Bobbie‐Jo Webb‐Robertson
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View article: Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility
Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility Open
Whereas most autoimmune diseases exhibit female predominance, type 1 diabetes (T1D) occurs more frequently in males after puberty, suggesting a role for sex hormones in disease modification. Because islet β cells actively shape local immun…
View article: Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D
Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D Open
Recent studies have reported the involvement of complement system proteins in the initiation and progression of islet autoimmunity (IA) in the study of Type 1 diabetes (T1D). However, the genetic factors of complement system proteins at th…
View article: Challenges and Opportunities in State‐of‐the‐Art Proteomics Analysis for Biomarker Development From Plasma Extracellular Vesicles
Challenges and Opportunities in State‐of‐the‐Art Proteomics Analysis for Biomarker Development From Plasma Extracellular Vesicles Open
Extracellular vesicles (EVs) are membrane‐bound particles secreted by cells, playing crucial roles in intercellular communication. The composition of EVs can undergo changes in response to stress and disease conditions, making them excelle…
View article: Assessing the Impact of Measurement Precision on Metabolite Identification Probability in Multidimensional Mass Spectrometry-Based, Reference-Free Metabolomics
Assessing the Impact of Measurement Precision on Metabolite Identification Probability in Multidimensional Mass Spectrometry-Based, Reference-Free Metabolomics Open
Identification of compounds with minimal ambiguity remains a central challenge in mass spectrometry-based metabolomics. Conventional compound identification relies on comparing analytical signatures (e.g., mass-to-charge ratio, collision c…
View article: Low Peripheral Blood Counts and Elevated Proinflammatory Cytokines Signal a Poor CD19 Chimeric Antigen Receptor T-cell Response in Acute Lymphoblastic Leukemia
Low Peripheral Blood Counts and Elevated Proinflammatory Cytokines Signal a Poor CD19 Chimeric Antigen Receptor T-cell Response in Acute Lymphoblastic Leukemia Open
CD19 chimeric antigen receptor T-cell (CAR-T) therapy has significantly improved outcomes for patients with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). However, approximately 20% of patients fail to achieve a compl…
View article: The oleaginous yeast Rhodosporidium toruloides engineered for biomass hydrolysate-derived (E)-α-bisabolene production
The oleaginous yeast Rhodosporidium toruloides engineered for biomass hydrolysate-derived (E)-α-bisabolene production Open
The oleaginous yeast Rhodosporidiumtoruloides has been exploited for many bioproducts, including several terpenes, owing to its oleaginous nature and biomass inhibitor tolerance. Here, we built upon previous (E)-α-bisabolene work by iterat…
View article: Genome-wide mapping of complement system proteins for islet autoimmunity in the DAISY and TEDDY children
Genome-wide mapping of complement system proteins for islet autoimmunity in the DAISY and TEDDY children Open
Background Type 1 diabetes (T1D) is characterized by the autoimmune destruction of the insulin-producing beta cells, and there is no cure yet for the disease. While islet autoantibodies are well-recognized biomarkers that mark the onset of…
View article: Data from a multi-year targeted proteomics study of a longitudinal birth cohort of type 1 diabetes
Data from a multi-year targeted proteomics study of a longitudinal birth cohort of type 1 diabetes Open
The deployment of liquid chromatography-mass spectrometry-based plasma proteomics experiments in a large cohort is sparse, leading to a lack of data available for benchmarking, method development or validation. Comprised of 6,426 plasma an…
View article: RNA Splicing Events in Circulation Distinguish Individuals With and Without New-onset Type 1 Diabetes
RNA Splicing Events in Circulation Distinguish Individuals With and Without New-onset Type 1 Diabetes Open
Context Alterations in RNA splicing may influence protein isoform diversity that contributes to or reflects the pathophysiology of certain diseases. Whereas specific RNA splicing events in pancreatic islets have been investigated in models…
View article: Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
Example of P-MartCancer workflow on example dataset demonstrating nearly all of P-MartCancer functionality.
View article: Data from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Data from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
P-MartCancer is an interactive web-based software environment that enables statistical analyses of peptide or protein data, quantitated from mass spectrometry–based global proteomics experiments, without requiring in-depth knowledge of sta…
View article: Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
Example of P-MartCancer workflow on example dataset demonstrating nearly all of P-MartCancer functionality.
View article: Data from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Data from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
P-MartCancer is an interactive web-based software environment that enables statistical analyses of peptide or protein data, quantitated from mass spectrometry–based global proteomics experiments, without requiring in-depth knowledge of sta…
View article: Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
Example of P-MartCancer workflow on example dataset demonstrating nearly all of P-MartCancer functionality.
View article: Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
Example of P-MartCancer workflow on example dataset demonstrating nearly all of P-MartCancer functionality.
View article: Data from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Data from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
P-MartCancer is an interactive web-based software environment that enables statistical analyses of peptide or protein data, quantitated from mass spectrometry–based global proteomics experiments, without requiring in-depth knowledge of sta…
View article: Inhibition of the eukaryotic initiation factor-2α kinase PERK decreases risk of autoimmune diabetes in mice
Inhibition of the eukaryotic initiation factor-2α kinase PERK decreases risk of autoimmune diabetes in mice Open
Preventing the onset of autoimmune type 1 diabetes (T1D) is feasible through pharmacological interventions that target molecular stress-responsive mechanisms. Cellular stresses, such as nutrient deficiency, viral infection, or unfolded pro…
View article: Associations between SARS-CoV-2 Infection or COVID-19 Vaccination and Human Milk Composition: A Multi-Omics Approach
Associations between SARS-CoV-2 Infection or COVID-19 Vaccination and Human Milk Composition: A Multi-Omics Approach Open
The risk of contracting SARS-CoV-2 via human milk-feeding is virtually non-existent. Adverse effects of COVID-19 vaccination for lactating individuals are not different from the general population, and no evidence has been found that their…
View article: Mapping Microhabitats: Metabolome Informed Proteome Imaging of Lignocellulose Decomposition by a Naturally Evolved Microbial Consortium
Mapping Microhabitats: Metabolome Informed Proteome Imaging of Lignocellulose Decomposition by a Naturally Evolved Microbial Consortium Open
The annotated protein database was curated to annotate MS/MS data in the manuscript titled 'Mapping Microhabitats: Metabolome Informed Proteome Imaging of Lignocellulose Decomposition by a Naturally Evolved Microbial Consortium'.
View article: Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images
Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images Open
Light-sheet microscopy has made possible the 3D imaging of both fixed and live biological tissue, with samples as large as the entire mouse brain. However, segmentation and quantification of that data remains a time-consuming manual undert…
View article: Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis
Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis Open
Background Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-c…
View article: A Composite Biomarker Signature of Type 1 Diabetes Risk Identified via Augmentation of Parallel Multi-Omics Data from a Small Cohort
A Composite Biomarker Signature of Type 1 Diabetes Risk Identified via Augmentation of Parallel Multi-Omics Data from a Small Cohort Open
Background Biomarkers of early pathogenesis of type 1 diabetes (T1D) are crucial to enable effective prevention measures in at-risk populations before significant damage occurs to their insulin producing beta-cell mass. We recently introdu…
View article: Corn stover variability drives differences in bisabolene production by engineered <i>Rhodotorula toruloides</i>
Corn stover variability drives differences in bisabolene production by engineered <i>Rhodotorula toruloides</i> Open
Microbial conversion of lignocellulosic biomass represents an alternative route for production of biofuels and bioproducts. While researchers have mostly focused on engineering strains such as Rhodotorula toruloides for better bisabolene p…
View article: New Onset Type 1 Diabetes Urine Metabolomics
New Onset Type 1 Diabetes Urine Metabolomics Open
Gas chromatography-mass spectrometry-based metabolomics to identify molecular signatures of Type 1 Diabetes (T1D) in urine. We utilize three cohorts in different stages post-diagnosis: (1) new onset, (2) within one year of diagnosis and (3…