Jiyan Mohammad
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View article: Reduced-order modeling of solute transport within physiologically realistic solid tumor microenvironment
Reduced-order modeling of solute transport within physiologically realistic solid tumor microenvironment Open
A bstract Solid tumors are characterized by densely packed extracellular matrices and limited vascularization, creating significant resistance to both diffusive and convective transport. In this study, we developed an integration of numeri…
View article: Hypoxia-Responsive Polymersomes for Stemness Reduction in Patient-Derived Solid Tumor Spheroids
Hypoxia-Responsive Polymersomes for Stemness Reduction in Patient-Derived Solid Tumor Spheroids Open
Aggressive solid tumors are associated with rapid growth, early hypoxia, the lack of targeted therapies, and a poor prognosis. The hypoxic niches within the rapidly growing solid tumors give rise to a stem cell-like phenotype with higher m…
View article: ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics
ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics Open
Cancer incidence is increasing, and the drugs are not very selective. These drugs cause adverse effects, and the cells become resistant. Therefore, new drugs are needed. Here, we evaluated the effects of ZIM, a candidate for chemotherapy, …
View article: Computational multiphase characterization of perfusion trends inside biomimetic reduced-order dense tumors
Computational multiphase characterization of perfusion trends inside biomimetic reduced-order dense tumors Open
Dense fibrous extracellular constitution of solid tumors exerts high resistance to diffusive transport into it; additionally, the scarcity of blood and lymphatic flows hinders convection. The complexity of fluidic transport mechanisms in s…
View article: Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways
Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways Open
Glutathione S-transferase pi-1 (GSTP1) plays an important role in regulating oxidative stress by conjugating glutathione to electrophiles. GSTP1 is overexpressed in breast, colon, lung, and prostate tumors, where it contributes to tumor pr…
View article: Piperlongumine potentiates the effects of gemcitabine in <i>in vitro</i> and <i>in vivo</i> human pancreatic cancer models
Piperlongumine potentiates the effects of gemcitabine in <i>in vitro</i> and <i>in vivo</i> human pancreatic cancer models Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers due to a late diagnosis and poor response to available treatments. There is a need to identify complementary treatment strategies that will enhance the efficacy and re…