Jinyun Zhu
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View article: Impacts of DRG point-based payment system on healthcare resource utilization and provider behavior: a pilot quasi-experimental study in China
Impacts of DRG point-based payment system on healthcare resource utilization and provider behavior: a pilot quasi-experimental study in China Open
Background Developing countries commonly face challenges regarding budget constraints and inadequate cost-accounting capabilities during the implementation of a Diagnosis-Related Group (DRG) payment system. China has initiated pilot reform…
View article: Minimally Invasive Aortic Regurgitation Surgery
Minimally Invasive Aortic Regurgitation Surgery Open
View article: BCAA catabolism targeted therapy for heart failure with preserved ejection fraction
BCAA catabolism targeted therapy for heart failure with preserved ejection fraction Open
Rationale: Heart failure with preserved ejection fraction (HFpEF) is a major unmet medical need with limited effective treatments. A significant contributing factor to HFpEF, a multifactorial disease, is underlying metabolic dysfunc…
View article: Deciphering the Pathogenic Landscape of Amyloid Light-Chain Cardiomyopathy
Deciphering the Pathogenic Landscape of Amyloid Light-Chain Cardiomyopathy Open
Amyloid light-chain cardiomyopathy (ALCA) is an infiltrative disorder marked by misfolded immunoglobulin light-chain deposition in the myocardium, ultimately leading to cardiac dysfunction. Despite its clinical severity, the underlying mec…
View article: Effects of aggregate morphology and particle size distribution modulus on the rheological properties and microstructure of low water/binder cement-based composites (LW/B-CC)
Effects of aggregate morphology and particle size distribution modulus on the rheological properties and microstructure of low water/binder cement-based composites (LW/B-CC) Open
View article: Automated and quantitative assessment of aortic root based on cardiac computed tomography angiography using a new deep-learning tool: a comparison study
Automated and quantitative assessment of aortic root based on cardiac computed tomography angiography using a new deep-learning tool: a comparison study Open
The DL method offers an effective and efficient tool for the quantification of aortic roots for TAVR planning.
View article: Tumour necrosis factor receptor-associated factor 7: a new member of the E3 ligase family in cardiac hypertrophy
Tumour necrosis factor receptor-associated factor 7: a new member of the E3 ligase family in cardiac hypertrophy Open
View article: Exploring the effect of the micropore on the microstructure development of low water-cement ratio composite (LW/B-CC) subjected to microwave pre-curing
Exploring the effect of the micropore on the microstructure development of low water-cement ratio composite (LW/B-CC) subjected to microwave pre-curing Open
Microwave pre-curing, as an energy-saving and efficient pre-curing method, is employed and further optimized to produce low water-cement ratio composite (LW/B-CC) in this study. Theoretically, by replacing part of the coarse sand with poro…
View article: Feasibility, Accuracy, and Validation of a New Deep Learning Tool for Fully Automated Assessment of Aortic Root Based on Cardiac Ct Angiography
Feasibility, Accuracy, and Validation of a New Deep Learning Tool for Fully Automated Assessment of Aortic Root Based on Cardiac Ct Angiography Open
View article: Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis
Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis Open
The role of growth differentiation factor (GDF)-11 in cardiac diseases has not been fully determined. Our study revealed that GDF-11 is not essential for myocardial development and physiological growth, whereas its absence exacerbates hear…
View article: Rediscovering the value of exercise in patients with hypertrophic cardiomyopathy
Rediscovering the value of exercise in patients with hypertrophic cardiomyopathy Open
It was previously thought that hypertrophic cardiomyopathy is the leading cause of sudden cardiac death in athletes. This was also extrapolated to the general population. Thereby, exercise was restrained in patients with hypertrophic cardi…
View article: Nano-Sized Hydroxyapatite Induces Apoptosis and Osteogenic Differentiation of Vascular Smooth Muscle Cells via JNK/c-JUN Pathway
Nano-Sized Hydroxyapatite Induces Apoptosis and Osteogenic Differentiation of Vascular Smooth Muscle Cells via JNK/c-JUN Pathway Open
JNK/c-JUN signaling pathway is critical for nHAp-induced calcification, which could be a potential therapeutic target for controlling the progression of VC.
View article: Nano-Hydroxyapatite Accelerates Vascular Calcification by Inhibiting Lysosomal Acidification in Smooth Muscle Cells.
Nano-Hydroxyapatite Accelerates Vascular Calcification by Inhibiting Lysosomal Acidification in Smooth Muscle Cells. Open
Background: Vascular calcification (VC) is a common characteristic of aging, diabetes, chronic renal failure, and atherosclerosis. The basic component of VC is hydroxyapatite (HAp). Nano-sized HAp (nHAp) has been identified as the initiato…
View article: Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair
Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair Open
Background: Age and other cardiovascular risk factors have been reported to impair the activities of mesenchymal stem cells (MSCs), which will affect the efficacy of stem cell transplantation. The objective of the study is to in…
View article: Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair
Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair Open
Backhround: Age and other cardiovascular risk factors have been reported to impair the activities of mesenchymal stem cells (MSCs), which will affect the efficacy of stem cell transplantation. The objective of the study is to investigate w…
View article: Stock selection strategy of A-share market based on rotation effect and random forest
Stock selection strategy of A-share market based on rotation effect and random forest Open
Due to the random nature of stock market, it is extremely difficult to capture market trends with traditional subjective analysis. Besides, the modeling and forecasting of quantitative investment strategies are not easy. Based on the resea…
View article: A Large-Scale Investigation of Hypoxia-Preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Nonhuman Primates
A Large-Scale Investigation of Hypoxia-Preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Nonhuman Primates Open
Rationale: The effectiveness of transplanted bone marrow mesenchymal stem cells (MSCs) for cardiac repair has been limited; thus, strategies for optimizing stem-cell–based myocardial therapy are needed. Objective: The present study was des…