Jinyan Du
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View article: Fast Reroute Mechanism for Satellite Networks Based on Segment Routing and Dual Timers Switching
Fast Reroute Mechanism for Satellite Networks Based on Segment Routing and Dual Timers Switching Open
Low-Earth-Orbit (LEO) satellite networks have the advantage of global internet coverage and low latency, and they have enjoyed great success in the past few years. In LEO satellite networks, laser-based inter-satellite links (ISLs) are wid…
Supplementary Figure 1 from Molecular Dissection of AKT Activation in Lung Cancer Cell Lines Open
PDF file - 1285K, HER2 amplification and Afatinib sensitivity in H1819 and Calu-3.
Supplementary Figures S1-S4 from Autophagy Induction with RAD001 Enhances Chemosensitivity and Radiosensitivity through Met Inhibition in Papillary Thyroid Cancer Open
Supplementary Figures S1-S4.
Data from Amplification of <i>CRKL</i> Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non–Small Cell Lung Cancers Open
We previously identified a region of recurrent amplification on chromosome 22q11.21 in a subset of primary lung adenocarcinomas. Here we show that CRKL, encoding for an adaptor protein, is amplified and overexpressed in non–small cell lung…
Supplementary Figures 1-9 from Amplification of <i>CRKL</i> Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non–Small Cell Lung Cancers Open
PDF file - 1.5MB
Data from Autophagy Induction with RAD001 Enhances Chemosensitivity and Radiosensitivity through Met Inhibition in Papillary Thyroid Cancer Open
Although autophagy is generally considered a prosurvival mechanism that preserves viability, there is evidence that it could drive an alternative programmed cell death pathway in cells with defects in apoptosis. Because the inhibition of a…
Supplementary Figure Legend and Tables 1 - 2 from Molecular Dissection of AKT Activation in Lung Cancer Cell Lines Open
PDF file - 103K, Supplemental Table 1. Cell lines assessed for persistent AKT-S473 phosphorylation in the absence of serum. Supplemental Table 2. Tyrosine kinase phosphorylation profiling.
Supplementary Figure 4 from Molecular Dissection of AKT Activation in Lung Cancer Cell Lines Open
PDF file - 2483K, Synergistic effects of mTOR kinase and rapalogue therapy with Dasatanib on HCC2429 cells.
Supplementary Figures S1-S4 from Autophagy Induction with RAD001 Enhances Chemosensitivity and Radiosensitivity through Met Inhibition in Papillary Thyroid Cancer Open
Supplementary Figures S1-S4.
Supplementary Figure 1 from Molecular Dissection of AKT Activation in Lung Cancer Cell Lines Open
PDF file - 1285K, HER2 amplification and Afatinib sensitivity in H1819 and Calu-3.
Data from Amplification of <i>CRKL</i> Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non–Small Cell Lung Cancers Open
We previously identified a region of recurrent amplification on chromosome 22q11.21 in a subset of primary lung adenocarcinomas. Here we show that CRKL, encoding for an adaptor protein, is amplified and overexpressed in non–small cell lung…
Supplementary Figure Legend and Tables 1 - 2 from Molecular Dissection of AKT Activation in Lung Cancer Cell Lines Open
PDF file - 103K, Supplemental Table 1. Cell lines assessed for persistent AKT-S473 phosphorylation in the absence of serum. Supplemental Table 2. Tyrosine kinase phosphorylation profiling.
Supplementary Figure 4 from Molecular Dissection of AKT Activation in Lung Cancer Cell Lines Open
PDF file - 2483K, Synergistic effects of mTOR kinase and rapalogue therapy with Dasatanib on HCC2429 cells.
Data from Molecular Dissection of AKT Activation in Lung Cancer Cell Lines Open
AKT is a critical signaling node downstream of phosphoinositide 3-kinase (PI3K), which is often activated in cancer. We analyzed the state of activation of AKT in 80 human non–small cell lung carcinoma cell lines under serum starvation con…
Supplementary Figures 1-9 from Amplification of <i>CRKL</i> Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non–Small Cell Lung Cancers Open
PDF file - 1.5MB
Data from Molecular Dissection of AKT Activation in Lung Cancer Cell Lines Open
AKT is a critical signaling node downstream of phosphoinositide 3-kinase (PI3K), which is often activated in cancer. We analyzed the state of activation of AKT in 80 human non–small cell lung carcinoma cell lines under serum starvation con…
Supplementary Figure 2 from Molecular Dissection of AKT Activation in Lung Cancer Cell Lines Open
PDF file - 1756K, SRC and ERK1/2 activation in lung cancer cell lines, and response to dasatinib.
Supplementary Figure 3 from Molecular Dissection of AKT Activation in Lung Cancer Cell Lines Open
PDF file - 1702K, The activation of AKT in HCC2429 cells is EGFR-independent.
Supplementary Figure 2 from Molecular Dissection of AKT Activation in Lung Cancer Cell Lines Open
PDF file - 1756K, SRC and ERK1/2 activation in lung cancer cell lines, and response to dasatinib.
Data from Autophagy Induction with RAD001 Enhances Chemosensitivity and Radiosensitivity through Met Inhibition in Papillary Thyroid Cancer Open
Although autophagy is generally considered a prosurvival mechanism that preserves viability, there is evidence that it could drive an alternative programmed cell death pathway in cells with defects in apoptosis. Because the inhibition of a…
Supplementary Figure 3 from Molecular Dissection of AKT Activation in Lung Cancer Cell Lines Open
PDF file - 1702K, The activation of AKT in HCC2429 cells is EGFR-independent.
Supplementary Figure Legend from High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma Open
PDF file - 17K
Data from High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma Open
Limited progress has been made in the treatment of advanced-stage pediatric solid tumors despite the accelerated pace of cancer discovery over the last decade. Tyrosine kinase inhibition is one tractable therapeutic modality for treating h…
Data from A Novel ALK Secondary Mutation and EGFR Signaling Cause Resistance to ALK Kinase Inhibitors Open
Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKI), including crizotinib, are effective treatments in preclinical models and in cancer patients with ALK-translocated cancers. However, their efficacy will ultimately be limite…
Supplementary Figures 1-4 from A Novel ALK Secondary Mutation and EGFR Signaling Cause Resistance to ALK Kinase Inhibitors Open
PDF file - 560K
Supplementary Tables 1 - 3 from High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma Open
PDF file - 33K, Sequences for pLKO.1 FAK-targeting and CAS-targeting shRNAs (S1); Median fluorescent intensity for six Ewing sarcoma cell lines and 293FT cells measuring the phosphorylation level of 62 tyrosine kinases (S2); PF-562271 down…
Supplementary Figure Legend from High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma Open
PDF file - 17K
Data from High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma Open
Limited progress has been made in the treatment of advanced-stage pediatric solid tumors despite the accelerated pace of cancer discovery over the last decade. Tyrosine kinase inhibition is one tractable therapeutic modality for treating h…
Supplementary Figures 1 - 5 from High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma Open
PDF file - 62K, Treatment of two Ewing sarcoma cell lines with A, dasatinib (SRC inhibitor) for 8 hours or B, PD0325901 (MEK inhibitor) for 72 hours eliminates phosphorylation of SRC and ERK, respectively (S1); Transduction with five FAK-d…
Data from A Novel ALK Secondary Mutation and EGFR Signaling Cause Resistance to ALK Kinase Inhibitors Open
Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKI), including crizotinib, are effective treatments in preclinical models and in cancer patients with ALK-translocated cancers. However, their efficacy will ultimately be limite…