Jiyi Hu
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View article: Autophagy-dependent sensitization effects of PARP inhibitors on recurrent nasopharyngeal carcinoma treated with carbon ion and photon irradiation
Autophagy-dependent sensitization effects of PARP inhibitors on recurrent nasopharyngeal carcinoma treated with carbon ion and photon irradiation Open
Tumor radioresistance and severe toxicity make reirradiation for recurrent nasopharyngeal carcinoma (NPC) a significant clinical challenge. This study aims to investigate the ability of the poly(ADP-ribose) polymerase (PARP) inhibitor olap…
View article: Correction: Changes in lymphocyte subsets pre- and post-particle radiotherapy in head and neck bone and soft tissue tumors
Correction: Changes in lymphocyte subsets pre- and post-particle radiotherapy in head and neck bone and soft tissue tumors Open
[This corrects the article DOI: 10.3389/fonc.2025.1543718.].
View article: The Circadian Rhythm Gene Network Could Distinguish Molecular Profile and Prognosis for Glioblastoma
The Circadian Rhythm Gene Network Could Distinguish Molecular Profile and Prognosis for Glioblastoma Open
Increasing evidence highlights the role of aberrant circadian rhythm gene expression in glioblastoma (GBM) progression, but the impact of the circadian rhythm gene network on GBM molecular profiles and prognosis remains unclear. A total of…
View article: Changes in lymphocyte subsets pre- and post-particle radiotherapy in head and neck bone and soft tissue tumors
Changes in lymphocyte subsets pre- and post-particle radiotherapy in head and neck bone and soft tissue tumors Open
Purpose Bone and soft tissue tumors present unique therapeutic challenges due to their heterogeneity and poor prognosis to standard treatments. Particle therapy offers improved dose distribution and potentially higher relative biological e…
View article: Long-term outcomes and prognostic factors of eye-preserving treatment with particle beam radiotherapy for orbital malignancies
Long-term outcomes and prognostic factors of eye-preserving treatment with particle beam radiotherapy for orbital malignancies Open
Particle radiotherapy following eye-preserving treatment provided a favorable local control and survivals with moderate acute and late toxicities, even in patients with unresectable disease. Particle radiotherapy was a promising strategy f…
View article: Clinical outcomes of particle beam radiation therapy for patients with newly-diagnosed major salivary gland tumors
Clinical outcomes of particle beam radiation therapy for patients with newly-diagnosed major salivary gland tumors Open
As a potentially safe and efficient treatment option for newly-diagnosed MSGTs, proton and carbon ion radiation offers an excellent alternative for traditional methods. More investigation is required to determine the long-term results and …
View article: Long-term Outcomes and Prognostic Factors of Eye-preserving Treatment with Particle Beam Radiotherapy for Orbital Malignancies
Long-term Outcomes and Prognostic Factors of Eye-preserving Treatment with Particle Beam Radiotherapy for Orbital Malignancies Open
Background This retrospective study report the clinical experience of eye-preserving treatment follow by particle beam radiotherapy (IMPT or CIRT) for orbital malignancies. And to evaluate prognostic factors for orbital and lacrimal gland …
View article: Long-term outcomes after particle radiation therapy in patients with nasopharyngeal adenoid cystic carcinoma
Long-term outcomes after particle radiation therapy in patients with nasopharyngeal adenoid cystic carcinoma Open
Background Nasopharyngeal adenoid cystic carcinoma (NACC) is a relatively rare salivary gland tumor that is generally associated with poor outcomes. High-dose radiotherapy is a key treatment for patients with NACC. This study reported the …
View article: Long-term Outcomes After Particle Radiation Therapy in Patients with Nasopharyngeal Adenoid Cystic Carcinoma
Long-term Outcomes After Particle Radiation Therapy in Patients with Nasopharyngeal Adenoid Cystic Carcinoma Open
Background Nasopharyngeal adenoid cystic carcinoma (NACC) a is a relatively rare salivary gland tumor and is generally associated with a poor outcome. High-dose radiotherapy is a key treatment in patients with NACC. This study reported the…
View article: A protocol for a randomized trial evaluating the role of <scp>carbon‐ion</scp> radiation therapy plus camrelizumab for patients with locoregionally recurrent nasopharyngeal carcinoma
A protocol for a randomized trial evaluating the role of <span>carbon‐ion</span> radiation therapy plus camrelizumab for patients with locoregionally recurrent nasopharyngeal carcinoma Open
Purpose Management of locoregionally recurrent nasopharyngeal carcinoma (LR NPC) is difficult. Although carbon‐ion radiation therapy (CIRT) could substantially improve the overall survival (OS) of those patients, around 40% of the patients…
View article: Carbon ion radiotherapy combined with immunotherapy: synergistic anti-tumor efficacy and preliminary investigation of ferroptosis
Carbon ion radiotherapy combined with immunotherapy: synergistic anti-tumor efficacy and preliminary investigation of ferroptosis Open
Carbon ion radiotherapy (CIRT) may yield satisfactory clinical outcomes for patients who are resistant to radiotherapy. However, the therapeutic impact of carbon ions is still limited in certain recurring or refractory tumors. Therefore, w…
View article: Preliminary clinical outcomes of head and neck squamous cell carcinoma treated with particle beam radiation therapy
Preliminary clinical outcomes of head and neck squamous cell carcinoma treated with particle beam radiation therapy Open
Purpose Further improvement in clinical outcomes is needed for patients with head and neck squamous cell carcinoma (HNSCC), as there is typically a poor prognosis at diagnosis. This study aimed to report the preliminary therapeutic outcome…
View article: Particle beam radiation therapy for head and neck rhabdomyosarcoma in adults
Particle beam radiation therapy for head and neck rhabdomyosarcoma in adults Open
CIRT, either used alone or in combination with PRT, is not only feasible and safe but also useful in local disease control for HNRMS. DM is the most important cause of treatment failure; thus, more effective systemic treatment is needed to…
View article: Feasibility of lattice radiotherapy using proton and carbon-ion pencil beam for sinonasal malignancy
Feasibility of lattice radiotherapy using proton and carbon-ion pencil beam for sinonasal malignancy Open
Despite minimal differences in PVDR, proton and carbon-ion LRT plans can better protect OARs than photon LRT plans.
View article: Mesenchymal Stem Cells Inhibits Migration and Vasculogenic Mimicry in Nasopharyngeal Carcinoma Via Exosomal MiR-125a
Mesenchymal Stem Cells Inhibits Migration and Vasculogenic Mimicry in Nasopharyngeal Carcinoma Via Exosomal MiR-125a Open
Vasculogenic mimicry (VM) is a kind of tumor vasculature providing blood supply for tumor growth, and the formation of VM is independent of vascular endothelial cells. Instead, VM structures are formed by differentiated tumor cells such as…
View article: Additional file 2 of Identification of molecular subtypes based on inflammatory response in lower-grade glioma
Additional file 2 of Identification of molecular subtypes based on inflammatory response in lower-grade glioma Open
Additional file 2. Gene list of hallmark inflammatory response.
View article: Additional file 1 of Identification of molecular subtypes based on inflammatory response in lower-grade glioma
Additional file 1 of Identification of molecular subtypes based on inflammatory response in lower-grade glioma Open
Additional file 1. The clinical information of LGG patients obtained from TCGA, CGGA, and GEO database.
View article: Mixed Photon and Carbon-Ion Beam Radiotherapy in the Management of Non-Metastatic Nasopharyngeal Carcinoma
Mixed Photon and Carbon-Ion Beam Radiotherapy in the Management of Non-Metastatic Nasopharyngeal Carcinoma Open
Background Carbon-ion radiotherapy (CIRT) may further increase the therapeutic ratio for patients with newly diagnosed nasopharyngeal carcinoma (NPC). The purpose of the current study is to examine the effectiveness and toxicity profile of…
View article: Development of a normal tissue complication probability (NTCP) model using an artificial neural network for radiation-induced necrosis after carbon ion re-irradiation in locally recurrent nasopharyngeal carcinoma
Development of a normal tissue complication probability (NTCP) model using an artificial neural network for radiation-induced necrosis after carbon ion re-irradiation in locally recurrent nasopharyngeal carcinoma Open
An ANN was built to predict radiation-induced necrosis after re-irradiation in rNPC. The best accuracy and area under receiver-operating characteristic (ROC) curve (AUC) were 66.7% and 0.689. The most predictive dosimetric and clinical par…
View article: Carbon-ion radiotherapy boost with standard dose proton radiation for incomplete-resected high-grade glioma: a phase 1 study
Carbon-ion radiotherapy boost with standard dose proton radiation for incomplete-resected high-grade glioma: a phase 1 study Open
Particle beam radiotherapy consisting of a CIRT boost of 15 Gy RBE (in 3 fractions) following standard dose PRT (60 Gy RBE in 30 fractions), and used in conjunction with TMZ, is safe and potentially effective for patients with HGG.
View article: Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies
Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies Open
Salvage CIRT provided relatively safe and effective short-term outcome for patients with unresectable or in-completely resected RI-SPM, as compared to historical data on re-irradiation using the conventional photon beam technology. However…
View article: The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx
The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx Open
CIRT alone or in combination with PBT appeared to be a promising modality for the treatment of NACC and produced satisfactory local disease control and toxicity profile. Distant metastasis remained to be a substantial mode for treatment fa…
View article: Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers
Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers Open
Adjuvant proton beam therapy and CIRT after radical surgical resection for head and neck cancers provided satisfactory therapeutic effectiveness, but no significant difference was observed between the two radiotherapy technologies. However…
View article: Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy
Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy Open
Perfusion imaging prior to PBRT is a strong predictor of survival in HGG. Novel perfusion MR-based nomogram with prospective validation could potentially be formally used in future clinical practice to individualize survival probability.
View article: Intensity-modulated proton and carbon-ion radiation therapy in the management of major salivary gland carcinomas
Intensity-modulated proton and carbon-ion radiation therapy in the management of major salivary gland carcinomas Open
Overall, intensity-modulated proton and/or carbon-ion radiation therapy provided satisfactory therapeutic effectiveness in our major SGCs patients with a low incidence of acute and late toxicities.
View article: Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study
Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study Open
In the current study, a significant association between pre-treatment FLT-PET and LPFS was observed in patients with locally advanced LR-NPC. Further investigations are warranted to confirm the predictive role of FLT-PET.