Jinzhuang Dou
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View article: Supplementary Table S10 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S10 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Differentially expressed genes of CD4 clusters
View article: Supplementary Table S18 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S18 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Differentially expressed genes of FCGR3A-positive vs FCGR3A-negative NK cells
View article: Supplementary Table S14 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S14 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Differentially expressed genes of CD8 clusters
View article: Supplementary Figures S1-S18 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Figures S1-S18 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Fig. S1. Patient disposition and characteristics. Fig. S2. Timing of OI biopsy collection did not correlate with response. Fig. S3. Major cell types identified in the tumor immune microenvironment. Fig. S4. CD4+ T cells identified in the t…
View article: Supplementary Table S19 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S19 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Statistical test for association of lymphocyte cluster proportion with progression
View article: Supplementary Table S7 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S7 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Single-cell RNA and TCR sequencing information and metrics
View article: Supplementary Table S9 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S9 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Sample-level cell counts of CD4 clusters
View article: Supplementary Table S20 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S20 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Clinical and single-cell features used in multivariable regression models
View article: Supplementary Table S15 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S15 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Statistical test for proportions of CD8+ T cell clusters in the tumor immune microenvironment stratified by histological response and timepoint
View article: Supplementary Table S16 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S16 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
CD8+ T-cell clonotypes with significant frequency changes in response to treatment
View article: Supplementary Table S12 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S12 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Differentially expressed genes of CD8+ T cells from MHRs vs non-MHRs at baseline
View article: Supplementary Table S8 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S8 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Statistical test for proportions of cell types in the tumor immune microenvironment stratified by histological response and timepoint
View article: Supplementary Table S13 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S13 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Sample-level cell counts of CD8 clusters
View article: Supplementary Tables S1-S6 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Tables S1-S6 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Table S1. Patient and tumor characteristics. Table S2. Representativeness of study participants. Table S3. Clinical and histopathologic characteristics of individual patients. Table S4. Treatment related adverse events that occurred after …
View article: Supplementary Table S11 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S11 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Statistical test for proportions of CD4+ T cell clusters in the tumor immune microenvironment stratified by histological response and timepoint
View article: Supplementary Table S17 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S17 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Alpha- and beta-chain sequence data of validated anti-HPV16 TCRs
View article: Data from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Data from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
In a phase II trial, patients with local-regionally advanced human papillomavirus–positive oropharyngeal carcinoma (n = 35) received ipilimumab (anti-CTLA4) and nivolumab (anti–PD-1) as induction immunotherapy and concurrently with …
View article: CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells
CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells Open
View article: Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
In a phase II trial, patients with local-regionally advanced human papillomavirus–positive oropharyngeal carcinoma (n = 35) received ipilimumab (anti-CTLA4) and nivolumab (anti–PD-1) as induction immunotherapy and concurrently with radioth…
View article: 2-(3,4-Dichlorophenoxy)triethylamine (DCPTA) Sustains Root Activity Through the Enhancement of Ascorbate-Glutathione in Spring Maize (Zea mays L.) Under Post-Tasseling Waterlogging
2-(3,4-Dichlorophenoxy)triethylamine (DCPTA) Sustains Root Activity Through the Enhancement of Ascorbate-Glutathione in Spring Maize (Zea mays L.) Under Post-Tasseling Waterlogging Open
In Northeast China, waterlogging has emerged as a significant challenge due to climate change, particularly during the June–August period when spring maize (Zea mays L.), at the post-tasseling phase, impedes a comprehensive understanding o…
View article: Molecular and Physiological Responses of Litopenaeus vannamei to Nitrogen and Phosphorus Stress
Molecular and Physiological Responses of Litopenaeus vannamei to Nitrogen and Phosphorus Stress Open
Environmental stressors such as nitrogen and phosphorus play a critical role in regulating the growth and physiological functions of Litopenaeus vannamei, a key species in aquaculture. This study investigates the effects of nitrogen and ph…
View article: Temporal recording of mammalian development and precancer
Temporal recording of mammalian development and precancer Open
View article: Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD
Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD Open
View article: Forecasting Acute Kidney Injury and Resource Utilization in ICU patients using longitudinal, multimodal models
Forecasting Acute Kidney Injury and Resource Utilization in ICU patients using longitudinal, multimodal models Open
Background Advances in artificial intelligence (AI) have realized the potential of revolutionizing healthcare, such as predicting disease progression via longitudinal inspection of Electronic Health Records (EHRs) and lab tests from patien…
View article: Label-aware distance mitigates temporal and spatial variability for clustering and visualization of single-cell gene expression data
Label-aware distance mitigates temporal and spatial variability for clustering and visualization of single-cell gene expression data Open
View article: Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial
Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial Open
There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord blood-derived natural killer (NK) cells expressing anti-CD19 chim…
View article: Depletion of effector regulatory T cells drives major response to induction dual immune checkpoint blockade
Depletion of effector regulatory T cells drives major response to induction dual immune checkpoint blockade Open
In a phase 2 trial, local-regionally advanced HPV-positive oropharyngeal carcinoma (OPC) patients received ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) as induction immunotherapy and concurrently with radiotherapy ( NCT03799445 ). Co…
View article: Forecasting Acute Kidney Injury and Resource Utilization in Icu Patients Using Longitudinal, Multimodal Models
Forecasting Acute Kidney Injury and Resource Utilization in Icu Patients Using Longitudinal, Multimodal Models Open
View article: Temporal recording of mammalian development and precancer
Temporal recording of mammalian development and precancer Open
Key to understanding many biological phenomena is knowing the temporal ordering of cellular events, which often require continuous direct observations [1, 2]. An alternative solution involves the utilization of irreversible genetic changes…
View article: Editorial: Advances in mathematical and computational oncology, volume III
Editorial: Advances in mathematical and computational oncology, volume III Open
EDITORIAL article Front. Oncol., 25 September 2023Sec. Cancer Genetics Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1282882