Jiyun Ahn
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View article: Copper deficiency disrupts OXPHOS and mitochondrial dynamics through MTCH2-dependent copper trafficking in skeletal muscle
Copper deficiency disrupts OXPHOS and mitochondrial dynamics through MTCH2-dependent copper trafficking in skeletal muscle Open
Copper is an essential trace element required for mitochondrial respiration and cellular metabolism, yet its role in skeletal muscle remains incompletely understood. Here, we show that skeletal muscle-specific deletion of the high-affinity…
View article: <i>Akkermansia muciniphila</i> Alleviates Sarcopenia in Senescence-Accelerated Mouse-Prone 8 Mice
<i>Akkermansia muciniphila</i> Alleviates Sarcopenia in Senescence-Accelerated Mouse-Prone 8 Mice Open
Akkermansia muciniphila, an intestinal bacterium, has garnered attention for its association with metabolic health and anti-inflammatory properties. However, its potential role in mitigating sarcopenia, particularly in the senescenc…
View article: Scutellarein attenuates cancer cachexia-induced muscle atrophy via targeted inhibition of the JAK/STAT pathway
Scutellarein attenuates cancer cachexia-induced muscle atrophy via targeted inhibition of the JAK/STAT pathway Open
Collectively, our findings suggest scutellarein as a promising candidate for the prevention and treatment of cancer cachexia, providing a novel therapeutic approach to address this critical unmet need in cancer care.
View article: Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyperactivation in aging models
Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyperactivation in aging models Open
Collectively, these findings suggest that NIC is a promising novel candidate for the prevention of frailty.
View article: A Natural Autophagy Activator <scp><i>Castanea crenata</i></scp> Flower Alleviates Skeletal Muscle Ageing
A Natural Autophagy Activator <span><i>Castanea crenata</i></span> Flower Alleviates Skeletal Muscle Ageing Open
Background Sarcopenia, characterized by a gradual decline in skeletal muscle mass and function with age, significantly impacts both quality of life and mortality. Autophagy plays a crucial role in maintaining muscle health. There is growin…
View article: Norharmane prevents muscle aging via activation of SKN-1/NRF2 stress response pathways
Norharmane prevents muscle aging via activation of SKN-1/NRF2 stress response pathways Open
Sarcopenia, the age-related decline in muscle mass and function, is a significant contributor to increased frailty and mortality in the elderly. Currently, no FDA-approved treatment exists for sarcopenia. Here, we identified norharmane (NR…
View article: Gardenia Fruit and Its Active Compound Crocin Protect Against Dexamethasone‐Induced Muscle Atrophy via Nrf2 Activation
Gardenia Fruit and Its Active Compound Crocin Protect Against Dexamethasone‐Induced Muscle Atrophy via Nrf2 Activation Open
Background: Muscle mass gradually declines with age and the development of an effective strategy to prevent this is important. Gardenia fruit ( Gardenia jasminoides ; GJ), commonly used as a natural food colorant and in traditional herbal …
View article: Effect of the combination of Lithospermum erythrorhizon and Lonicera japonica on dexamethasone-induced muscle atrophy in mice
Effect of the combination of Lithospermum erythrorhizon and Lonicera japonica on dexamethasone-induced muscle atrophy in mice Open
Skeletal muscle atrophy occurs in several pathological conditions. Among other reasons, high-dose or long-term administration of glucocorticoids increases circulating glucocorticoid levels and causes muscle atrophy. The purpose of this stu…
View article: Identification of novel anti-obesity saponins from the ovary of sea cucumber (Stichopus japonicus)
Identification of novel anti-obesity saponins from the ovary of sea cucumber (Stichopus japonicus) Open
View article: <i>Gracilaria chorda</i> attenuates obesity‐related muscle wasting through activation of <scp>SIRT1</scp>/<scp>PGC1α</scp> in skeletal muscle of mice
<i>Gracilaria chorda</i> attenuates obesity‐related muscle wasting through activation of <span>SIRT1</span>/<span>PGC1α</span> in skeletal muscle of mice Open
Gracilaria chorda (GC) is a red algal species that is primarily consumed in Asia. Here, we investigated the effect of GC on obesity‐related skeletal muscle wasting. Furthermore, elucidating its impact on the activation of sirtuin 1 (SIRT1)…
View article: Gromwell ameliorates glucocorticoid-induced muscle atrophy through the regulation of Akt/mTOR pathway
Gromwell ameliorates glucocorticoid-induced muscle atrophy through the regulation of Akt/mTOR pathway Open
View article: Identification of Novel Anti-Obesity Saponins from the Ovary of Sea Cucumber (<i>Stichopus Japonicus</i>)
Identification of Novel Anti-Obesity Saponins from the Ovary of Sea Cucumber (<i>Stichopus Japonicus</i>) Open
View article: Method Validation for Analysis of Advanced Glycation End Products in Mouse Muscle Using Liquid Chromatography–Tandem Mass Spectrometry
Method Validation for Analysis of Advanced Glycation End Products in Mouse Muscle Using Liquid Chromatography–Tandem Mass Spectrometry Open
View article: Gromwell (<i>Lithospermum erythrorhizon</i>) Attenuates High-Fat-Induced Skeletal Muscle Wasting by Increasing Protein Synthesis and Mitochondrial Biogenesis
Gromwell (<i>Lithospermum erythrorhizon</i>) Attenuates High-Fat-Induced Skeletal Muscle Wasting by Increasing Protein Synthesis and Mitochondrial Biogenesis Open
Gromwell (Lithospermum erythrorhizon, LE) can mitigate obesity-induced skeletal muscle atrophy in C2C12 myotubes and high-fat diet (HFD)-induced obese mice. The purpose of this study was to investigate the anti-skeletal muscle atrop…
View article: Justicia procumbens prevents hair loss in androgenic alopecia mice
Justicia procumbens prevents hair loss in androgenic alopecia mice Open
The plant Justicia procumbens is traditionally used in Asia to treat fever, cough, and pain. Previous studies have reported its anticancer and anti-asthmatic properties. However, its potential for preventing androgenic alopecia (AGA) has n…
View article: Dark tea extract attenuates age-related muscle loss by suppressing oxidative stress and inflammation in skeletal muscle of mice
Dark tea extract attenuates age-related muscle loss by suppressing oxidative stress and inflammation in skeletal muscle of mice Open
Dark tea (DT), a tea post-fermented by the Eurotium cristatum fungus, is known to attenuate oxidative damage and chronic inflammation. It also extends the lifespan of Caenorhabditis elegans fed a high-sugar diet. However, its impact on age…
View article: Induction of Fatty Acid Oxidation Underlies DNA Damage‐Induced Cell Death and Ameliorates Obesity‐Driven Chemoresistance
Induction of Fatty Acid Oxidation Underlies DNA Damage‐Induced Cell Death and Ameliorates Obesity‐Driven Chemoresistance Open
The DNA damage response is essential for preserving genome integrity and eliminating damaged cells. Although cellular metabolism plays a central role in cell fate decision between proliferation, survival, or death, the metabolic response t…
View article: Geniposide attenuates muscle atrophy via the inhibition of FoxO1 in senescence-accelerated mouse prone-8
Geniposide attenuates muscle atrophy via the inhibition of FoxO1 in senescence-accelerated mouse prone-8 Open
Although GP did not improve the AD pathology in SAMP8 mice, we suggest that GP has the potential to improve muscle deterioration caused by aging. This effect of GP may be attributed to the suppression of FoxO1 activity.
View article: Fuzhuan brick tea extract ameliorates obesity-induced skeletal muscle atrophy by alleviating mitochondrial dysfunction in mice
Fuzhuan brick tea extract ameliorates obesity-induced skeletal muscle atrophy by alleviating mitochondrial dysfunction in mice Open
Fuzhuan brick tea (FBT) is a post-fermented tea fermented by the fungus Eurotium cristatum and is mainly produced in Hunan Province, China. Our previous study revealed that FBT extract prevents obesity by increasing energy expenditure and …
View article: <i>Akkermansia muciniphila</i> promotes testosterone‐mediated hair growth inhibition in mice
<i>Akkermansia muciniphila</i> promotes testosterone‐mediated hair growth inhibition in mice Open
The beneficial effects of Akkermansia muciniphila ( Akk ) on gut health and inflammation reduction have been demonstrated; however, scientific evidence of hair growth enhancement by Akk has not been reported. Therefore, this study was unde…
View article: 6-Gingerol Ameliorates Adiposity and Inflammation in Adipose Tissue in High Fat Diet-Induced Obese Mice: Association with Regulating of Adipokines
6-Gingerol Ameliorates Adiposity and Inflammation in Adipose Tissue in High Fat Diet-Induced Obese Mice: Association with Regulating of Adipokines Open
We investigated the effects of 6-gingerol on adiposity and obesity-induced inflammation by focusing on the regulation of adipogenesis and adipokines in white adipose tissue (WAT) of diet-induced obese mice. C57BL/6 mice were fed a high-fat…
View article: Longevity through diet restriction and immunity
Longevity through diet restriction and immunity Open
The share of the population that is aging is growing rapidly. In an aging society, technologies and interventions that delay the aging process are of great interest. Dietary restriction (DR) is the most reproducible and effective nutrition…
View article: Whole red paprika (Capsicum annuum L.) and its orange-red pigment capsanthin ameliorate obesity-induced skeletal muscle atrophy in mice
Whole red paprika (Capsicum annuum L.) and its orange-red pigment capsanthin ameliorate obesity-induced skeletal muscle atrophy in mice Open
Red paprika (RP) is rich in carotenoids and capsanthin (CS) is its main carotenoid. We determined whether whole RP and CS can ameliorate obesogenic sarcopenia.C2C12 myotubes were co-treated with 500 μM of palmitic acid (PA) and 1 and 5 μg/…
View article: Millet seed oil activates β–catenin signaling and promotes hair growth
Millet seed oil activates β–catenin signaling and promotes hair growth Open
Alopecia, regardless of gender, exacerbates psychological stress in those affected. The rising prevalence of alopecia has fueled a research interest in preventing hair loss. This study investigates the potential of millet seed oil (MSO) in…
View article: The innate immune signaling component FBXC-58 mediates dietary restriction effects on healthy aging in Caenorhabditis elegans
The innate immune signaling component FBXC-58 mediates dietary restriction effects on healthy aging in Caenorhabditis elegans Open
Dietary restriction (DR) is a highly effective and reproducible intervention that prolongs longevity in many organisms. The molecular mechanism of action of DR is tightly connected with the immune system; however, the detailed mechanisms a…
View article: Identification of Novel Anti-Obesity Saponins from the Ovary of Sea Cucumber (Stichopus Japonicus)
Identification of Novel Anti-Obesity Saponins from the Ovary of Sea Cucumber (Stichopus Japonicus) Open
View article: Android Obesity Could Be Associated with a Higher Fall Risk than Gynoid Obesity Following a Standing-Slip: A Simulation-Based Biomechanical Analysis
Android Obesity Could Be Associated with a Higher Fall Risk than Gynoid Obesity Following a Standing-Slip: A Simulation-Based Biomechanical Analysis Open
View article: <i>Codium fragile</i> reduces adipose tissue expansion and fatty liver incidence by downregulating adipo‐ and lipogenesis
<i>Codium fragile</i> reduces adipose tissue expansion and fatty liver incidence by downregulating adipo‐ and lipogenesis Open
Codium fragile (C. fragile) is a marine alga with high functional food potential. Recent studies have proven C. fragile extract (CFE) effective against obesity. However, the exact underlying mechanism of CFE's anti-obesity effects remains …
View article: Castor Oil Plant (Ricinus communis L.) Leaves Improve Dexamethasone-Induced Muscle Atrophy via Nrf2 Activation
Castor Oil Plant (Ricinus communis L.) Leaves Improve Dexamethasone-Induced Muscle Atrophy via Nrf2 Activation Open
Skeletal muscle atrophy is characterized by reduced muscle function and size. Oxidative stress contributes to muscle atrophy but can be treated with antioxidants. This study investigated the antioxidant activity of a castor oil plant leaf …
View article: Antioxidant Activity of <i>Valeriana fauriei</i> Protects against Dexamethasone‐Induced Muscle Atrophy
Antioxidant Activity of <i>Valeriana fauriei</i> Protects against Dexamethasone‐Induced Muscle Atrophy Open
Skeletal muscle atrophy is defined as wasting or loss of muscle. Although glucocorticoids (GCs) are well‐known anti‐inflammatory drugs, their long‐term or high‐dose use induces skeletal muscle atrophy. Valeriana fauriei (VF) is used to tre…