Jiuhui Xu
YOU?
Author Swipe
View article: Neutrophil elastase promotes low molecular weight cyclin E1 formation to accelerate osteosarcoma proliferation
Neutrophil elastase promotes low molecular weight cyclin E1 formation to accelerate osteosarcoma proliferation Open
Introduction Osteosarcoma (OS) is the most common primary bone malignancy, characterized by aggressive local invasion and a high propensity for metastasis. We previously reported that cyclin E1 is upregulated in osteosarcoma. In this study…
View article: Correction: Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024
Correction: Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024 Open
[This corrects the article DOI: 10.3389/fonc.2025.1509457.].
View article: CD3L1 expression in osteosarcoma and chordoma: a retrospective analysis of 62 cases
CD3L1 expression in osteosarcoma and chordoma: a retrospective analysis of 62 cases Open
Purpose CD3L1 (ITPRIPL1), a natural ligand of CD3ε, is implicated in tumor-immune interactions and is overexpressed in several solid tumors. However, its expression and functional significance in osteosarcoma and chordoma remain uncharacte…
View article: Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024
Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024 Open
Background Liquid–liquid phase separation (LLPS) is a novel concept that could explain how living cells precisely modulate internal spatial and temporal functions. However, a comprehensive bibliometric analysis on LLPS and immune signaling…
View article: Integrative analysis of Ewing’s sarcoma reveals that the MIF-CD74 axis is a target for immunotherapy
Integrative analysis of Ewing’s sarcoma reveals that the MIF-CD74 axis is a target for immunotherapy Open
View article: The relevance of B7-H3 and tumor-associated macrophages in the tumor immune microenvironment of solid tumors: recent advances
The relevance of B7-H3 and tumor-associated macrophages in the tumor immune microenvironment of solid tumors: recent advances Open
B7 homolog 3 (B7-H3) is a member of the B7 ligand family. It is highly expressed in various human cancers, especially mesenchymal malignancies. B7-H3 regulates cancer progression through multiple signaling pathways such as JAK2/STAT3, NF-κ…
View article: Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune Open
Pyroptosis is an identified programmed cell death that has been highly linked to endoplasmic reticulum (ER) dynamics. However, the crucial proteins for modulating dynamic ER membrane curvature change that trigger pyroptosis are currently n…
View article: Clinical characteristics and predisposing factors of lung metastasis in sacral chordoma: a cross-sectional cohort study of 221 cases
Clinical characteristics and predisposing factors of lung metastasis in sacral chordoma: a cross-sectional cohort study of 221 cases Open
Introduction Limited studies are available on the topic of lung metastasis in sacral chordoma. The primary objective of this study was to investigate the prevalence, characteristics, associated factors, and prognosis of lung metastasis in …
View article: Intraoperative Resection Guidance and Rapid Pathological Diagnosis of Osteosarcoma using B7H3 Targeted Probe under NIR‐II Fluorescence Imaging
Intraoperative Resection Guidance and Rapid Pathological Diagnosis of Osteosarcoma using B7H3 Targeted Probe under NIR‐II Fluorescence Imaging Open
Complete removal of all tumor tissue with a wide surgical margin is essential for the treatment of osteosarcoma (OS). However, it's difficult, sometimes impossible, to achieve due to the invisible small satellite lesions and blurry tumor b…
View article: Extracellular vesicles as a new frontier of diagnostic biomarkers in osteosarcoma diseases: a bibliometric and visualized study
Extracellular vesicles as a new frontier of diagnostic biomarkers in osteosarcoma diseases: a bibliometric and visualized study Open
The use of liquid biopsy in cancer research has grown exponentially, offering potential for early detection, treatment stratification, and monitoring residual disease and recurrence. Exosomes, released by cancer cells, contain tumor-derive…
View article: Efficacy of bone defect therapy involving various surface treatments of titanium alloy implants: an in vivo and in vitro study
Efficacy of bone defect therapy involving various surface treatments of titanium alloy implants: an in vivo and in vitro study Open
View article: Efficacy of bone defect therapy involving various surface treatments of titanium alloy implants: An in vivo and in vitro study
Efficacy of bone defect therapy involving various surface treatments of titanium alloy implants: An in vivo and in vitro study Open
Multiple surface treatment methods for titanium alloy prostheses, widely used in orthopedics, are available; however, these can affect bone integration and regeneration efficiency. This study, through cell and animal experiments, we devise…
View article: The role of tumor immune microenvironment in chordoma: promising immunotherapy strategies
The role of tumor immune microenvironment in chordoma: promising immunotherapy strategies Open
Chordoma is a rare malignant bone tumor with limited therapeutic options, which is resistant to conventional chemotherapy and radiotherapy, and targeted therapy is also shown with little efficacy. The long-standing delay in researching its…
View article: Tocilizumab (monoclonal anti-IL-6R antibody) reverses anlotinib resistance in osteosarcoma
Tocilizumab (monoclonal anti-IL-6R antibody) reverses anlotinib resistance in osteosarcoma Open
Purpose Anlotinib, a tyrosine kinase inhibitor (TKI) has been in clinical application to inhibit malignant cell growth and lung metastasis in osteosarcoma (OS). However, a variety of drug resistance phenomena have been observed in the trea…
View article: Integrated analysis of single-cell and bulk RNA sequencing data reveals an immunostimulatory microenvironment in tumor thrombus of osteosarcoma
Integrated analysis of single-cell and bulk RNA sequencing data reveals an immunostimulatory microenvironment in tumor thrombus of osteosarcoma Open
View article: Distinct genomic features between osteosarcomas firstly metastasing to bone and to lung
Distinct genomic features between osteosarcomas firstly metastasing to bone and to lung Open
Osteosarcoma with mainly single-nucleotide variations other than structural variants might exhibit biological behavior predisposing toward bone metastases as well as better immunogenicity in tumor microenvironment.
View article: Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression
Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression Open
Background Chordoma is an extremely rare, locally aggressive malignant bone tumor originating from undifferentiated embryonic remnants. There are no effective therapeutic strategies for chordoma. Herein, we aimed to explore cellular intera…
View article: The malignancy of chordomas is enhanced via a circTLK1/miR-16-5p/Smad3 positive feedback axis
The malignancy of chordomas is enhanced via a circTLK1/miR-16-5p/Smad3 positive feedback axis Open
View article: Current progress and open challenges for applying tyrosine kinase inhibitors in osteosarcoma
Current progress and open challenges for applying tyrosine kinase inhibitors in osteosarcoma Open
Osteosarcoma (OS) is a mesenchymal-origin tumor that constitutes the most common primary malignant bone tumor. The survival rate of the patients has significantly improved since the introduction of neoadjuvant chemotherapy and extensive re…
View article: Molecular subtypes of osteosarcoma classified by cancer stem cell related genes define immunological cell infiltration and patient survival
Molecular subtypes of osteosarcoma classified by cancer stem cell related genes define immunological cell infiltration and patient survival Open
Recent studies have shown that tumor stemness has biological significance in tumorigenicity and tumor progression. However, the characteristics of TME immune infiltration in osteosarcoma mediated by the combined effects of multiple cancer …
View article: Distinct Genomic Features Between Osteosarcomas Firstly Metastasing to Bone and to Lung
Distinct Genomic Features Between Osteosarcomas Firstly Metastasing to Bone and to Lung Open
Background: Osteosarcoma (OS) initially metastasing to bone only shows distinct biological features compared to osteosarcoma that firstly metastasizes to the lung, which suggests us underlying different genomic pathogenetic mechanism. Howe…
View article: Immune-Related LncRNAs Affect the Prognosis of Osteosarcoma, Which Are Related to the Tumor Immune Microenvironment
Immune-Related LncRNAs Affect the Prognosis of Osteosarcoma, Which Are Related to the Tumor Immune Microenvironment Open
Background: Abnormal expression of lncRNA is closely related to the occurrence and metastasis of osteosarcoma. The tumor immune microenvironment (TIM) is considered to be an important factor affecting the prognosis and treatment of osteosa…
View article: circUSP34 accelerates osteosarcoma malignant progression by sponging miR‐16‐5p
circUSP34 accelerates osteosarcoma malignant progression by sponging miR‐16‐5p Open
Osteosarcoma (OS) is a primary and highly malignant mesenchymal tissue tumor. The specific pathological mechanism underlying disease initiation or progression remains unclear. Circular RNAs (circRNAs) are a type of covalently circular RNA …
View article: Circusp34 Promotes Osteosarcoma Proliferation and Invasion by Sponging Mir-16-5p: An in Vivo and in Vitro Analysis
Circusp34 Promotes Osteosarcoma Proliferation and Invasion by Sponging Mir-16-5p: An in Vivo and in Vitro Analysis Open
Background Osteosarcoma (OS) is a primary and highly malignant mesenchymal tissue tumor. Although it has achieved a significant breakthrough in therapeutic administration, the specific pathological mechanism remains unclear. CircRNAs are a…