Eugene Tan
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View article: Deep learning-based identification of environmental memory effects on the gross primary productivity of alpine grasslands on the Qinghai-Tibet Plateau
Deep learning-based identification of environmental memory effects on the gross primary productivity of alpine grasslands on the Qinghai-Tibet Plateau Open
Background The widely distributed grasslands of the Qinghai-Tibet Plateau play a vital role in the global carbon cycle and climate regulation. Gross primary productivity (GPP), an important indicator of ecosystem carbon sequestration capac…
View article: DS27 Checking blood pressure of patients having Mohs surgery: a survey of practice of UK- and Australasia-based Mohs surgeons
DS27 Checking blood pressure of patients having Mohs surgery: a survey of practice of UK- and Australasia-based Mohs surgeons Open
Mohs surgeons’ approach to preoperative hypertension appears to vary and may lead to cancelled lists (personal communication), as some consider hypertension a contributory risk factor for bleeding and haematoma. We sought to obtain formal …
View article: Environmental Impact of Dermatology and Action Towards It: A Narrative Review
Environmental Impact of Dermatology and Action Towards It: A Narrative Review Open
There is a dual interplay between the environment and healthcare, which is associated with around 6% of global greenhouse gas (GHG) emissions, high water consumption, and large volumes of waste. Dermatology encompasses peculiarities such a…
View article: Reducing inappropriate investigations for minor lower limb cellulitis
Reducing inappropriate investigations for minor lower limb cellulitis Open
Lower limb cellulitis is a frequently encountered condition in the acute hospital setting, yet many patients with only mild lower limb cellulitis undergo unnecessary collection of blood cultures and X-ray imaging. This leads to increased h…
View article: Photoluminescent Carbon Dot: An Overview on Synthesis Approaches and Applications of Carbon Dot
Photoluminescent Carbon Dot: An Overview on Synthesis Approaches and Applications of Carbon Dot Open
In recent decade, due to the rapid development of nanotechnology and nanomaterials, carbon quantum dot (CQD) is recognized as a new rising zero-dimensional carbon-based nanomaterial as green substitute of heavy-metal-based nanomaterials wi…
View article: Application of a Random Forest Method to Estimate the Water Use Efficiency on the Qinghai Tibetan Plateau During the 1982–2018 Growing Season
Application of a Random Forest Method to Estimate the Water Use Efficiency on the Qinghai Tibetan Plateau During the 1982–2018 Growing Season Open
Water use efficiency (WUE) reflects the quantitative relationship between vegetation gross primary productivity (GPP) and surface evapotranspiration (ET), serving as a crucial indicator for assessing the coupling of carbon and water cycles…
View article: Under-representation of climate change and sustainability manuscripts in high-impact dermatology journals
Under-representation of climate change and sustainability manuscripts in high-impact dermatology journals Open
Earth’s changing climate is affecting the health of people worldwide. Dermatology is particularly affected by climate change due to the skin’s direct contact with the environment. The majority of physicians do not feel prepared to address …
View article: Plastics in dermatology: A review and solutions
Plastics in dermatology: A review and solutions Open
Hazards to human and planetary health are present at every stage of the plastic life cycle, yet plastic production is projected to triple by 2060. This review focuses on three key areas: the life cycle of plastic, the impact of microplasti…
View article: Evaluate the differences in carbon sink contribution of different ecological engineering projects
Evaluate the differences in carbon sink contribution of different ecological engineering projects Open
China has implemented a series of ecological engineering projects to help achieve the 2060 carbon neutrality target. However, the lack of quantitative research on ecological engineering and the contribution of climate change to terrestrial…
View article: An Uncommon and Under recognised Contributor of Foot Pain: A Case Study of Mueller Weiss syndrome
An Uncommon and Under recognised Contributor of Foot Pain: A Case Study of Mueller Weiss syndrome Open
Mueller-Weiss syndrome refers to spontaneous osteonecrosis of the navicular bone in adults. It is often bilateral, affecting women aged between 40 and 60 years. Herein, azwe present a case demonstrating characteristic imaging features on r…
View article: Bridging AI development with clinical relevance—A scoping review of skin cancer models since CLEAR Derm. Where to next?
Bridging AI development with clinical relevance—A scoping review of skin cancer models since CLEAR Derm. Where to next? Open
https://data.mendeley.com/datasets/c3pytzc4fz/2 (Open access). Table S1 Table S2 Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than …
View article: Data from A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic <i>BRAF</i>-Mutant Colorectal Cancer
Data from A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic <i>BRAF</i>-Mutant Colorectal Cancer Open
Preclinical evidence suggests that concomitant BRAF and EGFR inhibition leads to sustained suppression of MAPK signaling and suppressed tumor growth in BRAFV600E colorectal cancer models. Patients with refractory BRAFV600-mutant metastatic…
View article: Supplementary Tables 1 and 2 and Supplementary Figures 1 and 2 from A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic <i>BRAF</i>-Mutant Colorectal Cancer
Supplementary Tables 1 and 2 and Supplementary Figures 1 and 2 from A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic <i>BRAF</i>-Mutant Colorectal Cancer Open
Table S1. Pharmacokinetic parameters of encorafenib and alpelisib in patients at steady state (cycle 2 day 1). Table S2. Criteria for defining dose-limited toxicities. Supplementary Figure 1. Radiological images of response for a patient t…
View article: Supplementary Tables 1 and 2 and Supplementary Figures 1 and 2 from A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic <i>BRAF</i>-Mutant Colorectal Cancer
Supplementary Tables 1 and 2 and Supplementary Figures 1 and 2 from A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic <i>BRAF</i>-Mutant Colorectal Cancer Open
Table S1. Pharmacokinetic parameters of encorafenib and alpelisib in patients at steady state (cycle 2 day 1). Table S2. Criteria for defining dose-limited toxicities. Supplementary Figure 1. Radiological images of response for a patient t…
View article: Data from A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic <i>BRAF</i>-Mutant Colorectal Cancer
Data from A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic <i>BRAF</i>-Mutant Colorectal Cancer Open
Preclinical evidence suggests that concomitant BRAF and EGFR inhibition leads to sustained suppression of MAPK signaling and suppressed tumor growth in BRAFV600E colorectal cancer models. Patients with refractory BRAFV600-mutant metastatic…
View article: Neglected Cutaneous Skin Malignancy: A Patient with Concurrent Giant Basal Cell Carcinoma and Melanoma
Neglected Cutaneous Skin Malignancy: A Patient with Concurrent Giant Basal Cell Carcinoma and Melanoma Open
Background Giant basal cell carcinomas (BCCs) are a rare subtype of BCC that grow to be greater than 5 cm in diameter. With the increase in size, there is a corresponding increase in metastatic rate and state of local invasion, with a clin…
View article: Commercial Judicial Review in Singapore: Strategic or Spontaneous?
Commercial Judicial Review in Singapore: Strategic or Spontaneous? Open
This article examines the increasing use of judicial review under administrative law by corporate entities in Singapore to protect or even to assert strategic business interests. When used effectively, commercial judicial review can be a p…
View article: Poster Abstracts
Poster Abstracts Open
Aim: To compare anal electrostimulation and extracorporeal magnetic stimulation in complex programs of conservative treatment of anal incontinence.Method: The study included 59 people with anal incontinence.I group -22 patients (20 (90.9%)…
View article: A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic <i>BRAF</i> -Mutant Colorectal Cancer
A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic <i>BRAF</i> -Mutant Colorectal Cancer Open
Preclinical evidence suggests that concomitant BRAF and EGFR inhibition leads to sustained suppression of MAPK signaling and suppressed tumor growth in BRAFV600E colorectal cancer models. Patients with refractory BRAFV600-mutant metastatic…