Jun Yan
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View article: Ofatumumab for the Treatment of Anti‐Neurofascin 155 Autoimmune Nodopathy: A Case Series
Ofatumumab for the Treatment of Anti‐Neurofascin 155 Autoimmune Nodopathy: A Case Series Open
Introduction Autoimmune nodopathy (AN) is a rare immune‐mediated peripheral neuropathy, the diagnosis and treatment of which remain challenging. Anti‐neurofascin‐155 (NF155) AN present with weakness, tremor, ataxia, and cranial nerve invol…
View article: Repair of tetralogy of Fallot in neonates: a single-center case series
Repair of tetralogy of Fallot in neonates: a single-center case series Open
The curative effect of TOF repair in the neonatal period is well-documented, with its ability to prevent the effects of pulmonary artery development and collateral circulation formation. Consequently, we suggest considering TOF repair duri…
View article: Prediction Model for Familial Aggregated <scp>HBV</scp>‐Associated Hepatocellular Carcinoma Based on Serum Biomarkers
Prediction Model for Familial Aggregated <span>HBV</span>‐Associated Hepatocellular Carcinoma Based on Serum Biomarkers Open
Background Accurate assessment of the risk of familial aggregated hepatitis B virus (HBV)‐associated hepatocellular carcinoma (HCC) and regular surveillance for these patients at high risk may be valuable to reduce the occurrence and impro…
View article: Copper‐Catalyzed Domino Synthesis of Spiropyrazoline Oxindoles via Condensation of Indolin‐2‐One and Phenylhydrazine Derivatives
Copper‐Catalyzed Domino Synthesis of Spiropyrazoline Oxindoles via Condensation of Indolin‐2‐One and Phenylhydrazine Derivatives Open
We report a straightforward and efficient method for the synthesis of spiropyrazoline oxindoles using CuCl 2 as the Lewis acid catalyst. This approach involves a one‐pot domino process, consisting of a condensation step between indolin‐2‐o…
View article: Analysis of Synergistic Drivers of CO2 and NOX Emissions from Thermal Power Generating Units in Beijing–Tianjin–Hebei Region, 2010–2020
Analysis of Synergistic Drivers of CO2 and NOX Emissions from Thermal Power Generating Units in Beijing–Tianjin–Hebei Region, 2010–2020 Open
Synergistic control of the emissions of air pollutants and CO2 is critical to the dual challenges of air quality improvement and climate change in China. Based on the emission inventories of thermal power units in Beijing, Tianjin, and Heb…
View article: Biventricular function after Ebstein anomaly repair from a single-center echocardiography study
Biventricular function after Ebstein anomaly repair from a single-center echocardiography study Open
A high success rate of surgical correction of EbA, with an encouraging durability of the valve, was noted. Biventricular systolic function was maintained fairly in most patients with types A and B postoperatively. A late increase in RV sys…
View article: Association and mediation analyses among multiple metal exposure, mineralocorticoid levels, and serum ion balance in residents of northwest China
Association and mediation analyses among multiple metal exposure, mineralocorticoid levels, and serum ion balance in residents of northwest China Open
Toxic metals are vital risk factors affecting serum ion balance; however, the effect of their co-exposure on serum ions and the underlying mechanism remain unclear. We assessed the correlations of single metal and mixed metals with serum i…
View article: Effects of Metabolism-Related Indicators on Nonalcoholic Fatty Liver Disease in Nonobese Population Based on the National Health and Nutrition Examination Survey
Effects of Metabolism-Related Indicators on Nonalcoholic Fatty Liver Disease in Nonobese Population Based on the National Health and Nutrition Examination Survey Open
Objective. Nonalcoholic fatty liver disease (NAFLD) is becoming more prevalent in the nonobese population. The aim of this study was to investigate the combined effects of metabolism-related mixtures on NAFLD subjects in nonobese populatio…
View article: Bioreactor-based stem cell therapy for liver fibrosis
Bioreactor-based stem cell therapy for liver fibrosis Open
Stem cell therapy, achieved using mesenchymal stem cells (MSCs), has been highlighted for the treatment of liver fibrosis. Infusion into the circulatory system is a traditional application of MSCs; however, this approach is limited by phen…
View article: Liver cirrhosis and complications from the perspective of dysbiosis
Liver cirrhosis and complications from the perspective of dysbiosis Open
The gut-liver axis refers to the intimate relationship and rigorous interaction between the gut and the liver. The intestinal barrier’s integrity is critical for maintaining liver homeostasis. The liver operates as a second firewall in thi…
View article: The species distribution and antimicrobial resistance profiles of Nocardia species in China: A systematic review and meta-analysis
The species distribution and antimicrobial resistance profiles of Nocardia species in China: A systematic review and meta-analysis Open
Background Nocardia species can cause local or disseminated infection. Prompt diagnosis and appropriate treatment of nocardiosis are required, because it can cause significant morbidity and mortality. Knowledge of local species distributio…
View article: Screening of a potential bioinformatics-based biomarker in keloid and its correlation with immune infiltration
Screening of a potential bioinformatics-based biomarker in keloid and its correlation with immune infiltration Open
Keloid is a pathological result caused by cutaneous injury and irritation, which is on account of excessive deposition of collagen matrix and the growth of fibrous tissue. Long term and uncontrolled chronic inflammation is also one of the …
View article: Association of multi-heavy metals exposure and lung function in a typical rural population of Northwest China
Association of multi-heavy metals exposure and lung function in a typical rural population of Northwest China Open
Background: Heavy metal exposure is associated with decreased lung function, but the relationship between metals co-exposure and lung function in rural areas of northwest China remains unclear. Therefore, the purpose of this study is to ex…
View article: Identification of nanoparticle-mediated siRNA-ASPN as a key gene target in the treatment of keloids
Identification of nanoparticle-mediated siRNA-ASPN as a key gene target in the treatment of keloids Open
Background: Keloid, also known as connective tissue hyperplasia, is a benign proliferative disorder with a global distribution. The available therapeutic interventions are steroid injections, surgical removal of keloids, radiotherapy, comp…
View article: Association of multi-heavy metals exposure and lung function in a typical rural cohort of Northwest China
Association of multi-heavy metals exposure and lung function in a typical rural cohort of Northwest China Open
Background Heavy metal exposure is associated with decreased lung function, but the relationship between metals co-exposure and lung function in rural areas of northwest China remains unclear. Therefore, the purpose of this study is to exp…
View article: Expression and prognostic value of Melanoma-associated antigen D2 in gliomas
Expression and prognostic value of Melanoma-associated antigen D2 in gliomas Open
Introduction The melanoma-associated antigen D4 (MAGED2) is one of the melanoma-associated antigen family members. It is commonly overexpressed in a variety of malignancies. However, the mechanism and function of MAGED2 in glioma remain un…
View article: FGL2-targeted T cells induced tumor-specific brain resident TRM cells preventing glioblastoma recurrence
FGL2-targeted T cells induced tumor-specific brain resident TRM cells preventing glioblastoma recurrence Open
Tissue-resident memory T cells (TRM) specific to previously encountered pathogens have been characterized, but tumor-specific TRM cells in brain have not been reported in the literature. We discovered that T cells armed with FGL2-blocking …
View article: The Effect of Smoking Habits on Blood Cadmium and Lead Levels in Residents Living Near a Mining and Smelting Area in Northwest China: a Cross-Sectional Study
The Effect of Smoking Habits on Blood Cadmium and Lead Levels in Residents Living Near a Mining and Smelting Area in Northwest China: a Cross-Sectional Study Open
Few studies have focused on environmental cadmium (Cd) and lead (Pb) exposure while exploring the effect of smoking on blood Cd (BCd) and blood Pb (BPb) levels. Moreover, essential trace elements affect the absorption, accumulation, and to…
View article: Association among Helicobacter pylori Infection, Tooth Loss, and Heavy Medal Exposure in a Chinese Rural Population
Association among Helicobacter pylori Infection, Tooth Loss, and Heavy Medal Exposure in a Chinese Rural Population Open
Previous research suggests that heavy metals may be associated with increased susceptibility to Helicobacter pylori infection. This study investigated the effect of heavy metal exposure (Pb and Cd) on tooth loss and H. pylori infection in …
View article: Recent Progress on the Mild Deprotection of Dithioketals, Dithioacetals, and Oxathiolanes
Recent Progress on the Mild Deprotection of Dithioketals, Dithioacetals, and Oxathiolanes Open
Reactions for the deprotection of carbonyl derivatives have been of considerable interest to the scientific community. In recent years efforts have been made to develop mild, experimentally simple, and environmentally friendly methods. Thi…
View article: Effects of lead and cadmium co-exposure on liver function in residents near a mining and smelting area in northwestern China
Effects of lead and cadmium co-exposure on liver function in residents near a mining and smelting area in northwestern China Open
Chronic exposure to environmental cadmium (Cd) and lead (Pb) may have adverse effects on the human health. In this study, we aimed to determine the primary and interactive effects of Cd and Pb exposure on liver function in residents near a…
View article: Analysis of antibiotic-induced drug resistance of <i>Salmonella</i> enteritidis and its biofilm formation mechanism
Analysis of antibiotic-induced drug resistance of <i>Salmonella</i> enteritidis and its biofilm formation mechanism Open
This research was to explore antibiotic-induced drug resistance of Salmonella enteritidis and its biofilm formation mechanism. Kirby-Bauer (K-B) disk method recommended by Clinical and Laboratory Standards Institute (CLSI) was used to test…
View article: Therapeutic Management of VA-ECMO Support for Cardiogenic Shock: Case Report.
Therapeutic Management of VA-ECMO Support for Cardiogenic Shock: Case Report. Open
Introduction: Cardiogenic shock is considered a serious stage of heart disease, and there is no better way to treat this. Veno-arterial Extracorporeal membrane oxygenation (VA-ECMO) is a well-established technology that can be used as pote…
View article: A Strengthening Mechanism and Influencing Factors of Coal Fly Ash using Microbial-Induced Carbonate Precipitation
A Strengthening Mechanism and Influencing Factors of Coal Fly Ash using Microbial-Induced Carbonate Precipitation Open
Coal fly ash (CFA) that is discharged from coal-fired power plants has characteristics of fine particles, a small specific gravity and a large pore ratio. The dust suppression and strengthening of CFA is usually carried out by spraying wat…
View article: Study on Happening and Extincting Mechanism of a Squall Line along the Eastern Helan Mountain
Study on Happening and Extincting Mechanism of a Squall Line along the Eastern Helan Mountain Open
In the afternoon of June 17, 2020, a squall line occurred over the eastern region of Helan Mountain in Ningxia, accompanied by lightning, strong wind and short-term heavy precipitation, which affected north and middle part of Ningxia and W…
View article: Effect of Helicobacter Pylori on Plasma Metabolic Phenotype in Patients With Gastric Cancer
Effect of Helicobacter Pylori on Plasma Metabolic Phenotype in Patients With Gastric Cancer Open
Background Although Helicobacter pylori (Hp) as high risk factor for gastric cancer have been investigated from human trial, present data is inadequate to explain the effect of Hp on the changes of metabolic phenotype of gastric cancer in …
View article: Contemporary Patterns of Management of Tetralogy of Fallot: Data from a Single Center in China
Contemporary Patterns of Management of Tetralogy of Fallot: Data from a Single Center in China Open
Background: There is scarce research on large cohorts with tetralogy of Fallot (TOF) from China. The database in Fuwai Hospital was reviewed to ascertain current trends in the management of TOF and to determine the prevalence of various su…