Jiping Tang
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View article: Estimated glucose disposal rate and risk of incident hyperuricemia: insights from CHARLS
Estimated glucose disposal rate and risk of incident hyperuricemia: insights from CHARLS Open
Hyperuricemia (HUA) is a widespread public health problem worldwide, the etiology of HUA is complex, and there is still a lack of accurate indicators to assess HUA when conducting mass epidemiologic screening. Recent studies have shown tha…
View article: Licochalcone D mitigates intracerebral hemorrhage-induced ferroptosis of neurons through COX2 inhibition
Licochalcone D mitigates intracerebral hemorrhage-induced ferroptosis of neurons through COX2 inhibition Open
Objective This study aims to assess LCD’s neuroprotective pharmacological effects against SBI post-ICH and identify its ferroptosis-inhibiting targets. Methods Animal models of ICH and cellular models of SBI were established. Subsequently,…
View article: TERT/FOXO1 signaling promotes islet β-cell dysfunction in type 2 diabetes mellitus by regulating ATG9A-mediated autophagy
TERT/FOXO1 signaling promotes islet β-cell dysfunction in type 2 diabetes mellitus by regulating ATG9A-mediated autophagy Open
BACKGROUND Type 2 diabetes mellitus (T2DM) is a severe global health problem that causes prolonged disease exposure and an elevated risk for chronic complications, posing a substantial health burden. Although therapies, such as GLP-1 recep…
View article: Nomogram for predicting postoperative clinical remission of hypertension in patients with adrenal tumors
Nomogram for predicting postoperative clinical remission of hypertension in patients with adrenal tumors Open
Nomograms have been demonstrated to perform well in predicting postoperative clinical remission of hypertension in patients with adrenal tumors. This may assist clinicians in distinguishing between patients with adrenal tumors who are like…
View article: Efferocytosis: A new therapeutic target for stroke
Efferocytosis: A new therapeutic target for stroke Open
Efferocytosis refers to the process that phagocytes recognize and remove the apoptotic cells, which is essential for maintaining tissue homeostasis both in physiological and pathological conditions. Numerous studies have demonstrated that …
View article: Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage
Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage Open
Ferroptosis contributes to brain injury after germinal matrix hemorrhage (GMH). Mitochondrial ferritin (FTMT), a novel mitochondrial outer membrane protein, reduces oxidative stress in neurodegenerative diseases. In vitro, Deferiprone has …
View article: Graphical Abstract: Angew. Chem. Int. Ed. 17/2024
Graphical Abstract: Angew. Chem. Int. Ed. 17/2024 Open
In their Research Article (e202319677), Alessandro Porchetta et al. rationally designed PAM-engineered DNA hairpins as input-responsive activators of Cas12a.By utilizing the trans-cleavage activity of Cas12a as a signal transduction method…
View article: UDP-Glucose/P2Y14 Receptor Signaling Exacerbates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats
UDP-Glucose/P2Y14 Receptor Signaling Exacerbates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats Open
BACKGROUND: Subarachnoid hemorrhage (SAH) is a severe subtype of stroke with poor outcomes. Abnormal glucose metabolism often occurs after SAH, but the strict control of blood glucose levels is not always beneficial. This study aimed to in…
View article: Graphical Abstract: Angew. Chem. Int. Ed. 4/2024
Graphical Abstract: Angew. Chem. Int. Ed. 4/2024 Open
In their Research Article (e202314784
View article: The biphasic role of Hspb1 on ferroptotic cell death in Parkinson's disease
The biphasic role of Hspb1 on ferroptotic cell death in Parkinson's disease Open
Rationale: Ferroptosis-driven loss of dopaminergic neurons plays a pivotal role in the pathogenesis of Parkinson's disease (PD). In PD patients, Hspb1 is commonly observed at abnormally high levels in the substantia nigra. The precise cons…
View article: Editorial: Modulation of microglia reactivity and plasticity in CNS injury
Editorial: Modulation of microglia reactivity and plasticity in CNS injury Open
EDITORIAL article Front. Cell. Neurosci., 12 September 2023Sec. Non-Neuronal Cells Volume 17 - 2023 | https://doi.org/10.3389/fncel.2023.1277382
View article: Editorial: Crosstalk between peripheral and local immune response in the pathophysiology of stroke and neurodegeneration diseases
Editorial: Crosstalk between peripheral and local immune response in the pathophysiology of stroke and neurodegeneration diseases Open
EDITORIAL article Front. Cell. Neurosci., 05 September 2023Sec. Cellular Neuropathology Volume 17 - 2023 | https://doi.org/10.3389/fncel.2023.1270834
View article: Fractalkine Enhances Hematoma Resolution and Improves Neurological Function via CX3CR1/AMPK/PPARγ Pathway After GMH
Fractalkine Enhances Hematoma Resolution and Improves Neurological Function via CX3CR1/AMPK/PPARγ Pathway After GMH Open
BACKGROUND: Hematoma clearance has been a proposed therapeutic strategy for hemorrhagic stroke. This study investigated the impact of CX3CR1 (CX3C chemokine receptor 1) activation mediated by r-FKN (recombinant fractalkine) on hematoma res…