Jiuwei Cui
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View article: Amivantamab Plus Lazertinib in Atypical <i>EGFR</i> -Mutated Advanced Non–Small Cell Lung Cancer: Results From CHRYSALIS-2
Amivantamab Plus Lazertinib in Atypical <i>EGFR</i> -Mutated Advanced Non–Small Cell Lung Cancer: Results From CHRYSALIS-2 Open
PURPOSE For patients with advanced non–small cell lung cancer (NSCLC) harboring atypical epidermal growth factor receptor ( EGFR ) mutations (eg, S768I, L861Q, G719X), efficacy of current treatment options is limited. PATIENTS AND METHODS …
View article: Harnessing multi-omics approaches to decipher tumor evolution and improve diagnosis and therapy in lung cancer
Harnessing multi-omics approaches to decipher tumor evolution and improve diagnosis and therapy in lung cancer Open
With the advancement of novel technologies such as whole-genome sequencing, single-cell sequencing, and spatial transcriptomics, single-omics analyses have already promoted the research of tumorigenesis as well as development and have part…
View article: Efficacy and Safety of <scp>EGF</scp> / <scp>EGFR</scp> Vaccines in <scp>EGFR</scp> ‐Driven Solid Tumors: A Systematic Review and Meta‐Analysis of Controlled and Single‐Arm Studies
Efficacy and Safety of <span>EGF</span> / <span>EGFR</span> Vaccines in <span>EGFR</span> ‐Driven Solid Tumors: A Systematic Review and Meta‐Analysis of Controlled and Single‐Arm Studies Open
Background Despite multiple clinical trials, the benefits and safety of epidermal growth factor (EGF)/EGF receptor (EGFR) vaccines in EGFR‐driven solid tumors remain unclear due to small sample sizes and heterogeneous study designs. This s…
View article: Spirosalen–scandium catalysts enable the epimerization-tolerant closed-loop circularity of poly( <scp>l</scp> -lactic acid)
Spirosalen–scandium catalysts enable the epimerization-tolerant closed-loop circularity of poly( <span>l</span> -lactic acid) Open
Although poly(l-lactic acid) (PLLA) has attracted broad interest as a sustainable plastic, its chemical recycling to a monomer has been an elusive endeavour. A major obstacle for this process is that the epimerization of l-lactide (l-LA) t…
View article: Association between human herpesvirus 6 status and sarcopenia risk: a UK biobank cohort study with sex-specific patterns and telomere length modification
Association between human herpesvirus 6 status and sarcopenia risk: a UK biobank cohort study with sex-specific patterns and telomere length modification Open
Background Sarcopenia represents a significant global health concern affecting older adults, yet its relationship with infectious agents remains poorly understood. This study investigated the association between human herpesvirus 6 (HHV-6)…
View article: Long-term follow-up results from the GLORY study: phase II study of gumarontinib in East Asian patients with MET exon 14 skipping mutated non-small cell lung cancer
Long-term follow-up results from the GLORY study: phase II study of gumarontinib in East Asian patients with MET exon 14 skipping mutated non-small cell lung cancer Open
Gumarontinib showed promising efficacy and acceptable toxicities in East Asian population, with a rapid onset of action, substantial and durable response, which can be converted into a long-term survival benefit.
View article: Delayed Repolarization Caused by <scp>hERG</scp> Block With Different Drug Modalities Can Be Detected in Stem Cell‐Derived Cardiomyocytes: Incubation Time Matters
Delayed Repolarization Caused by <span>hERG</span> Block With Different Drug Modalities Can Be Detected in Stem Cell‐Derived Cardiomyocytes: Incubation Time Matters Open
The intrinsic characteristics of oligonucleotides pose a challenge for their assessment in conventional primary in vitro cardiac models, which were designed for the acute application of small molecule agents and are not suitable for transf…
View article: Another power of antibody-drug conjugates: immunomodulatory effect and clinical applications
Another power of antibody-drug conjugates: immunomodulatory effect and clinical applications Open
Antibody-drug conjugates (ADCs) enhance tumour immunogenicity through multidimensional immune modulation beyond targeted cytotoxicity. The immune remodelling of the tumour microenvironment (TME) suggests potential synergistic mechanisms wi…
View article: Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery
Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery Open
Despite advances in disease treatment, our understanding of how damaged organs recover and the mechanisms governing this process remain poorly defined. Here, we mapped the transcriptional and regulatory landscape of human cardiac recovery …
View article: Explainable deep learning model WAL-net for individualised assessment of potentially reversible malnutrition in patients with cancer: a multicentre cohort study
Explainable deep learning model WAL-net for individualised assessment of potentially reversible malnutrition in patients with cancer: a multicentre cohort study Open
Persistent malnutrition is associated with poor clinical outcomes in cancer. However, assessing its reversibility can be challenging. The present study aimed to utilise machine learning (ML) to predict reversible malnutrition (RM) in patie…
View article: Polyvinylpyrrolidone‐Encapsulated Total Flavonoids Nanoparticles for Enhancing Antioxidant and Anticancer Activities
Polyvinylpyrrolidone‐Encapsulated Total Flavonoids Nanoparticles for Enhancing Antioxidant and Anticancer Activities Open
Total flavonoids (TFs) extracted from Rosa davurica Pall. are known for their diverse biological activities, including antioxidant and anticancer properties. However, their application is significantly constrained by low solubility and poo…
View article: Associations of flavonoid intakes with metabolic dysfunction-associated steatotic liver disease in US adults
Associations of flavonoid intakes with metabolic dysfunction-associated steatotic liver disease in US adults Open
The incidence of Metabolic dysfunction-associated steatotic liver disease (MASLD) is rising annually. Dietary intervention is a cornerstone of MASLD management. Flavonoids, which have anti-inflammatory properties, are thought to benefit MA…
View article: Updated overall survival data and predictive biomarkers of autologous NK cells plus Sintilimab as second-line treatment for advanced non-small cell lung cancer
Updated overall survival data and predictive biomarkers of autologous NK cells plus Sintilimab as second-line treatment for advanced non-small cell lung cancer Open
Purpose Combination strategies involving immune checkpoint inhibitors (ICIs) have been a prominent focus of research in the treatment of non-small cell lung cancer (NSCLC). Our prior findings demonstrated that the combination of autologous…
View article: Effects of albumin and weight-standardized hand grip strength on survival for cancer patients with frailty
Effects of albumin and weight-standardized hand grip strength on survival for cancer patients with frailty Open
Objective: While albumin and the weight-standardized hand grip strength (HGS/W) serve as valuable prognostic indicators for cancer patients, their correlation with the prognosis in frail cancer patients remains inadequately explored. This …
View article: A Novel Definition and Grading Diagnostic Criteria for Tumour‐Type‐Specific Comprehensive Cachexia Risk
A Novel Definition and Grading Diagnostic Criteria for Tumour‐Type‐Specific Comprehensive Cachexia Risk Open
Background The existing diagnostic criteria for cancer cachexia do not meet clinical needs. We aimed to establish novel comprehensive evaluation scales for cachexia specific to patients with solid tumours. Methods This study included 12 65…
View article: Oxidative balance score is associated with increased risk of sarcopenia and sarcopenic obesity in non-elderly adults: results from NHANES 2011–2018
Oxidative balance score is associated with increased risk of sarcopenia and sarcopenic obesity in non-elderly adults: results from NHANES 2011–2018 Open
This study reveals a robust inverse correlation between OBS and both sarcopenia and sarcopenic obesity in adults aged 20-59. These results suggest that an antioxidant-rich diet and healthy lifestyle practices, including low-fat diets, adeq…
View article: Sensor‐enabled Orthopedic Implants for Musculoskeletal Monitoring
Sensor‐enabled Orthopedic Implants for Musculoskeletal Monitoring Open
Next‐generation smart implants, in addition to providing essential mechanical and physiological functions, can self‐monitor, assess bone tissue health, and enable personalized treatment customization. However, integrating traditional ortho…
View article: Effect of comorbidity classes on survival of patients with gastrointestinal tract cancer
Effect of comorbidity classes on survival of patients with gastrointestinal tract cancer Open
We identified two classes of comorbidities that were associated with overall survival in patients with GTC. The combination of different comorbidities class plays a vital role in the prognosis of GTC.
View article: Diagnostic Criteria for Cancer‐Associated Cachexia: Insights from a Multicentre Cohort Study
Diagnostic Criteria for Cancer‐Associated Cachexia: Insights from a Multicentre Cohort Study Open
Background To explore the association between cachexia, as defined by different diagnostic criteria, and the risk of mortality in individuals with cancer. We also examined which diagnostic criteria are more feasible and appropriate for can…
View article: Urinary phthalate metabolites associated with increased prevalence of gallstone disease in U.S. adults: data from the NHANES study
Urinary phthalate metabolites associated with increased prevalence of gallstone disease in U.S. adults: data from the NHANES study Open
Higher urinary phthalate metabolite concentrations were associated with increased gallstone risk. These novel findings suggest phthalate exposure may contribute to lithogenic pathogenesis. Future prospective and mechanistic research is war…
View article: The relationship between life’s essential 8 score and depression symptom severity: evidence from a nationally representative sample of U.S. adults
The relationship between life’s essential 8 score and depression symptom severity: evidence from a nationally representative sample of U.S. adults Open
This study indicates a significant negative correlation between overall cardiovascular health measured by LE8 scores and depression. Prioritizing interventions targeting lifestyle modifications to alleviate the burden of depression in publ…
View article: FBXW7 in gastrointestinal cancers: from molecular mechanisms to therapeutic prospects
FBXW7 in gastrointestinal cancers: from molecular mechanisms to therapeutic prospects Open
F-box and WD repeat domain-containing 7 (FBXW7), formerly known as hCdc4, hAGO Fbw7, or SEL10, plays a specific recognition function in SCF-type E3 ubiquitin ligases. FBXW7 is a well-established cancer suppressor gene that specifically con…