Jiong‐Wei Wang
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View article: Delivery of Antisense Oligonucleotides Using the Nano‐Cell Vesicle Technology System (nCVTs) for Targeted Cancer Therapy
Delivery of Antisense Oligonucleotides Using the Nano‐Cell Vesicle Technology System (nCVTs) for Targeted Cancer Therapy Open
Nucleic acid therapeutics (NATs) promise to revolutionize the fight against diseases like cancer, yet their full potential remains untapped due to significant delivery challenges. In this study, innovative nano‐cell vesicle technology syst…
View article: Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH
Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH Open
Increasing evidence implicates ceramides in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH). However, the therapeutic potential of liver-targeted ceramide lowering remains unclear. In this study, we demonstrate …
View article: The Global Syndemic of Modifiable Cardiovascular Risk Factors Projected From 2025 to 2050
The Global Syndemic of Modifiable Cardiovascular Risk Factors Projected From 2025 to 2050 Open
Although the projected decline in age-standardized DALYs of modifiable cardiovascular risk factors suggest improved management of CVDs, crude DALYs will continue to rise due to population growth and aging.
View article: Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile
Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile Open
Introduction Malaria is a vector-borne parasitic disease that affects millions worldwide. To achieve the objective set by the World Health Organization of reducing malaria cases by 2030, antimalarial drugs with novel modes of action are re…
View article: Optothermal‐Stimulated Persistent Luminescence Imaging and Therapy (OSPLIT)
Optothermal‐Stimulated Persistent Luminescence Imaging and Therapy (OSPLIT) Open
Persistent luminescent nanomaterials have significantly advanced in vivo bioimaging and biosensing by emitting photons after excitation ceases, effectively minimizing tissue autofluorescence. However, their application in biomedical fields…
View article: Hypertension inhibition by Dubosiella newyorkensis via reducing pentosidine synthesis
Hypertension inhibition by Dubosiella newyorkensis via reducing pentosidine synthesis Open
View article: Polydopamine and hyaluronic acid-coated dual-responsive silica nanoparticles for targeted atherosclerosis imaging and therapy
Polydopamine and hyaluronic acid-coated dual-responsive silica nanoparticles for targeted atherosclerosis imaging and therapy Open
An NB/SPDA@HA nanotheranostic platform, responsive to both acidic conditions and hyaluronidase, is proposed for photoacoustic imaging-guided therapy of atherosclerosis.
View article: Single-point mutated lanmodulin as a high-performance MRI contrast agent for vascular and kidney imaging
Single-point mutated lanmodulin as a high-performance MRI contrast agent for vascular and kidney imaging Open
Magnetic resonance imaging contrast agents can enhance diagnostic precision but often face limitations such as short imaging windows, low tissue specificity, suboptimal contrast enhancement, or potential toxicity, which affect resolution a…
View article: Dual‐Function Nanoscale Coordination Polymer Nanoparticles for Targeted Diagnosis and Therapeutic Delivery in Atherosclerosis
Dual‐Function Nanoscale Coordination Polymer Nanoparticles for Targeted Diagnosis and Therapeutic Delivery in Atherosclerosis Open
Atherosclerosis is the primary cause of cardiovascular events such as heart attacks and strokes. However, current medical practice lacks non‐invasive, reliable approaches for both imaging atherosclerotic plaques and delivering therapeutic …
View article: The burden of cardiovascular disease in Asia from 2025 to 2050: a forecast analysis for East Asia, South Asia, South-East Asia, Central Asia, and high-income Asia Pacific regions
The burden of cardiovascular disease in Asia from 2025 to 2050: a forecast analysis for East Asia, South Asia, South-East Asia, Central Asia, and high-income Asia Pacific regions Open
This was supported by the NUHS Seed Fund (NUHSRO/2022/058/RO5+6/Seed-Mar/03), National Medical Research Council Research Training Fellowship (MH 095:003/008-303), National University of Singapore Yong Loo Lin School of Medicine's Junior Ac…
View article: Gut‐liver axis: Potential mechanisms of action of food‐derived extracellular vesicles
Gut‐liver axis: Potential mechanisms of action of food‐derived extracellular vesicles Open
Food‐derived extracellular vesicles (FEVs) are nanoscale membrane vesicles obtained from dietary materials such as breast milk, plants and probiotics. Distinct from other EVs, FEVs can survive the harsh degrading conditions in the gastroin…
View article: ApoE maintains neuronal integrity via microRNA and H3K27me3-mediated repression
ApoE maintains neuronal integrity via microRNA and H3K27me3-mediated repression Open
ApoE regulates neurogenesis, although how it influences genetic programs remains elusive. Cortical neurons induced from isogenic control and ApoE-/- human neural stem cells (NSCs) recapitulated key transcriptomic signatures of in…
View article: Rising global burden of cancer attributable to high BMI from 2010 to 2019
Rising global burden of cancer attributable to high BMI from 2010 to 2019 Open
View article: Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity Open
Background Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have revealed diverse aetiologies. Among them, familial DCM is the major form of DCM…
View article: Cardiovascular Outcomes in Acute Coronary Syndrome and Malnutrition
Cardiovascular Outcomes in Acute Coronary Syndrome and Malnutrition Open
View article: Endothelial progenitor cells as an emerging cardiovascular risk factor in the field of food and nutrition research: advances and challenges
Endothelial progenitor cells as an emerging cardiovascular risk factor in the field of food and nutrition research: advances and challenges Open
Dietary modifications can help prevent many cardiovascular disease (CVD) events. Endothelial progenitor cells (EPCs) actively contribute to cardiovascular system maintenance and could function as surrogate markers for evaluating improvemen…
View article: Injectable liposomal DHA alleviates atherosclerosis progression and enhances plaque stability
Injectable liposomal DHA alleviates atherosclerosis progression and enhances plaque stability Open
View article: Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis
Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis Open
Extracellular vesicles (EVs) can be produced from red blood cells (RBCs) on a large scale and used to deliver therapeutic payloads efficiently. However, not much is known about the native biological properties of RBCEVs. Here, we demonstra…
View article: Extracellular Vesicles and Their Mimetics: A Comparative Study of Their Pharmacological Activities and Immunogenicity Profiles
Extracellular Vesicles and Their Mimetics: A Comparative Study of Their Pharmacological Activities and Immunogenicity Profiles Open
Extracellular vesicles (EVs), which are miniaturised carriers loaded with functional proteins, lipids, and nucleic acid material, are naturally secreted by cells and show intrinsic pharmacological effects in several conditions. As such, th…
View article: Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis
Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis Open
Milk-derived extracellular vesicles (mEVs) have been proposed as a potential nanomedicine for intestinal disorders; however, their impact on intestinal barrier integrity in gut inflammation and associated metabolic diseases has not been ex…
View article: Trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the Global Burden of Disease Study 2019
Trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the Global Burden of Disease Study 2019 Open
View article: Protection against Doxorubicin-Induced Cardiotoxicity by Ergothioneine
Protection against Doxorubicin-Induced Cardiotoxicity by Ergothioneine Open
Background: Anthracyclines such as doxorubicin remain a primary treatment for hematological malignancies and breast cancers. However, cardiotoxicity induced by anthracyclines, possibly leading to heart failure, severely limits their applic…
View article: The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019
The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019 Open
View article: Chloroquine induces eryptosis in<i>P. falciparum-infected</i>red blood cells and the release of extracellular vesicles with a unique protein profile
Chloroquine induces eryptosis in<i>P. falciparum-infected</i>red blood cells and the release of extracellular vesicles with a unique protein profile Open
Malaria is a vector-borne parasitic disease that affects millions worldwide. In order to reach the objective, set by the World Health Organization to decrease the cases by 2030, antimalarial drugs with novel modes of action are required. P…
View article: Pomelo (<i>Citrus Maxima</i>) Peel Extract Supported <i>Lactiplantibacillus Plantarum</i> 299V Growth Selectively and Improved the Safety and Shelf Life of Salmon Fillets When Formulated in a Probiotic Edible Coating
Pomelo (<i>Citrus Maxima</i>) Peel Extract Supported <i>Lactiplantibacillus Plantarum</i> 299V Growth Selectively and Improved the Safety and Shelf Life of Salmon Fillets When Formulated in a Probiotic Edible Coating Open
View article: Temporal Changes in Extracellular Vesicle Hemostatic Protein Composition Predict Favourable Left Ventricular Remodeling after Acute Myocardial Infarction
Temporal Changes in Extracellular Vesicle Hemostatic Protein Composition Predict Favourable Left Ventricular Remodeling after Acute Myocardial Infarction Open
The subset of plasma extracellular vesicles (EVs) that coprecipitate with low-density lipoprotein (LDL-EVs) carry coagulation and fibrinolysis pathway proteins as cargo. We investigated the association between LDL-EV hemostatic/fibrinolysi…
View article: Protection against doxorubicin-induced cardiotoxicity by ergothioneine
Protection against doxorubicin-induced cardiotoxicity by ergothioneine Open
Anthracyclines such as doxorubicin remain the first line of treatment for haematological malignancies, and breast cancers. However, the potential risk of cardiac injury by anthracyclines, which may lead to severe myopathy or heart failure,…
View article: Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing
Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing Open
View article: The synthesis of extracellular vesicles by the protistan parasite Blastocystis
The synthesis of extracellular vesicles by the protistan parasite Blastocystis Open
Blastocystis is a genus of single-celled protist belonging to the stramenopile group. Prior studies have shown that isolates of Blastocystis subtype 7 (ST7) induced higher levels of intestinal epithelial cell damage and gut microbiota dysb…
View article: Type 2 diabetes mellitus in metabolic-associated fatty liver disease vs. type 2 diabetes mellitus non-alcoholic fatty liver disease: a longitudinal cohort analysis
Type 2 diabetes mellitus in metabolic-associated fatty liver disease vs. type 2 diabetes mellitus non-alcoholic fatty liver disease: a longitudinal cohort analysis Open
The identification and treatment of NAFLD in patients with T2DM is a major concern and the premature change to MAFLD results in an over-diagnosis of fatty liver, exaggerated mortality, and morbidity in patients with T2DM. The definition of…