Jo E. Lomax
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View article: Phenotype of ribonuclease 1 deficiency in mice
Phenotype of ribonuclease 1 deficiency in mice Open
Biological roles for extracellular RNA (eRNA) have become apparent. For example, eRNA can induce contact activation in blood via activation of the plasma proteases factor XII (FXII) and factor XI (FXI). We sought to reveal the biological r…
View article: Cytosolic Delivery of Proteins by Bioreversible Esterification
Cytosolic Delivery of Proteins by Bioreversible Esterification Open
Cloaking its carboxyl groups with a hydrophobic moiety is shown to enable a protein to enter the cytosol of a mammalian cell. Diazo compounds derived from (p-methylphenyl)glycine were screened for the ability to esterify the green fluoresc…
View article: Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology
Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology Open
Pancreatic-type ribonucleases (ptRNases) comprise a class of highly conserved secretory endoribonucleases in vertebrates. The prototype of this enzyme family is ribonuclease 1 (RNase 1). Understanding the physiological roles of RNase 1 is …