Jinzhen Guo
YOU?
Author Swipe
View article: Genome-Wide Analysis of DNA Methylation Signatures Linking Prenatal Exposure to the Chinese Great Famine and Blood Lipids in Late Adulthood: The Genomic Research of the Chinese Famine (GRECF) Study
Genome-Wide Analysis of DNA Methylation Signatures Linking Prenatal Exposure to the Chinese Great Famine and Blood Lipids in Late Adulthood: The Genomic Research of the Chinese Famine (GRECF) Study Open
Background/Objectives: Prenatal exposure to famine can lead to lasting health effects through changes in DNA methylation. This study aims to evaluate the impact of prenatal exposure to the Chinses Great Famine (1959–1961) on human epigenom…
View article: Predicting death and survival without major morbidity for extremely preterm infants using information on hospital admission: a multicenter cohort study
Predicting death and survival without major morbidity for extremely preterm infants using information on hospital admission: a multicenter cohort study Open
Using commonly available predictors on NICU admission including gestational age, birth weight, invasive ventilation on NICU admission, antenatal steroids use, sex, and 5-min Apgar score, we successfully developed and validated two distinct…
View article: Interaction between histone residue H3K56 and mismatch repair protein MutSβ drives CAG repeat expansion
Interaction between histone residue H3K56 and mismatch repair protein MutSβ drives CAG repeat expansion Open
DNA repair protein MutSβ promotes CAG repeat expansions, which cause ~20 untreatable neurodegenerative disorders including Huntington's disease (HD). However, how MutSβ is recruited onto chromatin to enable repeat expansion is unknown. Her…
View article: Opting for conservative management over surgery for neonatal ovarian cysts
Opting for conservative management over surgery for neonatal ovarian cysts Open
Objective To explore the suitability of conservative management for neonatal ovarian cysts in newborns. Methods A retrospective cohort study was conducted, involving infants diagnosed with neonatal abdominal/pelvic cysts at two separate me…
View article: Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS–STING-dependent apoptosis
Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS–STING-dependent apoptosis Open
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin ( HTT ) gene. The repeat-expanded HTT encodes a mutated HTT (mHTT), which is known to induce DNA double-strand breaks (…
View article: Vancomycin Dosing Regimens based on Monte Carlo Simulation for Treated Gram-positive cocci Infection in neonates: A retrospective observational study
Vancomycin Dosing Regimens based on Monte Carlo Simulation for Treated Gram-positive cocci Infection in neonates: A retrospective observational study Open
Background: The pharmacodynamic and pharmacokinetic profiles of vancomycin in neonatal population have been previously reported. However, a consensus still has not been reached about optimal recommended dose. Few studies on neonatal popula…
View article: Novel pathogenic variant (c.2947C > T) of the carbamoyl phosphate synthetase 1 gene in neonatal-onset deficiency
Novel pathogenic variant (c.2947C > T) of the carbamoyl phosphate synthetase 1 gene in neonatal-onset deficiency Open
Background Carbamoyl phosphate synthetase 1 deficiency (CPS1D) is a rare autosomal recessive urea cycle disorder characterized by hyperammonaemia. The biochemical measurement of the intermediate metabolites is helpful for CPS1D diagnosis; …
View article: The Utility of Peripheral Blood Leucocyte Ratios as Biomarkers in Neonatal Sepsis: A Systematic Review and Meta-Analysis
The Utility of Peripheral Blood Leucocyte Ratios as Biomarkers in Neonatal Sepsis: A Systematic Review and Meta-Analysis Open
Background Early stage diagnosis of neonatal sepsis (NS) remains a major roadblock due to non-specific symptoms and the absence of precise laboratory index tests. The full blood count is a relatively cheap, universal, and rapid diagnostic …
View article: Variation of Neonatal Outcomes and Care Practices for Preterm Infants <34 Weeks' Gestation in Different Regions of China: A Cohort Study
Variation of Neonatal Outcomes and Care Practices for Preterm Infants <34 Weeks' Gestation in Different Regions of China: A Cohort Study Open
Background: To compare outcomes and care practices of preterm infants born at <34 weeks' gestation in the different regions of China from 2015 to 2018. Methods: This cohort study enrolled all infants born at <34 weeks and admitted to…
View article: Terminal 10q26.12 deletion is associated with neonatal asymmetric crying facies syndrome: a case report and literature review
Terminal 10q26.12 deletion is associated with neonatal asymmetric crying facies syndrome: a case report and literature review Open
Background The terminal 10q26 deletion syndrome is a clinically heterogeneous disorder without identified genotype–phenotype correlations. We reported a case of congenital asymmetric crying facies (ACF) syndrome with 10q26.12qter deletion …
View article: Magnetic compression anastomosis for rectal atresia following necrotizing enterocolitis
Magnetic compression anastomosis for rectal atresia following necrotizing enterocolitis Open
Rationale: Rectal atresia caused by necrotizing enterocolitis (NEC) is a serious and rare complication in children. Magnetic compression anastomosis (MCA) has been effectively applied in children with congenital oesophageal atresia and bil…
View article: Magnetic compression for anastomosis in treating an infant born with long-gap oesophageal atresia
Magnetic compression for anastomosis in treating an infant born with long-gap oesophageal atresia Open
These results suggest that MCA is feasible and effective for treating LGEA in infants.
View article: [A clinical analysis of bacterial meningitis in full-term and preterm infants].
[A clinical analysis of bacterial meningitis in full-term and preterm infants]. Open
There are certain differences in the clinical manifestations between full-term and preterm infants with bacterial meningitis. Preterm infants tend to have a higher incidence rate of poor prognosis.
View article: [Efficacy of different preparations of budesonide combined with pulmonary surfactant in the treatment of neonatal respiratory distress syndrome: a comparative analysis].
[Efficacy of different preparations of budesonide combined with pulmonary surfactant in the treatment of neonatal respiratory distress syndrome: a comparative analysis]. Open
A combination of PS and continuous inhalation of budesonide aerosol has a better efficacy in the treatment of NRDS than a combination of PS and budesonide solution. The difference in reducing the incidence of BDP between the two administra…