Jiuchun Qiu
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View article: Reveal the mechanism of brain function with fluorescence microscopy at single-cell resolution: from neural decoding to encoding
Reveal the mechanism of brain function with fluorescence microscopy at single-cell resolution: from neural decoding to encoding Open
As a key pathway for understanding behavior, cognition, and emotion, neural decoding and encoding provide effective tools to bridge the gap between neural mechanisms and imaging recordings, especially at single-cell resolution. While neura…
View article: SAKPE: A Site Attention Kinetic Parameters Prediction Method for Enzyme Engineering
SAKPE: A Site Attention Kinetic Parameters Prediction Method for Enzyme Engineering Open
0. Abstract The quantitative determination of enzyme kinetic parameters traditionally relies on experimental methods that are both time-intensive and costly. Machine learning models have demonstrated significant potential for predicting en…
View article: Association of Estimated Glomerular Filtration Rate (eGFR) and High-Sensitivity C-Reactive Protein (Hs-CRP) with the Risk of New-Onset Atrial Fibrillation in Patients with Diabetes
Association of Estimated Glomerular Filtration Rate (eGFR) and High-Sensitivity C-Reactive Protein (Hs-CRP) with the Risk of New-Onset Atrial Fibrillation in Patients with Diabetes Open
In diabetic patients, decreased eGFR and elevated hs-CRP were independently linked to an increased risk of new-onset AF, emphasizing the importance of monitoring these factors for early detection and prevention of AF.
View article: Jailed high-pressure balloon technique is superior to jailed wire technique in protecting side branch of coronary bifurcation lesions
Jailed high-pressure balloon technique is superior to jailed wire technique in protecting side branch of coronary bifurcation lesions Open
Objectives. This study investigated the influence of higher pressure protection with a small diameter balloon of side branch (SB) on bifurcation lesions. Background. Of the different coronary stent implantation techniques, the modified jai…
View article: Dysglycemia and arrhythmias
Dysglycemia and arrhythmias Open
The incidence of type 2 diabetes mellitus is growing in epidemic proportions and has become one of the most critical public health concerns. Cardiovascular complications associated with diabetes are the leading cause of morbidity and morta…
View article: Case report: reuse of tirofiban leads to very severe thrombocytopenia
Case report: reuse of tirofiban leads to very severe thrombocytopenia Open
Background Telofiban is a class of small molecule non-peptide tyrosine derivatives containing RGD sequences. It is the only platelet surface glycoprotein (GP) IIb/IIIa receptor antagonist (GPI) currently marketed in China. In patients with…
View article: Catheter ablation of idiopathic left fascicular ventricular tachycardia: Implications of false tendons for mapping and ablation
Catheter ablation of idiopathic left fascicular ventricular tachycardia: Implications of false tendons for mapping and ablation Open
Introduction The anatomical substrate for idiopathic left ventricular tachycardia (ILVT) remains speculative. Purkinje networks surrounding false tendons (FTs) might be involved in the reentrant circuit of ILVT. The objective was to evalua…
View article: NADPH Oxidase Mediates Oxidative Stress and Ventricular Remodeling through SIRT3/FOXO3a Pathway in Diabetic Mice
NADPH Oxidase Mediates Oxidative Stress and Ventricular Remodeling through SIRT3/FOXO3a Pathway in Diabetic Mice Open
Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, predisposed to the development of diabetic cardiomyopathy (DCM) in type 2 diabetes mellitus. In this study, we have successfully established…
View article: Pioglitazone Inhibits Diabetes-Induced Atrial Mitochondrial Oxidative Stress and Improves Mitochondrial Biogenesis, Dynamics, and Function Through the PPAR-γ/PGC-1α Signaling Pathway
Pioglitazone Inhibits Diabetes-Induced Atrial Mitochondrial Oxidative Stress and Improves Mitochondrial Biogenesis, Dynamics, and Function Through the PPAR-γ/PGC-1α Signaling Pathway Open
Background: Oxidative stress contributes to adverse atrial remodeling in diabetes mellitus. This remodeling can be prevented by the PPAR-γ agonist pioglitazone via its antioxidant and anti-inflammatory effects. In this study, we examined t…
View article: Xanthine Oxidase Inhibitor Allopurinol Prevents Oxidative Stress‐Mediated Atrial Remodeling in Alloxan‐Induced Diabetes Mellitus Rabbits
Xanthine Oxidase Inhibitor Allopurinol Prevents Oxidative Stress‐Mediated Atrial Remodeling in Alloxan‐Induced Diabetes Mellitus Rabbits Open
Background There are several mechanisms, including inflammation, oxidative stress and abnormal calcium homeostasis, involved in the pathogenesis of atrial fibrillation. In diabetes mellitus ( DM ), increased oxidative stress may be attribu…
View article: Alogliptin, a Dipeptidyl Peptidase‐4 Inhibitor, Alleviates Atrial Remodeling and Improves Mitochondrial Function and Biogenesis in Diabetic Rabbits
Alogliptin, a Dipeptidyl Peptidase‐4 Inhibitor, Alleviates Atrial Remodeling and Improves Mitochondrial Function and Biogenesis in Diabetic Rabbits Open
Background There is increasing evidence implicating atrial mitochondrial dysfunction in the pathogenesis of atrial fibrillation. In this study, we explored whether alogliptin, a dipeptidyl peptidase‐4 inhibitor, can prevent mitochondrial d…
View article: Apocynin attenuates left ventricular remodeling in diabetic rabbits
Apocynin attenuates left ventricular remodeling in diabetic rabbits Open
Inhibition of NADPH oxidase using apocynin is an effective upstream therapy for preventing diabetes-induced adverse remodeling of the left ventricular myocardium.