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia Open
Key Points Heterozygous alterations of Pax5, the most common target of genetic alteration in ALL, promote ALL in mouse mutagenesis models. Leukemia development is accompanied by the acquisition of genetic alterations commonly observed in h…
View article: The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias Open