Joachim Wink
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View article: Exploring marine-derived bacterial compounds targeting the μ-opioid receptor agonists through metabolic profiling to molecular modeling
Exploring marine-derived bacterial compounds targeting the μ-opioid receptor agonists through metabolic profiling to molecular modeling Open
Given the severe side effects of prolonged morphine use, the search for safer alternatives is a global priority. This study investigates marine bacteria from sediments along the Bejaia coast, Algeria, to identify opioid-like bioactive comp…
View article: Isolation, characterisation and description of the roseoflavin producer <i>Streptomyces berlinensis</i> sp. nov.
Isolation, characterisation and description of the roseoflavin producer <i>Streptomyces berlinensis</i> sp. nov. Open
The Gram‐positive bacteria Streptomyces davaonensis and Streptomyces cinnabarinus have been the only organisms known to produce roseoflavin, a riboflavin (vitamin B 2 ) derived red antibiotic. Using a selective growth medium and a phenotyp…
View article: Streptomyces iakyrus TA 36 as First-Reported Source of Quinone Antibiotic γ–Rubromycin
Streptomyces iakyrus TA 36 as First-Reported Source of Quinone Antibiotic γ–Rubromycin Open
A wide range of bioactive compounds with potential medical applications are produced by members of the genus Streptomyces. A new actinomycete producer of the antibiotic γ-rubromycin, designated TA 36, was isolated from an alpine soil sampl…
View article: Bursts in biosynthetic gene cluster transcription are accompanied by surges of natural compound production in the myxobacterium <i>Sorangium</i> sp.
Bursts in biosynthetic gene cluster transcription are accompanied by surges of natural compound production in the myxobacterium <i>Sorangium</i> sp. Open
A better understanding of the genetic regulation of the biosynthesis of microbial compounds could accelerate the discovery of new biologically active molecules and facilitate their production. To this end, we have investigated the time cou…
View article: Streptomyces lasiicapitis KSA18 isolated from Saharan soil in Algeria effective against most bacteria and fungi
Streptomyces lasiicapitis KSA18 isolated from Saharan soil in Algeria effective against most bacteria and fungi Open
Saharan soil still represents a formidable source of microorganisms that produce bioactive substances. Twentythree Actinobacteria strains were isolated from sand samples collected from saharian field in Algeria. Isolates were evaluated for…
View article: Diversity of Myxobacteria Isolated from Indonesian Mangroves and Their Potential for New Antimicrobial Sources
Diversity of Myxobacteria Isolated from Indonesian Mangroves and Their Potential for New Antimicrobial Sources Open
Mangroves are unique intertidal ecosystems that provide ecological niches to different microbes, which play various roles in nutrient recycling and diverse environmental activities. The association between myxobacteria and mangroves are hi…
View article: Persicamidines—Unprecedented Sesquarterpenoids with Potent Antiviral Bioactivity against Coronaviruses
Persicamidines—Unprecedented Sesquarterpenoids with Potent Antiviral Bioactivity against Coronaviruses Open
A new family of highly unusual sesquarterpenoids (persicamidines A–E) exhibiting significant antiviral activity was isolated from a newly discovered actinobacterial strain, Kibdelosporangium persicum sp. nov., collected from a hot desert i…
View article: Bursts in biosynthetic gene cluster transcription are accompanied by surges of natural compound production in the myxobacterium<i>Sorangium</i>sp
Bursts in biosynthetic gene cluster transcription are accompanied by surges of natural compound production in the myxobacterium<i>Sorangium</i>sp Open
We have investigated the time course of genome-wide transcription in the myxobacterium Sorangium sp. So ce836 in relation to its production of natural compounds. Time-resolved RNA sequencing revealed that core biosynthesis genes from 48 bi…
View article: Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin**
Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin** Open
Herein, we describe the myxobacterial natural product Corramycin isolated from Corallococcus coralloides . The linear peptide structure contains an unprecedented (2 R ,3 S )‐γ‐ N ‐methyl‐β‐hydroxy‐histidine moiety. Corramycin exhibits anti…
View article: Structure elucidation, biosynthesis, total synthesis and antibacterial in-vivo efficacy of myxobacterial Corramycin
Structure elucidation, biosynthesis, total synthesis and antibacterial in-vivo efficacy of myxobacterial Corramycin Open
Herein, we describe the myxobacterial natural product Corramycin (1) isolated from Corallococcus coralloides (C. coralloides). Corramycin is a linear peptide containing an unprecedented (2R,3S) N-methyl-β-hydroxy histidine moiety and exh…
View article: Exploring the Antibiotic Production Potential of Heterotrophic Bacterial Communities Isolated from the Marine Sponges Crateromorpha meyeri, Pseudaxinella reticulata, Farrea similaris, and Caulophacus arcticus through Synergistic Metabolomic and Genomic Analyses
Exploring the Antibiotic Production Potential of Heterotrophic Bacterial Communities Isolated from the Marine Sponges Crateromorpha meyeri, Pseudaxinella reticulata, Farrea similaris, and Caulophacus arcticus through Synergistic Metabolomic and Genomic Analyses Open
The discovery of novel secondary metabolites is actively being pursued in new ecosystems. Sponge-associated bacteria have been in the limelight in recent years on account of their ability to produce bioactive compounds. In this study, hete…
View article: Winogradskyella luteola sp.nov., Erythrobacter ani sp. nov., and Erythrobacter crassostrea sp.nov., isolated from the hemolymph of the Pacific Oyster Crassostrea gigas
Winogradskyella luteola sp.nov., Erythrobacter ani sp. nov., and Erythrobacter crassostrea sp.nov., isolated from the hemolymph of the Pacific Oyster Crassostrea gigas Open
Three new bacterial strains, WHY3 T , WH131 T , and WH158 T , were isolated and described from the hemolymph of the Pacific oyster Crassostrea gigas utilizing polyphasic taxonomic techniques. The 16S rRNA gene sequence analysis revealed th…
View article: Four new members of the family Cytophagaceae: Chryseosolibacter histidini gen. nov., sp. nov., Chryseosolibacter indicus gen. nov., sp. nov., Dawidia cretensis, gen. nov., sp. nov., and Dawidia soli, gen. nov., sp. nov. isolated from diverse habitat
Four new members of the family Cytophagaceae: Chryseosolibacter histidini gen. nov., sp. nov., Chryseosolibacter indicus gen. nov., sp. nov., Dawidia cretensis, gen. nov., sp. nov., and Dawidia soli, gen. nov., sp. nov. isolated from diverse habitat Open
Four novel strains were isolated: PWU4 T and PWU20 T were both from soil in Germany, PWU5 T was isolated from soil in India and PWU37 T was obtained from sheep faeces collected on the Island of Crete. Cells of each were observed to be Gram…
View article: Corallococcus soli sp. Nov., a Soil Myxobacterium Isolated from Subtropical Climate, Chalus County, Iran, and Its Potential to Produce Secondary Metabolites
Corallococcus soli sp. Nov., a Soil Myxobacterium Isolated from Subtropical Climate, Chalus County, Iran, and Its Potential to Produce Secondary Metabolites Open
A novel myxobacterial strain ZKHCc1 1396T was isolated in 2017 from a soil sample collected along Chalus Road connecting Tehran and Mazandaran, Iran. It was a Gram-negative, rod-shaped bacterial strain that displayed the general features o…
View article: Photobacterium arenosum WH24, Isolated from the Gill of Pacific Oyster Crassostrea gigas from the North Sea of Germany: Co-cultivation and Prediction of Virulence
Photobacterium arenosum WH24, Isolated from the Gill of Pacific Oyster Crassostrea gigas from the North Sea of Germany: Co-cultivation and Prediction of Virulence Open
Cream colored bacteria from marine agar, strain WH24, WH77, and WH80 were isolated from the gill of the Crassostrea gigas a Pacific oyster with a filter-feeding habit that compels accompanying bacteria to demonstrate a high metabolic capac…
View article: Characterization of Winogradskyella luteola sp.nov., Erythrobacter ani sp.nov., and Erythrobacter crassostrea sp.nov., three novel species of two different genus Winogradskyella and Erythrobacter, from the hemolymph of Pacific Oyster Crassostrea gigas. Prediction of bioremediation
Characterization of Winogradskyella luteola sp.nov., Erythrobacter ani sp.nov., and Erythrobacter crassostrea sp.nov., three novel species of two different genus Winogradskyella and Erythrobacter, from the hemolymph of Pacific Oyster Crassostrea gigas. Prediction of bioremediation Open
Three new bacterial strains, WHY3 T , WH131 T , and WH158 T , were isolated and described from the hemolymph of the Pacific oyster Crassostrea gigas utilizing polyphasic taxonomic techniques. The 16S rRNA gene sequence analysis revealed th…
View article: Antimicrobial potential of culturable actinobacteria isolated from the Pacific oyster Crassostrea gigas (Bivalvia, Ostreidae)
Antimicrobial potential of culturable actinobacteria isolated from the Pacific oyster Crassostrea gigas (Bivalvia, Ostreidae) Open
Aims Explore the diversity of culturable actinobacteria isolated from the Pacific oyster Crassostrea gigas with special emphasis on their antimicrobial activity. Methods and Results For the characterization of the isolated actinobacteria, …
View article: Metabolic Profile, Biotransformation, Docking Studies and Molecular Dynamics Simulations of Bioactive Compounds Secreted by CG3 Strain
Metabolic Profile, Biotransformation, Docking Studies and Molecular Dynamics Simulations of Bioactive Compounds Secreted by CG3 Strain Open
Actinobacteria isolated from untapped environments and exposed to extreme conditions such as saltpans are a promising source of novel bioactive compounds. These microorganisms can provide new molecules through either the biosynthetic pathw…
View article: Qipengyuania pacifica sp. nov., a Novel Carotenoid-Producing Marine Bacterium of the Family Erythrobacteraceae, Isolated from Sponge (Demospongiae), and Antimicrobial Potential of Its Crude Extract
Qipengyuania pacifica sp. nov., a Novel Carotenoid-Producing Marine Bacterium of the Family Erythrobacteraceae, Isolated from Sponge (Demospongiae), and Antimicrobial Potential of Its Crude Extract Open
A marine Alphaproteobacterium designated as strain NZ-96T was isolated in February 2021, from a sponge species (Demospongiae) collected in muddy sediments with boulders and old chimneys in Otago/Canterbury Slope, Pacific Ocean, New Zealand…
View article: Combination and improvement of conventional DNA extraction methods in Actinobacteria to obtain high-quantity and high-quality DNA
Combination and improvement of conventional DNA extraction methods in Actinobacteria to obtain high-quantity and high-quality DNA Open
Background and Objectives: DNA extraction is an important step of any molecular experiment. DNA could not be easily extracted from members of actinomycetes by the usual methods of lysis. Due to the low efficiency of the conventional DNA ex…
View article: Taxonomy and Antimicrobial Activity of Gliding Bacterium from Indonesian Mangroves
Taxonomy and Antimicrobial Activity of Gliding Bacterium from Indonesian Mangroves Open
The discovery of new antibiotic is needed, due to the increasing antimicrobial resistance in nature. Therefore, this study aims to isolate gliding bacteria and to ascertain their antimicrobial activity against pathogenic microbes. This res…
View article: Pacificimonas pallium sp. nov., an Isolated Bacterium from the Mantle of Pacific Oyster Crassostrea gigas in Germany, and Prediction of One-Carbon Metabolism
Pacificimonas pallium sp. nov., an Isolated Bacterium from the Mantle of Pacific Oyster Crassostrea gigas in Germany, and Prediction of One-Carbon Metabolism Open
A yellow bacterium from marine agar, strain WHA3T, was isolated from the mantel of the Pacific oysters Crassostrea gigas in the Wilhelmshaven Sea in northern Germany. Based on the 16S rRNA gene sequence, strain WHA3T had a high similarity …
View article: Four New Members of The Family Cytophagaceae: Cryseosolum Histidinii gen. nov., sp. nov., Cryseosolum Indiensis gen. nov., sp. nov., Reichenbachia Cretensis, gen. nov., sp. nov., and Reichenbachia Soli, gen. nov., sp. nov. Isolated From Diverse Habitat
Four New Members of The Family Cytophagaceae: Cryseosolum Histidinii gen. nov., sp. nov., Cryseosolum Indiensis gen. nov., sp. nov., Reichenbachia Cretensis, gen. nov., sp. nov., and Reichenbachia Soli, gen. nov., sp. nov. Isolated From Diverse Habitat Open
Four strains isolated, PWU4T, PWU20T, PWU5T and PWU37T were from both of soil in Germany, India and a faces sheep collected in Crete Island, respectively. Cells were Gram-negative, strictly aerobic, rod shaped, grew optimally between 28oC …
View article: Alteriqipengyuania abyssalis sp. nov., a Novel Member of the Class Alphaproteobacteria Isolated from Sponge, and Emended Description of the Genus Alteriqipengyuania
Alteriqipengyuania abyssalis sp. nov., a Novel Member of the Class Alphaproteobacteria Isolated from Sponge, and Emended Description of the Genus Alteriqipengyuania Open
A novel Gram-negative, aerobic, motile, lemon-yellow-colored, and non-spore-forming rod-shaped bacterium designated strain NZ-12BT was isolated in February 2021 from a sponge species (Crateromorpha) collected at the southern Kermadec Ridge…
View article: Zooshikella harenae sp. nov., Isolated from Pacific Oyster Crassostrea gigas, and Establishment of Zooshikella ganghwensis subsp. marina subsp. nov. and Zooshikella ganghwensis subsp. ganghwensis subsp. nov.
Zooshikella harenae sp. nov., Isolated from Pacific Oyster Crassostrea gigas, and Establishment of Zooshikella ganghwensis subsp. marina subsp. nov. and Zooshikella ganghwensis subsp. ganghwensis subsp. nov. Open
Here, we describe the polyphasic taxonomy of a novel isolated strain WH53T from the genus Zooshikella isolated from the sand sediment located between the lumen of the Crassostrea gigas From Germany. Phylogenetic analysis determined that th…
View article: Ecological and Pharmacological Activities of Polybrominated Diphenyl Ethers (PBDEs) from the Indonesian Marine Sponge Lamellodysidea herbacea
Ecological and Pharmacological Activities of Polybrominated Diphenyl Ethers (PBDEs) from the Indonesian Marine Sponge Lamellodysidea herbacea Open
Two known Polybrominated Diphenyl Ethers (PBDEs), 3,4,5-tribromo-2-(2′,4′-dibromophenoxy)phenol (1d) and 3,4,5,6-tetrabromo-2-(2′,4′-dibromophenoxy)phenol (2b), were isolated from the Indonesian marine sponge Lamellodysidea herbacea. The s…
View article: Isolation of Nannocystis species from Iran and exploring their natural products
Isolation of Nannocystis species from Iran and exploring their natural products Open
Several different techniques were employed for the isolation of Nannocystis from various sources. A polyphasic approach was used for identification. Twelve strains of N. pusilla, N. exedens, and N. konarekensis with distinctive distributio…
View article: Amycolatomycins A and B, Cyclic Hexapeptides Isolated from an Amycolatopsis sp. 195334CR
Amycolatomycins A and B, Cyclic Hexapeptides Isolated from an Amycolatopsis sp. 195334CR Open
The rare actinobacterium Amycolatopsis sp. strain 195334CR was found to produce previously undescribed cyclic hexapeptides, which we named amycolatomycin A and B (1 and 2). Their planar structures were determined by high-resolution mass sp…