Jiwei Mao
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View article: Metabolic Engineering of Yeasts: A Key Cell Factory Platform for Advanced Biomanufacturing
Metabolic Engineering of Yeasts: A Key Cell Factory Platform for Advanced Biomanufacturing Open
With mounting concerns over finite fossil fuel reserves and climate change, increasing attention is being paid to an emerging bioeconomy [...]
View article: Metabolic Engineering of Yeasts for the Production of the Triterpene Squalene: Current Status and Future Prospective
Metabolic Engineering of Yeasts for the Production of the Triterpene Squalene: Current Status and Future Prospective Open
Squalene, a linear triterpene compound characterized by its distinctive isoprenoid backbone with six transisoprene units, is widely used in the medicinal, nutraceutical, and cosmetic industries. The escalating global demand for squalene, c…
View article: <scp>LncRNA H19</scp>‐Encoded Micropeptide <scp>altH19</scp> Promotes <scp>DNA</scp> Replication and Mitosis in Myeloma Cells by Enhancing the Phosphorylation of <scp>CDK2</scp> at Threonine 160
<span>LncRNA H19</span>‐Encoded Micropeptide <span>altH19</span> Promotes <span>DNA</span> Replication and Mitosis in Myeloma Cells by Enhancing the Phosphorylation of <span>CDK2</span> at Threonine 160 Open
Micropeptides are endogenous peptides translated from alternative open reading frames (alt‐ORFs) within coding or non‐coding genes. Emerging evidence suggests that some micropeptides play critical roles in both physiological and pathologic…
View article: Nitrogen removal capability and mechanism of a novel low-temperature-tolerant simultaneous nitrification-denitrification bacterium Acinetobacter kyonggiensis AKD4
Nitrogen removal capability and mechanism of a novel low-temperature-tolerant simultaneous nitrification-denitrification bacterium Acinetobacter kyonggiensis AKD4 Open
A low-temperature-tolerant simultaneous nitrification-denitrification bacterial strain of Acinetobacter kyonggiensis (AKD4) was identified. It showed high efficiency in total nitrogen (TN) removal (92.45% at 10°C and 87.51% at 30°C), indic…
View article: Relieving metabolic burden to improve robustness and bioproduction by industrial microorganisms
Relieving metabolic burden to improve robustness and bioproduction by industrial microorganisms Open
Metabolic burden is defined by the influence of genetic manipulation and environmental perturbations on the distribution of cellular resources. The rewiring of microbial metabolism for bio-based chemical production often leads to a metabol…
View article: Fine-tuning of p-coumaric acid synthesis to increase (2S)-naringenin production in yeast
Fine-tuning of p-coumaric acid synthesis to increase (2S)-naringenin production in yeast Open
(2S)-Naringenin is a key precursor for biosynthesis of various high-value flavonoids and possesses a variety of nutritional and pharmaceutical properties on human health. Systematic optimization approaches have been employed to improve (2S…
View article: Additional file 2 of Optimizing yeast for high-level production of kaempferol and quercetin
Additional file 2 of Optimizing yeast for high-level production of kaempferol and quercetin Open
Additional file 2: Feeding profile for glucose limited fed-batch fermentation of kaempferol and quercetin.
View article: Optimization of Pinocembrin Biosynthesis in <i>Saccharomyces cerevisiae</i>
Optimization of Pinocembrin Biosynthesis in <i>Saccharomyces cerevisiae</i> Open
The flavonoid pinocembrin and its derivatives have gained increasing interest for their benefits on human health. While pinocembrin and its derivatives can be produced in engineered Saccharomyces cerevisiae, yields remain low. Here, we des…
View article: A <i>p</i>-Coumaroyl-CoA Biosensor for Dynamic Regulation of Naringenin Biosynthesis in <i>Saccharomyces cerevisiae</i>
A <i>p</i>-Coumaroyl-CoA Biosensor for Dynamic Regulation of Naringenin Biosynthesis in <i>Saccharomyces cerevisiae</i> Open
In vivo biosensors that can convert metabolite concentrations into measurable output signals are valuable tools for high-throughput screening and dynamic pathway control in the field of metabolic engineering. Here, we present a novel biose…
View article: Fine-tuning of coumaric acid synthesis to increase naringenin production in yeast
Fine-tuning of coumaric acid synthesis to increase naringenin production in yeast Open
(2 S )-Naringenin is a key precursor for biosynthesis of various high-value flavonoids and possesses a variety of nutritional and pharmaceutical properties on human health. Systematic optimization approaches have been employed to improve (…
View article: Front Cover Picture: Bioproduction of Enantiopure (<i>R</i>)‐ and (<i>S</i>)‐2‐Phenylglycinols from Styrenes and Renewable Feedstocks (Adv. Synth. Catal. 7/2021)
Front Cover Picture: Bioproduction of Enantiopure (<i>R</i>)‐ and (<i>S</i>)‐2‐Phenylglycinols from Styrenes and Renewable Feedstocks (Adv. Synth. Catal. 7/2021) Open
The front cover picture illustrates whole cells-based cascade reactions to produce (R)- and (S)-2-phenylglycinols from simple chemicals. Artificial enzyme cascades were developed for the one-pot green syntheses of (R)- and (S)-2-phenylglyc…
View article: Yeast optimizes metal utilization based on metabolic network and enzyme kinetics
Yeast optimizes metal utilization based on metabolic network and enzyme kinetics Open
Significance Metal ions are essential to all living cells, as they can serve as cofactors of enzymes to drive catalysis of biochemical reactions. We present a constraint-based model of yeast that relates metabolism with metal ions via enzy…
View article: A high-throughput method for screening of L-tyrosine high-yield strains by <i>Saccharomyces cerevisiae</i>
A high-throughput method for screening of L-tyrosine high-yield strains by <i>Saccharomyces cerevisiae</i> Open
A biosensor screening assay based on the synthesis of betaxanthin was applied to relatively high throughput screening of the L-tyrosine mutant library. In the assays, fluorescence output showed a linear relationship between extracellular L…
View article: POT1-mediated δ-integration strategy for high-copy, stable expression of heterologous proteins in Saccharomyces cerevisiae
POT1-mediated δ-integration strategy for high-copy, stable expression of heterologous proteins in Saccharomyces cerevisiae Open
In biotechnological industry, increased expression cassette stability and copy number serve as important means of maintaining consistently high production levels of heterologous proteins in Saccharomyces cerevisiae. In this study, we combi…
View article: Deletion of genes encoding fatty acid desaturases leads to alterations in stress sensitivity in Pichia pastoris
Deletion of genes encoding fatty acid desaturases leads to alterations in stress sensitivity in Pichia pastoris Open
Unsaturated fatty acids (UFAs) are key compounds which have important roles in maintaining cell membrane physiological functions and the adaption to tough conditions. Defects of fatty acid desaturases will change cellular UFA constitution.…