Jinlong Zhao
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View article: Dasatinib and Quercetin alleviate type 2 diabetic osteoporosis by regulating serum metabolite and gut microbiome
Dasatinib and Quercetin alleviate type 2 diabetic osteoporosis by regulating serum metabolite and gut microbiome Open
Type 2 diabetic osteoporosis (T2DOP) is a complex metabolic bone disorder characterized by reduced bone density and increased risk of osteoporosis in patients with type 2 diabetes mellitus. The etiology of T2DOP is multifactorial, involvin…
View article: POS1010 DECIPHERING THE TRANSCRIPTOMIC LANDSCAPE OF SYSTEMIC LUPUS ERYTHEMATOSUS-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION
POS1010 DECIPHERING THE TRANSCRIPTOMIC LANDSCAPE OF SYSTEMIC LUPUS ERYTHEMATOSUS-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION Open
View article: Negative rumination in depression subtypes with melancholic features and anxious distress
Negative rumination in depression subtypes with melancholic features and anxious distress Open
Background Aberrant cognition is one of the crucial symptoms of depression. However, whether the negative rumination participates in depression with melancholic features or anxious distress remains unclear. Methods In this study, we addres…
View article: Causes of failed anterior cruciate ligament reconstruction: A retrospective case series
Causes of failed anterior cruciate ligament reconstruction: A retrospective case series Open
Rationale: The number of anterior cruciate ligament reconstruction (ACLR) surgeries in China is steadily increasing. To enhance the success rate of ACLR, it is crucial to understand the reasons for ACLR failure. The purpose of this study i…
View article: Epiregulin drives keratinocyte hyperproliferation in sorafenib-induced hand-foot skin reaction: A mechanistic and therapeutic insight
Epiregulin drives keratinocyte hyperproliferation in sorafenib-induced hand-foot skin reaction: A mechanistic and therapeutic insight Open
View article: Hyperthyroidism increases the risk of osteoarthritis in individuals aged 60–80 years
Hyperthyroidism increases the risk of osteoarthritis in individuals aged 60–80 years Open
View article: Knowledge Graph of Endoscopic Techniques Applied to the Treatment of Lumbar Disc Herniation
Knowledge Graph of Endoscopic Techniques Applied to the Treatment of Lumbar Disc Herniation Open
Study Design: Bibliometric analysis. Objective: This study explored the current research status, hotspots, and trends in the application of endoscopic techniques for treating lumbar disc herniation (LDH). Background: Endoscopic techniques …
View article: Inverse association of the systemic immune-inflammation index with serum anti-ageing protein Klotho levels in individuals with osteoarthritis: A cross-sectional study
Inverse association of the systemic immune-inflammation index with serum anti-ageing protein Klotho levels in individuals with osteoarthritis: A cross-sectional study Open
Background The association between the systemic immune-inflammation index (SII) and the serum soluble-Klotho concentration (pg/ml) in osteoarthritis (OA) patients is unknown. This study aimed to investigate the relationship between the SII…
View article: Analysis of the causes of primary revision after unicompartmental knee arthroplasty: A case series
Analysis of the causes of primary revision after unicompartmental knee arthroplasty: A case series Open
BACKGROUND Unicompartmental knee arthroplasty (UKA) has great advantages in the treatment of unicompartmental knee osteoarthritis, but its revision rate is higher than that of total knee arthroplasty. AIM To summarize and analyse the cause…
View article: Associations of recurrent lumbar disc herniation after percutaneous endoscopic lumbar discectomy with age, body mass index, modic change, disc degeneration and sacral slope: A quantitative review
Associations of recurrent lumbar disc herniation after percutaneous endoscopic lumbar discectomy with age, body mass index, modic change, disc degeneration and sacral slope: A quantitative review Open
Recurrent lumbar disc herniation (rLDH) seriously affects the quality of life of patients and increases the medical burden. The purpose of the present study was to determine the risk factors for rLDH after percutaneous endoscopic lumbar di…
View article: Liuwei Dihuang Pills Enhance Osteogenic Differentiation in MC3T3-E1 Cells through the Activation of the Wnt/β-Catenin Signaling Pathway
Liuwei Dihuang Pills Enhance Osteogenic Differentiation in MC3T3-E1 Cells through the Activation of the Wnt/β-Catenin Signaling Pathway Open
Objective: The therapeutic efficacy and molecular mechanisms of traditional Chinese medicines (TCMs), such as Liuwei Dihuang pills (LWDH pills), in treating osteoporosis (OP) remain an area of active research and interest in modern medicin…
View article: Risk factors for symptomatic rotator cuff tears: a retrospective case–control study
Risk factors for symptomatic rotator cuff tears: a retrospective case–control study Open
Background The incidence and diagnostic rate of rotator cuff tears (RCTs) have increased significantly. The purpose of this study was to investigate and analyze the risk factors for symptomatic RCTs to provide a basis for their prevention …
View article: Interplay of Systemic Immune-Inflammation Index and Serum Klotho Levels: Unveiling a New Dimension in Rheumatoid Arthritis Pathology
Interplay of Systemic Immune-Inflammation Index and Serum Klotho Levels: Unveiling a New Dimension in Rheumatoid Arthritis Pathology Open
Aim: The association between the systemic immune-inflammation index (SII) and serum Klotho concentrations (pg/ml) in patients with rheumatoid arthritis (RA) has not been elucidated. The purpose of this study was to clarify the relat…
View article: Higher systemic immune-inflammation index is associated with sarcopenia in individuals aged 18–59 years: a population-based study
Higher systemic immune-inflammation index is associated with sarcopenia in individuals aged 18–59 years: a population-based study Open
View article: Effectiveness of Chinese Herbal Medicine in Postoperative FatigueSyndrome Following Total Joint Arthroplasty or Hip Fracture Surgery:Evidence from Randomized Controlled Trials
Effectiveness of Chinese Herbal Medicine in Postoperative FatigueSyndrome Following Total Joint Arthroplasty or Hip Fracture Surgery:Evidence from Randomized Controlled Trials Open
Background:: There is no high-quality, evidence-based protocol for the treatment of postoperative fatigue syndrome (POFS) after total joint arthroplasty (TJA) or fracture surgery with Chinese herbal medicine (CHM). Purpose:: The purpose of…
View article: Efficacy and safety of curcumin therapy for knee osteoarthritis: A Bayesian network meta-analysis
Efficacy and safety of curcumin therapy for knee osteoarthritis: A Bayesian network meta-analysis Open
Curcumin, either alone or in combination with other treatments, is considered to have good clinical efficacy and safety in KOA treatment. Drug combinations containing curcumin may have the dual effect of enhancing efficacy and reducing adv…
View article: Longbie capsules reduce bone loss in the subchondral bone of rats with comorbid osteoporosis and osteoarthritis by regulating metabolite alterations
Longbie capsules reduce bone loss in the subchondral bone of rats with comorbid osteoporosis and osteoarthritis by regulating metabolite alterations Open
Background and objective With the development of global population aging, comorbidity (≥2 diseases) is a common health problem among elderly people. Osteoarthritis (OA) and osteoporosis (OP) are common in elderly individuals. There is a la…
View article: Effects of resveratrol in an animal model of osteoporosis: a meta-analysis of preclinical evidence
Effects of resveratrol in an animal model of osteoporosis: a meta-analysis of preclinical evidence Open
Background Resveratrol is a natural polyphenol compound that is widely present in herbal medicines such as Reynoutria japonica Houtt. , Veratrum nigrum L. , and Catsiatora Linn and is used in traditional Chinese medicine to treat metabolic…
View article: Intravenous Tranexamic Acid Significantly Improved Visualization and Shortened the Operation Time in Arthroscopic Rotator Cuff Repair: A Systematic Review and Meta-analysis of Level I and II Studies
Intravenous Tranexamic Acid Significantly Improved Visualization and Shortened the Operation Time in Arthroscopic Rotator Cuff Repair: A Systematic Review and Meta-analysis of Level I and II Studies Open
View article: Pharmacological Interventions for Glucocorticoid-Induced Osteoporosis: An Umbrella Review
Pharmacological Interventions for Glucocorticoid-Induced Osteoporosis: An Umbrella Review Open
There is still a lack of high-quality evidence-based studies on the efficacy of drug treatment for glucocorticoid-induced osteoporosis (GIOP). The purpose of this umbrella review is to comprehensively evaluate the existing evidence to dete…
View article: Potential Mechanisms Underlying the Therapeutic Roles of Gancaofuzi Decoction in Cold-dampness Obstruction Syndrome-type KneeOsteoarthritis
Potential Mechanisms Underlying the Therapeutic Roles of Gancaofuzi Decoction in Cold-dampness Obstruction Syndrome-type KneeOsteoarthritis Open
Background: The key active components and potential molecular mechanism of Gancao Fuzi decoction (GFD) in the treatment of cold-dampness obstruction-type knee osteoarthritis (KOA) remain unclear. Objective: To explore the mechanism of GFD …
View article: Network pharmacology identifies fisetin as a treatment for osteoporosis that activates the Wnt/β-catenin signaling pathway in BMSCs
Network pharmacology identifies fisetin as a treatment for osteoporosis that activates the Wnt/β-catenin signaling pathway in BMSCs Open
Background Although fisetin may exist widely in many natural herbs, its anti-OP mechanism is still unclear. The aim of this study is to explore the molecular anti-osteoporosis (OP) mechanism of fisetin based on network pharmacology and cel…
View article: ‘Two-step’ percutaneous procedure for repairing the atrial septal defect with severe pulmonary hypertension: a case report
‘Two-step’ percutaneous procedure for repairing the atrial septal defect with severe pulmonary hypertension: a case report Open
Atrial septal defect is the most common type of congenital heart disease. Interventional closure is currently the best treatment for the atrial septal defect. However, the repair strategy for atrial septal defect accompanies by severe pulm…
View article: Combination of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) in the treatment of knee osteoarthritis: a meta-analysis of randomised controlled trials
Combination of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) in the treatment of knee osteoarthritis: a meta-analysis of randomised controlled trials Open
Objectives The purpose of this meta-analysis was to investigate the efficacy and safety of mesenchymal stem cells (MSCs) combined with platelet-rich plasma (PRP) in the treatment of knee osteoarthritis (KOA). Design Systematic review and m…
View article: Influence of type 2 diabetes microangiopathy on bone mineral density and bone metabolism: A meta-analysis
Influence of type 2 diabetes microangiopathy on bone mineral density and bone metabolism: A meta-analysis Open
Type 2 diabetes microangiopathy can reduce the lumbar spine, femoral neck and Ward's triangle BMD and has a higher risk of osteoporosis or osteoporosis fractures. The levels of P1NP, PTH, CTX and OC in the serum of patients with type 2 dia…
View article: Risk factors for postoperative delirium following total hip or knee arthroplasty: A meta-analysis
Risk factors for postoperative delirium following total hip or knee arthroplasty: A meta-analysis Open
Objectives The purpose of this study was to identify risk factors for delirium after total joint arthroplasty (TJA) and provide theoretical guidance for reducing the incidence of delirium after TJA. Methods The protocol for this meta-analy…
View article: Effectiveness of Yushen Hezhi therapy for postmenopausal osteoporosis: An overview of systematic reviews of randomized controlled trials
Effectiveness of Yushen Hezhi therapy for postmenopausal osteoporosis: An overview of systematic reviews of randomized controlled trials Open
Objective To review systematic reviews (SRs) and meta-analyses (MAs) of Yushen Hezhi therapy (YSHZT) for postmenopausal osteoporosis (PMOP) to provide an evidence-based recommendation for researchers and decision makers. Methods We searche…
View article: Infectious native valve endocarditis by Streptococcus agalactiae species: Case report of pathogen identification only through metagenomic sequencing technology
Infectious native valve endocarditis by Streptococcus agalactiae species: Case report of pathogen identification only through metagenomic sequencing technology Open
Introduction: Streptococcus agalactiae is a common pathogen in infective endocarditis, but the positive rate of traditional blood culture diagnosis is not high. It is challenging to obtain a good outcome in the absence of pathogen informat…
View article: PB1929: PRELIMINARY STUDY OF EVALUATION IRON OVERLOAD MYOCARDIAL INJURY BY LOAD CT MYOCARDIAL PERFUSION IMAGING
PB1929: PRELIMINARY STUDY OF EVALUATION IRON OVERLOAD MYOCARDIAL INJURY BY LOAD CT MYOCARDIAL PERFUSION IMAGING Open
Background: Currently, Iron overload cardiomyopathy(IOC) is assumed to be the most common cause of mortality in patients with secondary iron overload and is a major comorbidity in patients with genetic hemochromatosis. At present, there is…