Jin‐Song Shi
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View article: <i>De novo</i> design of phospho-tyrosine peptide binders
<i>De novo</i> design of phospho-tyrosine peptide binders Open
Phosphorylation on tyrosine is a key step in many signaling pathways. Despite recent progress in de novo design of protein binders, there are no current methods for designing binders that recognize phosphorylated proteins and peptides; thi…
View article: Isolation of indigenous Bacillus velezensis from aging tobacco leaves for improving the flavor of flue-cured tobacco
Isolation of indigenous Bacillus velezensis from aging tobacco leaves for improving the flavor of flue-cured tobacco Open
Introduction Aging of flue-cured tobacco is a slow microbial fermentation process that usually lasts for 2–3 years, which plays an important role in improving the quality of final products. Methods Re-dried tobacco leaves from seven Chines…
View article: Hyaluronidases improve the hyaluronic acid yield during the fermentation of Streptococcus zooepidemicus
Hyaluronidases improve the hyaluronic acid yield during the fermentation of Streptococcus zooepidemicus Open
Background Hyaluronic acid (HA), a linear acidic mucopolysaccharide with exceptional biocompatibility, is extensively utilized in pharmaceuticals and cosmetics. Industrial HA production predominantly relies on Streptococcus zooepidemicus f…
View article: Adaptive evolution refines short-term citric acid stress responses in Lactiplantibacillus plantarum: Insights into enhanced acid tolerance
Adaptive evolution refines short-term citric acid stress responses in Lactiplantibacillus plantarum: Insights into enhanced acid tolerance Open
View article: Featured Cover: Cover Image, Volume 24, Issue 4
Featured Cover: Cover Image, Volume 24, Issue 4 Open
View article: Apple Cider Vinegar Powder Mitigates Liver Injury in High-Fat-Diet Mice via Gut Microbiota and Metabolome Remodeling
Apple Cider Vinegar Powder Mitigates Liver Injury in High-Fat-Diet Mice via Gut Microbiota and Metabolome Remodeling Open
Background/Objectives: High-fat-diet (HFD) consumption drives chronic liver injury via gut dysbiosis and metabolic disturban. Apple cider vinegar, rich in polyphenols and organic acids, shows potential in metabolic regulation. This study a…
View article: Highly active β-galactosidase from Lactobacillus delbrueckii for enhanced lactose-derived oligosaccharide synthesis
Highly active β-galactosidase from Lactobacillus delbrueckii for enhanced lactose-derived oligosaccharide synthesis Open
View article: High-Level Extracellular Expression of Collagenase ColH in Bacillus subtilis for Adipose-Derived Cells Extraction
High-Level Extracellular Expression of Collagenase ColH in Bacillus subtilis for Adipose-Derived Cells Extraction Open
Collagenase has a wide range of applications in the medicine, cosmetic, and food industries. Inefficient expression of collagenase impedes its industrial production and commercial applications. In this study, a secretory expression system …
View article: Enhanced l-serine synthesis in Corynebacterium glutamicum by exporter engineering and Bayesian optimization of the medium composition
Enhanced l-serine synthesis in Corynebacterium glutamicum by exporter engineering and Bayesian optimization of the medium composition Open
View article: Engineering <scp>UDP</scp>‐sugar synthesis pathways for exopolysaccharide biosynthesis in <i>Streptococcus thermophilus</i><scp>AR333</scp>
Engineering <span>UDP</span>‐sugar synthesis pathways for exopolysaccharide biosynthesis in <i>Streptococcus thermophilus</i><span>AR333</span> Open
BACKGROUND Exopolysaccharide (EPS) produced by Streptococcus thermophilus can significantly improve the viscosity, texture and taste of dairy products, which have broad application potential in the food industry. However, EPS production is…
View article: Microbial-Driven Tradeoffs in Fermented Chili Paste: Salinity Modulates Flavor Enrichment and Biogenic Amines Synthesis
Microbial-Driven Tradeoffs in Fermented Chili Paste: Salinity Modulates Flavor Enrichment and Biogenic Amines Synthesis Open
View article: Changes in flavor profile of sauce-flavor baijiu: Perceptual interactions between 1-propanol and aroma compounds
Changes in flavor profile of sauce-flavor baijiu: Perceptual interactions between 1-propanol and aroma compounds Open
View article: Enhanced Lactose-Derived Oligosaccharides Biosynthesis with a Highly Active Β-Galactosidase from Lactobacillus Delbrueckii
Enhanced Lactose-Derived Oligosaccharides Biosynthesis with a Highly Active Β-Galactosidase from Lactobacillus Delbrueckii Open
View article: Evolution of aroma compounds in round soy sauce aroma type baijiu during aging and the effect of aging markers on the lasting aroma in finished glass
Evolution of aroma compounds in round soy sauce aroma type baijiu during aging and the effect of aging markers on the lasting aroma in finished glass Open
Soy sauce aroma type Baijiu (SSAB) is a complex blend of seven rounds of raw SSAB, each with distinct aroma profiles that evolve during maturation. Tracking the aging of individual rounds is crucial for understanding flavor development. Th…
View article: A comprehensive review on microbial hyaluronan-degrading enzymes: from virulence factors to biotechnological tools
A comprehensive review on microbial hyaluronan-degrading enzymes: from virulence factors to biotechnological tools Open
View article: Regulatory significance of terminator: A systematic approach for dissecting terminator-mediated enhancement of upstream mRNA stability
Regulatory significance of terminator: A systematic approach for dissecting terminator-mediated enhancement of upstream mRNA stability Open
View article: Identification and Characterization of a Highly Active Hyaluronan Lyase from Enterobacter asburiae
Identification and Characterization of a Highly Active Hyaluronan Lyase from Enterobacter asburiae Open
Hyaluronic acid (HA) is a well-known functional marine polysaccharide. The utilization and derivative development of HA are of great interest. Hyaluronan lyase has wide application prospects in the production of HA oligosaccharides and low…
View article: Restricted intake of sulfur-containing amino acids reversed the hepatic injury induced by excess <i>Desulfovibrio</i> through gut–liver axis
Restricted intake of sulfur-containing amino acids reversed the hepatic injury induced by excess <i>Desulfovibrio</i> through gut–liver axis Open
Diet is a key player in gut-liver axis. However, the effect of different dietary patterns on gut microbiota and liver functions remains unclear. Here, we used rodent standard chow and purified diet to mimic two common human dietary pattern…
View article: Lactiplantibacillus plantarum and Komagataeibacter europaeus enhance energy metabolism, acetic acid and aromatic amino acids catabolism flux in cider vinegar fermentation
Lactiplantibacillus plantarum and Komagataeibacter europaeus enhance energy metabolism, acetic acid and aromatic amino acids catabolism flux in cider vinegar fermentation Open
Fruit vinegar is typically produced through a two-stage submerged fermentation involving Saccharomyces cerevisiae (alcohol fermentation) and Acetobacter pasteurianus (acetic acid fermentation). In order to enhance its flavor and nutritiona…
View article: Exploring the contribution of temperature-adapted microbiota to enzyme profile of saccharification in Daqu using metagenomics and metaproteomics
Exploring the contribution of temperature-adapted microbiota to enzyme profile of saccharification in Daqu using metagenomics and metaproteomics Open
Temperature is a critical factor that influences the microbiota in Daqu, which provides essential enzymes for the saccharification process in Baijiu (Chinese liquor) production. However, the relationship between temperature-adapted microbi…
View article: Selective synthesis of rebaudioside M2 through structure-guided engineering of glycosyltransferase UGT94D1
Selective synthesis of rebaudioside M2 through structure-guided engineering of glycosyltransferase UGT94D1 Open
Rebaudioside M2 (Reb M2), a novel steviol glycoside derivative, has limited industrial applications due to its low synthetic yield and selectivity. Herein, we identify UGT94D1 as a selective glycosyltransferase for rebaudioside D (Reb D), …
View article: Rapid detection of six <i>Oceanobacillus</i> species in <i>Daqu</i> starter using single‐cell Raman spectroscopy combined with machine learning
Rapid detection of six <i>Oceanobacillus</i> species in <i>Daqu</i> starter using single‐cell Raman spectroscopy combined with machine learning Open
Many traditional fermented foods and beverages industries around the world request the addition of multi‐species starter cultures. However, the microbial community in starter cultures is subject to fluctuations due to their exposure to an …
View article: Restricted intake of sulfur-containing amino acids reversed the hepatic injury induced by excess<i>Desulfovibrio</i>through gut-liver axis
Restricted intake of sulfur-containing amino acids reversed the hepatic injury induced by excess<i>Desulfovibrio</i>through gut-liver axis Open
Gut-liver axis has been a study focus for liver diseases. Diet is a key player in influencing the gut microbiota. However, the effect of different dietary patterns on gut microbiota and liver functions remains unclear. Here, we used mouse …
View article: Engineering protein translocation and unfolded protein response enhanced human PH-20 secretion in Pichia pastoris
Engineering protein translocation and unfolded protein response enhanced human PH-20 secretion in Pichia pastoris Open
Hyaluronidases catalyze the degradation of hyaluronan (HA), which is finding rising applications in medicine, cosmetic, and food industries. Recombinant expression of hyaluronidases in microbial hosts has been given special attention as a …
View article: Changes in Flavor Profile of Sauce-Flavor Baijiu: Perceptual Interactions between 1-Propanol and Aroma Compounds
Changes in Flavor Profile of Sauce-Flavor Baijiu: Perceptual Interactions between 1-Propanol and Aroma Compounds Open
View article: Unlocking the Potential of Collagenases: Structures, Functions, and Emerging Therapeutic Horizons
Unlocking the Potential of Collagenases: Structures, Functions, and Emerging Therapeutic Horizons Open
View article: Highly Active Secretory Β-Galactosidase from Lactobacillus Delbrueckii for Enhanced Lactose-Derived Oligosaccharide Synthesis
Highly Active Secretory Β-Galactosidase from Lactobacillus Delbrueckii for Enhanced Lactose-Derived Oligosaccharide Synthesis Open
View article: Chitotriose Enhanced Antitumor Activity of Doxorubicin through Egr1 Upregulation in MDA-MB-231 Cells
Chitotriose Enhanced Antitumor Activity of Doxorubicin through Egr1 Upregulation in MDA-MB-231 Cells Open
Dietary supplementation is proposed as a strategy to reduce the side effects of conventional chemotherapy for triple-negative breast cancer (TNBC). Chitosan oligosaccharides (COS), a functional carbohydrate, have been identified to potenti…
View article: Predicting the multispecies solid-state vinegar fermentation process using single-cell Raman spectroscopy combined with machine learning
Predicting the multispecies solid-state vinegar fermentation process using single-cell Raman spectroscopy combined with machine learning Open
Microbial community is a key contributing factor for flavor formation in natural food fermentation. However, it is a challenge to maintain batch-to-batch uniformity during the fermentation process due to the diversity and variability of mi…
View article: Microbial biogeography of pit mud from an artificial brewing ecosystem on a large time scale: all roads lead to Rome
Microbial biogeography of pit mud from an artificial brewing ecosystem on a large time scale: all roads lead to Rome Open
The fermentation process of strong-flavor Baijiu occurs in an underground cellar surrounded by mud, where grains are decomposed and generate new flavor substances. Pit mud microbiome plays a pivotal role in the formation of Baijiu flavor, …