Explanipedia

Development of a Safety-Assessed Media Ingredient (SAMI) Framework for Streamlined Safety Assessment of Cultivated Meat and Seafood Products Open

Kimberly J. Ong, Kora Kukk, D. Powell, Wei Ning Chen, S. H. Goh , et al. · 2025

Cultivated meat and seafood, produced through cell culture technology, offers an alternative to conventional meat production. This industry employs novel food technologies that rely on culture media substances for cell growth. Assessing th…

Life-Cycle Risk Assessment of Second-Generation Cellulose Nanomaterials Open

James D. Ede, Amanda K. Charlton-Sevcik, Julia Griffin, P. Srinivasan, Yueyang Zhang , et al. · 2025

A nanomaterial life-cycle risk assessment (Nano LCRA) was conducted for second-generation functionalized cellulose nanomaterials (CNs) in five case studies, including applications in water filtration, food contact packaging (including as a…

Nanocellulose and its modified forms in the food industry: Applications, safety, and regulatory perspectives Open

Zijin Qin, Wei Long Ng, James D. Ede, Jo Anne Shatkin, Jiannan Feng , et al. · 2024

Nanocellulose (NC), known for its unique properties including high mechanical strength, low density, and extensive surface area, presents significant potential for broad application in the food sector. Through further modification, NC can …

Regioselectively Carboxylated Cellulose Nanofibril Models from Dissolving Pulp: C6 via TEMPO Oxidation and C2,C3 via Periodate–Chlorite Oxidation Open

Mengzhe Guo, James D. Ede, Christie M. Sayes, Jo Anne Shatkin, Nicole M. Stark , et al. · 2024

Regioselective C6 and C2,C3 carboxylated cellulose nanofibrils (CNFs) have been robustly generated from dissolving pulp, a readily available source of unmodified cellulose, via stoichiometrically optimized 2,2,6,6-tetramethylpyperidine-1-o…

Aqueous exfoliation and dispersion of monolayer and bilayer graphene from graphite using sulfated cellulose nanofibrils Open

Benjamin Pingrey, James D. Ede, Christie M. Sayes, Jo Anne Shatkin, Nicole M. Stark , et al. · 2024

High-quality graphene in 42% monolayer and rest in bilayer was efficiently aqueously exfoliated in the presence of amphiphilic sulfated cellulose nanofibrils (SCNFs) or simultaneously with sulfated cellulose.

Cultured Meat Safety Research Priorities: Regulatory and Governmental Perspectives Open

Kimberly J. Ong, Yadira Tejeda-Saldana, Breanna Duffy, Dwayne Holmes, Kora Kukk , et al. · 2023

As with every new technology, safety demonstration is a critical component of bringing products to market and gaining public acceptance for cultured meat and seafood. This manuscript develops research priorities from the findings of a seri…

Cultured Meat Safety Research Priorities: Regulatory and Governmental Perspectives Open

Kimberly J. Ong, Yadira Tejeda-Saldana, Breanna Duffy, Dwayne Holmes, Kora Kukk , et al. · 2023

As with every new technology, safety demonstration is a critical component of bringing products to market and gaining public acceptance for cultured meat and seafood. This manuscript develops research priorities from the findings from a se…

Review on Hybrid Reinforced Polymer Matrix Composites with Nanocellulose, Nanomaterials, and Other Fibers Open

M. Özgür Seydibeyoğlu, Alperen Doğru, Jinwu Wang, Mitchell L. Rencheck, Yousoo Han , et al. · 2023

The use of composite materials has seen many new innovations for a large variety of applications. The area of reinforcement in composites is also rapidly evolving with many new discoveries, including the use of hybrid fibers, sustainable m…

Food safety considerations and research priorities for the cultured meat and seafood industry Open

Kimberly J. Ong, Jeremiah Johnston, Isha Datar, Vincent Sewalt, Dwayne Holmes , et al. · 2021

Cell‐cultured meat and seafood offer a sustainable opportunity to meet the world's increasing demand for protein in a climate‐changed world. A responsible, data‐driven approach to assess and demonstrate safety of cell‐cultured meat and sea…

Food Safety Considerations and Research Priorities for the Cultured Meat and Seafood Industry Open

Kimberly J. Ong, Jeremiah Johnston, Isha Datar, Vincent Sewalt, Dwayne Holmes , et al. · 2021

Cell-cultured meat and seafood offer a sustainable opportunity to meet the world’s increasing demand for protein in a climate-changed world. A responsible, data-driven approach to assess and demonstrate safety of cell-cultured meat and sea…

Fluorescently Labeled Cellulose Nanofibers for Environmental Health and Safety Studies Open

Ilabahen Patel, Jeremiah W. Woodcock, Ryan Beams, Stephan J. Stranick, Ryan C. Nieuwendaal , et al. · 2021

An optimal methodology for locating and tracking cellulose nanofibers (CNFs) in vitro and in vivo is crucial to evaluate the environmental health and safety properties of these nanomaterials. Here, we report the use of a new boron-dipyrrom…

Characterization of a Human In Vitro Intestinal Model for the Hazard Assessment of Nanomaterials Used in Cancer Immunotherapy Open

Matthew Gibb, Sahar H. Pradhan, Marina R. Mulenos, Henry Lujan, James Y. Liu , et al. · 2021

There is momentum in biomedical research to improve the structure and function of in vitro intestinal models that better represent human biology. To build a more comprehensive model, three human cell-types were co-cultured and characterize…

A methodology for developing key events to advance nanomaterial-relevant adverse outcome pathways to inform risk assessment Open

Sabina Halappanavar, James D. Ede, Indrani Mahapatra, Harald F. Krug, Eileen D. Kuempel , et al. · 2020

Significant advances have been made in the development of Adverse Outcome Pathways (AOPs) over the last decade, mainly focused on the toxicity mechanisms of chemicals. These AOPs, although relevant to manufactured nanomaterials (MNs), do n…

Physical, chemical, and toxicological characterization of sulfated cellulose nanocrystals for food-related applications using <i>in vivo</i> and <i>in vitro</i> strategies Open

James D. Ede, Kimberly J. Ong, Marina R. Mulenos, Sahar H. Pradhan, Matthew Gibb , et al. · 2020

Cellulose nanocrystals (CNCs) are a next-generation cellulose product with many unique properties including applications in the food industry as a food additive, food coating, and in food-contact packaging material. While CNC is anticipate…

Translating Scientific Advances in the AOP Framework to Decision Making for Nanomaterials Open

James D. Ede, Vladimir Lobaskin, Ulla Vogel, Iseult Lynch, Sabina Halappanavar , et al. · 2020

Much of the current innovation in advanced materials is occurring at the nanoscale, specifically in manufactured nanomaterials (MNs). MNs display unique attributes and behaviors, and may be biologically and physically unique, making them v…

Physical, chemical, and toxicological characterization of fibrillated forms of cellulose using an in vitro gastrointestinal digestion and co-culture model Open

Sahar H. Pradhan, Marina R. Mulenos, London R. Steele, Matthew Gibb, James D. Ede , et al. · 2020

Fibrillated cellulose is a next-generation material in development for a variety of applications, including use in food and food-contact materials. An alternative testing strategy including simulated digestion was developed to compare the …

A 90-day dietary study with fibrillated cellulose in Sprague-Dawley rats Open

Kimberly J. Ong, James D. Ede, Cassidy A. Pomeroy-Carter, Christie M. Sayes, Marina R. Mulenos , et al. · 2020

Risk Analysis of Cellulose Nanomaterials by Inhalation: Current State of Science Open

James D. Ede, Kimberly J. Ong, Michael Goergen, Alan W. Rudie, Cassidy A. Pomeroy-Carter , et al. · 2019

Cellulose nanomaterials (CNs) are emerging advanced materials with many unique properties and growing commercial significance. A life-cycle risk assessment and environmental health and safety roadmap identified potential risks from inhalat…

A systematic process for identifying key events for advancing the development of nanomaterial relevant adverse outcome pathways Open

Sabina Halappanavar, James D. Ede, Jo Anne Shatkin, Harald F. Krug · 2019

Adverse outcome pathways (AOPs) represent a sequence of key events (KEs) between a molecular initiating event (MIE) and an adverse outcome (AO) and span many levels of biological organization including molecular, cellular, tissue, organ, o…

Comment on Shvedova et al. (2016), “gender differences in murine pulmonary responses elicited by cellulose nanocrystals” Open

Jo Anne Shatkin, Günter Oberdörster · 2016

The role of the food matrix and gastrointestinal tract in the assessment of biological properties of ingested engineered nanomaterials (iENMs): State of the science and knowledge gaps Open

David Julian McClements, Glen M. DeLoid, Georgios Pyrgiotakis, Jo Anne Shatkin, Hang Xiao , et al. · 2016

NIST-TAPPI Workshop on Measurement Needs for Cellulose Nanomaterial Open

Chelsea S. Davis, Robert J. Moon, Sean Ireland, Linda Johnston, Jo Anne Shatkin , et al. · 2015

be identified in this document in order to describe an experimental procedure or concept adequately.Such identification is

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