Jiuzhou Zhao
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View article: Innovative diagnostic approaches for lung cancer: integrating traditional cytology with qPCR for rapid and reliable results
Innovative diagnostic approaches for lung cancer: integrating traditional cytology with qPCR for rapid and reliable results Open
View article: EGFR exon 20 insertions mutation in lung adenocarcinoma and its response by high-dose of Furmonertinib: a real-world study
EGFR exon 20 insertions mutation in lung adenocarcinoma and its response by high-dose of Furmonertinib: a real-world study Open
View article: Clinical application of targeted next-generation sequencing in pneumonia diagnosis among cancer patients
Clinical application of targeted next-generation sequencing in pneumonia diagnosis among cancer patients Open
Background Cancer patients are highly susceptible to infections due to their immunocompromised state from both the malignancy and intensive treatments. Accurate and timely identification of causative pathogens is crucial for effective mana…
View article: Grain Refinement and Strengthening Mechanisms of Pwaamed Tc4 Alloy Subjected to Dynamic Compression within a Wide Temperature Range
Grain Refinement and Strengthening Mechanisms of Pwaamed Tc4 Alloy Subjected to Dynamic Compression within a Wide Temperature Range Open
View article: An Integrated Multi-Omics-Based Machine Learning Model to Determine the Preoperative Nature of Parotid Tumors
An Integrated Multi-Omics-Based Machine Learning Model to Determine the Preoperative Nature of Parotid Tumors Open
View article: Revealing the Atomic-Scale Mechanism of Organic Corrosion Inhibitors in Suppressing Anodic Dissolution of Metals Via Ab Initio Molecular Dynamics and Metadynamics Simulations: A Case Study of Sorbitol on Aluminum
Revealing the Atomic-Scale Mechanism of Organic Corrosion Inhibitors in Suppressing Anodic Dissolution of Metals Via Ab Initio Molecular Dynamics and Metadynamics Simulations: A Case Study of Sorbitol on Aluminum Open
View article: The Prognostic Significance of Tertiary Lymphoid Structure Assessment with Hematoxylin and Eosin Sections in Esophageal Squamous Cell Carcinoma
The Prognostic Significance of Tertiary Lymphoid Structure Assessment with Hematoxylin and Eosin Sections in Esophageal Squamous Cell Carcinoma Open
Purpose To explore the potential prognostic prediction values of tertiary lymphoid structure (TLS) assessed using hematoxylin-eosin staining sections in esophageal squamous cell carcinoma（ESCC） Methods We conducted a comprehensive study in…
View article: First report of furmonertinib as a first-line treatment in advanced lung adenocarcinoma patients harboring EGFR exon 20 insertion mutations after the kinase domain αC-helix: Two case reports and a literature review
First report of furmonertinib as a first-line treatment in advanced lung adenocarcinoma patients harboring EGFR exon 20 insertion mutations after the kinase domain αC-helix: Two case reports and a literature review Open
Rationale: Many studies have shown that first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors are less effective in patients with epidermal growth factor receptor (EGFR) exon 20 insertion (ex20ins) mutati…
View article: Significant benefit of high-dose furmonertinib in the treatment of leptomeningeal metastases from non-small-cell lung cancer with EGFR ex19Del mutation: Two case reports and a literature review
Significant benefit of high-dose furmonertinib in the treatment of leptomeningeal metastases from non-small-cell lung cancer with EGFR ex19Del mutation: Two case reports and a literature review Open
Background: Leptomeningeal metastases (LMs) are a devastating metastatic complication of non-small-cell lung cancer (NSCLC). There is no standard treatment for epidermal growth factor receptor (EGFR) mutant NSCLC, and improving the clinica…
View article: [Misdiagnosis of adenoid cystic carcinoma of oropharynx: a case report].
[Misdiagnosis of adenoid cystic carcinoma of oropharynx: a case report]. Open
Adenoid cystic carcinoma usually occurs in the salivary glands of the head and neck. It is a malignant tumor with a high degree of malignancy, resistance to radiotherapy and chemotherapy and poor prognosis. The clinical course of a…
View article: Surgical treatment of preauricular fistulas: a 12-year single-center clinical observation
Surgical treatment of preauricular fistulas: a 12-year single-center clinical observation Open
Objective This study aimed to assess the effects of surgical timing and approach on operative duration, postoperative suture removal time, and postoperative recurrence rate in the management of preauricular fistula. A 12-year single-center…
View article: Protection of the marginal mandibular branches of the facial nerves by different surgical procedures in comprehensive cervical lymphadenectomy for locally advanced oral and oropharyngeal cancer: a multicenter experience
Protection of the marginal mandibular branches of the facial nerves by different surgical procedures in comprehensive cervical lymphadenectomy for locally advanced oral and oropharyngeal cancer: a multicenter experience Open
View article: Development and clinical applications of an enclosed automated targeted NGS library preparation system
Development and clinical applications of an enclosed automated targeted NGS library preparation system Open
The rapid development of next-generation sequencing (NGS) technology has promoted its wide clinical application in precision medicine for oncology. However, laborious and time-consuming manual operations, highly skilled personnel requireme…
View article: EOAI, a ubiquitin-specific peptidase 5 inhibitor, prevents non-small cell lung cancer progression by inducing DNA damage
EOAI, a ubiquitin-specific peptidase 5 inhibitor, prevents non-small cell lung cancer progression by inducing DNA damage Open
View article: Repair of postoperative defects of oral cancer with submental island flaps based on vascular pedicles of different states: a multicenter retrospective study
Repair of postoperative defects of oral cancer with submental island flaps based on vascular pedicles of different states: a multicenter retrospective study Open
View article: Primary resistance to first- and second-generation ALK inhibitors in a non-small cell lung cancer patient with coexisting ALK rearrangement and an ALK F1174L-cis-S1189C de novo mutation: A case report
Primary resistance to first- and second-generation ALK inhibitors in a non-small cell lung cancer patient with coexisting ALK rearrangement and an ALK F1174L-cis-S1189C de novo mutation: A case report Open
The effectiveness of the tyrosine kinase inhibitor ALK (TKI) for non-small cell lung cancer has been confirmed. However, resistance to ALK-TKIs seems inevitable. Mutations in the ALK kinase domain have been reported as an important mechani…
View article: <i>In-situ</i> composite microstructure formation of immiscible alloy solidified in space
<i>In-situ</i> composite microstructure formation of immiscible alloy solidified in space Open
The immiscible alloy Ti-Co-Gd is solidified in space by using the Electrostatic Levitation Device on board the Chinese Space Station. A sample with in-situ composite structure is obtained. The microstructure formation and gravity effect ar…
View article: Case Report: A good response to furmonertinib second-line treatment of an advanced lung adenocarcinoma patient with a rare EGFR exon 20 N771_P772insH mutation: A case report and literature review
Case Report: A good response to furmonertinib second-line treatment of an advanced lung adenocarcinoma patient with a rare EGFR exon 20 N771_P772insH mutation: A case report and literature review Open
Background: Lung adenocarcinoma with the classical EGFR 19 deletion and exon 21 L858R point mutations has exhibited good responses to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) treatment. However, the sensitivi…
View article: Case report: sequential use of almonertinib based on the EGFR exon 20 insertion mutation achieves long-term control for advanced non-small cell lung cancer patients
Case report: sequential use of almonertinib based on the EGFR exon 20 insertion mutation achieves long-term control for advanced non-small cell lung cancer patients Open
Almonertinib had the most substantial effect, and its use has not been previously reported for NSCLC patients with EGFR ex20ins mutations. The successful application of almonertinib reported here indicates that is a potential new tr…
View article: Clinicopathologic characteristics and diagnostic methods of RET rearrangement in Chinese non-small cell lung cancer patients
Clinicopathologic characteristics and diagnostic methods of RET rearrangement in Chinese non-small cell lung cancer patients Open
RET rearrangement occurs in 1.52% of Chinese NSCLCs and has identifiable clinicopathologic characteristics. RET IHC has a low sensitivity, disavowing its use in routine practice. While NGS and FISH has good performance in ide…
View article: Protection of the Marginal Mandibular Branches of the Facial Nerves by Different Surgical Procedures in Comprehensive Cervical Lymphadenectomy for Locally Advanced Oral and Oropharyngeal Cancer: A Multicenter Experience
Protection of the Marginal Mandibular Branches of the Facial Nerves by Different Surgical Procedures in Comprehensive Cervical Lymphadenectomy for Locally Advanced Oral and Oropharyngeal Cancer: A Multicenter Experience Open
Background and objective: Tumor treatment has been progressive. Targeted therapy and immunotherapy have contributed in the surgical success of several patients with advanced oral and oropharyngeal cancer. Surgery is the primary treatment f…
View article: Reactive Oxygen Species Bridge the Gap between Chronic Inflammation and Tumor Development
Reactive Oxygen Species Bridge the Gap between Chronic Inflammation and Tumor Development Open
According to numerous animal studies, adverse environmental stimuli, including physical, chemical, and biological factors, can cause low‐grade chronic inflammation and subsequent tumor development. Human epidemiological evidence has confir…
View article: Cell-free DNA from cerebrospinal fluid can be used to detect the EGFR mutation status of lung adenocarcinoma patients with central nervous system metastasis
Cell-free DNA from cerebrospinal fluid can be used to detect the EGFR mutation status of lung adenocarcinoma patients with central nervous system metastasis Open
The EGFR mutation status of CSF was different from that of plasma and is correlated with patient prognosis. CSF could be helpful in detecting the EGFR mutation status of patients, particularly in cases of LM.
View article: Octahedron of Zero-Valent and Mono-Valent Copper Anchored on Nitrogen Doping Porous Carbon to Enhance Heterogeneous Electro-Fenton Like Activity
Octahedron of Zero-Valent and Mono-Valent Copper Anchored on Nitrogen Doping Porous Carbon to Enhance Heterogeneous Electro-Fenton Like Activity Open
View article: Corrigendum to ‘Stat2-Drp1 mediated mitochondrial mass increase is necessary for pro-inflammatory differentiation of macrophages’[Redox Biology 37 (2020) 101761]
Corrigendum to ‘Stat2-Drp1 mediated mitochondrial mass increase is necessary for pro-inflammatory differentiation of macrophages’[Redox Biology 37 (2020) 101761] Open
View article: Coexistence of a novel CCNY-ALK and ATIC-ALK double-fusion in one patient with ALK-positive NSCLC and response to crizotinib: a case report
Coexistence of a novel CCNY-ALK and ATIC-ALK double-fusion in one patient with ALK-positive NSCLC and response to crizotinib: a case report Open
Anaplastic lymphoma kinase (ALK) rearrangement, one of the common oncogene rearrangements in the mutational history of lung adenocarcinoma, occurs in approximately 5% of non-small cell lung cancer (NSCLC) patients who could be effectively …
View article: Stat2-Drp1 mediated mitochondrial mass increase is necessary for pro-inflammatory differentiation of macrophages
Stat2-Drp1 mediated mitochondrial mass increase is necessary for pro-inflammatory differentiation of macrophages Open
Macrophage recruitment and pro-inflammatory differentiation are hallmarks of various diseases, including infection and sepsis. Although studies suggest that mitochondria may regulate macrophage immune responses, it remains unclear whether …
View article: Next-Generation Sequencing Identified a Novel Crizotinib-Sensitive PLB1-ALK Rearrangement in Lung Large-Cell Neuroendocrine Carcinoma
Next-Generation Sequencing Identified a Novel Crizotinib-Sensitive PLB1-ALK Rearrangement in Lung Large-Cell Neuroendocrine Carcinoma Open
Clinical Practice Points•Lung large-cell neuroendocrine carcinoma (LCNEC) is diagnosed in approximately 3% of all patients with lung cancer, and is generally associated with high rate of metastases and poor survival. Anaplastic lymphoma ki…
View article: Formation of nano-dispersed Cu particles during aging of a Fe-Cu alloy and dislocation effect
Formation of nano-dispersed Cu particles during aging of a Fe-Cu alloy and dislocation effect Open
The microstructure evolution in a Fe-Cu alloy with/without pre-deformation during the aging treatment is investigated numerically. The results demonstrate that although the Cu precipitates first nucleate on dislocations, the summit of the …
View article: Combined plasma and tissue genotyping of <scp>EGFR</scp> T790M benefits <scp>NSCLC</scp> patients: a real‐world clinical example
Combined plasma and tissue genotyping of <span>EGFR</span> T790M benefits <span>NSCLC</span> patients: a real‐world clinical example Open
Acquired resistance to epidermal growth factor receptor ( EGFR )‐tyrosine kinase inhibitors ( TKI s) is a prevalent clinical problem in the management of advanced non‐small‐cell lung cancer ( NSCLC ) with TKI ‐sensitizing mutations in the …