James M. Fox
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View article: Label-free DIA-NN enabled RIME (DIANNeR) reveals glucocorticoid receptor interaction networks in breast, bladder, and blood across normal untransformed cells, cancer cell lines, and PDXs
Label-free DIA-NN enabled RIME (DIANNeR) reveals glucocorticoid receptor interaction networks in breast, bladder, and blood across normal untransformed cells, cancer cell lines, and PDXs Open
The glucocorticoid receptor (GR) coordinates diverse transcriptional responses to glucocorticoids, regulating metabolism, inflammation, homeostasis, and development. Although GR is expressed in nearly every cell type, its activity is tissu…
View article: Lower hepatocellular carcinoma surveillance in metabolic dysfunction‐associated steatotic liver disease: Impact on treatment eligibility
Lower hepatocellular carcinoma surveillance in metabolic dysfunction‐associated steatotic liver disease: Impact on treatment eligibility Open
Background and Aim This study aimed to compare the determinants and impact of hepatocellular carcinoma (HCC) surveillance rates for people with metabolic dysfunction‐associated steatotic liver disease (MASLD) versus other chronic liver dis…
View article: Corrigendum: CD317-Positive Immune Stromal Cells in Human “Mesenchymal Stem Cell” Populations
Corrigendum: CD317-Positive Immune Stromal Cells in Human “Mesenchymal Stem Cell” Populations Open
[This corrects the article DOI: 10.3389/fimmu.2022.903796.].
View article: CD317-Positive Immune Stromal Cells in Human “Mesenchymal Stem Cell” Populations
CD317-Positive Immune Stromal Cells in Human “Mesenchymal Stem Cell” Populations Open
Heterogeneity of bone marrow mesenchymal stromal cells (MSCs, frequently referred to as “mesenchymal stem cells”) clouds biological understanding and hampers their clinical development. In MSC cultures most commonly used in research and th…
View article: Identification of CD317-Positive Pro-inflammatory Immune Stromal Cells in Human Mesenchymal Stromal Cell Preparations
Identification of CD317-Positive Pro-inflammatory Immune Stromal Cells in Human Mesenchymal Stromal Cell Preparations Open
Mesenchymal stromal cell (MSC) heterogeneity clouds biological understanding and hampers their clinical development. In MSC cultures most commonly used in research and therapy, we have identified an MSC subtype characterised by CD317 expre…
View article: P51 Trends in mortality in systemic lupus erythematosus: an analysis of SLE inpatient mortality at university hospital coventry and warwickshire NHS trust from 2007–2016
P51 Trends in mortality in systemic lupus erythematosus: an analysis of SLE inpatient mortality at university hospital coventry and warwickshire NHS trust from 2007–2016 Open
Background The aim of this study was to determine the causes of mortality in patients with systemic lupus erythematosus (SLE) at the University Hospital Coventry and Warwickshire (UHCW) NHS Trust over a 10yr period. Methods This was a retr…
View article: Flow cytometric methodology for the detection of de novo human T-cell leukemia virus -1 infection in vitro: A tool to study novel infection inhibitors
Flow cytometric methodology for the detection of de novo human T-cell leukemia virus -1 infection in vitro: A tool to study novel infection inhibitors Open
Methodology to detect and study de novo human T-cell leukemia virus (HTLV)-1 infection is required to further our knowledge of the viruses' mechanisms of infection and to study potential therapeutic interventions. Whilst methodology curren…
View article: Glycans modify mesenchymal stem cell differentiation to impact on the function of resulting osteoblasts
Glycans modify mesenchymal stem cell differentiation to impact on the function of resulting osteoblasts Open
Glycans are inherently heterogeneous, yet glycosylation is essential in eukaryotes, and glycans show characteristic cell type-dependent distributions. By using an immortalized human mesenchymal stromal cell (MSC) line model, we show that b…
View article: Bioresource of Cervical Tissue Explants from Healthy Women
Bioresource of Cervical Tissue Explants from Healthy Women Open
The York Tissue Bank was established in 2013 at the University of York as a repository for cells and tissues to facilitate clinical and translational research at the university and with collaborative external tissue bank applicants. The bi…
View article: Methodology for reliable and reproducible cryopreservation of human cervical tissue
Methodology for reliable and reproducible cryopreservation of human cervical tissue Open
Repeat testing revealed that tissue viability between fresh and freeze-thawed samples was comparable at all four time points (days 0, 1, 7 and 14) with no apparent reductions of viability, thus demonstrating this method of cryopreserving c…
View article: Update: Homing of Mesenchymal Stem Cells
Update: Homing of Mesenchymal Stem Cells Open
An Update to: Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing Giselle Chamberlain, James Fox, Brian Ashton, and Jim Middleton Stem Cells 2007;25:2739–2749
View article: Long Terminal Repeat Circular DNA as Markers of Active Viral Replication of Human T Lymphotropic Virus-1 in Vivo
Long Terminal Repeat Circular DNA as Markers of Active Viral Replication of Human T Lymphotropic Virus-1 in Vivo Open
Clonal expansion of human T-lymphotropic virus type-1 (HTLV-1) infected cells in vivo is well documented. Unlike human immunodeficiency virus type 1 (HIV-1), HTLV-1 plasma RNA is sparse. The contribution of the “mitotic” spread of HTLV-1 c…
View article: Seroprevalence of <scp>HTLV</scp>‐1 and HTLV‐2 amongst mothers and children in Malawi within the context of a systematic review and meta‐analysis of <scp>HTLV</scp> seroprevalence in Africa
Seroprevalence of <span>HTLV</span>‐1 and HTLV‐2 amongst mothers and children in Malawi within the context of a systematic review and meta‐analysis of <span>HTLV</span> seroprevalence in Africa Open
Objectives Human T‐lymphotropic virus ( HTLV )‐1 causes T‐cell leukaemia and myelopathy. Together with HTLV ‐2, it is endemic in some African nations. Seroprevalence data from Malawi are scarce, with no reports on associated disease incide…
View article: CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells
CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells Open
CCR5 is a chemokine receptor expressed on leukocytes and a coreceptor used by HIV-1 to enter CD4+ T lymphocytes and macrophages. Stimulation of CCR5 by chemokines triggers internalization of chemokine-bound CCR5 molecules in a process call…
View article: Prevalence of hepatitis C virus in mothers and their children in Malawi
Prevalence of hepatitis C virus in mothers and their children in Malawi Open
Objectives Hepatitis C virus ( HCV ) prevalence is poorly mapped in the East African region; with the advent of novel HCV therapies, better epidemiological data are required to target the infection. We sought to estimate HCV prevalence in …