Jinping Cai
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Chicken Shank Color Determined by Inhibition of Dermal Melanin ( <span> <i>ID</i> </span> ) is Mediated by a Structural Variation Regulating <span> <i>CDKN2A</i> </span> Expression Open
Shank color in chickens is a classic quantitative trait governed by four genetic loci. Among these, the Inhibition of dermal melanin ( ID ) locus, which suppresses dermal melanogenesis in the shank, is the sole sex‐linked mutation and its …
Study on the Interactions Process of Coupled Model of Furrow Opener–Soil–Pot Seedling Based on Discrete Approach Open
The upright state of pot seedlings in the process of rice mechanized throwing operations has an important influence on the growth rate and yield of rice, and pot seedling uprightness is affected by the influence of soil backfilling during …
Recognition and localization of ratoon rice rolled stubble rows based on monocular vision and model fusion Open
Introduction Ratoon rice, as a high-efficiency rice cultivation mode, is widely applied around the world. Mechanical righting of rolled rice stubble can significantly improve yield in regeneration season, but lack of automation has become …
The Influence of Electrostatic Spraying with Waist-Shaped Charging Devices on the Distribution of Long-Range Air-Assisted Spray in Greenhouses Open
Electrostatic spraying is considered an effective means to improve the efficacy of pesticide application and reduce pesticide consumption. However, the effectiveness of electrostatic spraying needs further validation in greenhouse environm…
View article: Development of a streamlined NGS-based TCGA classification scheme for gastric cancer and its implications for personalized therapy
Development of a streamlined NGS-based TCGA classification scheme for gastric cancer and its implications for personalized therapy Open
The NGS method successfully maps the mutational landscape of GC, providing a practical TCGA classification surrogate to optimize patient-specific treatment strategies.
Tumor immune microenvironment analysis of non-small cell lung cancer development through multiplex immunofluorescence Open
This study offers an in-depth analysis of immune changes in NSCLC, demonstrating that the transition from AIS/MIA to invasive stage I NSCLC leads to immune activation, while the advancement from stage I to stage III cancer results in immun…
Peer victimization and children’s internet addiction in China: a moderated mediation model Open
Background Peer victimization used to be considered as a crucial risk factor for children addicted to the internet. Whereas some victimized ones are function better than would be expected. Variability across individuals indicates that it i…
View article: Lenvatinib plus anti-PD-1 antibodies as conversion therapy for patients with unresectable intermediate-advanced hepatocellular carcinoma: a single-arm, phase II trial
Lenvatinib plus anti-PD-1 antibodies as conversion therapy for patients with unresectable intermediate-advanced hepatocellular carcinoma: a single-arm, phase II trial Open
Background Over 70% of the patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage and lose the opportunity for radical surgery. Combination therapy of tyrosine kinase inhibitors (TKIs) and anti-programmed cell deat…
SMR-RS: An Improved Mask R-CNN Specialized for Rolled Rice Stubble Row Segmentation Open
As a highly productive rice, ratoon rice is widely planted worldwide, but the rolling of rice stubble in mechanical harvesting severely limits its total yield; based on this, some scholars have proposed rolled rice stubble righting machine…
View article: Chromosome 11q13 amplification correlates with poor response and prognosis to PD-1 blockade in unresectable hepatocellular carcinoma
Chromosome 11q13 amplification correlates with poor response and prognosis to PD-1 blockade in unresectable hepatocellular carcinoma Open
Background & aims Little is known about molecular biomarkers that predict the response and prognosis in unresectable hepatocellular carcinoma (HCC) treated with programmed death (PD)-1 inhibitors. Methods A total of 62 HCC patients who und…
View article: Plasma-only circulating tumor DNA analysis detects minimal residual disease and predicts early relapse in hepatocellular carcinoma patients undergoing curative resection
Plasma-only circulating tumor DNA analysis detects minimal residual disease and predicts early relapse in hepatocellular carcinoma patients undergoing curative resection Open
Background Minimal residual disease (MRD) is considered an essential factor leading to relapse within 2 years (early relapse) after radical surgery, which is challenging to be detected by conventional imaging. Circulating tumor DNA (ctDNA)…
View article: PD-1/PD-L1 Inhibitor Plus Chemotherapy Versus PD-1/PD-L1 Inhibitor in Microsatellite Instability Gastrointestinal Cancers: A Multicenter Retrospective Study
PD-1/PD-L1 Inhibitor Plus Chemotherapy Versus PD-1/PD-L1 Inhibitor in Microsatellite Instability Gastrointestinal Cancers: A Multicenter Retrospective Study Open
PURPOSE To investigate the efficacy of PD-1/PD-L1 inhibitors plus chemotherapy versus anti–PD-1/PD-L1 monotherapy in advanced microsatellite instability (MSI)/mismatch repair-deficient (dMMR) gastrointestinal cancers. METHODS We retrospect…
View article: Development and validation of postoperative circulating tumor DNA combined with clinicopathological risk factors for recurrence prediction in patients with stages I-III colorectal cancer
Development and validation of postoperative circulating tumor DNA combined with clinicopathological risk factors for recurrence prediction in patients with stages I-III colorectal cancer Open
Background Circulating tumor DNA (ctDNA) detection following curative-intent surgery could directly reflect the presence of minimal residual disease, which is ultimately the cause of clinical recurrence. However, ctDNA is not postoperative…
View article: The Optimal Therapy after Progression on Immune Checkpoint Inhibitors in MSI Metastatic Gastrointestinal Cancer Patients: A Multicenter Retrospective Cohort Study
The Optimal Therapy after Progression on Immune Checkpoint Inhibitors in MSI Metastatic Gastrointestinal Cancer Patients: A Multicenter Retrospective Cohort Study Open
Background: In microsatellite instability (MSI)/mismatch repair-deficient (dMMR) gastrointestinal cancers, the optimum therapy after the progression of immune checkpoint inhibitors (ICIs) is yet unknown. Here, we compared the efficacy of p…
View article: Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer
Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer Open
Background Gastrointestinal (GI) cancer is the second most common cancer type with mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) phenotype that is expected to respond to immune-checkpoint inhibitors (ICIs). Howev…
View article: Mutations of PI3K-AKT-mTOR pathway as predictors for immune cell infiltration and immunotherapy efficacy in dMMR/MSI-H gastric adenocarcinoma
Mutations of PI3K-AKT-mTOR pathway as predictors for immune cell infiltration and immunotherapy efficacy in dMMR/MSI-H gastric adenocarcinoma Open
Background A significant subset of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastric adenocarcinomas (GAC) are resistant to immune checkpoint inhibitors (ICIs), yet the underlying mechanism remains largely un…
View article: Efficacy and predictive biomarkers of immunotherapy in Epstein-Barr virus-associated gastric cancer
Efficacy and predictive biomarkers of immunotherapy in Epstein-Barr virus-associated gastric cancer Open
Background Epstein-Barr virus (EBV)-associated gastric cancer (GC) (EBVaGC) is a distinct molecular subtype of GC with a favorable prognosis. However, the exact effects and potential mechanisms of EBV infection on immune checkpoint blockad…
View article: A novel 8-gene panel for prediction of early biochemical recurrence in patients with prostate cancer after radical prostatectomy.
A novel 8-gene panel for prediction of early biochemical recurrence in patients with prostate cancer after radical prostatectomy. Open
Approximately 25% of prostate cancer (PCa) cases experience biochemical recurrence (BCR) following radical prostatectomy (RP). The patients with BCR, especially with BCR ≤2 year after RP (early BCR), are more likely to develop clinical met…
Identification of BIK as an unfavorable prognostic marker and novel therapeutic target in microsatellite stable colorectal cancer harboring KRAS mutations. Open
KRAS mutations lead to persistent activation of multiple downstream effectors that drive the cancer phenotype. Approximately 30%-50% of colorectal cancer (CRC) patients harbor KRAS mutations, which confer more aggressive tumor biology and …
View article: Mutations of PI3K-AKT-mTOR Pathway as Predictors for Immune Cell Infiltration and Immunotherapy Efficacy in dMMR/MSI-H Gastric Adenocarcinoma
Mutations of PI3K-AKT-mTOR Pathway as Predictors for Immune Cell Infiltration and Immunotherapy Efficacy in dMMR/MSI-H Gastric Adenocarcinoma Open
Background: A significant subset of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastric adenocarcinomas (GAC) are resistant to immune checkpoint inhibitors (ICIs), yet the underlying mechanism remains largely u…
Prevalence and spectrum of germline cancer susceptibility gene variants and somatic second hits in colorectal cancer. Open
Colorectal cancer (CRC) is one of the most heritable cancers, and genetic factors play an important role in the increased CRC risk. However, the well-established CRC-risk genes were limited for explaining the increased risk of CRC individu…