Jian‐Jiang Zhong
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View article: Integrin-specific binding macrocyclic RGD peptides functionalized with dinitrophenol as multivalent antibody-recruiting molecules to enhance cytotoxicity in cancer immunotherapy
Integrin-specific binding macrocyclic RGD peptides functionalized with dinitrophenol as multivalent antibody-recruiting molecules to enhance cytotoxicity in cancer immunotherapy Open
We developed a novel multivalent antibody-recruiting molecule (D3) functionalized with a macrocyclic RGD peptide with high selectivity for α v β 3 integrins and an excellent cytotoxic effect in tumor cells.
View article: Advances in Understanding Renin–Angiotensin System-Mediated Anti-Tumor Activity of Natural Polyphenols
Advances in Understanding Renin–Angiotensin System-Mediated Anti-Tumor Activity of Natural Polyphenols Open
The imbalance of the renin–angiotensin system (RAS), characterized by the overactivation of the pro-tumor ACE/AngII/AT1R axis, is closely linked to tumor growth, angiogenesis, metastasis, and poor prognosis. Natural polyphenols, such as EG…
View article: Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast
Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast Open
Mushroom’s specialized secondary metabolites possess important pharmacological activities, but their biosynthetic pathway elucidation is extremely challenging, not to mention reprogramming of their biosynthetic networks to target metabolit…
View article: A Comprehensive Survey of Reward Models: Taxonomy, Applications, Challenges, and Future
A Comprehensive Survey of Reward Models: Taxonomy, Applications, Challenges, and Future Open
Reward Model (RM) has demonstrated impressive potential for enhancing Large Language Models (LLM), as RM can serve as a proxy for human preferences, providing signals to guide LLMs' behavior in various tasks. In this paper, we provide a co…
View article: Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes: A dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system
Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes: A dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system Open
Background: In the in-vitro expansion of mesenchymal stem cells (MSCs), replicative or stress-induced senescence poses a significant challenge, leading to the loss of their cellular properties and therapeutic functions. Currently, there is…
View article: Macrocyclic RGD-peptides with high selectivity for α<sub>v</sub>β<sub>3</sub> integrin in cancer imaging and therapy
Macrocyclic RGD-peptides with high selectivity for α<sub>v</sub>β<sub>3</sub> integrin in cancer imaging and therapy Open
We developed a novel macrocyclic RGD-peptides (2-c) with high selectivity for α v β 3 Integrin in specific tumor imaging and therapy via one-pot Srt A-mediated on-resin in situ cyclization strategy.
View article: Hyaluronan delays human amniotic epithelial stem cell senescence by regulating CD44 isoform switch to activate AKT/mTOR signals
Hyaluronan delays human amniotic epithelial stem cell senescence by regulating CD44 isoform switch to activate AKT/mTOR signals Open
The replicative senescence of human amniotic epithelial stem cells (hAECs) is a major concern towards its clinical application. This study found that a 300-kDa hyaluronic acid (HA) could effectively delay the replicative senescence of hAEC…
View article: Aminomutation catalyzed by CO<sub>2</sub>self-sufficient cascade amino acid decarboxylases
Aminomutation catalyzed by CO<sub>2</sub>self-sufficient cascade amino acid decarboxylases Open
Molecular editing of an amino group from α-position of amino acids to its β-position is of scientific interest and could be economically appealing. Here we reconstructed an in vitro biotransformation pathway composed of two cascade decarbo…
View article: Rational Design of Daunorubicin C-14 Hydroxylase Based on the Understanding of Its Substrate-Binding Mechanism
Rational Design of Daunorubicin C-14 Hydroxylase Based on the Understanding of Its Substrate-Binding Mechanism Open
Doxorubicin is one of the most widely used antitumor drugs and is currently produced via the chemical conversion method, which suffers from high production costs, complex product separation processes, and serious environmental pollution. B…
View article: Diversity of endophytic fungi of<i>Paeonia lactiflora</i>Pallas and screening for fungal paeoniflorin producers
Diversity of endophytic fungi of<i>Paeonia lactiflora</i>Pallas and screening for fungal paeoniflorin producers Open
Endophytic fungi from Paeonia lactiflora Pallas, which is mainly distributed in China, were characterized and screened to identify those capable of producing paeoniflorin. A total of 101 isolates obtained from the roots, stems and leaves o…
View article: Biotechnology and Bioengineering: Volume 115, Number 10, October 2018
Biotechnology and Bioengineering: Volume 115, Number 10, October 2018 Open
right asymmetry in tissue microarchitectures.To investigate this phenomenon, fl uorescence staining of nuclei was used to reveal such orientation,
View article: Erratum for “Combination of traditional mutation and metabolic engineering to enhance ansamitocin P‐3 production in <i>Actinosynnema pretiosum</i>” (Vol. 114, Issue 12, pp. 2794–2806)
Erratum for “Combination of traditional mutation and metabolic engineering to enhance ansamitocin P‐3 production in <i>Actinosynnema pretiosum</i>” (Vol. 114, Issue 12, pp. 2794–2806) Open
This erratum is being published to correct a typographical error in Figure 5d,e, which led to the wrong unit mg/g DCW being reported for malonyl-CoA and methylmalonyl-CoA concentrations. The correct unit for malonyl-CoA and methylmalonyl-C…
View article: Advances in bio‐based production of dicarboxylic acids longer than C4
Advances in bio‐based production of dicarboxylic acids longer than C4 Open
Growing concerns of environmental pollution and fossil resource shortage are major driving forces for bio‐based production of chemicals traditionally from petrochemical industry. Dicarboxylic acids (DCAs) are important platform chemicals w…
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Advances in ginsenoside
View article: One-step purification and immobilization of extracellularly expressed sortase A by magnetic particles to develop a robust and recyclable biocatalyst
One-step purification and immobilization of extracellularly expressed sortase A by magnetic particles to develop a robust and recyclable biocatalyst Open
Sortase A (SrtA) is a transpeptidase widely used to site-specifically modify peptides and proteins and shows promise for industrial applications. In this study, a novel strategy was developed for constructing immobilized-SrtA as a robust a…
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Long noncoding RNA linc-ITGB1 promotes cell migration and invasion in human breast cancer Oxygenation cascade analysis in conversion of n-octane catalyzed by cytochrome P450 CYP102A3 mutants at the P331 siteEvaluating the autoinduction exp…
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Fabrication of multiwalled carbon nanotubepolyaniline/platinum nanocomposite fi lms toward improved performance for a cholesterol amperometric biosensor Identifi cation of 1H-indene-(1,3,5,6)-tetrol derivatives as potent pancreatic lipase …
View article: Synergistic antitumor efficacy of antibacterial helvolic acid from <i>Cordyceps taii</i> and cyclophosphamide in a tumor mouse model
Synergistic antitumor efficacy of antibacterial helvolic acid from <i>Cordyceps taii</i> and cyclophosphamide in a tumor mouse model Open
The antibacterial agent helvolic acid, which was isolated from the active antitumor fraction of Cordyceps taii, showed potent cytotoxicity against different human cancer cells. In the present study, the in vivo antitumor effect of helvolic…
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Isolation and
View article: Device-level jitter as a probe of ultrafast traps in high-k MOSFETs
Device-level jitter as a probe of ultrafast traps in high-k MOSFETs Open
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