Joachim Pircher
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View article: Icosapent ethyl reduces arterial thrombosis by inhibition of cyclooxygenase-1–induced platelet reactivity
Icosapent ethyl reduces arterial thrombosis by inhibition of cyclooxygenase-1–induced platelet reactivity Open
Large, randomized trials testing omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation to reduce cardiovascular events have reported contradictory results. Interpretation of these trials is challenging, because different dosages an…
View article: Aging platelets shift their hemostatic properties to inflammatory functions
Aging platelets shift their hemostatic properties to inflammatory functions Open
Platelets are crucial players in hemostasis and thrombosis but also contribute to immune regulation and host defense, using different receptors, signaling pathways, and effector functions, respectively. Whether distinct subsets of platelet…
View article: Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis
Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis Open
B cell immunity carries the inherent risk of deviating into autoimmunity and malignancy, which are both strongly associated with genetic variants or alterations that increase immune signaling. Here, we investigated the interplay of autoimm…
View article: Effect and sustainability of a stepwise implemented multidisciplinary antimicrobial stewardship programme in a university hospital emergency department
Effect and sustainability of a stepwise implemented multidisciplinary antimicrobial stewardship programme in a university hospital emergency department Open
Objectives To explore effectiveness and sustainability of guideline adherence and antibiotic consumption after establishing treatment guidelines and initiating antimicrobial stewardship (AMS) ward rounds in a university hospital emergency …
View article: <i>Jak2</i> <i>V617F</i> clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk
<i>Jak2</i> <i>V617F</i> clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk Open
JAK2 V617F (JAK2VF) clonal hematopoiesis (CH) has been associated with atherothrombotic cardiovascular disease (CVD). We assessed the impact of Jak2VF CH on arterial thrombosis and explored the underlying mechanisms. A meta-analysis of 3 l…
View article: Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation
Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation Open
Thrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk. In recent years the pathoph…
View article: Author Correction: Vascular surveillance by haptotactic blood platelets in inflammation and infection
Author Correction: Vascular surveillance by haptotactic blood platelets in inflammation and infection Open
The original version of this Article contained an error in the "Introduction", as reference was missing.The original version read incorrectly "[…] since the abrogation of lamellipodia formation does not
View article: Single platelet and megakaryocyte morpho-dynamics uncovered by multicolor reporter mouse strains <i>in vitro</i> and <i>in vivo</i>
Single platelet and megakaryocyte morpho-dynamics uncovered by multicolor reporter mouse strains <i>in vitro</i> and <i>in vivo</i> Open
Visualizing cell behavior and effector function on a single cell level has been crucial for understanding key aspects of mammalian biology. Due to their small size, large number and rapid recruitment into thrombi, there is a lack of data o…
View article: Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction
Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction Open
In our detailed histologic analysis of arterial thrombi, thrombus composition and especially abundance of leukocyte subsets differed between patients with AIS and AMI. The presence and amount of NETs were associated with patients' outcome …
View article: Rivaroxaban Reduces Arterial Thrombosis by Inhibition of FXa-Driven Platelet Activation via Protease Activated Receptor-1
Rivaroxaban Reduces Arterial Thrombosis by Inhibition of FXa-Driven Platelet Activation via Protease Activated Receptor-1 Open
Rationale: A reduced rate of myocardial infarction has been reported in patients with atrial fibrillation treated with FXa (factor Xa) inhibitors including rivaroxaban compared with vitamin K antagonists. At the same time, low-dose rivarox…
View article: Platelet Proteasome Activity and Metabolism Is Upregulated during Bacterial Sepsis
Platelet Proteasome Activity and Metabolism Is Upregulated during Bacterial Sepsis Open
Dysregulation of platelet function can contribute to the disease progression in sepsis. The proteasome represents a critical and vital element of cellular protein metabolism in platelets and its proteolytic activity has been associated wit…
View article: Eosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps
Eosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps Open
This study uses genetic and pharmacologic approaches to demonstrate novel roles of eosinophils in the progression of atherosclerosis and arterial thrombosis.
View article: Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis
Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis Open
Genetically modified mice are indispensable for establishing the roles of platelets in arterial thrombosis and hemostasis. Microfluidics assays using anticoagulated whole blood are commonly used as integrative proxy tests for platelet func…
View article: Platelet–Neutrophil Crosstalk in Atherothrombosis
Platelet–Neutrophil Crosstalk in Atherothrombosis Open
Atherothrombosis is a frequent cause of cardiovascular mortality. It is mostly triggered by plaque rupture and exposure of the thrombogenic subendothelial matrix, which initiates platelet aggregation and clot formation. Current antithrombo…
View article: Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3 Open
The RNase Regnase-1 is a master RNA regulator in macrophages and T cells that degrades cellular and viral RNA upon NF-κB signaling. The roles of its family members, however, remain largely unknown. Here, we analyzed Regnase-3–deficient mic…
View article: Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis
Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis Open
Heart failure due to dilated cardiomyopathy is frequently caused by myocarditis. However, the pathogenesis of myocarditis remains incompletely understood. Here, we report the presence of neutrophil extracellular traps (NETs) in cardiac tis…
View article: Perioptic Cerebrospinal Fluid Dynamics in Idiopathic Intracranial Hypertension
Perioptic Cerebrospinal Fluid Dynamics in Idiopathic Intracranial Hypertension Open
Purpose: To examine the cerebrospinal fluid (CSF) dynamics along the entire optic nerve in patients with idiopathic intracranial hypertension (IIH) and papilledema by computed tomographic (CT) cisternography. Methods: Retrospective analysi…
View article: Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation
Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation Open
Neutrophils are a hallmark of arterial thrombi in patients suffering from acute myocardial infarction and in mouse models of arterial thrombosis. Inhibition of PAD could represent an interesting strategy for the treatment of arterial throm…
View article: Maturation of Platelet Function During Murine Fetal Development In Vivo
Maturation of Platelet Function During Murine Fetal Development In Vivo Open
Objective— Platelet function has been intensively studied in the adult organism. However, little is known about the function and hemostatic capacity of platelets in the developing fetus as suitable in vivo models are lacking. Approach and …