Explanipedia

Microbiome signatures of <i>Clostridioides difficile</i> toxin production and toxin gene presence: a shotgun metagenomic approach Open

Jiye Kwon, Maria Correa, Yong Kong, William Pelletiers, Martina Wade , et al. · 2025

Clostridioides difficile is an opportunistic gastrointestinal pathogen capable of asymptomatic colonization and causes diseases ranging from diarrhea to pseudomembranous colitis. Accurate diagnosis of C. difficile infection (CDI) is challe…

How well do disease-specific studies and WHO-CHOICE cost estimates align? Example of estimating cost per episode of diarrhoea and respiratory syncytial virus in 128 low-income and middle-income countries Open

Xiao Li, Joke Bilcke, Ernest O. Asare, Catherine Wenger, Jiye Kwon , et al. · 2025

Objective Non-disease-specific WHO-CHOICE (CHOosing Interventions that are Cost-Effective) unit costs are often used in cost and cost-effectiveness studies in the absence of country-specific data. This study aims to compare reported countr…

Utilizing virus genomic surveillance to predict vaccine effectiveness Open

Jiye Kwon, Ke Li, Joshua L. Warren, Sameer Pandya, Anne M. Hahn , et al. · 2025

As new vaccines are being developed for fast-evolving viruses, determining when and how to update them, and what data should inform these decisions, remains a significant challenge. We developed a model to inform these vaccine updates in n…

Cost-effectiveness analysis of alternative infant and neonatal rotavirus vaccination schedules in Malawi Open

Catherine Wenger, Ernest O. Asare, Jiye Kwon, Xiao Li, Edson Mwinjiwa , et al. · 2025

Rotavirus is the leading cause of severe diarrhea among children under five worldwide, especially in low- and middle-income countries (LMICs). Although vaccination is the best strategy to prevent rotavirus, obstacles leading to poor vaccin…

None: Estimation of Rotavirus Vaccine Effectiveness Based on Whole Genome Sequences Open

Jiye Kwon, Jose Jaimes, Mary E. Wikswo, Eileen J. Klein, Mary Allen Staat , et al. · 2025

Estimation of Rotavirus Vaccine Effectiveness Based on Whole Genome Sequences Open

Jiye Kwon, Jose Jaimes, Mary E. Wikswo, Eileen J. Klein, Mary Allen Staat , et al. · 2025

Introduction Rotavirus vaccine evaluations have noted small differences in vaccine effectiveness (VE) against rotavirus genotypes, defined by the two outer capsid proteins (VP7 or G-type and VP4 or P-type). However, the genomic landscape o…

Estimation of Rotavirus Vaccine Effectiveness Based on Whole Genome Sequences Open

Jiye Kwon, Jose Jaimes, Mary E. Wikswo, Eileen J. Klein, Mary Allen Staat , et al. · 2025

Introduction Rotavirus vaccine evaluations have noted small differences in vaccine effectiveness (VE) against rotavirus genotypes, defined by the two outer capsid proteins (VP7 or G-type and VP4 or P-type). However, the genomic landscape o…

Prospective comparison of the digestive tract resistome and microbiota in cattle raised in grass-fed versus grain-fed production systems Open

Jiye Kwon, Windy Tanner, Yong Kong, Martina Wade, Chad Bitler , et al. · 2025

Most antimicrobials sold in the United States are used in food animals. Farm management practices contribute to antibacterial resistance (AR). Controversially, grass-fed diets have been recommended over grain-fed diets to reduce AR in beef…

Cost-effectiveness Analysis of Alternative Infant and Neonatal Rotavirus Vaccination Schedules in Malawi Open

Catherine Wenger, Ernest O. Asare, Jiye Kwon, Xiao Li, Edson Mwinjiwa , et al. · 2024

Rotavirus is the leading cause of severe diarrhea among children under five worldwide, especially in low- and middle-income countries (LMICs). Although vaccination is the best strategy for preventing rotavirus infection, obstacles leading …

Cost per episode of diarrhea and respiratory syncytial virus (RSV) in 128 low- and middle-income countries: how well do disease-specific and WHO-CHOICE estimates align? Open

Xiao Li, Joke Bilcke, Ernest O. Asare, Catherine Wenger, Jiye Kwon , et al. · 2024

Objective Non-disease-specific WHO-CHOICE unit costs are often used in cost and cost-effectiveness studies in the absence of country-specific data. This study aims to compare reported country-specific disease costs and the corresponding WH…

Participant Diversity in United States Randomized Controlled Trials of Antibacterials for <i>Staphylococcus aureus</i> Infections, 2000–2021 Open

Jiye Kwon, William Pelletiers, Jessica Galloway-Peña, David van Duin, Leila Ledbetter , et al. · 2024

Background Equitable representation of members from historically marginalized groups is important in clinical trials, which inform standards of care. The goal of this study was to characterize the demographics and proportional subgroup rep…

Planning for Mpox on a College Campus: A Model-Based Decision-Support Tool Open

Alexandra Savinkina, Melanie H. Chitwood, Jiye Kwon, Virginia E. Pitzer, Gregg Gonsalves , et al. · 2023

National Institutes of Health National Institute on Drug Abuse and National Institute of Allergy and Infectious Diseases.

Estimated Testing, Tracing, and Vaccination Targets for Containment of the US Mpox Outbreak Open

Melanie H. Chitwood, Jiye Kwon, Alexandra Savinkina, Jo Walker, Alyssa Bilinski , et al. · 2023

This decision analytic model estimates the levels of community testing, contract tracing, and vaccination required to reduce the effective reproduction number of the mpox virus among the high-risk group of men who have sex with men.

Estimation of Rotavirus Vaccine Effectiveness Based on Whole Genome Sequences Open

James D. Chappell, John V. Williams, Geoffrey A. Weinberg, Michael D. Bowen, Jiye Kwon , et al. · 2023

Containing monkeypox on a college campus: a model-based analysis Open

Alexandra Savinkina, Melanie H. Chitwood, Jiye Kwon, Virginia E. Pitzer, Gregg Gonsalves , et al. · 2022

We developed a stochastic dynamic transmission model of Monkeypox Virus (hMPXV) to simulate potential spread of hMPXV on a university campus. We used the model to evaluate containment strategies, including detection and isolation of cases …

Testing, Tracing, and Vaccination Targets for Containment of the US Monkeypox Outbreak: A Modeling Study Open

Melanie H. Chitwood, Jiye Kwon, Alexandra Savinkina, Jo Walker, Alyssa Bilinski , et al. · 2022

We estimate the levels of community testing, contact tracing, and vaccination required to reduce the effective reproduction number (Rt) of Monkeypox Virus (MPXV) below 1 for high risk men who have sex with men. We found that the critical t…

Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia Open

Melinda M. Pettigrew, Jiye Kwon, Janneane F. Gent, Yong Kong, Martina Wade , et al. · 2022

Antibiotic resistance is a major threat to public health. Treatment strategies involving shorter antibiotic courses have been proposed as a strategy to lower the potential for antibiotic resistance.

Gastrointestinal Microbiome Disruption and Antibiotic-Associated Diarrhea in Children Receiving Antibiotic Therapy for Community-Acquired Pneumonia Open

Jiye Kwon, Yong Kong, Martina Wade, Derek J. Williams, C. Buddy Creech , et al. · 2022

Antibiotic-associated diarrhea (AAD) is a common side effect of antibiotics. We examined the gastrointestinal microbiota in children treated with β-lactams for community-acquired pneumonia. Data were from 66 children (n = 198 samples), age…

Defining facets of social distancing during the COVID-19 pandemic: Twitter analysis Open

Jiye Kwon, Connor B. Grady, Josemari Feliciano, Samah Fodeh · 2020

Defining Facets of Social Distancing during the COVID-19 Pandemic: Twitter Analysis Open

Jiye Kwon, Connor B. Grady, Josemari Feliciano, Samah Fodeh · 2020

Social distancing has been one of the primary mitigation strategies in the United States to control the spread of novel coronavirus disease (COVID-19) and can be viewed as a multi-faceted public health measure. Using Twitter data, we aim t…

Influence of News Media and Public Health Agencies during Pre-Pandemic COVID-19: Twitter Analysis (Preprint) Open

Connor B. Grady, Josemari Feliciano, Jiye Kwon, Samah Fodeh · 2020

UNSTRUCTURED Health communication is crucial during public health threats. Twitter has been used extensively to produce and spread content during the COVID-19 pandemic. This study seeks to analyze the sentiment and themes of tweets from u…

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