Jitender Mehla
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View article: Predicting permeation of compounds across the outer membrane of P. aeruginosa using molecular descriptors
Predicting permeation of compounds across the outer membrane of P. aeruginosa using molecular descriptors Open
View article: Molecular determinants of avoidance and inhibition of <i>Pseudomonas aeruginosa</i> MexB efflux pump
Molecular determinants of avoidance and inhibition of <i>Pseudomonas aeruginosa</i> MexB efflux pump Open
Transporters of the resistance-nodulation-cell division (RND) superfamily of proteins are the dominant multidrug efflux power of Gram-negative bacteria. The major RND efflux pump of Pseudomonas aeruginosa is MexAB-OprM, in which the inner …
View article: Molecular determinants of avoidance and inhibition of<i>Pseudomonas aeruginosa</i>MexB efflux pump
Molecular determinants of avoidance and inhibition of<i>Pseudomonas aeruginosa</i>MexB efflux pump Open
Transporters of the Resistance-Nodulation-cell Division (RND) superfamily of proteins are the dominant multidrug efflux power of Gram-negative bacteria. The major RND efflux pump of Pseudomonas aeruginosa is MexAB-OprM, in which the inner …
View article: Proton transfer activity of the reconstituted <i>Mycobacterium tuberculosis</i> MmpL3 is modulated by substrate mimics and inhibitors
Proton transfer activity of the reconstituted <i>Mycobacterium tuberculosis</i> MmpL3 is modulated by substrate mimics and inhibitors Open
Transporters belonging to the Resistance-Nodulation-cell Division (RND) superfamily of proteins such as Mycobacterium tuberculosis MmpL3 and its analogs are the focus of intense investigations due to their importance in the physiology of C…
View article: Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa
Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa Open
Efflux pump avoidance and inhibition are desired properties for the optimization of antibacterial activities against Gram-negative bacteria. However, molecular and physicochemical interactions defining the interface between compounds and e…
View article: YhcB (DUF1043), a novel cell division protein conserved across gamma-proteobacteria
YhcB (DUF1043), a novel cell division protein conserved across gamma-proteobacteria Open
YhcB, an uncharacterized protein conserved across gamma-proteobacteria, is composed predominantly of a single Domain of Unknown Function (DUF 1043) with an N-terminal transmembrane α-helix. Here, we show that E. coli YhcB is a conditionall…
View article: ZapG (YhcB/DUF1043), a novel cell division protein in gamma-proteobacteria linking the Z-ring to septal peptidoglycan synthesis
ZapG (YhcB/DUF1043), a novel cell division protein in gamma-proteobacteria linking the Z-ring to septal peptidoglycan synthesis Open
View article: Defining new chemical space for drug penetration into Gram-negative bacteria
Defining new chemical space for drug penetration into Gram-negative bacteria Open
View article: Machine Learning Algorithm Identifies an Antibiotic Vocabulary for Permeating Gram-Negative Bacteria
Machine Learning Algorithm Identifies an Antibiotic Vocabulary for Permeating Gram-Negative Bacteria Open
Drug discovery faces a crisis. The industry has used up the "obvious" space in which to find novel drugs for biomedical applications, and productivity is declining. One strategy to combat this is rational approaches to expand the search sp…
View article: Development of a Fragment-Based Machine Learning Algorithm for Designing Hybrid Drugs Optimized for Permeating Gram-Negative Bacteria
Development of a Fragment-Based Machine Learning Algorithm for Designing Hybrid Drugs Optimized for Permeating Gram-Negative Bacteria Open
Gram-negative bacteria are a serious health concern due to the strong multidrug resistance that they display, partly due to the presence of a permeability barrier comprising two membranes with active efflux. New approaches are urgently nee…
View article: Making the Right Choice: Critical Parameters of the Y2H Systems
Making the Right Choice: Critical Parameters of the Y2H Systems Open
View article: Global landscape of cell envelope protein complexes in Escherichia coli
Global landscape of cell envelope protein complexes in Escherichia coli Open
View article: Virus-host protein-protein interactions of mycobacteriophage Giles
Virus-host protein-protein interactions of mycobacteriophage Giles Open
View article: Bam35 Tectivirus Intraviral Interaction Map Unveils New Function and Localization of Phage ORFan Proteins
Bam35 Tectivirus Intraviral Interaction Map Unveils New Function and Localization of Phage ORFan Proteins Open
The family Tectiviridae comprises a group of tailless, icosahedral, membrane-containing bacteriophages that can be divided into two groups by their hosts, either Gram-negative or Gram-positive bacteria. While the first group is composed of…
View article: The phosphocarrier protein HPr of the bacterial phosphotransferase system globally regulates energy metabolism by directly interacting with multiple enzymes in Escherichia coli
The phosphocarrier protein HPr of the bacterial phosphotransferase system globally regulates energy metabolism by directly interacting with multiple enzymes in Escherichia coli Open
The histidine-phosphorylatable phosphocarrier protein (HPr) is an essential component of the sugar-transporting phosphotransferase system (PTS) in many bacteria. Recent interactome findings suggested that HPr interacts with several carbohy…
View article: A Comparison of Two-Hybrid Approaches for Detecting Protein–Protein Interactions
A Comparison of Two-Hybrid Approaches for Detecting Protein–Protein Interactions Open
View article: The Protein Interactome of Mycobacteriophage Giles Predicts Functions for Unknown Proteins
The Protein Interactome of Mycobacteriophage Giles Predicts Functions for Unknown Proteins Open
Mycobacteriophages are viruses that infect mycobacterial hosts and are prevalent in the environment. Nearly 700 mycobacteriophage genomes have been completely sequenced, revealing considerable diversity and genetic novelty. Here, we have d…
View article: Mapping Protein–Protein Interactions Using Yeast Two-Hybrid Assays
Mapping Protein–Protein Interactions Using Yeast Two-Hybrid Assays Open
Yeast two-hybrid (Y2H) screens are an efficient system for mapping protein–protein interactions and whole interactomes. The screens can be performed using random libraries or collections of defined open reading frames (ORFs) called ORFeome…