Jinping Gu
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View article: Resin Glycosides with α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitory Activities from the Seeds of Cuscuta japonica
Resin Glycosides with α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitory Activities from the Seeds of Cuscuta japonica Open
In the present study, seven previously undescribed resin glycosides, designated cusponins I-VII (1–7), together with one known analog (8), were isolated from the seeds of Cuscuta japonica, a traditional medicine used in China. Structural e…
View article: Nuclear Magnetic Resonance-Based Metabolomics Reveals Systemic Metabolic Disarray in the Transition from Acute Kidney Injury To Chronic Kidney Disease
Nuclear Magnetic Resonance-Based Metabolomics Reveals Systemic Metabolic Disarray in the Transition from Acute Kidney Injury To Chronic Kidney Disease Open
View article: Mechanistic Study of 1h-Nmrmetabolomics on the Treatment of Hepatic Fibrosis by Fuzheng Huayu Capsule
Mechanistic Study of 1h-Nmrmetabolomics on the Treatment of Hepatic Fibrosis by Fuzheng Huayu Capsule Open
View article: Effects of the CYP3A inhibitors, voriconazole, itraconazole, and fluconazole on the pharmacokinetics of osimertinib in rats
Effects of the CYP3A inhibitors, voriconazole, itraconazole, and fluconazole on the pharmacokinetics of osimertinib in rats Open
Background Osimertinib, as third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is the first-line treatment approved to treat advanced T790M mutation-positive tumors. Triazole antifungals are therapeutic …
View article: Identification of potential serum biomarkers for congenital heart disease children with pulmonary arterial hypertension by metabonomics
Identification of potential serum biomarkers for congenital heart disease children with pulmonary arterial hypertension by metabonomics Open
Background Pulmonary arterial hypertension is a common complication in patients with congenital heart disease. In the absence of early diagnosis and treatment, pediatric patients with PAH has a poor survival rate. Here, we explore serum bi…
View article: NMR-Based Metabolomics to Analyze the Effects of a Series of Monoamine Oxidases-B Inhibitors on U251 Cells
NMR-Based Metabolomics to Analyze the Effects of a Series of Monoamine Oxidases-B Inhibitors on U251 Cells Open
Alzheimer’s disease (AD) is a typical progressive neurodegenerative disorder, and with multiple possible pathogenesis. Among them, coumarin derivatives could be used as potential drugs as monoamine oxidase-B (MAO-B) inhibitors. Our lab has…
View article: The stereoselective metabolic disruption of cypermethrin by a sub-acute study based on metabolomics
The stereoselective metabolic disruption of cypermethrin by a sub-acute study based on metabolomics Open
Due to the massive application of cypermethrins (CYPs) for pest control in China, the adverse effects on non-target organisms have aroused great attention. However, comparative studies between its different stereoisomers remain scarce, esp…
View article: NMR-Based Metabolomic Analysis of Cardiac Tissues Clarifies Molecular Mechanisms of CVB3-Induced Viral Myocarditis and Dilated Cardiomyopathy
NMR-Based Metabolomic Analysis of Cardiac Tissues Clarifies Molecular Mechanisms of CVB3-Induced Viral Myocarditis and Dilated Cardiomyopathy Open
Viral myocarditis (VMC), which is defined as inflammation of the myocardium with consequent myocardial injury, may develop chronic disease eventually leading to dilated cardiomyopathy (DCM). Molecular mechanisms underlying the progression …
View article: Inhibitory effects of CYP3A4 inhibitors voriconazole, itraconazole, and fluconazole on the pharmacokinetic profiles of ceritinib in rats by HPLC-MS/MS
Inhibitory effects of CYP3A4 inhibitors voriconazole, itraconazole, and fluconazole on the pharmacokinetic profiles of ceritinib in rats by HPLC-MS/MS Open
Introduction: Ceritinib is a second-line drug used to treat patients with non-small cell lung cancer (NSCLC) who have acquired resistance to crizotinib. Triazole antifungals are therapeutic choices for patients with cancer to reduce the ri…
View article: Study of Chemical Compositions and Anticancer Effects of Paris polyphylla var. Chinensis Leaves
Study of Chemical Compositions and Anticancer Effects of Paris polyphylla var. Chinensis Leaves Open
Paris polyphylla var. chinensis (Franch.) Hara is a perennial herb belonging to the Trilliaceae family. Ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q–TOF MS) was used to detect the composition o…
View article: NMR-Based Metabolomic Analysis of Sera in Mouse Models of CVB3-Induced Viral Myocarditis and Dilated Cardiomyopathy
NMR-Based Metabolomic Analysis of Sera in Mouse Models of CVB3-Induced Viral Myocarditis and Dilated Cardiomyopathy Open
Viral myocarditis (VMC) is an inflammatory heart condition which can induce dilated cardiomyopathy (DCM). However, molecular mechanisms underlying the progression of VMC into DCM remain exclusive. Here, we established mouse models of VMC a…
View article: Development and Validation of a Novel Lc-Ms/Ms Method for Simultaneous Quantitative Determination of Tyrosine Kinase Inhibitors in Human Plasma
Development and Validation of a Novel Lc-Ms/Ms Method for Simultaneous Quantitative Determination of Tyrosine Kinase Inhibitors in Human Plasma Open
View article: NMR-Based Metabolomics Analysis Predicts Response to Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer
NMR-Based Metabolomics Analysis Predicts Response to Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer Open
Triple-negative breast cancer (TNBC) is the most fatal type of breast cancer (BC). Due to the lack of relevant targeted drug therapy, in addition to surgery, chemotherapy is still the most common treatment option for TNBC. TNBC is heteroge…
View article: Effect of Drying Methods on Volatile Compounds of Burdock (Arctium lappa L.) Root Tea as Revealed by Gas Chromatography Mass Spectrometry-Based Metabolomics
Effect of Drying Methods on Volatile Compounds of Burdock (Arctium lappa L.) Root Tea as Revealed by Gas Chromatography Mass Spectrometry-Based Metabolomics Open
Burdock (Arctium lappa L.) is one of the nutritional foods widely planted in many countries. Dried burdock root (BR) is available as a herbal tincture and tea in many Asian countries with good flavor and taste. In this study, the volatile …
View article: Discovery of benzamide-hydroxypyridinone hybrids as potent multi-targeting agents for the treatment of Alzheimer's disease
Discovery of benzamide-hydroxypyridinone hybrids as potent multi-targeting agents for the treatment of Alzheimer's disease Open
A novel class of benzamide-hydroxypyridinone (HPO) derivatives were innovatively designed, synthesised, and biologically evaluated as potential multitargeting candidates for the treatment of Alzheimer's disease (AD) through pharmacophores-…
View article: Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity
Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity Open
View article: Nuclear magnetic resonance‐based tissue metabolomic analysis clarifies molecular mechanisms of gastric carcinogenesis
Nuclear magnetic resonance‐based tissue metabolomic analysis clarifies molecular mechanisms of gastric carcinogenesis Open
Gastric cancer (GC) is one of the deadliest cancers worldwide, and the progression of gastric carcinogenesis (GCG) covers multiple complicated pathological stages. Molecular mechanisms of GCG are still unclear. Here, we undertook NMR‐based…
View article: Simultaneous Quantification and Pharmacokinetic Study of Nine Bioactive Components of Orthosiphon stamineus Benth. Extract in Rat Plasma by UHPLC-MS/MS
Simultaneous Quantification and Pharmacokinetic Study of Nine Bioactive Components of Orthosiphon stamineus Benth. Extract in Rat Plasma by UHPLC-MS/MS Open
Orthosiphon stamineus Benth. (OS) is a traditional folk medicine for the treatment of kidney stones and other urinary tract diseases. In this study, a rapid and sensitive Ultra high-performance liquid chromatography (UHPLC)-MS/MS approach …
View article: Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease
Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease Open
View article: Metabolomic modulations of HepG2 cells exposed to bisphenol analogues
Metabolomic modulations of HepG2 cells exposed to bisphenol analogues Open
View article: Metabolomics Analysis in Serum from Patients with Colorectal Polyp and Colorectal Cancer by <sup>1</sup>H-NMR Spectrometry
Metabolomics Analysis in Serum from Patients with Colorectal Polyp and Colorectal Cancer by <sup>1</sup>H-NMR Spectrometry Open
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Colorectal adenomatous polyps are at high risk for the development of CRC. In this report, we described the metabolic changes in the sera from patients…
View article: Metabolomic analysis reveals altered metabolic pathways in a rat model of gastric carcinogenesis
Metabolomic analysis reveals altered metabolic pathways in a rat model of gastric carcinogenesis Open
Gastric cancer (GC) is one of the most malignant tumors with a poor prognosis. Alterations in metabolic pathways are inextricably linked to GC progression. However, the underlying molecular mechanisms remain elusive. We performed NMR-based…
View article: <sup>1</sup>H NMR-Based Analysis of Serum Metabolites in Monocrotaline-Induced Pulmonary Arterial Hypertensive Rats
<sup>1</sup>H NMR-Based Analysis of Serum Metabolites in Monocrotaline-Induced Pulmonary Arterial Hypertensive Rats Open
Aims . To study the changes of the metabolic profile during the pathogenesis in monocrotaline (MCT) induced pulmonary arterial hypertension (PAH). Methods . Forty male Sprague-Dawley (SD) rats were randomly divided into 5 groups (, each). …