Jiwon Hong
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View article: Histones are critical toxic factors in gut lymph of severe acute pancreatitis: Neutralization by baicalin and baicalein for protection
Histones are critical toxic factors in gut lymph of severe acute pancreatitis: Neutralization by baicalin and baicalein for protection Open
Histones are key toxic factors in the gut lymph of SAP and their antagonism by baicalin and baicalein offers a novel therapeutic strategy.
View article: Effect of epicanthoplasty on the descent of the eyebrow
Effect of epicanthoplasty on the descent of the eyebrow Open
Background: Epicanthoplasty is an additional surgical technique for blepharoplasty, often performed in conjunction with ptosis correction surgery or eyelid crease surgery, rather than as a standalone procedure. Numerous studies have report…
View article: High-fat feeding drives the intestinal production and assembly of C <sub>16:0</sub> ceramides in chylomicrons
High-fat feeding drives the intestinal production and assembly of C <sub>16:0</sub> ceramides in chylomicrons Open
Consumption of a diet rich in saturated fat increases lipid absorption from the intestine, assembly into chylomicrons, and delivery to metabolic tissues via the lymphatic and circulatory systems. Accumulation of ceramide lipids, composed o…
View article: Chemical Modifications on the αvβ6 Integrin Targeting A20FMDV2 Peptide: A Review
Chemical Modifications on the αvβ6 Integrin Targeting A20FMDV2 Peptide: A Review Open
Integrin proteins have received a significant increase in attention in recent scientific endeavors. The current trend uses the pre‐established knowledge that the arginyl‐glycyl‐aspartic acid (RGD) structural motif present in the A20FMDV2 p…
View article: Multiomics profiling of buffy coat and plasma unveils etiology-specific signatures in hepatocellular carcinoma
Multiomics profiling of buffy coat and plasma unveils etiology-specific signatures in hepatocellular carcinoma Open
Background/Aims: Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide. Despite identification of several biomarkers for HCC diagnosis, challenges such as low sensitivity and intratumoral heterogeneity have impede…
View article: Luminal Delivery of Pectin-Modified Oxygen Microbubbles Mitigates Rodent Experimental Intestinal Ischemia
Luminal Delivery of Pectin-Modified Oxygen Microbubbles Mitigates Rodent Experimental Intestinal Ischemia Open
This proof-of-concept study has demonstrated that luminal OMBp5 decreases ischemic injury to the proximal small intestine. There is a need to improve oxygen delivery over the full length of the intestine. These findings support further stu…
View article: <i>Lactobacillus gasseri</i> and <i>Gardnerella vaginalis</i> produce extracellular vesicles that contribute to the function of the vaginal microbiome and modulate host–<i>Trichomonas vaginalis</i> interactions
<i>Lactobacillus gasseri</i> and <i>Gardnerella vaginalis</i> produce extracellular vesicles that contribute to the function of the vaginal microbiome and modulate host–<i>Trichomonas vaginalis</i> interactions Open
Trichomonas vaginalis is an extracellular protozoan parasite of the human urogenital tract, responsible for a prevalent sexually transmitted infection. Trichomoniasis is accompanied by a dysbiotic microbiome that is characterised by the de…
View article: The Anti-Tubercular Aminolipopeptide Trichoderin A Displays Selective Toxicity against Human Pancreatic Ductal Adenocarcinoma Cells Cultured under Glucose Starvation
The Anti-Tubercular Aminolipopeptide Trichoderin A Displays Selective Toxicity against Human Pancreatic Ductal Adenocarcinoma Cells Cultured under Glucose Starvation Open
Pancreatic ductal adenocarcinoma remains a highly debilitating condition with no effective disease-modifying interventions. In our search for natural products with promising anticancer activity, we identified the aminolipopeptide trichoder…
View article: QC report of RNA-Seq data
QC report of RNA-Seq data Open
RNA-Seq QC data for Joni White's PhD thesis.
View article: THERAPEUTIC THORACIC DUCT DRAINAGE: A SYSTEMATIC REVIEW OF THE EASTERN EUROPEAN EXPERIENCE AND FUTURE POTENTIAL
THERAPEUTIC THORACIC DUCT DRAINAGE: A SYSTEMATIC REVIEW OF THE EASTERN EUROPEAN EXPERIENCE AND FUTURE POTENTIAL Open
Thoracic duct drainage (TDD) is gaining renewed interest, largely due to accumulation of evidence supporting the gut-lymph model, where toxic mesenteric lymph from the intestine contributes to development of multi-organ failure in acute an…
View article: Fluorescent Tracers for In Vivo Imaging of Lymphatic Targets
Fluorescent Tracers for In Vivo Imaging of Lymphatic Targets Open
The lymphatic system continues to gain importance in a range of conditions, and therefore, imaging of lymphatic vessels is becoming more widespread for research, diagnosis, and treatment. Fluorescent lymphatic imaging offers advantages ove…
View article: Vmeasur: A software package for experimental and clinical measurement of mesenteric lymphatic contractile function over an extended vessel length
Vmeasur: A software package for experimental and clinical measurement of mesenteric lymphatic contractile function over an extended vessel length Open
Objective Conventionally, in vivo mesenteric lymphatic contractile function is measured using a high magnification transmission microscope (field of view 0.3–1.5 mm), which precludes visualization of extended lengths of vessels embedded in…
View article: Methods for studying pulmonary lymphatics
Methods for studying pulmonary lymphatics Open
The pulmonary lymphatics are critical for proper lung function, yet seldom considered in lung pathology. Newer and more convenient methods for studying lung lymphatics are now available and might create new diagnosis and treatment opportun…
View article: The complex, bidirectional role of extracellular vesicles in infection
The complex, bidirectional role of extracellular vesicles in infection Open
Cells from all domains of life release extracellular vesicles (EVs), packages that carry a cargo of molecules that participate in communication, co-ordination of population behaviours, virulence and immune response mechanisms. Mammalian EV…
View article: Chaiqin chengqi decoction ameliorates acute pancreatitis in mice via inhibition of neuron activation-mediated acinar cell SP/NK1R signaling pathways
Chaiqin chengqi decoction ameliorates acute pancreatitis in mice via inhibition of neuron activation-mediated acinar cell SP/NK1R signaling pathways Open
CQCQD ameliorated cerulein-induced AP and its associated pain via inhibiting neuron activation-mediated pancreatic acinar cell SP-NK1R signaling pathways and its active compounds baicalin, emodin, and magnolol contributed to this effect.
View article: Effect of the Extracellular Vesicle RNA Cargo From Uropathogenic Escherichia coli on Bladder Cells
Effect of the Extracellular Vesicle RNA Cargo From Uropathogenic Escherichia coli on Bladder Cells Open
Iron restriction in mammals, part of innate antimicrobial defense, may be sensed as a signal by an infecting pathogen. Iron-dependent regulators not only activate the pathogen's specific iron acquisition and storage mechanisms needed for s…
View article: Chaiqin chengqi decoction alleviates severity of acute pancreatitis via inhibition of TLR4 and NLRP3 inflammasome: Identification of bioactive ingredients via pharmacological sub-network analysis and experimental validation
Chaiqin chengqi decoction alleviates severity of acute pancreatitis via inhibition of TLR4 and NLRP3 inflammasome: Identification of bioactive ingredients via pharmacological sub-network analysis and experimental validation Open
CQCQD attenuated the severity of AP at least in part by inhibiting the TLR4/NLRP3 pro-inflammatory pathways. Its active ingredients, emodin, baicalin, rhein and chrysin contributed to these beneficial effects.
View article: Preventing ventilator-induced lung injury
Preventing ventilator-induced lung injury Open
BACKGROUND: Mechanical ventilation is commonly used in Intensive Care Units for supplying supplementary oxygen to critically ill people. However, mechanical ventilation itself often damages the recipient’s lungs. This damage is termed vent…
View article: Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans
Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans Open
The intestinal lymphatic system transports fluid, immune cells, dietary lipids, and highly lipophilic drugs from the intestine to the systemic circulation. These transport functions are important to health and when dysregulated contribute …
View article: The role of host molecules in communication with the resident and pathogenic microbiota: A review
The role of host molecules in communication with the resident and pathogenic microbiota: A review Open
The human body harbours around 100 trillion microbial cells within a network of complex ecosytems. There is now a well-established correlation between microbes and health in conditions associated with chronic inflammation, and much researc…
View article: Lymphatic Uptake of Liposomes after Intraperitoneal Administration Primarily Occurs via the Diaphragmatic Lymphatics and is Dependent on Liposome Surface Properties
Lymphatic Uptake of Liposomes after Intraperitoneal Administration Primarily Occurs via the Diaphragmatic Lymphatics and is Dependent on Liposome Surface Properties Open
Drugs are commonly administered via the intraperitoneal (IP) route to treat localized infections and cancers in patients and to test drug efficacy and toxicity in preclinical studies. Despite this, there remain large gaps in our understand…
View article: Novel frameshift mutations in <i>DSPP</i> cause dentin dysplasia type II
Novel frameshift mutations in <i>DSPP</i> cause dentin dysplasia type II Open
Peer Reviewed
View article: Analysis of the <i>Escherichia coli</i> extracellular vesicle proteome identifies markers of purity and culture conditions
Analysis of the <i>Escherichia coli</i> extracellular vesicle proteome identifies markers of purity and culture conditions Open
Bacteria release nano‐sized extracellular vesicles (EVs) into the extracellular milieu. Bacterial EVs contain molecular cargo originating from the parent bacterium and have important roles in bacterial survival and pathogenesis. Using 8‐pl…
View article: Renal Lymphatics: Anatomy, Physiology, and Clinical Implications
Renal Lymphatics: Anatomy, Physiology, and Clinical Implications Open
Renal lymphatics are abundant in the cortex of the normal kidney but have been largely neglected in discussions around renal diseases. They originate in the substance of the renal lobule as blind-ended initial capillaries, and can either f…
View article: Comparison of Subtyping Approaches and the Underlying Drivers of Microbial Signatures for Chronic Rhinosinusitis
Comparison of Subtyping Approaches and the Underlying Drivers of Microbial Signatures for Chronic Rhinosinusitis Open
Chronic rhinosinusitis (CRS) is a major human health problem that significantly reduces quality of life. While various microbes have been implicated, there is no clear understanding of the role they play in CRS pathogenesis. Another equall…
View article: Strong inhibition of neutrophil–sperm interaction in cattle by selective phosphatidylinositol 3-kinase inhibitors†
Strong inhibition of neutrophil–sperm interaction in cattle by selective phosphatidylinositol 3-kinase inhibitors† Open
The vast majority of sperm are lost from the female reproductive tract in hours following natural mating or artificial insemination in mammals. Multiple complex processes including uterine contractions, mucus barriers, and phagocytosis of …