Explanipedia

A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1 Open

Tianhao Zou, Ran Liu, Gengqiao Wang, Zhengting Jiang, Chuanzheng Wang , et al. · 2025

Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1 Open

Ran Liu, Gengqiao Wang, Zhengting Jiang, Tianhao Zou, Chuanzheng Wang , et al. · 2025

Tumor necrosis factor α (TNFα) maintains homeostasis through promoting cell survival or cell death; however, how this process is regulated by metabolic pathways remains largely unknown. Here, we identify adenosine kinase (ADK), the key enz…

RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation Open

Zezhao Chen, Xiaosong Gu, Hongbo Chen, Huijing Zhang, Jianping Liu , et al. · 2025

The capacity of cells to sense and respond to nutrient availability is essential for metabolic homeostasis. Failure in this process may cause cell death and associated diseases. While nutrient sensing in metabolic pathways is well understo…

Multi-objective layout optimization of hospital outpatient clinics based on NSGA II Open

Yanlin Zhao, Jinyang Gu · 2025

<i>Lachnospiraceae-bacterium</i> alleviates ischemia-reperfusion injury in steatotic donor liver by inhibiting ferroptosis via the Foxo3-Alox15 signaling pathway Open

Shenghe Deng, Huan Cao, Tongxi Li, Xueling Wang, Junpeng Meng , et al. · 2025

Ischemia-reperfusion injury (IRI) is a major obstacle in liver transplantation, especially with steatotic donor livers. Dysbiosis of the gut microbiota has been implicated in modulating IRI, and Lachnospiraceae plays a pivotal role …

ZBP1/RIP3-Dependent Necroptosis Plays a Role in Hypoxia-Induced Hepatocyte Death and Contributes to Ischemia-Reperfusion Injury Open

Jiacheng Lin, Min Xu, Hui Ji, Weifan Huang, Yuge Zhou , et al. · 2025

Necroptosis‐Mediated Synergistic Photodynamic and Glutamine‐Metabolic Therapy Enabled by a Biomimetic Targeting Nanosystem for Cholangiocarcinoma Open

Zheng Qichang, Tianhao Zou, Weimin Wang, Chen Zhang, Shaobo Hu , et al. · 2024

Targeted delivery of glutamine metabolism inhibitors holds promise for cholangiocarcinoma therapy, yet effective delivery vehicles remain a challenge. This study reports the development of a biomimetic nanosystem, termed R‐CM@MSN@BC, integ…

ZBP1-mediated apoptosis and inflammation exacerbate steatotic liver ischemia/reperfusion injury Open

Yizhi Liu, Huan Cao, Shu‐Hua Zhang, Mao Cai, Tianhao Zou , et al. · 2024

Steatotic donor livers are becoming more and more common in liver transplantation. However, the current use of steatotic grafts is less acceptable than normal grafts due to their higher susceptibility to ischemia/reperfusion (I/R) injury. …

Early detection of hepatocellular carcinoma via no end-repair enzymatic methylation sequencing of cell-free DNA and pre-trained neural network Open

Zhenzhong Deng, Yongkun Ji, Bing Han, Zhongming Tan, Yuqi Ren , et al. · 2023

Applied machine learning to analyze and predict CO2 adsorption behavior of metal-organic frameworks Open

Xiaoqiang Li, Xiong Zhang, Junjie Zhang, Jinyang Gu, Shibiao Zhang , et al. · 2023

Machine learning provides new insights for designing MOFs with high CO2 adsorption capacity and understanding the CO2 adsorption mechanism. In this work, 348 data points from published reports were collected and four tree-based models were…

Graphical Abstract: Angew. Chem. Int. Ed. 30/2023 Open

Anna Hartmann, S. Dutta, Ranjit Mallick, Akhila K. Sahoo, Piermichele Kobauri , et al. · 2023

Supramolecular ChemistryIn their Communication (e202305525), Mark J. Mac-Lachlan use a single PtÀPt bond to glue two cyclometalated hosts together and generate a flytrap-like molecule.This compound traps inorganic ions, assembles and disas…

Dual FGFR and VEGFR inhibition synergistically restrain hexokinase 2-dependent lymphangiogenesis and immune escape in intrahepatic cholangiocarcinoma Open

Min Peng, Hui Li, Huấn Cao, Yamei Huang, Weiping Yu , et al. · 2023

UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis Open

Tao Zhang, Na Zhang, Jing Xing, Shuhua Zhang, Yulu Chen , et al. · 2023

Additional file 1 of Early detection of hepatocellular carcinoma via no end-repair enzymatic methylation sequencing of cell-free DNA and pre-trained neural network Open

Zhenzhong Deng, Yongkun Ji, Bing Han, Zhongming Tan, Yuqi Ren , et al. · 2023

Additional file 1. Samples_information.

SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation Open

Lingjie Yan, Tao Zhang, Kai Wang, Zezhao Chen, Yuanxin Yang , et al. · 2022

Activation of RIPK1-driven cell death and inflammation play important roles in the progression of nonalcoholic steatohepatitis (NASH). However, the mechanism underlying RIPK1 activation in NASH remains unclear. Here we identified SENP1, a …

Dual FGFR and VEGFR inhibition synergistically restrain hexokinase 2-dependent lymphangiogenesis and immune escape in intrahepatic cholangiocarcinoma Open

Min Peng, Yamei Huang, Chuanlai Shen, Weiping Yu, Hui Li , et al. · 2022

Background Intrahepatic cholangiocarcinoma (iCCA) patients often lose the chance of radical resection due to early lymphatic metastasis. And most of the therapy in cholangiocarcinoma has been limited and ineffective. Herein, we examined th…

Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex Open

Liping Xie, Yanmei Yuan, Simiao Xu, Sijia Lü, Jinyang Gu , et al. · 2022

Natural Killer Cells in Hepatic Ischemia-Reperfusion Injury Open

Miao Huang, Hao Cai, Bing Han, Yuhan Xia, Xiaoni Kong , et al. · 2022

Ischemia-reperfusion injury can be divided into two phases, including insufficient supply of oxygen and nutrients in the first stage and then organ injury caused by immune inflammation after blood flow recovery. Hepatic ischemia-reperfusio…

C‐C motif chemokine ligand 5 confines liver regeneration by down‐regulating reparative macrophage‐derived hepatocyte growth factor in a forkhead box O 3a–dependent manner Open

Miao Huang, Junzhe Jiao, Hao Cai, Yichi Zhang, Yuhan Xia , et al. · 2022

Background and Aims Liver regeneration (LR) is vital for the recovery of liver function after hepatectomy. Limited regeneration capacity, together with insufficient remnant liver volume, is a risk factor for posthepatectomy liver failure (…

Living donor liver transplantation combined with splenectomy in a child with Niemann-Pick disease type B: single-centre experience of perioperative anticoagulation regimen Open

Han Ding, Jian Wang, Yichi Zhang, Shuai Zhao, Bing Han , et al. · 2022

Identification and characterization of a 25-lncRNA prognostic signature for early recurrence in hepatocellular carcinoma Open

Yi Fu, Xindong Wei, Qiu-Qin Han, Jiamei Le, Yujie Ma , et al. · 2021

Deep learning for differential diagnosis of malignant hepatic tumors based on multi-phase contrast-enhanced CT and clinical data Open

Ruitian Gao, Shuai Zhao, Kedeerya Aishanjiang, Hao Cai, Ting Wei , et al. · 2021

Defects in Macrophage Reprogramming in Cancer Therapy: The Negative Impact of PD-L1/PD-1 Open

Hao Cai, Yichi Zhang, Jian Wang, Jinyang Gu · 2021

Classically activated M1 macrophages and alternatively activated M2 macrophages are two polarized subsets of macrophages at the extreme ends of a constructed continuum. In the field of cancer research, M2 macrophage reprogramming is define…

Circular RNAs and Hepatocellular Carcinoma: New Epigenetic Players With Diagnostic and Prognostic Roles Open

Kedeerya Aishanjiang, Xindong Wei, Yi Fu, Xinjie Lin, Yujie Ma , et al. · 2021

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Due to the lack of potent diagnosis and prognosis biomarkers and effective therapeutic targets, the overall prognosis of survival is poor in HCC…

ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway Open

Chunmei Yang, Hui Yuan, Jinyang Gu, Dengfei Xu, Mingwei Wang , et al. · 2021

The development of resistance to anticancer drugs is believed to cause chemotherapy failure in pancreatic cancer (PC). The efflux of anticancer drugs mediated by ATP-binding cassette (ABC) transporters is a widely accepted mechanism for ch…

DJ-1 Deficiency in Hepatocytes Improves Liver Ischemia-Reperfusion Injury by Enhancing Mitophagy Open

Min Xu, Hualian Hang, Miao Huang, Jichang Li, Dongwei Xu , et al. · 2021

Potential Role of Adjuvant Lenvatinib in Improving Disease-Free Survival for Patients With High-Risk Hepatitis B Virus-Related Hepatocellular Carcinoma Following Liver Transplantation: A Retrospective, Case Control Study Open

Bing Han, Han Ding, Shuai Zhao, Yichi Zhang, Jian Wang , et al. · 2020

Background and Aim Although liver transplantation (LT) is one of the most effective treatments for the patients with hepatocellular carcinoma (HCC), the high-risk patients suffer from a high ratio of tumor recurrence after LT. Lenvatinib, …

RNA conversion of COVID‐19 in respiratory and alimentary specimens during asymptomatic convalescence Open

Yichi Zhang, Tingting Su, Bing Han, Miao Huang, Xueshi Zhou , et al. · 2020

RNA conversion of COVID-19 in respiratory and alimentary specimens during asymptomatic convalescenceTo the Editor, Few studies concerning novel coronavirus disease 2019 (COVID-19) have focused on the follow-up of recovered patients, especi…

Adjuvant Therapy Using Lenvatinib Prevents Recurrence of High-Risk Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma Following Liver Transplantation: A Retrospective Case Control Study Open

Bing Han, Han Ding, Shuai Zhao, Yichi Zhang, Jian Wang , et al. · 2020

Background: Although liver transplantation (LT) is one of the most effective treatments for the patients with hepatocellular carcinoma (HCC), the high-risk patients suffer from a high ratio of tumor recurrence after LT. So this study was d…

Characterization of hepatitis B virus infection and viral <span>DNA</span> integration in non‐Hodgkin lymphoma Open

Mengge Li, Yuling Shen, Yi‐Ming Chen, Haifeng Gao, Jiaqin Zhou , et al. · 2020

Hepatitis B virus (HBV) infection has been reported to be associated with non‐Hodgkin lymphoma (NHL). However, the evidence is limited to the seroepidemiological study. There is a lack of evidence showing the HBV infection and integration …

Jinyang Gu YOU? Author Swipe