Hai Lin
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Hydroxyapatite microspheres encapsulated within hybrid hydrogel promote skin regeneration through the activation of Calcium Signaling and Motor Protein pathway Open
Hydroxyapatite (HAp), traditionally recognized for its efficacy in bone regeneration, has rarely been explored for skin regeneration applications. This investigation explored HAp microspheres with distinct physicochemical properties tailor…
View article: Embracing technological revolution: A panorama of machine learning in dentistry
Embracing technological revolution: A panorama of machine learning in dentistry Open
This review explores the clinical applications of machine learning in dentistry, encompassing disciplines like cariology, endodontics, periodontology, oral medicine, oral and maxillofacial surgery, prosthodontics and orthodontics. It serve…
Coordination Engineering Based on Graphitic Carbon Nitrides for Long‐Life and High‐Capacity Lithium‐Sulfur Batteries Open
Lithium‐sulfur (Li‐S) batteries have received tremendous academic and industrial attentions owing to their ultrahigh energy density. However, technical challenges including lithium dendrite formation, polysulfide shuttling and sluggish sul…
Scattering terahertz wave regulation of coded metasurface based on phase change material Open
By using the combination of resonant plasma-coded metasurface and phase change material GST, a tunable cell structure was designed. Using these units, the encoded metasurface was constructed to achieve different beam regulation functions. …
Appraising the methodological quality of systematic reviews in biomaterials journals using the AMSTAR tool Open
Background Evidence-based biomaterials research as represented by systematic reviews (SRs) has gained attentions. However, the methodological quality of such SRs varies which may cause issues for future research. This study aims to assess …
Collagen hydrogel viscoelasticity regulates MSC chondrogenesis in a ROCK-dependent manner Open
Mesenchymal stem cell (MSC) chondrogenesis in three-dimensional (3D) culture involves dynamic changes in cytoskeleton architecture during mesenchymal condensation before morphogenesis. However, the mechanism linking dynamic mechanical prop…
The Most Promising Targeted Preparation for the Treatment of Migraine from the Pathophysiological Mechanism: Aimed at CGRP Drugs Open
Migraine is a common disorder of brain dysfunction. At present, there are four theories: trigeminal neurovascular theory, vascular dysfunction theory, neurogenic inflammation theory, and diffusion inhibition theory, which provide new ideas…
The influence of tag sequence on recombinant humanized collagen (rhCol) and the evaluation of rhCol on Schwann cell behaviors Open
Recombinant humanized collagen (rhCol) was an extracellular matrix (ECM)-inspired biomimetic biomaterial prepared by biosynthesis technology, which was considered non-allergenic and could possibly activate tissue regeneration. The influenc…
The Most Promising Targeted Preparation for the Treatment of Migraine from the Pathophysiological Mechanism: Aimed at CGRP Drugs Open
Migraine is a common disorder of brain dysfunction. At present, there are four theories: trigeminal neurovascular theory, vascular dysfunction theory, neurogenic inflammation theory, and diffusion inhibition theory, which provide new ideas…
Characterization of recombinant humanized collagen type III and its influence on cell behavior and phenotype Open
Collagen made a tremendous impact in the field of regenerative medicine as a bioactive material. For decades, collagen has been used not only as a scaffolding material but also as an active component in regulating cells' biological behavio…
View article: A unique biomimetic modification endows polyetherketoneketone scaffold with osteoinductivity by activating cAMP/PKA signaling pathway
A unique biomimetic modification endows polyetherketoneketone scaffold with osteoinductivity by activating cAMP/PKA signaling pathway Open
Osteoinductivity of a biomaterial scaffold can notably enhance the bone healing performance. In this study, we developed a biomimetic and hierarchically porous polyetherketoneketone (PEKK) scaffold with unique osteoinductivity using a comb…
Corrigendum: Advances in regenerative sports medicine research Open
[This corrects the article DOI: 10.3389/fbioe.2022.908751.].
Advances in Regenerative Sports Medicine Research Open
Regenerative sports medicine aims to address sports and aging-related conditions in the locomotor system using techniques that induce tissue regeneration. It also involves the treatment of meniscus and ligament injuries in the knee, Achill…
Evidence-based biomaterials research Open
The fast development of biomaterials science and engineering has generated significant number of studies and publications as well as tremendous amount of research data. A methodology is needed to translate such research data and results to…
A regulatory perspective on recombinant collagen-based medical devices Open
As a class of novel biomaterials manufactured by synthetic biology technologies, recombinant collagens are candidates for a variety of medical applications. In this article, a regulatory scientific perspective on recombinant collagens and …
In vivo Evaluation of Fibrous Collagen Dura Substitutes Open
Dura substitutes are applied in duraplasty to repair lost or damaged dura. Collagen-based dura substitutes are mainstream products in both the US and Chinese markets. In this study, dura substitute devices with potential dura regeneration …
In situ Fabrication of Nano ZnO/BCM Biocomposite Based on MA Modified Bacterial Cellulose Membrane for Antibacterial and Wound Healing Open
Therefore, the constructed nZnO/BCM has great potential for biomedical applications as an efficient antibacterial wound dressing.
Polymeric injectable fillers for cosmetology: Current status, future trends, and regulatory perspectives Open
Injectable fillers have become a vital part of cosmetology. A wide variety of injectable fillers are developed for either correction of facial wrinkles and folds or facial contouring. As the most popular filler products, polymeric injectab…
In situ sol-gel synthesis of hyaluronan derivatives bio-nanocomposite hydrogels Open
The main driving idea of the present study was the comparison between two different chemical modifications of hyaluronic acid (HA) followed by the development of nanocomposite hydrogels directly in situ by biomineralization of photocrossli…
The role of antimiR-26a-5p/biphasic calcium phosphate in repairing rat femoral defects Open
Although miRNAs have been implicated in the osteogenic differentiation of stem cells, their role in bone repair and reconstruction in tissue‑engineered bone grafts remains unclear. We previously reported that microRNA (miR)‑26a‑5p inhibite…
Bionic cartilage acellular matrix microspheres as a scaffold for engineering cartilage Open
Bionic cartilage acellular matrix microspheres (BCAMMs) made from decelluarized bionic cartilage microspheres (BCMs).
A Combined Approach of Double Network Hydrogel and Nanocomposites Based on Hyaluronic Acid and Poly(ethylene glycol) Diacrylate Blend Open
In this study, an innovative polymer blend, based on double network (DN) approach, has been developed by integrating a poly(ethylene glycol) diacrylate (PEGDA) network into a chemically modified hyaluronic acid sodium salt (HAs) hydrogel m…
Bioactive composites based on double network approach with tailored mechanical, physico‐chemical, and biological features Open
Hyaluronic acid (HA)‐based hydrogels are one of the most promising naturally derived biomaterials for tissue engineering applications, as they can play an important role in many key cellular processes. In this study, HA was chemically func…