Jinyeon Shin
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View article: Lymphedema pathogenesis involves antigen-driven expansion of CD4+ T cells in skin
Lymphedema pathogenesis involves antigen-driven expansion of CD4+ T cells in skin Open
Introduction Lymphedema, a progressive condition involving unresolved swelling and inflammation, affects as many as 1 in 1000 Americans. Although CD4+ T cells are implicated in the chronic inflammatory process, antigen-specific responses a…
View article: TGF-β–mediated epithelial-mesenchymal transition of keratinocytes promotes fibrosis in secondary lymphedema
TGF-β–mediated epithelial-mesenchymal transition of keratinocytes promotes fibrosis in secondary lymphedema Open
Secondary lymphedema is characterized by fibrosis and impaired lymphatic function. Although TGF-β is a key regulator of fibrosis in this disease, the cellular mechanisms regulating this process remain unknown. Epithelial-mesenchymal transi…
View article: Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels
Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels Open
BACKGROUND: Dysregulation of TRPV4 (transient receptor potential vanilloid type 4)–mediated signaling has been associated with inflammation and tissue fibrosis, both of which are key features in the pathophysiology of lymphatic system dise…
View article: 141. Inflammation-mediated Vascular Changes in Breast Cancer-related Lymphedema
141. Inflammation-mediated Vascular Changes in Breast Cancer-related Lymphedema Open
View article: 131. Vascularized Lymph Node Transplant Reduces Mast Cell Tissue Infiltration in Breast Cancer Related Lymphedema
131. Vascularized Lymph Node Transplant Reduces Mast Cell Tissue Infiltration in Breast Cancer Related Lymphedema Open
View article: Inhibition of Th2 Differentiation Accelerates Chronic Wound Healing by Facilitating Lymphangiogenesis
Inhibition of Th2 Differentiation Accelerates Chronic Wound Healing by Facilitating Lymphangiogenesis Open
Background/Objectives: Chronic wounds pose a significant healthcare burden, and there remains no effective animal model for study. We aimed to develop a mouse model of chronic wounds that remain open for at least 4 weeks and to investigate…
View article: Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses
Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses Open
Patients with systemic lupus erythematosus (SLE) are photosensitive, developing skin inflammation with even ambient ultraviolet radiation (UVR), and this cutaneous photosensitivity can be associated with UVR-induced flares of systemic dise…
View article: Regulation of VEGFR3 signaling in lymphatic endothelial cells
Regulation of VEGFR3 signaling in lymphatic endothelial cells Open
The receptor tyrosine kinase vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3) is the principal transmembrane receptor responsible for sensing and coordinating cellular responses to environmental lymphangiogenic stimuli in lymp…
View article: Role of inducible nitric oxide (iNOS) and nitrosative stress in regulating sex differences in secondary lymphedema
Role of inducible nitric oxide (iNOS) and nitrosative stress in regulating sex differences in secondary lymphedema Open
Secondary lymphedema is a common complication following surgical treatment of solid tumors. Although more prevalent in women due to higher breast cancer rates, men also develop lymphedema, often with more severe manifestations. Despite the…
View article: Investigating the Antigens Driving T-Cell Responses in Lymphedema: An Interrogation of Insulin and Insulin Receptor Signaling
Investigating the Antigens Driving T-Cell Responses in Lymphedema: An Interrogation of Insulin and Insulin Receptor Signaling Open
View article: TRPV4-Expressing Tissue-Resident Macrophages Regulate the Function of Collecting Lymphatic Vessels via Thromboxane A2 Receptors in Lymphatic Muscle Cells
TRPV4-Expressing Tissue-Resident Macrophages Regulate the Function of Collecting Lymphatic Vessels via Thromboxane A2 Receptors in Lymphatic Muscle Cells Open
Rationale TRPV4 channels are critical regulators of blood vascular function and have been shown to be dysregulated in many disease conditions in association with inflammation and tissue fibrosis. These are key features in the pathophysiolo…
View article: P31. Immune Repertoire in Lymphedema: Characterizing the Dendritic Cell Subsets in a Lymphedema Mouse Model
P31. Immune Repertoire in Lymphedema: Characterizing the Dendritic Cell Subsets in a Lymphedema Mouse Model Open
PURPOSE: Secondary lymphedema (LE) is a chronic T-cell mediated disease. Clonal analysis of the CD4+ Tcells in clinical LE skin biopsies suggests that specific T-cell activating antigens contribute to the T-cell responses that are necessar…
View article: 20. Identifying Risk Alleles For Secondary Lymphedema: A Genome-wide Study
20. Identifying Risk Alleles For Secondary Lymphedema: A Genome-wide Study Open
Purpose: Secondary lymphedema (LE) is well recognized as a T-helper (Th) mediated inflammatory disease. However, the fact that only 30% of patients undergoing axillary lymph node dissection (ALND) develop LE, suggest that some patients may…
View article: Dysregulation of Lymphatic Endothelial VEGFR3 Signaling in Disease
Dysregulation of Lymphatic Endothelial VEGFR3 Signaling in Disease Open
Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3), a receptor tyrosine kinase encoded by the FLT4 gene, plays a significant role in the morphogenesis and maintenance of lymphatic vessels. Under both normal and pathologic condit…
View article: The Future of Lymphedema: Potential Therapeutic Targets for Treatment
The Future of Lymphedema: Potential Therapeutic Targets for Treatment Open
View article: Skin microbiome alterations in upper extremity secondary lymphedema
Skin microbiome alterations in upper extremity secondary lymphedema Open
Lymphedema is a chronic condition that commonly occur from lymphatic injury following surgical resection of solid malignancies. While many studies have centered on the molecular and immune pathways that perpetuate lymphatic dysfunction, th…
View article: 145. Prolonged Exposure to VEGF-C Induces Resistance to Subsequent Stimulation of VEGFR3 in Lymphatic Endothelial Cells
145. Prolonged Exposure to VEGF-C Induces Resistance to Subsequent Stimulation of VEGFR3 in Lymphatic Endothelial Cells Open
PURPOSE: Despite the fact that lymphedematous tissues have high concentrations of VEGF-C, functional regeneration of lymphatics in patients with lymphedema is impaired and contributes to the pathophysiology of this disease. The molecular m…
View article: 154. Non-invasive Detection of Subclinical Skin Changes in Lymphedema: A Promising Screening Method for Early Stage Disease
154. Non-invasive Detection of Subclinical Skin Changes in Lymphedema: A Promising Screening Method for Early Stage Disease Open
PURPOSE: Current diagnostic measures for lymphedema are limited in detesting subclinical disease. The purpose of this study was to quantify early skin changes in lymphedematous skin and evaluate their correlation with indocyanine-green (IC…
View article: 148. Extravasated Lymph from Secondary Lymphedema Patients Increases Cellular Permeability and Decreases Lymphatic Endothelial Cell VEGFR3 Expression
148. Extravasated Lymph from Secondary Lymphedema Patients Increases Cellular Permeability and Decreases Lymphatic Endothelial Cell VEGFR3 Expression Open
PURPOSE: The initial stages of lymphedema are characterized by accumulation of interstitial fluid in the tissues. However, the functional effects of interstitial fluid accumulation on surrounding tissue lymphatics remain unknown. We theref…
View article: Supplementary Data from Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments
Supplementary Data from Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments Open
Figure S1, S2, S3, S4, S5, S6 and S7
View article: Supplementary Data from Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments
Supplementary Data from Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments Open
Figure S1, S2, S3, S4, S5, S6 and S7
View article: Data from Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments
Data from Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments Open
Proliferation of aberrant, dysfunctional lymphatic vessels around solid tumors is a common histologic finding. Studies have shown that abnormalities in lymphatic function result in accumulation of inflammatory cells with an immunosuppressi…
View article: Data from Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments
Data from Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments Open
Proliferation of aberrant, dysfunctional lymphatic vessels around solid tumors is a common histologic finding. Studies have shown that abnormalities in lymphatic function result in accumulation of inflammatory cells with an immunosuppressi…
View article: PC32. Non-invasive Detection of Subclinical Skin Changes in Lymphedema: A Promising Screening Method for Early Stage Disease
PC32. Non-invasive Detection of Subclinical Skin Changes in Lymphedema: A Promising Screening Method for Early Stage Disease Open
PURPOSE: Current diagnostic measures for lymphedema are limited in detesting subclinical disease. The purpose of this study was to quantify early skin-changes in lymphedematous skin and evaluate their correlation with indocyanine-green (IC…
View article: Topical captopril: a promising treatment for secondary lymphedema
Topical captopril: a promising treatment for secondary lymphedema Open
View article: Keratinocytes coordinate inflammatory responses and regulate development of secondary lymphedema
Keratinocytes coordinate inflammatory responses and regulate development of secondary lymphedema Open
Epidermal changes are histological hallmarks of secondary lymphedema, but it is unknown if keratinocytes contribute to its pathophysiology. Using clinical lymphedema specimens and mouse models, we show that keratinocytes play a primary rol…
View article: The Food Delivery App Information Design Suggestion for Foreigners in South Korea
The Food Delivery App Information Design Suggestion for Foreigners in South Korea Open
Many foreigners living in South Korea faces various problems in their daily lives, such as language barriers, cultural differences, etc. This also applies to making food orders via mobile applications. A lot of foreigners have difficulties…
View article: 802 Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses
802 Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses Open
Patients with systemic lupus erythematosus (SLE) are photosensitive, developing skin inflammation with even ambient ultraviolet radiation (UVR), and this cutaneous photosensitivity can be associated with UVR-induced flares of systemic dis…
View article: 1204 Improving lymphatic function to reduce B cell responses in lupus
1204 Improving lymphatic function to reduce B cell responses in lupus Open
Background In SLE, that ultraviolet radiation exposure can induce both photosensitive skin responses and increased autoantibody titers suggests a critical and targetable role for the communication from skin to draining lymph nodes in regul…
View article: Tumor-Associated Lymphatics Upregulate MHC-II to Suppress Tumor-Infiltrating Lymphocytes
Tumor-Associated Lymphatics Upregulate MHC-II to Suppress Tumor-Infiltrating Lymphocytes Open
Steady-state lymphatic endothelial cells (LECs) can induce peripheral tolerance by presenting endogenous antigens on MHC class I (MHC-I) molecules. Recent evidence suggests that lymph node LECs can cross-present tumor antigens on MHC-I to …