Joachim Brouwers
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View article: Tiny-TIM intestinal fluids versus human intestinal fluids: A comparison of their composition and solubilizing capacity for poorly soluble drugs
Tiny-TIM intestinal fluids versus human intestinal fluids: A comparison of their composition and solubilizing capacity for poorly soluble drugs Open
The tiny-TIM system offers an in vitro platform for the simulation of physiological processes occurring in human stomach and small intestine aiding in drug product development by predicting the bioperformance of oral formulations under fas…
View article: Gastrointestinal Bile Salt Concentrations in Healthy Adults Under Fasted and Fed Conditions: A Systematic Review and Meta-Analysis for Mechanistic Physiologically-Based Pharmacokinetic (PBPK) Modelling
Gastrointestinal Bile Salt Concentrations in Healthy Adults Under Fasted and Fed Conditions: A Systematic Review and Meta-Analysis for Mechanistic Physiologically-Based Pharmacokinetic (PBPK) Modelling Open
Bile salts are biosurfactants released into the intestinal lumen which play an important role in the solubilisation of fats and certain drugs. Their concentrations vary along the gastrointestinal tract (GIT). This is significant for implem…
View article: Challenges in Predicting Colonic Luminal and Tissue Concentrations of Mesalamine and Acetyl Mesalamine Using Physiologically Based Biopharmaceutics Modeling
Challenges in Predicting Colonic Luminal and Tissue Concentrations of Mesalamine and Acetyl Mesalamine Using Physiologically Based Biopharmaceutics Modeling Open
View article: A quantification of gastric and duodenal fluid volumes in older adults using MRI
A quantification of gastric and duodenal fluid volumes in older adults using MRI Open
View article: Investigating the effect of whey and casein proteins on drug solubility from a paediatric drug absorption perspective
Investigating the effect of whey and casein proteins on drug solubility from a paediatric drug absorption perspective Open
Considering the predominantly milk-based diet of neonates and infants and their immature gastrointestinal digestion, milk proteins may affect drug behaviour and absorption in this population. Using in vitro models, this study investigated …
View article: Characterization of luminal contents from the fasted human proximal colon
Characterization of luminal contents from the fasted human proximal colon Open
To treat colonic diseases more effectively, improved therapies are urgently needed. In this respect, delivering drugs locally to the colon is a key strategy to achieve higher local drug concentrations while minimizing systemic side effects…
View article: Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients
Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients Open
View article: Correction: Van der Veken et al. Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study. Pharmaceutics 2022, 14, 1935
Correction: Van der Veken et al. Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study. Pharmaceutics 2022, 14, 1935 Open
In the original publication [...]
View article: Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding
Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding Open
Tacrolimus is a crucial immunosuppressant for organ transplant patients, requiring therapeutic drug monitoring due to its variable exposure after oral intake. Physiologically based pharmacokinetic (PBPK) modelling has provided insights int…
View article: Characterization of neonatal and infant enterostomy fluids - part II: Drug solubility
Characterization of neonatal and infant enterostomy fluids - part II: Drug solubility Open
View article: Characterization of Aspirated Duodenal Fluids from Parkinson’s Disease Patients
Characterization of Aspirated Duodenal Fluids from Parkinson’s Disease Patients Open
Parkinson’s disease, one of the most common neurodegenerative diseases, may not only affect the motor system, but also the physiology of the gastrointestinal tract. Delayed gastric emptying, impaired motility and altered intestinal bacteri…
View article: Characterization of neonatal and infant enterostomy fluids
Characterization of neonatal and infant enterostomy fluids Open
View article: The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients
The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients Open
View article: Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study
Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study Open
The volume and distribution of fluids available in the gastrointestinal (GI) tract may substantially affect oral drug absorption. Magnetic resonance imaging (MRI) has been used in the past to quantify these fluid volumes in adults and its …
View article: Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids
Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids Open
Drug solubility in intestinal fluid is a key parameter controlling absorption after the administration of a solid oral dosage form. To measure solubility in vitro simulated intestinal fluids have been developed, but there are multiple reci…
View article: Investigating the Mechanisms behind the Positive Food Effect of Abiraterone Acetate: In Vitro and Rat In Situ Studies
Investigating the Mechanisms behind the Positive Food Effect of Abiraterone Acetate: In Vitro and Rat In Situ Studies Open
The anticancer agent abiraterone suffers from an extensive positive food effect after oral intake of the prodrug abiraterone acetate (Zytiga). The underlying processes determining postprandial abiraterone absorption were investigated in th…
View article: Practical and operational considerations related to paediatric oral drug formulation: An industry survey
Practical and operational considerations related to paediatric oral drug formulation: An industry survey Open
View article: The Influence of Fed State Lipolysis Inhibition on the Intraluminal Behaviour and Absorption of Fenofibrate from a Lipid-Based Formulation
The Influence of Fed State Lipolysis Inhibition on the Intraluminal Behaviour and Absorption of Fenofibrate from a Lipid-Based Formulation Open
The bioavailability of lipophilic drugs may or may not be increased when administered with food due to increased solubilisation in fed state gastrointestinal (GI) fluids. The in vivo interplay between drug solubilisation, lipid phase diges…
View article: Structured Solubility Behaviour in Bioequivalent Fasted Simulated Intestinal Fluids
Structured Solubility Behaviour in Bioequivalent Fasted Simulated Intestinal Fluids Open
View article: Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review
Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review Open
View article: Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective
Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective Open
View article: Fasted intestinal solubility limits and distributions applied to the biopharmaceutics and developability classification systems
Fasted intestinal solubility limits and distributions applied to the biopharmaceutics and developability classification systems Open
View article: UNGAP best practice for improving solubility data quality of orally administered drugs
UNGAP best practice for improving solubility data quality of orally administered drugs Open
An important goal of the European Cooperation in Science and Technology (COST) Action UNGAP (UNderstanding Gastrointestinal Absorption-related Processes, www.ungap.eu) is to improve standardization of methods relating to the study of oral …
View article: Exploring the Effect of Esomeprazole on Gastric and Duodenal Fluid Volumes and Absorption of Ritonavir
Exploring the Effect of Esomeprazole on Gastric and Duodenal Fluid Volumes and Absorption of Ritonavir Open
Proton-pump inhibitors (PPIs), frequently prescribed to lower gastric acid secretion, often exert an effect on the absorption of co-medicated drug products. A previous study showed decreased plasma levels of the lipophilic drug ritonavir a…
View article: Multidimensional analysis of human intestinal fluid composition
Multidimensional analysis of human intestinal fluid composition Open
View article: Interplay of Supersaturation and Solubilization: Lack of Correlation between Concentration-Based Supersaturation Measurements and Membrane Transport Rates in Simulated and Aspirated Human Fluids
Interplay of Supersaturation and Solubilization: Lack of Correlation between Concentration-Based Supersaturation Measurements and Membrane Transport Rates in Simulated and Aspirated Human Fluids Open
Supersaturating formulations are increasingly being used to improve the absorption of orally administered poorly water-soluble drugs. To better predict outcomes in vivo, we must be able to accurately determine the degree of supersaturation…
View article: Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems Open
Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in discovery is still high, and their development is usually limited by ou…
View article: In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration
In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration Open
View article: Linking the concentrations of itraconazole and 2-hydroxypropyl-β-cyclodextrin in human intestinal fluids after oral intake of Sporanox®
Linking the concentrations of itraconazole and 2-hydroxypropyl-β-cyclodextrin in human intestinal fluids after oral intake of Sporanox® Open
View article: Human intestinal fluid factors affecting intestinal drug permeation in vitro
Human intestinal fluid factors affecting intestinal drug permeation in vitro Open