Jlenia Monfregola
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View article: Author response: Ezrin defines TSC complex activation at endosomal compartments through EGFR–AKT signaling
Author response: Ezrin defines TSC complex activation at endosomal compartments through EGFR–AKT signaling Open
View article: Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling
Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling Open
Endosomes have emerged as major signaling hubs where different internalized ligand-receptor complexes are integrated and the outcome of signaling pathways are organized to regulate the strength and specificity of signal transduction events…
View article: Author response: Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling
Author response: Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling Open
View article: Plasmodium berghei liver stage parasites exploit host GABARAP proteins for TFEB activation
Plasmodium berghei liver stage parasites exploit host GABARAP proteins for TFEB activation Open
Plasmodium , the causative agent of malaria, infects hepatocytes prior to establishing a symptomatic blood stage infection. During this liver stage development, parasites reside in a parasitophorous vacuole (PV), whose membrane acts as the…
View article: Ezrin defines TSC complex activation at endosomal compartments through EGFR–AKT signaling
Ezrin defines TSC complex activation at endosomal compartments through EGFR–AKT signaling Open
Endosomes have emerged as major signaling hubs where different internalized ligand–receptor complexes are integrated and the outcome of signaling pathways are organized to regulate the strength and specificity of signal transduction events…
View article: Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling
Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling Open
Endosomes have emerged as major signaling hubs where different internalized ligand-receptor complexes are integrated and the outcome of signaling pathways are organized to regulate the strength and specificity of signal transduction events…
View article: Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling
Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling Open
Endosomes have emerged as major signaling hubs where different internalized ligand-receptor complexes are integrated and the outcome of signaling pathways are organized to regulate the strength and specificity of signal transduction events…
View article: Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation
Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation Open
View article: RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome
RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome Open
View article: Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex
Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex Open
The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy 1 . The phosphorylation of TFEB by the mechanistic target of rapamycin complex 1 (mTORC1) 2–5 is unique in its mTORC1 substrate recruitment mechanism…
View article: Structural basis for mTORC1-dependent regulation of the lysosomal and autophagic transcription factor TFEB
Structural basis for mTORC1-dependent regulation of the lysosomal and autophagic transcription factor TFEB Open
The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy. The phosphorylation of TFEB by the mechanistic target of rapamycin complex 1 (mTORC1) is unique in its mTORC1 substrate recruitment mechanism, which…
View article: Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders Open
Lysosomal storage disorders characterized by altered metabolism of heparan sulfate, including Mucopolysaccharidosis (MPS) III and MPS-II, exhibit lysosomal dysfunctions leading to neurodegeneration and dementia in children. In lysosomal st…
View article: A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome
A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome Open
View article: TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway
TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway Open
View article: mTOR-dependent phosphorylation controls TFEB nuclear export
mTOR-dependent phosphorylation controls TFEB nuclear export Open
View article: mTOR-dependent phosphorylation controls TFEB nuclear export
mTOR-dependent phosphorylation controls TFEB nuclear export Open
The transcriptional activation of catabolic processes during starvation is induced by the nuclear translocation and consequent activation of transcription factor EB (TFEB), a master modulator of autophagy and lysosomal biogenesis. However,…
View article: mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy
mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy Open
The mammalian target of rapamycin complex 1 (mTORC1) kinase promotes cell growth by activating biosynthetic pathways and suppressing catabolic pathways, particularly that of macroautophagy. A prerequisite for mTORC1 activation is its trans…
View article: Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses
Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses Open
The molecular mechanisms that regulate late endosomal maturation and function are not completely elucidated, and direct evidence of a calcium sensor is lacking. Here we identify a novel mechanism of late endosomal maturation that involves …
View article: Impairment of chaperone‐mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis
Impairment of chaperone‐mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis Open
Metabolite accumulation in lysosomal storage disorders ( LSD s) results in impaired cell function and multi‐systemic disease. Although substrate reduction and lysosomal overload‐decreasing therapies can ameliorate disease progression, the …