Jithesh Kottur
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View article: Mechanism of DNA degradation by CBASS Cap5 endonuclease immune effector
Mechanism of DNA degradation by CBASS Cap5 endonuclease immune effector Open
Bacterial CBASS immune defense systems commonly kill virally infected cells by degrading genomic DNA in a form of cell suicide or abortive infection. We present a high-resolution structure of the CBASS effector Cap5, activated by a cyclic …
View article: Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation
Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation Open
Burkholderia cenocepacia is an opportunistic and infective bacterium containing an orphan DNA methyltransferase called M.BceJIV with roles in regulating gene expression and motility of the bacterium. M.BceJIV recognizes a GTWWAC motif (whe…
View article: H19 influenza A virus exhibits species-specific MHC class II receptor usage
H19 influenza A virus exhibits species-specific MHC class II receptor usage Open
View article: Nucleic acid mediated activation of a short prokaryotic Argonaute immune system
Nucleic acid mediated activation of a short prokaryotic Argonaute immune system Open
View article: Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides
Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides Open
View article: <i>Burkholderia cenocepacia</i>epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation
<i>Burkholderia cenocepacia</i>epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation Open
Burkholderia cenocepacia is an opportunistic and infective bacterium containing an orphan DNA methyltransferase (M.BceJIV) with roles in regulating gene expression and motility of the bacterium. M.BceJIV recognizes a GTWWAC motif (where W …
View article: Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer
Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer Open
As a core chromatin-regulatory scaffolding protein, WDR5 mediates numerous protein-protein interactions (PPIs) with other partner oncoproteins. However, small-molecule inhibitors that block these PPIs exert limited cell-killing effects. He…
View article: Nucleic Acid Mediated Activation of a Short Prokaryotic Argonaute Immune System
Nucleic Acid Mediated Activation of a Short Prokaryotic Argonaute Immune System Open
The continual pressure of invading DNA has led bacteria to develop numerous immune systems, including a short prokaryotic Argonaute (pAgo) TIR-APAZ system (SPARTA) that is activated by invading DNA to unleash its TIR domain for NAD(P) + hy…
View article: Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals
Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals Open
The RNA N7-methyltransferase (MTase) activity of SARS-CoV-2’s nsp14 protein is essential for viral replication and is a target for the development of new antivirals. Nsp14 uses S-adenosyl methionine (SAM) as the methyl donor to cap the 5’ …
View article: High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development Open
View article: Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic Open
View article: High resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
High resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development Open
View article: A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models Open
WDR5-degrader-E3 ligase ternary complex structure–based design led to a highly effective WDR5 degrader with robust in vivo antitumor activities.
View article: A polar filter in DNA polymerases prevents ribonucleotide incorporation
A polar filter in DNA polymerases prevents ribonucleotide incorporation Open
The presence of ribonucleotides in DNA can lead to genomic instability and cellular lethality. To prevent adventitious rNTP incorporation, the majority of the DNA polymerases (dPols) possess a steric filter. The dPol named MsDpo4 (Mycobact…
View article: Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Open
DNA synthesis by DNA polymerases (dPols) is central to duplication and maintenance of the genome in all living organisms. dPols catalyze the formation of a phosphodiester bond between the incoming deoxynucleoside triphosphate and the termi…
View article: DNA polymerase IV - DNA ternary complex 14
DNA polymerase IV - DNA ternary complex 14 Open
DNA synthesis by DNA polymerases (dPols) is central to duplication and maintenance of the genome in all living organisms. dPols catalyze the formation of a phosphodiester bond between the incoming deoxynucleoside triphosphate and the termi…
View article: A rescue act: Translesion <scp>DNA</scp> synthesis past <scp><i>N</i></scp><sup>2</sup>‐deoxyguanosine adducts
A rescue act: Translesion <span>DNA</span> synthesis past <span><i>N</i></span><sup>2</sup>‐deoxyguanosine adducts Open
Genomic DNA is continually subjected to a number of chemical insults that result in the formation of modified nucleotides—termed as DNA lesions. The N 2 ‐atom of deoxyguanosine is particularly reactive and a number of chemicals react at th…
View article: Erratum: Corrigendum: Fast native-SAD phasing for routine macromolecular structure determination
Erratum: Corrigendum: Fast native-SAD phasing for routine macromolecular structure determination Open