Jimin Gao
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View article: A dual attention and multi-scale fusion network for diabetic retinopathy image analysis
A dual attention and multi-scale fusion network for diabetic retinopathy image analysis Open
Robust classification of medical images is crucial for reliable automated diagnosis, yet remains challenging due to heterogeneous lesion appearances and imaging inconsistencies. We introduce DWAM-MSFINET (Dual Window Adaptation and Multi-S…
View article: Investigation of the Melt-Rotation Effects on Fiber Orientation Variation and Geometrical Shrinkage in FRP Injection-Molded Parts
Investigation of the Melt-Rotation Effects on Fiber Orientation Variation and Geometrical Shrinkage in FRP Injection-Molded Parts Open
The study focuses on the asymmetric shrinkage typically occurring between the upstream and downstream regions of FRP injection-molded products, a challenge that is particularly difficult to manage and improve. Specifically, two sets of fou…
View article: Venetoclax and hypomethylating agents versus induction chemotherapy for newly diagnosed acute myeloid leukemia patients: a systematic review and meta-analysis
Venetoclax and hypomethylating agents versus induction chemotherapy for newly diagnosed acute myeloid leukemia patients: a systematic review and meta-analysis Open
View article: Optimized BCMA/CS1 bispecific TRuC-T cells secreting IL-7 and CCL21 robustly control multiple myeloma
Optimized BCMA/CS1 bispecific TRuC-T cells secreting IL-7 and CCL21 robustly control multiple myeloma Open
Introduction Challenges remain in reducing antigen escape and tumor recurrence while CAR-T cell therapy has substantially improved outcomes in the treatment of multiple myeloma. T cell receptor fusion construct (TRuC)-T cells, which utiliz…
View article: 1493 The armoured T-cell antigen coupler receptor (TAC) T cells with the integrated CD28 signaling, TAC28-T
1493 The armoured T-cell antigen coupler receptor (TAC) T cells with the integrated CD28 signaling, TAC28-T Open
View article: Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma
Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma Open
View article: Data from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure
Data from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure Open
Purpose: The carcinogenic capacity of B[a]P/B[a]PDE is supported by epidemiologic studies. However, the molecular mechanisms responsible for B[a]P/B[a]PDE-caused lung cancer have not been well investigated. We evaluated here the rol…
View article: Data from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure
Data from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure Open
Purpose: The carcinogenic capacity of B[a]P/B[a]PDE is supported by epidemiologic studies. However, the molecular mechanisms responsible for B[a]P/B[a]PDE-caused lung cancer have not been well investigated. We evaluated here the rol…
View article: supplementary methods and figure legends from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure
supplementary methods and figure legends from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure Open
supplementary methods and figure legends
View article: Supplementary Figure 1-6, Supplementary Tables 1-3 from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure
Supplementary Figure 1-6, Supplementary Tables 1-3 from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure Open
Supplementary Figure 1-6, Supplementary Tables 1-3. Supplementary Table 1 Clinic pathologic characteristics of 54 cases of lung cancer patients; Supplementary Table 2 The number of mouse for TNFa expression quantitative analysis; Supplemen…
View article: Supplementary Figure 1-6, Supplementary Tables 1-3 from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure
Supplementary Figure 1-6, Supplementary Tables 1-3 from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure Open
Supplementary Figure 1-6, Supplementary Tables 1-3. Supplementary Table 1 Clinic pathologic characteristics of 54 cases of lung cancer patients; Supplementary Table 2 The number of mouse for TNFa expression quantitative analysis; Supplemen…
View article: supplementary methods and figure legends from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure
supplementary methods and figure legends from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure Open
supplementary methods and figure legends
View article: Development of FAP-Targeted Chimeric Antigen Receptor NK-92 Cells for Non-Small Cell Lung Cancer
Development of FAP-Targeted Chimeric Antigen Receptor NK-92 Cells for Non-Small Cell Lung Cancer Open
In this study, we successfully constructed hFAP-CAR-NK-92 cells and confirmed that hFAP-CAR-NK-92 cells could target hFAP-positive NSCLC to inhibit the progression of NSCLC by activating the Caspase-3/GSDME pyroptosis pathway.
View article: Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors
Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors Open
Background Chimeric antigen receptor T (CAR-T) cell therapy has made significant advances for hematological malignancies but encounters obstacles in the treatment of solid tumors mainly due to tumor immunosuppressive microenvironment. Meth…
View article: Safety and Feasibility of Anti-CD19 CAR T Cells Expressing Inducible IL-7 and CCL19 in Patients with Relapsed or Refractory Large B-cell Lymphoma
Safety and Feasibility of Anti-CD19 CAR T Cells Expressing Inducible IL-7 and CCL19 in Patients with Relapsed or Refractory Large B-cell Lymphoma Open
Chimeric antigen receptor (CAR) T cell therapy provides a potentially curative option for patients with relapsed or refractory large B-cell lymphoma (R/R LBCL). However, there are major limitations of this therapy which result in treatment…
View article: Combination of 4-1BB and DAP10 promotes proliferation and persistence of NKG2D(bbz) CAR-T cells
Combination of 4-1BB and DAP10 promotes proliferation and persistence of NKG2D(bbz) CAR-T cells Open
Chimeric antigen receptor (CAR)-T cell therapy has been shown to have considerable therapeutic effects in hematological malignancies, and NKG2D(z) CAR-T cell therapy has been verified to be safe based on clinical trials. However, due to th…
View article: Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing
Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing Open
Effective skin wound healing is a complex process involving anti‐inflammation, fibrosis, matrix reconstruction, and angiogenesis. This work aimed to integrate the macrophage‐mediated anti‐inflammation and fibroblast‐assisted matrix reconst…
View article: A novel multimeric <scp>sCD19</scp>‐streptavidin fusion protein for functional detection and selective expansion of <scp>CD19</scp>‐targeted <scp>CAR‐T</scp> cells
A novel multimeric <span>sCD19</span>‐streptavidin fusion protein for functional detection and selective expansion of <span>CD19</span>‐targeted <span>CAR‐T</span> cells Open
Background CARs are engineered receptors comprising an immunoglobulin single‐chain variable fragment (scFv) that identifies and binds to the target antigen, a transmembrane domain, and an intracellular T‐cell signaling domain. CD19 is a B …
View article: Functional Recovery with Electro-Acupuncture Stimulation in an Mecp2-Knockout Rat Model of Rett Syndrome
Functional Recovery with Electro-Acupuncture Stimulation in an Mecp2-Knockout Rat Model of Rett Syndrome Open
View article: The BCMA-Targeted Fourth-Generation CAR-T Cells Secreting IL-7 and CCL19 for Therapy of Refractory/Recurrent Multiple Myeloma
The BCMA-Targeted Fourth-Generation CAR-T Cells Secreting IL-7 and CCL19 for Therapy of Refractory/Recurrent Multiple Myeloma Open
Chimeric antigen receptor (CAR) technology has revolutionized cancer treatment, particularly in malignant hematological tumors. Currently, the BCMA-targeted second-generation CAR-T cells have showed impressive efficacy in the treatment of …
View article: GM-CSF-Loaded Nanoparticles for Photothermal-Assisted Immunotherapy against Orthotopic Bladder Cancer
GM-CSF-Loaded Nanoparticles for Photothermal-Assisted Immunotherapy against Orthotopic Bladder Cancer Open
This study reported the construction of GM-CSF-loaded chitosan/graphene oxide nanoparticles for photothermal therapy-assisted immunotherapy against murine orthotopic bladder cancer. The encapsulated GM-CSF in chitosan/graphene oxide nanopa…
View article: Sequential administration of anti-PD-1 and anti-Tim-3 combined with an SA-GM-CSF-anchored vaccine overcomes adaptive immune resistance to reject established bladder cancer
Sequential administration of anti-PD-1 and anti-Tim-3 combined with an SA-GM-CSF-anchored vaccine overcomes adaptive immune resistance to reject established bladder cancer Open
Program death receptor-1 (PD-1) and T-cell immunoglobulin and mucin domain-containing protein-3 (Tim-3) play an important role in tumor immune evasion. PD-1 blockade could produce an effective anti-tumor effect but the response rate was lo…
View article: Gain of function mutant p53 protein activates AKT through the Rac1 signaling to promote tumorigenesis
Gain of function mutant p53 protein activates AKT through the Rac1 signaling to promote tumorigenesis Open
Tumor suppressor p53 is the most frequently mutated gene in human cancer. Mutant p53 (mutp53) not only loses the tumor suppressive activity of wild type p53, but often gains new oncogenic activities to promote tumorigenesis, defined as mut…
View article: Screening and identification of serum biomarkers of osteoarticular tuberculosis based on mass spectrometry
Screening and identification of serum biomarkers of osteoarticular tuberculosis based on mass spectrometry Open
Background In view of the current difficulty of clinically diagnosing osteoarticular tuberculosis, our aim was to use mass spectrometry to establish diagnostic models and to screen and identify serum proteins which could serve as potential…
View article: Increased Tim-3 expression on TILs during treatment with the Anchored GM-CSF vaccine and anti-PD-1 antibodies is inversely correlated with response in prostate cancer
Increased Tim-3 expression on TILs during treatment with the Anchored GM-CSF vaccine and anti-PD-1 antibodies is inversely correlated with response in prostate cancer Open
Programmed death receptor-1 (PD-1) and T cell immunoglobulin and mucin domain-containing protein-3 (Tim-3) play important roles in tumor immune evasion. PD-1 blockade could produce an effective antitumor effect in many solid tumors except …
View article: Graded diacylglycerol kinases α and ζ activities ensure mucosal‐associated invariant T‐cell development in mice
Graded diacylglycerol kinases α and ζ activities ensure mucosal‐associated invariant T‐cell development in mice Open
Mucosal‐associated invariant T (MAIT) cells participate in both protective immunity and pathogenesis of diseases. Most murine MAIT cells express an invariant TCRVα19‐Jα33 (iVα19) TCR, which triggers signals crucial for their development. H…
View article: Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice
Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice Open
Mucosal-associated invariant T (MAIT) cells and invariant NK T (iNKT) cells account for the major lymphocyte populations that express invariant TCRα-chains. MAIT cells mostly express the TCRVα19-Jα33 TCR in mice and the TCRVα7.2-Jα33 TCR i…
View article: Circulating Mucosal-Associated Invariant T Cells in a Large Cohort of Healthy Chinese Individuals From Newborn to Elderly
Circulating Mucosal-Associated Invariant T Cells in a Large Cohort of Healthy Chinese Individuals From Newborn to Elderly Open
Mucosal-associated invariant T (MAIT) cells, which are enriched in human blood and express a semi-invariant TCR chain, play important roles in conditions such as infectious diseases and cancer. The influence of age on levels and functional…
View article: The pilot-scale preparation of the SA-hGM-CSF bi-functional fusion protein
The pilot-scale preparation of the SA-hGM-CSF bi-functional fusion protein Open
The granulocyte-macrophage colony-stimulating factor (GM-CSF) can be used to induce a powerful immune response. Based on the specific binding of biotin and streptavidin, SA-hGM-CSF was anchored on the surface of biotinylated tumor cells, w…
View article: Combination immunotherapy with interleukin‐2 surface‐modified tumor cell vaccine and programmed death receptor‐1 blockade against renal cell carcinoma
Combination immunotherapy with interleukin‐2 surface‐modified tumor cell vaccine and programmed death receptor‐1 blockade against renal cell carcinoma Open
Immunotherapy may be an effective way to prevent postoperative recurrence of renal cell carcinoma. Streptavidin‐interleukin‐2 ( SA ‐ IL ‐2) surface‐modified tumor cell vaccine developed through our protein‐anchor technology could induce sp…