Jinzhe Zhou
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View article: Single‐Cell Transcriptomic Analysis Reveals Epithelial‐Mesenchymal Transition and Key Gene AGRN as a Universal Programme in Gastrointestinal Tumours by an Artificial Intelligence‐Derived Prognostic Index
Single‐Cell Transcriptomic Analysis Reveals Epithelial‐Mesenchymal Transition and Key Gene AGRN as a Universal Programme in Gastrointestinal Tumours by an Artificial Intelligence‐Derived Prognostic Index Open
Gastrointestinal (GI) tumours account for a significant proportion of cancer cases and deaths globally; GI tumours show similarities regarding their development, diagnosis and treatment. Genomic and transcriptome analyses have been used to…
View article: Shortcoming of ypStage staging system: Lack of differentiation for preoperative treatment
Shortcoming of ypStage staging system: Lack of differentiation for preoperative treatment Open
The eighth edition of the AJCC staging manual initially proposed the ypTNM staging system, which was specifically designed to assess the staging and predict the prognosis of cancer patients undergoing preoperative treatment. Nevertheless, …
View article: Identification of Hub Genes for Psoriasis and Cancer by Bioinformatic Analysis
Identification of Hub Genes for Psoriasis and Cancer by Bioinformatic Analysis Open
Psoriasis increases the risk of developing various cancers, including colon cancer. The pathogenesis of the co‐occurrence of psoriasis and cancer is not yet clear. This study is aimed at analyzing the pathogenesis of psoriasis combined wit…
View article: Bioinformatics analysis of the shared pathogenesis of psoriasis and Crohn's disease
Bioinformatics analysis of the shared pathogenesis of psoriasis and Crohn's disease Open
Background There exists a bidirectional causal relationship between psoriasis and Crohn's disease, where psoriasis can increase the risk of Crohn's disease, and Crohn's disease can also increase the risk of psoriasis. However, the underlyi…
View article: Integrated muti-omics analyses and experimental validation reveal the clinical and biological Significances of APBB1IP in Colon Cancer
Integrated muti-omics analyses and experimental validation reveal the clinical and biological Significances of APBB1IP in Colon Cancer Open
Background： Tumor-associated macrophages(TAMs), especially M2 macrophages, plays a critical role in Colorectal cancer initiation, promotion, and metastasis. However, the underlying mechanisms still remain unresolved. Methods： The profile o…
View article: Impact of endoscopic metallic stent placement and emergency surgery on detection of viable circulating tumor cells for acute malignant left-sided colonic obstruction
Impact of endoscopic metallic stent placement and emergency surgery on detection of viable circulating tumor cells for acute malignant left-sided colonic obstruction Open
Background Self-expanding metal stents (SEMS) served as a bridge to surgery (BTS). However, this method may be associated with worse long-term prognosis and relapse of CRC patients. Therefore, we attempted to clarify this in the angle of c…
View article: Identification of Hub Genes for Psoriasis and Cancer by Bioinformatics Analysis
Identification of Hub Genes for Psoriasis and Cancer by Bioinformatics Analysis Open
View article: Impact of endoscopic metallic stent placement and emergency surgery on detection of viable circulating tumor cells for acute malignant left-sided colonic obstruction
Impact of endoscopic metallic stent placement and emergency surgery on detection of viable circulating tumor cells for acute malignant left-sided colonic obstruction Open
Background: Self-expanding metal stents (SEMS) served as a bridge to surgery (BTS). However, this method may be associated with worse long-term prognosis and relapse of CRC patients. Therefore, we attempted to clarify this in the angle of …
View article: Distributed Airflow Sensing Based on High-Spatial-Resolution BOTDA and a Self-Heated High-Attenuation Fiber
Distributed Airflow Sensing Based on High-Spatial-Resolution BOTDA and a Self-Heated High-Attenuation Fiber Open
An all-fiber distributed airflow sensing method based on a differential pulse-width pair Brillouin optical time domain analysis (DPP-BOTDA) and a self-heated high-attenuation fiber (HAF) is proposed and demonstrated. The HAF heated the sen…
View article: Hollow CeO2 with ROS-Scavenging Activity to Alleviate Colitis in Mice
Hollow CeO2 with ROS-Scavenging Activity to Alleviate Colitis in Mice Open
This study reveals the therapeutic effects of CeO2-based nanomedicine toward colitis and elucidates the specific signalling pathway involved, which provides potential alternative therapeutic options for patients with inflammatio…
View article: PLXNC1: A Novel Potential Immune-Related Target for Stomach Adenocarcinoma
PLXNC1: A Novel Potential Immune-Related Target for Stomach Adenocarcinoma Open
Background Gastric cancer is associated with tumor microenvironment and chronic inflammation, but the underlying tumor-promoting mechanisms still remain unknown. Methods The ATAC-seq was used to identify genes with chromatin accessibilitie…
View article: [Corrigendum] Chemopreventive effect of 4'‑hydroxychalcone on intestinal tumorigenesis in Apc<sup>Min</sup> mice
[Corrigendum] Chemopreventive effect of 4'‑hydroxychalcone on intestinal tumorigenesis in Apc<sup>Min</sup> mice Open
Subsequently to the publication of the above article, the authors have realized that, in Fig. 1, the chemical structure of 4’‑hydroxychalcone was presented without one of its requisite double bonds. A corrected version of Fig. 1, including…
View article: Propensity score‐matched comparison of stenting as a bridge to surgery and emergency surgery for acute malignant left‐sided colonic obstruction
Propensity score‐matched comparison of stenting as a bridge to surgery and emergency surgery for acute malignant left‐sided colonic obstruction Open
View article: Chemopreventive effect of 4'‑hydroxychalcone on intestinal tumorigenesis in Apc<i><sup>Min</sup></i> mice
Chemopreventive effect of 4'‑hydroxychalcone on intestinal tumorigenesis in Apc<i><sup>Min</sup></i> mice Open
[This corrects the article DOI: 10.3892/ol.2021.12474.].
View article: Propensity Score-Matched Comparison of Stenting as Bridge to Surgery and Emergency Surgery for Acute Malignant Left-Sided Colonic Obstruction
Propensity Score-Matched Comparison of Stenting as Bridge to Surgery and Emergency Surgery for Acute Malignant Left-Sided Colonic Obstruction Open
PurposeBridge to elective surgery (BTS) using self-expanding metal stents (SEMS) is a common alternative to emergency surgery (ES) for acute malignant left-sided colonic obstruction (AMLCO). However, the study regarding long-term impact of…
View article: Comprehensive analysis of differentially expressed circRNAs revealed a ceRNA network in pancreatic ductaladenocarcinoma
Comprehensive analysis of differentially expressed circRNAs revealed a ceRNA network in pancreatic ductaladenocarcinoma Open
Our study identified differentially expressed circRNAs in PDAC, suggesting that circRNAs may also act as biomarkers for PDAC. Additional investigations of function and up-stream regulation of differentially expressed circRNA in PDAC are st…
View article: Therapeutic inhibition of SGK1 suppresses colorectal cancer
Therapeutic inhibition of SGK1 suppresses colorectal cancer Open
Colorectal cancer (CRC) is one of the leading causes of death worldwide. Thus, the development of new therapeutic targets for CRC treatment is urgently needed. SGK1 is involved in various cellular activities, and its dysregulation can resu…
View article: Therapeutic Suppression of miR-4261 Attenuates Colorectal Cancer by Targeting MCC
Therapeutic Suppression of miR-4261 Attenuates Colorectal Cancer by Targeting MCC Open
View article: Therapeutic Inhibition of miR-4260 Suppresses Colorectal Cancer via Targeting MCC and SMAD4
Therapeutic Inhibition of miR-4260 Suppresses Colorectal Cancer via Targeting MCC and SMAD4 Open
Dysregulation of microRNAs (miRNAs, miRs) and their putative target genes have been increasingly reported to contribute to colorectal cancer. However, miRNAs that directly target the mutated in colorectal cancer (MCC) gene, a tumor suppres…
View article: Development of a new analog of SGK1 inhibitor and its evaluation as a therapeutic molecule of colorectal cancer
Development of a new analog of SGK1 inhibitor and its evaluation as a therapeutic molecule of colorectal cancer Open
Colorectal cancer (CRC) is one of the most leading causes of cancer-related death worldwide. The serum and glucocorticoid inducible kinase SGK1 is highly expressed and involved in several tumors. GSK650394, a SGK1 inhibitor, has been prove…
View article: miR-224 Controls Human Colorectal Cancer Cell Line HCT116 Proliferation by Targeting Smad4
miR-224 Controls Human Colorectal Cancer Cell Line HCT116 Proliferation by Targeting Smad4 Open
Background: Better understanding the molecular mechanisms responsible for the genesis and progression of colorectal cancer would help advance the novel therapeutics. miR-224 has been identified to be elevated in colorectal cancer an…
View article: Deregulated Cardiac Specific MicroRNAs in Postnatal Heart Growth
Deregulated Cardiac Specific MicroRNAs in Postnatal Heart Growth Open
The heart is recognized as an organ that is terminally differentiated by adulthood. However, during the process of human development, the heart is the first organ with function in the embryo and grows rapidly during the postnatal period. M…
View article: Comparisons of Clinical Outcomes and Prognoses in Patients With Gastroesophageal Junction Adenocarcinoma, by Transthoracic and Transabdominal Hiatal Approaches
Comparisons of Clinical Outcomes and Prognoses in Patients With Gastroesophageal Junction Adenocarcinoma, by Transthoracic and Transabdominal Hiatal Approaches Open
To compare the clinical outcomes and prognoses in patients with gastroesophageal junction adenocarcinoma (Siewert type II/III), by transthoracic and transabdominal hiatal approaches. Siewert II/III gastroesophageal junction adenocarcinomas…