Feng Cheng
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View article: Mitophagy Reprograms Lactate Metabolism to Suppress THBS1 via H3K18la Reduction, Alleviating Intervertebral Disc Degeneration
Mitophagy Reprograms Lactate Metabolism to Suppress THBS1 via H3K18la Reduction, Alleviating Intervertebral Disc Degeneration Open
Mitophagy alleviates intervertebral disc degeneration (IVDD) by suppressing cGAS-STING and NLRP3 inflammasome-mediated pyroptosis pathways; however, its metabolic regulatory mechanism remains unexplored. Herein, we discovered that mitophag…
View article: YAP ameliorates CCl4-induced acute liver injury by activating autophagy via modulating p300/CBP-mediated FoxO3 acetylation
YAP ameliorates CCl4-induced acute liver injury by activating autophagy via modulating p300/CBP-mediated FoxO3 acetylation Open
Carbon tetrachloride (CCl4) induces hepatocyte necroptosis and perturbs local and systemic immunity, driving Acute Liver Injury (ALI). Yes-associated protein (YAP), a transcriptional coactivator orchestrating cell survival, diff…
View article: A Mini‐Review on Chinese Ancient Porcelain Research: Application of <scp>EDXRF</scp> Technology in Archaeology and Cultural Heritage Conservation
A Mini‐Review on Chinese Ancient Porcelain Research: Application of <span>EDXRF</span> Technology in Archaeology and Cultural Heritage Conservation Open
In recent years, energy‐dispersive X‐ray fluorescence (EDXRF) has emerged as a nondestructive compositional analysis technique widely used in archaeology and cultural heritage preservation. This technology extracts elemental composition da…
View article: Identification of Potential Diagnostic Biomarkers and Drug Targets for Endometriosis from a Genetic Perspective: A Mendelian Randomization Study
Identification of Potential Diagnostic Biomarkers and Drug Targets for Endometriosis from a Genetic Perspective: A Mendelian Randomization Study Open
Objectives: Endometriosis (EM) is a chronic disease severely impacting reproductive health, with its exact cause still unclear. In-depth understanding of the etiology and pathogenesis of EM from the perspective of genetics and exploring in…
View article: Yap Ameliorates Ccl4-Induced Acute Liver Injury by Activating Autophagy Via Modulating P300/Cbp-Mediated Foxo3 Acetylation
Yap Ameliorates Ccl4-Induced Acute Liver Injury by Activating Autophagy Via Modulating P300/Cbp-Mediated Foxo3 Acetylation Open
View article: Analyzing Student Online Learning Behaviors and Academic Performance in Science Education Using Machine Learning Techniques
Analyzing Student Online Learning Behaviors and Academic Performance in Science Education Using Machine Learning Techniques Open
This study investigates the factors influencing student engagement and performance in online science education through the application of machine learning models, specifically Random Forests, Decision Trees, and Support Vector Machines (SV…
View article: Analysis of the causal relationship between immune cells and rheumatoid arthritis from the perspective of genetic variation: a bidirectional two-sample Mendelian randomization study
Analysis of the causal relationship between immune cells and rheumatoid arthritis from the perspective of genetic variation: a bidirectional two-sample Mendelian randomization study Open
Background Immune factors are crucial in the pathogenesis of rheumatoid arthritis (RA), and immune cells play a key role in the development of RA. However, there is still disagreement regarding the specific roles of each type of immune cel…
View article: Dedifferentiation-like reprogramming of degenerative nucleus pulposus cells into notochordal-like cells by defined factors
Dedifferentiation-like reprogramming of degenerative nucleus pulposus cells into notochordal-like cells by defined factors Open
View article: DAM: Dynamic Adapter Merging for Continual Video QA Learning
DAM: Dynamic Adapter Merging for Continual Video QA Learning Open
We present a parameter-efficient method for continual video question-answering (VidQA) learning. Our method, named DAM, uses the proposed Dynamic Adapter Merging to (i) mitigate catastrophic forgetting, (ii) enable efficient adaptation to …
View article: Only the Curve Shape Matters: Training Foundation Models for Zero-Shot Multivariate Time Series Forecasting through Next Curve Shape Prediction
Only the Curve Shape Matters: Training Foundation Models for Zero-Shot Multivariate Time Series Forecasting through Next Curve Shape Prediction Open
We present General Time Transformer (GTT), an encoder-only style foundation model for zero-shot multivariate time series forecasting. GTT is pretrained on a large dataset of 200M high-quality time series samples spanning diverse domains. I…
View article: Structure–Performance Correlation Inspired Platinum-Assisted Anode with a Homogeneous Ionomer Layer for Proton Exchange Membrane Water Electrolysis
Structure–Performance Correlation Inspired Platinum-Assisted Anode with a Homogeneous Ionomer Layer for Proton Exchange Membrane Water Electrolysis Open
PEMWE is becoming one of the most promising technologies for efficient and green hydrogen production, while the anode OER process is deeply restricted by the now commercially used iridium oxide with sluggish reaction kinetics and super hig…
View article: New vision of convection induced freckle formation theory in nickel-based superalloys by electron microscopy
New vision of convection induced freckle formation theory in nickel-based superalloys by electron microscopy Open
Freckles, one of the common defects in blades used in heavy-duty gas turbines, hugely deteriorate the mechanical properties and liability of blades under service conditions. The thermal-solutal convection theory is a widely adopted formati…
View article: Silencing circATXN1 in Aging Nucleus Pulposus Cell Alleviates Intervertebral Disc Degeneration via Correcting Progerin Mislocalization
Silencing circATXN1 in Aging Nucleus Pulposus Cell Alleviates Intervertebral Disc Degeneration via Correcting Progerin Mislocalization Open
Circular RNAs (circRNAs) play a critical regulatory role in degenerative diseases; however, their functions and therapeutic applications in intervertebral disc degeneration (IVDD) have not been explored. Here, we identified that a novel ci…
View article: A New Method for Ship Detection in SAR Image Based on Finsler Information Geometry
A New Method for Ship Detection in SAR Image Based on Finsler Information Geometry Open
This article introduces a novel ship detection method for Synthetic Aperture Radar (SAR) images that leverages the principles of Finsler information geometry.It employs the curvature features of a statistical manifold as a discriminative m…
View article: CuS Assisted Fe(III)-Induced&nbsp;Peracetic Acid Activation&nbsp;For Bisphenol a Degradation: Significance of Synergetic Roles of Copper and Sulfur in Enhanced Fenton-Like Process
CuS Assisted Fe(III)-Induced Peracetic Acid Activation For Bisphenol a Degradation: Significance of Synergetic Roles of Copper and Sulfur in Enhanced Fenton-Like Process Open
View article: PARs: Predicate-based Association Rules for Efficient and Accurate Model-Agnostic Anomaly Explanation
PARs: Predicate-based Association Rules for Efficient and Accurate Model-Agnostic Anomaly Explanation Open
While new and effective methods for anomaly detection are frequently introduced, many studies prioritize the detection task without considering the need for explainability. Yet, in real-world applications, anomaly explanation, which aims t…
View article: Use of a combination of diaphragmatic ultrasound and muscle relaxation monitoring in predicting post-extubation adverse respiratory events among elderly patients in an anesthesia intensive care unit
Use of a combination of diaphragmatic ultrasound and muscle relaxation monitoring in predicting post-extubation adverse respiratory events among elderly patients in an anesthesia intensive care unit Open
View article: Approaches of Combining Machine Learning with NMR-based Pore Structure Characterization for Reservoir Evaluation
Approaches of Combining Machine Learning with NMR-based Pore Structure Characterization for Reservoir Evaluation Open
Tight gas, a category of Deep Green Energy Resources, rely on advanced intelligent monitoring methods for their extraction. Conventional logging for reservoir evaluation relies on logging data and the manual setting of evaluation criteria …
View article: Use of a combination of diaphragmatic ultrasound and muscle relaxation monitoring in predicting post-extubation adverse respiratory events among elderly patients in an anesthesia intensive care unit
Use of a combination of diaphragmatic ultrasound and muscle relaxation monitoring in predicting post-extubation adverse respiratory events among elderly patients in an anesthesia intensive care unit Open
Objective The purpose of this study was to examine the feasibility of using a combination of diaphragmatic ultrasound and muscle relaxation monitoring in predicting adverse respiratory events after extubation among elderly patients in an a…
View article: Unified Coarse-to-Fine Alignment for Video-Text Retrieval
Unified Coarse-to-Fine Alignment for Video-Text Retrieval Open
The canonical approach to video-text retrieval leverages a coarse-grained or fine-grained alignment between visual and textual information. However, retrieving the correct video according to the text query is often challenging as it requir…
View article: MicroRNAs in the Regulation of RIG-I-like Receptor Signaling Pathway: Possible Strategy for Viral Infection and Cancer
MicroRNAs in the Regulation of RIG-I-like Receptor Signaling Pathway: Possible Strategy for Viral Infection and Cancer Open
The retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) play a crucial role as pattern-recognition receptors within the innate immune system. These receptors, present in various cell and tissue types, serve as essential sensors fo…
View article: Joint Oscillation Damping and Inertia Provision Service for Converter-Interfaced Generation
Joint Oscillation Damping and Inertia Provision Service for Converter-Interfaced Generation Open
Power systems dominated by converter-interfaced distributed energy resources (DERs) typically exhibit weaker damping capabilities and lower inertia, compromising system stability. Although individual DER controllers are evolving to provide…
View article: New vision of convection induced freckle formation theory in Nickel-based superalloys by electron microscopy
New vision of convection induced freckle formation theory in Nickel-based superalloys by electron microscopy Open
Freckles, one of the common defects in blades used in heavy duty gas turbines, hugely deteriorates blades mechanical properties and liability under service conditions. Thermal-solutal convection theory is a widely adopted formation mechani…
View article: Exosomes from circ-Astn1-modified adipose-derived mesenchymal stem cells enhance wound healing through miR-138-5p/SIRT1/FOXO1 axis regulation
Exosomes from circ-Astn1-modified adipose-derived mesenchymal stem cells enhance wound healing through miR-138-5p/SIRT1/FOXO1 axis regulation Open
Circ-Astn1 promotes the therapeutic effect of ADSC-Exos and thus improves wound healing in diabetes via miR-138-5p absorption and SIRT1 upregulation. Based on our data, we advocate targeting the circ-Astn1/miR-138-5p/SIRT1 axis as a…
View article: Non-Typhoidal Salmonella Infections Among Children in Fuzhou, Fujian, China: A 10-Year Retrospective Review from 2012 to 2021
Non-Typhoidal Salmonella Infections Among Children in Fuzhou, Fujian, China: A 10-Year Retrospective Review from 2012 to 2021 Open
S. Typhimurium was the dominant serotype and greatly increased among children in Fuzhou city. There are significant differences in clinical symptoms, laboratory test results, and drug resistance between S. Typhimurium and non…
View article: Neutrophil extracellular traps induced by interleukin 8 via CXCR1/2 promote the progression of gastric carcinoma through transcription factor IIB-related factor 1 and cyclin
Neutrophil extracellular traps induced by interleukin 8 via CXCR1/2 promote the progression of gastric carcinoma through transcription factor IIB-related factor 1 and cyclin Open
View article: Front Cover: Digital light processing (DLP)‐based (bio)printing strategies for tissue modeling and regeneration
Front Cover: Digital light processing (DLP)‐based (bio)printing strategies for tissue modeling and regeneration Open
Digital light processing (DLP)-based bioprinting technology has been exploited for a wide range of applications in tissue repair, tissue regeneration, disease modeling and drug screening. In article number e270, Li and co-workers comprehen…
View article: Supplementary Figures 1-2 from Concordant Gene Expression Signatures Predict Clinical Outcomes of Cancer Patients Undergoing Systemic Therapy
Supplementary Figures 1-2 from Concordant Gene Expression Signatures Predict Clinical Outcomes of Cancer Patients Undergoing Systemic Therapy Open
Supplementary Figures 1-2 from Concordant Gene Expression Signatures Predict Clinical Outcomes of Cancer Patients Undergoing Systemic Therapy
View article: Supplementary Figure Legends 1-2, Methods from Concordant Gene Expression Signatures Predict Clinical Outcomes of Cancer Patients Undergoing Systemic Therapy
Supplementary Figure Legends 1-2, Methods from Concordant Gene Expression Signatures Predict Clinical Outcomes of Cancer Patients Undergoing Systemic Therapy Open
Supplementary Figure Legends 1-2, Methods from Concordant Gene Expression Signatures Predict Clinical Outcomes of Cancer Patients Undergoing Systemic Therapy
View article: Data from Concordant Gene Expression Signatures Predict Clinical Outcomes of Cancer Patients Undergoing Systemic Therapy
Data from Concordant Gene Expression Signatures Predict Clinical Outcomes of Cancer Patients Undergoing Systemic Therapy Open
Conventional development of multivariate gene expression models (GEM) predicting therapeutic response of cancer patients is based on analysis of patients treated with specific regimens, which limits generalization to different or novel dru…