Jinlin Miao
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View article: Brain network predictors of changes in symptoms and serum BDNF following antidepressant treatment with escitalopram and Yueju Pill in major depressive disorder: a randomised, double-blind, placebo-controlled pilot study
Brain network predictors of changes in symptoms and serum BDNF following antidepressant treatment with escitalopram and Yueju Pill in major depressive disorder: a randomised, double-blind, placebo-controlled pilot study Open
Background Yueju Pill, a classic traditional Chinese medicine, shows antidepressant effects rapidly. However, biomarkers that can predict its treatment outcomes in major depressive disorder (MDD) are still lacking. Multimodal magnetic reso…
View article: Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization
Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization Open
Vascular restenosis is a serious clinical issue initiated and aggravated by macrophage inflammation, with no effective treatments available, in cardiovascular and autoimmune diseases. However, the untapped mechanisms and new targets that c…
View article: The dual role of tissue regulatory T cells in tissue repair: return to homeostasis or fibrosis
The dual role of tissue regulatory T cells in tissue repair: return to homeostasis or fibrosis Open
Tissue resident regulatory T cells (tissue Tregs) are vital for maintaining immune homeostasis and controlling inflammation. They aid in repairing damaged tissues and influencing the progression of fibrosis. However, despite extensive rese…
View article: Id2 exacerbates the development of rheumatoid arthritis by increasing IFN‐γ production in CD4<sup>+</sup> T cells
Id2 exacerbates the development of rheumatoid arthritis by increasing IFN‐γ production in CD4<sup>+</sup> T cells Open
Purpose This research investigates the role of inhibitor of differentiation 2 (Id2) in the synthesis of pro‐inflammatory cytokines, specifically interferon‐γ (IFN‐γ) and interleukin‐17 (IL‐17), by various subsets of T cells, and its pathog…
View article: The Pathogenic Role of Expanded CD8⁺CD28null Angiogenic T Cells in ANCA-Associated Vasculitis
The Pathogenic Role of Expanded CD8⁺CD28null Angiogenic T Cells in ANCA-Associated Vasculitis Open
Objectives: Angiogenic T cells (Tang) are crucial in promoting angiogenesis, with the loss of CD28 serving as a marker for highly differentiated and senescent T cells. This study aims to investigate the characteristics and potential roles …
View article: CD147 regulates the formation and function of immune synapses
CD147 regulates the formation and function of immune synapses Open
CD147 is a T cell activation-associated molecule which is closely involved in the formation of the immune synapse (IS). However, the precise role of CD147 in T cell activation and IS formation remains unclear. In the present study, we demo…
View article: Combination immunotherapy of glioblastoma with dendritic cell cancer vaccines, anti-PD-1 and poly I:C
Combination immunotherapy of glioblastoma with dendritic cell cancer vaccines, anti-PD-1 and poly I:C Open
View article: Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial
Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial Open
View article: Combination Immunotherapy of Glioblastoma with Dendritic Cell Cancer Vaccines, Anti-PD-1 and Poly I:C: A Case Report
Combination Immunotherapy of Glioblastoma with Dendritic Cell Cancer Vaccines, Anti-PD-1 and Poly I:C: A Case Report Open
Glioblastoma (GBM) is a lethal cancer with limited therapeutic options. Dendritic cell (DC)-based cancer vaccines represent a promising approach for GBM treatment. Clinical studies suggest that other immunotherapeutic agents including anti…
View article: TNF-α inhibitor ameliorates immune-related arthritis and pneumonitis in humanized mice
TNF-α inhibitor ameliorates immune-related arthritis and pneumonitis in humanized mice Open
Objectives This study aimed at establishing a mouse model of immune-related adverse in humanized BALB/c-hPD1/hCTLA4 mice to investigate their potential pathogenesis and explore therapeutic targets for immune-related arthritis and pneumonit…
View article: Th1-Like Treg Cells Are Increased But Deficient in Function in Rheumatoid Arthritis
Th1-Like Treg Cells Are Increased But Deficient in Function in Rheumatoid Arthritis Open
Objectives This study aimed to investigate the changes in quantity and function of T helper (Th)-like T regulatory (Treg) cell subsets in peripheral blood (PB) and synovial fluid (SF) of rheumatoid arthritis (RA) patients and to understand…
View article: Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant Efficacy
Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant Efficacy Open
Background: Current mainstream treatment of major depressive disorder (MDD) has a disadvantage in delayed onset of efficacy, making detection of early signatures predicative of the long-term treatment efficacy urgent. Methods: MDD patients…
View article: CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma Open
View article: Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial
Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial Open
View article: The impact of cell type and context-dependent regulatory variants on human immune traits
The impact of cell type and context-dependent regulatory variants on human immune traits Open
View article: Alignment of single-cell RNA-seq samples without overcorrection using kernel density matching
Alignment of single-cell RNA-seq samples without overcorrection using kernel density matching Open
Single-cell RNA sequencing (scRNA-seq) technology is poised to replace bulk cell RNA sequencing for many biological and medical applications as it allows users to measure gene expression levels in a cell type–specific manner. However, data…
View article: The impact of cell-type and context-dependent regulatory variants on human immune traits
The impact of cell-type and context-dependent regulatory variants on human immune traits Open
This data repository contains large processed data for our publication: The impact of cell-type and context-dependent regulatory variants on human immune traits
View article: The impact of cell-type and context-dependent regulatory variants on human immune traits
The impact of cell-type and context-dependent regulatory variants on human immune traits Open
This data repository contains large processed data for our publication: The impact of cell-type and context-dependent regulatory variants on human immune traits
View article: Additional file 4 of The impact of cell type and context-dependent regulatory variants on human immune traits
Additional file 4 of The impact of cell type and context-dependent regulatory variants on human immune traits Open
Additional file 4 The concensus peak set with fragment counts from H3K27ac CUT&Tag experiments.
View article: Additional file 1 of The impact of cell type and context-dependent regulatory variants on human immune traits
Additional file 1 of The impact of cell type and context-dependent regulatory variants on human immune traits Open
Additional file 1 A master file for Table S1-8.
View article: Additional file 3 of The impact of cell type and context-dependent regulatory variants on human immune traits
Additional file 3 of The impact of cell type and context-dependent regulatory variants on human immune traits Open
Additional file 3 A table for all colocalization results.
View article: CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells Open
View article: CD147 Expressed on Memory CD4+ T Cells Limits Th17 Responses in Patients With Rheumatoid Arthritis
CD147 Expressed on Memory CD4+ T Cells Limits Th17 Responses in Patients With Rheumatoid Arthritis Open
Rheumatoid arthritis (RA) is a common autoimmune disease in which T helper-type 17 (Th17) cells have been critically involved. CD147 is a T cell activation-associated molecule and is involved in T cell development. However, it remains uncl…
View article: 18F-FDG-PET/CT Plays a Key Role in Formulating Treatment Strategies for Takayasu Arteritis
18F-FDG-PET/CT Plays a Key Role in Formulating Treatment Strategies for Takayasu Arteritis Open
Backgroud and Objective: Clinical evaluation alone cannot satisfy the prognosis of TAK. PET-CTmolecular imaging may be a useful tool to supplement the prognosis of TAK. The purpose of this study was to observe whether THE TAK patients who …
View article: Impact of cell-type and context-dependent regulatory variants on human immune traits
Impact of cell-type and context-dependent regulatory variants on human immune traits Open
The effects of trait-associated variants are often studied in a single relevant cell-type or context. However, for many complex traits, multiple cell-types are involved. This applies particularly to immune-related traits, for which many im…
View article: Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial
Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial Open
Summary Background SARS-CoV-2 is a novel human coronavirus, there is no specific antiviral drugs. It has been proved that host-cell-expressed CD147 could bind spike protein of SARS-CoV-2 and involve in host cell invasion. Antibody against …
View article: SARS-CoV-2 invades host cells via a novel route: CD147-spike protein
SARS-CoV-2 invades host cells via a novel route: CD147-spike protein Open
SUMMARY Currently, COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been widely spread around the world; nevertheless, so far there exist no specific antiviral drugs for treatment of the disease, which po…
View article: Alignment of single-cell RNA-seq samples without over-correction using kernel density matching
Alignment of single-cell RNA-seq samples without over-correction using kernel density matching Open
Single-cell RNA sequencing (scRNA-seq) technology is poised to replace bulk cell RNA sequencing for most biological and medical applications as it allows users to measure gene expression levels in a cell-type-specific manner. However, data…
View article: Factors Associated with Caregiver Burden in Primary Caregivers of Patients with Adolescent Scoliosis: A Descriptive Cross-Sectional Study
Factors Associated with Caregiver Burden in Primary Caregivers of Patients with Adolescent Scoliosis: A Descriptive Cross-Sectional Study Open
BACKGROUND Primary caregivers for patients with scoliosis suffer from considerable distress and burden. However, a few studies have examined the factors related to burden of caregivers of patients with adolescent scoliosis, particularly in…
View article: Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients
Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients Open
BACKGROUND Patients with systemic lupus erythematosus (SLE), especially with lupus nephritis (LN), undergo vascular damage and repair during the course of the disease. Since the recently identified angiogenic T cells (Tang) are involved in…