Jinwei Chai
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View article: Correction: Tick cysteine protease inhibitors suppress immune responses in mannan-induced psoriasis-like inflammation
Correction: Tick cysteine protease inhibitors suppress immune responses in mannan-induced psoriasis-like inflammation Open
[This corrects the article DOI: 10.3389/fimmu.2024.1344878.].
View article: Proteome Profiling of Red Blood Cells from Patients with COPD Links Proteasome Activation with Abnormal Cell Morphology and Function
Proteome Profiling of Red Blood Cells from Patients with COPD Links Proteasome Activation with Abnormal Cell Morphology and Function Open
This study provides the in-depth RBC protein profile in COPD, identifying proteasome activation as a key molecular signature. These findings reveal novel biomarkers linked to RBC dysfunction that may contribute to the systemic pathology of…
View article: DASA: a direction-aware and self-adaptive A algorithm with learned heuristic for UAV path planning of smart city
DASA: a direction-aware and self-adaptive A algorithm with learned heuristic for UAV path planning of smart city Open
Path planning is a fundamental component in the development of robotics, autonomous navigation, and intelligent systems, playing a pivotal role in the functioning of smart cities. Within the realm of smart cities, where infrastructure is b…
View article: Mindfulness cognitive-based therapy combined with metaphor therapy can improve problematic social media use
Mindfulness cognitive-based therapy combined with metaphor therapy can improve problematic social media use Open
Introduction Problematic Social Media Use (PSMU) refers to an individual’s long-term, high-intensity use of social media. Although this behavior is not pathological, it has a negative impact on the physical and mental health of individuals…
View article: Talking with the Past: Analyzing Users’ Conversational Patterns and Perceptions with a Large Language Model-Driven Historical Digital Human
Talking with the Past: Analyzing Users’ Conversational Patterns and Perceptions with a Large Language Model-Driven Historical Digital Human Open
View article: Tick cysteine protease inhibitors suppress immune responses in mannan-induced psoriasis-like inflammation
Tick cysteine protease inhibitors suppress immune responses in mannan-induced psoriasis-like inflammation Open
Protease inhibitors regulate various biological processes and prevent host tissue/organ damage. Specific inhibition/regulation of proteases is clinically valuable for treating several diseases. Psoriasis affects the skin in the limbs and s…
View article: Cathelicidin-HG Alleviates Sepsis-Induced Platelet Dysfunction by Inhibiting GPVI-Mediated Platelet Activation
Cathelicidin-HG Alleviates Sepsis-Induced Platelet Dysfunction by Inhibiting GPVI-Mediated Platelet Activation Open
Platelet activation contributes to sepsis development, leading to microthrombosis and increased inflammation, which results in disseminated intravascular coagulation and multiple organ dysfunction. Although Cathelicidin can alleviate sepsi…
View article: Cath-KP, a novel peptide derived from frog skin, prevents oxidative stress damage in a Parkinson’s disease model
Cath-KP, a novel peptide derived from frog skin, prevents oxidative stress damage in a Parkinson’s disease model Open
Parkinson's disease (PD) is a neurodegenerative condition that results in dyskinesia, with oxidative stress playing a pivotal role in its progression. Antioxidant peptides may thus present therapeutic potential for PD. In this study, a nov…
View article: Novel Amphibian Bowman–Birk-Like Inhibitor with Antioxidant and Anticoagulant Effects Ameliorates Pancreatitis Symptoms in Mice
Novel Amphibian Bowman–Birk-Like Inhibitor with Antioxidant and Anticoagulant Effects Ameliorates Pancreatitis Symptoms in Mice Open
Acute pancreatitis (AP) is a serious inflammatory disorder and still lacks effective therapy globally. In this study, a novel Ranacyclin peptide, Ranacin, was identified from the skin of Pelophylax nigromaculatus frog. Ranacin adopt…
View article: The Potent Antitumor Activity of Smp43 against Non-Small-Cell Lung Cancer A549 Cells via Inducing Membranolysis and Mitochondrial Dysfunction
The Potent Antitumor Activity of Smp43 against Non-Small-Cell Lung Cancer A549 Cells via Inducing Membranolysis and Mitochondrial Dysfunction Open
Research has been conducted to investigate the potential application of scorpion venom-derived peptides in cancer therapy. Smp43, a cationic antimicrobial peptide from Scorpio maurus palmatus venom, has been found to exhibit suppressive ac…
View article: The first Brevinin-1 antimicrobial peptide with LPS-neutralizing and anti-inflammatory activities in vitro and in vivo
The first Brevinin-1 antimicrobial peptide with LPS-neutralizing and anti-inflammatory activities in vitro and in vivo Open
Antimicrobial peptide is one important component of the first protective barrier of organisms. They not only have potent antimicrobial activity which can protect the body from the invading pathogens, but also participate in the immune regu…
View article: Smp24, a Scorpion-Venom Peptide, Exhibits Potent Antitumor Effects against Hepatoma HepG2 Cells via Multi-Mechanisms In Vivo and In Vitro
Smp24, a Scorpion-Venom Peptide, Exhibits Potent Antitumor Effects against Hepatoma HepG2 Cells via Multi-Mechanisms In Vivo and In Vitro Open
Scorpion-venom-derived peptides have become a promising anticancer agent due to their cytotoxicity against tumor cells via multiple mechanisms. The suppressive effect of the cationic antimicrobial peptide Smp24, which is derived from the v…
View article: The Strong Anti-Tumor Effect of Smp24 in Lung Adenocarcinoma A549 Cells Depends on Its Induction of Mitochondrial Dysfunctions and ROS Accumulation
The Strong Anti-Tumor Effect of Smp24 in Lung Adenocarcinoma A549 Cells Depends on Its Induction of Mitochondrial Dysfunctions and ROS Accumulation Open
Non-small cell lung cancer (NSCLC) is the leading cause of death in lung cancer due to its aggressiveness and rapid migration. The potent antitumor effect of Smp24, an antimicrobial peptide derived from Egyptian scorpion Scorpio maurus pal…
View article: Scorpion Peptide Smp24 Exhibits a Potent Antitumor Effect on Human Lung Cancer Cells by Damaging the Membrane and Cytoskeleton In Vivo and In Vitro
Scorpion Peptide Smp24 Exhibits a Potent Antitumor Effect on Human Lung Cancer Cells by Damaging the Membrane and Cytoskeleton In Vivo and In Vitro Open
Smp24, a cationic antimicrobial peptide identified from the venom gland of the Egyptian scorpion Scorpio maurus palmatus, shows variable cytotoxicity on various tumor (KG1a, CCRF-CEM and HepG2) and non-tumor (CD34+, HRECs, HACAT) cell line…
View article: Multiple Mechanistic Action of Brevinin‐1FL Peptide against Oxidative Stress Effects in an Acute Inflammatory Model of Carrageenan‐Induced Damage
Multiple Mechanistic Action of Brevinin‐1FL Peptide against Oxidative Stress Effects in an Acute Inflammatory Model of Carrageenan‐Induced Damage Open
Amphibian skin is acknowledged to contain an antioxidant system composed of various gene‐encoded antioxidant peptides, which exert significant effects on host defense. Nevertheless, recognition of such peptides is in its infancy so far. He…
View article: Antimicrobial and Anti-inflammatory Effects of a Novel Peptide From the Skin of Frog Microhyla pulchra
Antimicrobial and Anti-inflammatory Effects of a Novel Peptide From the Skin of Frog Microhyla pulchra Open
Brevinins are an important antimicrobial peptide (AMP) family identified in the skin of Ranidae frogs and generally contain a characteristic ranabox structure at their C-terminal sequence. Herein a novel AMP named brevinin-2MP has been ide…
View article: The toxin mimic FS48 from the salivary gland of Xenopsylla cheopis functions as a Kv1.3 channel-blocking immunomodulator of T cell activation
The toxin mimic FS48 from the salivary gland of Xenopsylla cheopis functions as a Kv1.3 channel-blocking immunomodulator of T cell activation Open
View article: The Protective Effects of Cath-MH With Anti-Propionibacterium Acnes and Anti-Inflammation Functions on Acne Vulgaris
The Protective Effects of Cath-MH With Anti-Propionibacterium Acnes and Anti-Inflammation Functions on Acne Vulgaris Open
Acne vulgaris is a common adolescent skin condition which is mainly caused by Propionibacterium acnes overcolonization and subsequent inflammation. Our previous studies have demonstrated that Cath-MH, an antimicrobial peptide from the skin…
View article: Brevinin-2GHk, a Peptide Derived from the Skin of Fejervarya limnocharis, Inhibits Zika Virus Infection by Disrupting Viral Integrity
Brevinin-2GHk, a Peptide Derived from the Skin of Fejervarya limnocharis, Inhibits Zika Virus Infection by Disrupting Viral Integrity Open
Several years have passed since the Zika virus (ZIKV) pandemic reoccurred in 2015–2016. However, there is still a lack of proved protective vaccines or effective drugs against ZIKV. The peptide brevinin-2GHk (BR2GK), pertaining to the brev…
View article: [Antibacterial mechanism of Brevinin-2GHk, an antimicrobial peptide from <i>Fejervarya limnocharis</i> skin].
[Antibacterial mechanism of Brevinin-2GHk, an antimicrobial peptide from <i>Fejervarya limnocharis</i> skin]. Open
BR2GK, as a broad-spectrum antibacterial peptide with also a strong antioxidant capacity, does not cause hemolysis and is capable of binding to LPS. BR2GK has an important value for future design and synthesis of antimicrobial peptides wit…
View article: FM-CATH, A Novel Cathelicidin From Fejervarya Multistriata, Shows Therapeutic Potential for Treatment of CLP-Induced Sepsis
FM-CATH, A Novel Cathelicidin From Fejervarya Multistriata, Shows Therapeutic Potential for Treatment of CLP-Induced Sepsis Open
Sepsis is an exacerbated inflammatory reaction induced by severe infection. As important defensive molecules in innate immunity, several AMPs are reported to prevent septic shock. In this study, we characterized a novel cathelicidin, FM-CA…
View article: Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties
Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties Open
Antimicrobial peptides form part of the innate immune response and play a vital role in host defense against pathogens. Here we report a new antimicrobial peptide belonging to the cathelicidin family, cathelicidin-MH (cath-MH), from the sk…
View article: Author response: Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties
Author response: Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Antimicrobial peptides form part of the in…
View article: Fejerlectin, a Lectin-like Peptide from the Skin of <i>Fejervarya limnocharis</i>, Inhibits HIV-1 Entry by Targeting Gp41
Fejerlectin, a Lectin-like Peptide from the Skin of <i>Fejervarya limnocharis</i>, Inhibits HIV-1 Entry by Targeting Gp41 Open
Human immunodeficiency virus type 1 (HIV-1) is mainly transmitted by sexual intercourse, and effective microbicides preventing HIV-1 transmission are still required. Amphibian skin is a rich source of defense peptides with antiviral activi…
View article: Anti-inflammatory effects of FS48, the first potassium channel inhibitor from the salivary glands of the flea Xenopsylla cheopis
Anti-inflammatory effects of FS48, the first potassium channel inhibitor from the salivary glands of the flea Xenopsylla cheopis Open
View article: Antipyretic, anti-inflammatory and analgesic activities of Periplaneta americana extract and underlying mechanisms
Antipyretic, anti-inflammatory and analgesic activities of Periplaneta americana extract and underlying mechanisms Open