Explanipedia

How to best preserve oocytes in female cancer patients exposed to DNA damage inducing therapeutics Open

Karla J. Hutt, J. B. Kerr, Clare L. Scott, J. K. Findlay, Andreas Strasser · 2013

The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion Open

J. B. Kerr, Leonie R. Brogan, Mark A. Myers, Karla J. Hutt, T Mladenovska , et al. · 2012

Reports indicate that germ-line stem cells present in adult mice can rapidly generate new oocytes and contribute to the primordial follicle reserve following conditions of ovotoxic stress. We further investigated the hypothesis that adult …

Estrogen Signaling in the Regulation of Female Reproductive Functions Open

J. K. Findlay, Seng H. Liew, Edward Simpson, Kenneth S. Korach · 2010

OVARIAN PHYSIOLOGY: FOLLICLE DEVELOPMENT, OOCYTE AND HORMONE RELATIONSHIPS Open

J. K. Findlay, J. B. Kerr, Kara L. Britt, Seng H. Liew, E R Simpson , et al. · 2009

The ovarian follicle is the fundamental unit of the ovary. It contains the oocyte that may eventually ovulate, undergo fertilization and form an embryo. It also provides the steroid and protein hormones required for maintenance of the ovar…

Quantification of healthy follicles in the neonatal and adult mouse ovary: evidence for maintenance of primordial follicle supply Open

Jeff B. Kerr, R. Duckett, Mark A. Myers, Kara L. Britt, T Mladenovska , et al. · 2006

Proliferation and partial meiotic maturation of germ cells in fetal ovaries is believed to establish a finite, non-renewable pool of primordial follicles at birth. The supply of primordial follicles in postnatal life should be depleted dur…

158. Effects of phytoestrogens on the ovarian and pituitary phenotypes of oestrogen deficient female aromatase knockout mice Open

Kara L. Britt, Edward Simpson, J. K. Findlay · 2004

Phytoestrogens can induce both estrogen agonistic and antagonistic effects, depending on the tissue, estrogen receptor content and endogenous levels of estrogen. Dietary phytoestrogens are promoted as alternatives to synthetic estrogens fo…

Effect of immunization against the amino-terminal peptide ( N) of the alpha43-subunit of inhibin on follicular atresia and expression of tissue inhibitor of matrix metalloproteinase (TIMP-1) in ovarian follicles of sheep Open

Anita Dhar, Lois A. Salamonsen, B. W. Doughton, R. W. Brown, J. K. Findlay · 1998

Ewes actively immunized against alpha N, the N-terminal peptide of inhibin alpha 43 precursor, have lowered fertility associated with ovulation failure, restricted tissue remodelling and reduced matrix metalloproteinase-2 activity in the f…

Endothelin in the ovine uterus during the oestrous cycle and early pregnancy Open

Simon C. Riley, Anna R. Butt, Bruce W. Doughton, S.X. Li, S-H. Zheng , et al. · 1994

Endothelin, which has potent vasoconstrictor and mitogenic actions, was measured by radioimmunoassay in tissue extracts of sheep endometrium and myometrium and was found to be present in similar amounts in both tissues during the oestrous …

Regulation of gene expression and cellular localization of prostaglandin synthase by oestrogen and progesterone in the ovine uterus Open

Lois A. Salamonsen, Anne Hampton, Judith A. Clements, J. K. Findlay · 1991

Expression of the gene for prostaglandin synthase (PGS) was examined in whole endometrial tissue derived from ewes during the oestrous cycle (Days 4-14), on Day 15 of pregnancy and following ovariectomy and treatment with ovarian steroid h…

Ovine follicular fluid inhibits thymidine incorporation by 3T3 fibroblasts in vitro Open

Ronald S. Carson, D.M. Robertson, J. K. Findlay · 1988

The ability of antral follicular fluid obtained from sheep follicles to inhibit 3T3 fibroblasts maintained for 48 h in concentrations of fetal calf serum optimal for cell growth was examined. Addition of pooled follicular fluid to cultures…

Effects of ovine follicular fluid on plasma LH and FSH secretion in ovariectomized ewes to indicate the site of action of inhibin Open

Iain J. Clarke, J. K. Findlay, J. T. Cummins, Warren J. Ewens · 1986

Ovariectomized ewes were given 2 ml s.c. injections of ovine follicular fluid (oFF) (N = 3) or serum (N = 3) and blood samples were collected each day for 3 days. Follicular fluid caused a significant (P less than 0.005) reduction in FSH w…

Permeability of rat ovarian follicles to LH during development and luteinization Open

Ronald S. Carson, Lois A. Salamonsen, J. K. Findlay · 1986

A 'double isotope' technique has been used to describe the temporal relationship between plasma and follicular concentrations of LH after injection of 51Cr and 125I-rat LH into immature rats. Radiolabelled LH was detectable in all follicle…

Inhibin secretion by the sheep ovary Open

J. K. Findlay, C. G. Tsonis, Linton Staples, Ross N. P. Cahill · 1986

An in-vitro bioassay for inhibin based on FSH content or release by rat pituitary cells was validated for measuring inhibin activity in ovine plasma and lymph. Dose-dependent increases in inhibin activity were detected in peripheral plasma…

Role of intrafollicular regulators and FSH in growth and development of large antral follicles in sheep Open

L. P. Cahill, Marc Antoine Driancourt, W.A. Chamley, J. K. Findlay · 1985

Manipulation of circulating concentrations of hormones and ovarian follicle status was carried out on Day 11-12 of the oestrous cycle in sheep. All follicles visible on the ovary were ablated by cautery and ewes were treated with oestradio…

Relationships between aromatase activity, follicular fluid oestradiol-17 and testosterone concentrations, and diameter and atresia of individual ovine follicles Open

C. G. Tsonis, Ronald S. Carson, J. K. Findlay · 1984

Aromatase activity was measured in granulosa cells using a 1-h in-vitro assay. This activity correlated with the concentration of oestradiol-17 beta and the ratio of oestradiol-17 beta to testosterone in follicular fluid of individual foll…

Identification at the onset of luteolysis of follicles capable of ovulation in the ewe Open

C. G. Tsonis, L. P. Cahill, Ronald S. Carson, J. K. Findlay · 1984

Follicles of various sizes at the surface of the ovary were ablated by electrocautery at the time of cloprostenol-induced luteolysis in ewes and the interval from cloprostenol treatment to the onset of the LH surge determined as an index o…

Prostaglandin F and 13,14-dihydro-15-keto prostaglandin F in the endometrium and uterine flushings of sheep before implantation Open

J. K. Findlay, N. Colvin, J B Swaney, Bruce W. Doughton · 1983

The concentrations of prostaglandin F (PGF) and its major metabolite, 13,14-dihydro-15-keto prostaglandin F-2 alpha (PGFM), were measured in caruncular and intercaruncular endometrium of pregnant and non-pregnant ewes on Days 9, 11, 13 and…

Oestrogen receptors and protein synthesis in caruncular and intercaruncular endometrium of sheep before implantation Open

J. K. Findlay, Iain J. Clarke, J B Swaney, N. Colvin, Bruce W. Doughton · 1982

The rate of protein synthesis was higher in caruncular (P less than 0.05) and intercaruncular endometrium (P less than 0.01) of pregnant compared to non-pregnant ewes on Day 11 (Day 0 = day of oestrus), but not on Days 9, 13 and 15. Cytoso…

The failure of prolactin to enhance the inhibitory effect of oestradiol-17 on LH synthesis and release in ewes Open

Patrick Wright, J. K. Findlay, G. A. Anderson · 1981

Groups of 5-6 ovariectomized ewes were treated with oestradiol-17 beta (100 mg implant) and/or bromocriptine (1 mg; 2 X daily) or with vehicle for 30 days during the anoestrous season. Oestradiol increased (P less than 0.05) the priming ef…

Protein, prostaglandin and steroid synthesis in caruncular and intercaruncular endometrium of sheep before implantation Open

J. K. Findlay, N Ackland, Robert D. Burton, A. J. Davis, F. M. M. Walker , et al. · 1981

The effect of the presence of a preimplantation embryo on protein concentration, rate of protein synthesis, beta-glucuronidase and acid phosphatase activities, steroid metabolism and prostaglandin F production in caruncular and intercarunc…

Estrogen Receptors in the Neuroendocrine Tissues of the Ewe in Relation to Breed, Season, and Stage of the Estrous Cycle Open

Iain J. Clarke, K. Burman, John W. Funder, J. K. Findlay · 1981

Estrogen receptors (ER) in the neuroendocrine tissues of female sheep have been studied with respect to breed, season, and stage of the estrous cycle. In the first study, cytoplasmic ER measured by Scatchard analysis in neuroendocrine tiss…

The influence of prostaglandin F-2 on pregnenolone metabolism by the autotransplated ovary of the ewe Open

H.-O. Hoppen, David Williams, J. K. Findlay · 1976

Eight ewes each with an autotransplanted ovary received infusions of tritium-labelled pregnenolone (41 muCi/hr) for 8 hr into the artery supplying the ovary, together with prostaglandin (PG) F-2alpha (30 mug/hr) for 3 hr beginning 2 hr aft…

Contents, Vol. 2, 1971/72 Open

Josephine Milner, J. R. GODING, I. Cumming, W.A. Chamley, JL Brown , et al. · 1971

M astroianni (Philadelphia): Physiology of the ovum transfer by the fallopian tube.J. Mulnard (Bruxelles): Environmental factors in preimplantation development of mouse ovum in vitro.-F.Leroy (Bruxelles): Histophotometric studies on DNA co…

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