Joachim P. Schmitt
YOU?
Author Swipe
View article: Pyrrolidine dithiocarbamate accelerates early recovery of intestinal microvascular oxygenation in a reversible model of hemorrhagic shock in rats
Pyrrolidine dithiocarbamate accelerates early recovery of intestinal microvascular oxygenation in a reversible model of hemorrhagic shock in rats Open
View article: Calpain inhibition in a transgenic model of calpastatin overexpression facilitates reversal of myocardial hypertrophy
Calpain inhibition in a transgenic model of calpastatin overexpression facilitates reversal of myocardial hypertrophy Open
Aims It was recently demonstrated that the intracellular signalling phosphatase calcineurin is subject to cleavage by the protease calpain, resulting in a truncated calcineurin fragment that is a strong inductor of myocardial hypertrophy. …
View article: Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy
Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy Open
View article: From Ca2+ dysregulation to heart failure: β-adrenoceptor activation by RKIP postpones molecular damages and subsequent cardiac dysfunction in mice carrying mutant PLNR9C by correction of aberrant Ca2+-handling
From Ca2+ dysregulation to heart failure: β-adrenoceptor activation by RKIP postpones molecular damages and subsequent cardiac dysfunction in mice carrying mutant PLNR9C by correction of aberrant Ca2+-handling Open
Impaired cardiomyocyte Ca2+ handling is a central hallmark of heart failure (HF), which causes contractile dysfunction and arrhythmias. However, the underlying molecular mechanisms and the precise contribution of defects in Ca
View article: Publisher Correction: Magnetic resonance reveals early lipid deposition in murine prediabetes as predictive marker for cardiovascular injury
Publisher Correction: Magnetic resonance reveals early lipid deposition in murine prediabetes as predictive marker for cardiovascular injury Open
View article: Magnetic resonance reveals early lipid deposition in murine prediabetes as predictive marker for cardiovascular injury
Magnetic resonance reveals early lipid deposition in murine prediabetes as predictive marker for cardiovascular injury Open
People with diabetes have an increased cardiovascular risk and a poorer outcome after myocardial infarction (MI). However, the exact underlying mechanisms are still unclear, as is the question of which non-invasive measures could be used t…
View article: Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel
Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel Open
The erythrocyte S1P transporter Mfsd2b is also expressed in the heart. We hypothesized that S1P transport by Mfsd2b is involved in cardiac function. Hypertension-induced cardiac remodeling was induced by 4-weeks Angiotensin II (AngII) admi…
View article: Senolysis ameliorates increased susceptibility to ventricular arrhythmias in prediabetes
Senolysis ameliorates increased susceptibility to ventricular arrhythmias in prediabetes Open
Background Obesity and associated prediabetes are major risk factors for cardiovascular disease that promote cellular senescence and predispose to ventricular arrhythmias (VA). In consequence, targeting cellular senescence may represent a …
View article: Cardiomyocytes, cardiac endothelial cells and fibroblasts contribute to anthracycline-induced cardiac injury through RAS-homologous small GTPases RAC1 and CDC42
Cardiomyocytes, cardiac endothelial cells and fibroblasts contribute to anthracycline-induced cardiac injury through RAS-homologous small GTPases RAC1 and CDC42 Open
The clinical use of the DNA damaging anticancer drug doxorubicin (DOX) is limited by irreversible cardiotoxicity, which depends on the cumulative dose. The RAS-homologous (RHO) small GTPase RAC1 contributes to DOX-induced DNA damage format…
View article: Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues
Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues Open
Noonan syndrome (NS), the most common among RASopathies, is caused by germline variants in genes encoding components of the RAS-MAPK pathway. Distinct variants, including the recurrent Ser257Leu substitution in RAF1, are associated with se…
View article: Phospholamban pentamerization increases sensitivity and dynamic range of cardiac relaxation
Phospholamban pentamerization increases sensitivity and dynamic range of cardiac relaxation Open
Aims A key event in the regulation of cardiac contraction and relaxation is the phosphorylation of phospholamban (PLN) that relieves the inhibition of the sarco/endoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a). PLN exists in an equilibrium…
View article: Inducible over‐expression of cardiac Nos1ap causes short <scp>QT</scp> syndrome in transgenic mice
Inducible over‐expression of cardiac Nos1ap causes short <span>QT</span> syndrome in transgenic mice Open
Recent evidence demonstrated that alterations in the QT interval duration on the ECG are not only determined by mutations in genes for ion channels, but also by modulators of ion channels. Changes in the QT interval duration beyond certain…
View article: Implementation of 2D barcode medication labels and smart pumps in pediatric acute care: Lessons learned
Implementation of 2D barcode medication labels and smart pumps in pediatric acute care: Lessons learned Open
Background: In pediatric intensive care, prescription, application, and interpretation of drug doses are highly weight-dependent. The use of standardized concentrations simplifies the preparation of drugs and increases safety. For the safe…
View article: Downregulation of eNOS and preserved endothelial function in endothelial-specific arginase 1-deficient mice
Downregulation of eNOS and preserved endothelial function in endothelial-specific arginase 1-deficient mice Open
Arginase 1 (Arg1) is a ubiquitous enzyme belonging to the urea cycle that catalyzes the conversion of l-arginine into l-ornithine and urea. In endothelial cells (ECs), Arg1 was proposed to limit the availability of l-arginine for the endot…
View article: Red blood cell eNOS is cardioprotective in acute myocardial infarction
Red blood cell eNOS is cardioprotective in acute myocardial infarction Open
View article: Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs
Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs Open
Noonan syndrome (NS), the most common among the RASopathies, is caused by germline variants in genes encoding components of the RAS-MAPK pathway. Distinct variants, including the recurrent Ser257Leu substitution in RAF1, are associated wit…
View article: Investigations regarding the role of NOS1AP in the heart using a conditional overexpression mouse model
Investigations regarding the role of NOS1AP in the heart using a conditional overexpression mouse model Open
Background 35.3% of deaths in 2019 in Germany are caused by cardiovascular diseases (Destatis). 95% of these people were 60 years and older. To increase survival rate in elderly patients we investigate the relevance of altered expression o…
View article: Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers
Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers Open
View article: 4-Methylumbelliferone Attenuates Macrophage Invasion and Myocardial Remodeling in Pressure-Overloaded Mouse Hearts
4-Methylumbelliferone Attenuates Macrophage Invasion and Myocardial Remodeling in Pressure-Overloaded Mouse Hearts Open
Cardiac wall stress induces local and systemic inflammatory responses that are increasingly recognized as key modulators of extracellular matrix remodeling. Hyaluronic acid interacts with immune cells and mesenchymal cells thereby modulati…
View article: Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx)
Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx) Open
Significance Titin oxidation alters titin stiffness, which greatly contributes to overall myocardial stiffness. This stiffness is frequently increased in heart disease, such as diastolic heart failure. We have quantified the degree of oxid…
View article: Congress Abstracts
Congress Abstracts Open
Objectives: Thrombin inhibition was recently reported to protect against diabetic cardiomyopathy in mice, in part by downregulating protease-activated receptors PAR1 and PAR4.PAR1 is highly abundant in cardiac fibroblasts, PAR4 is reported…
View article: Raf kinase inhibitor protein: lessons of a better way for β‐adrenergic receptor activation in the heart
Raf kinase inhibitor protein: lessons of a better way for β‐adrenergic receptor activation in the heart Open
Stimulation of β‐adrenergic receptors (βARs) provides the most efficient physiological mechanism to enhance contraction and relaxation of the heart. Activation of βARs allows rapid enhancement of myocardial function in order to fuel the mu…
View article: Adaptive Ventricular Remodelling after Myocardial Infarction Involves Titin-Based Cardiomyocyte Stiffening and Elevated Titin Turnover
Adaptive Ventricular Remodelling after Myocardial Infarction Involves Titin-Based Cardiomyocyte Stiffening and Elevated Titin Turnover Open
View article: Titin-Based Cardiac Myocyte Stiffening Contributes to Early Adaptive Ventricular Remodeling After Myocardial Infarction
Titin-Based Cardiac Myocyte Stiffening Contributes to Early Adaptive Ventricular Remodeling After Myocardial Infarction Open
Rationale: Myocardial infarction (MI) increases the wall stress in the viable myocardium and initiates early adaptive remodeling in the left ventricle to maintain cardiac output. Later remodeling processes include fibrotic reorganization t…
View article: Erratum: Cardiac RKIP induces a beneficial β-adrenoceptor–dependent positive inotropy
Erratum: Cardiac RKIP induces a beneficial β-adrenoceptor–dependent positive inotropy Open