Joakim B. Stenbäck
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View article: Accurate and Cost‐Efficient Whole Genome Sequencing of Hepatitis B Virus Using Nanopore
Accurate and Cost‐Efficient Whole Genome Sequencing of Hepatitis B Virus Using Nanopore Open
Deep sequencing of the whole hepatitis B virus genome increases the analytical resolution and has the potential to improve molecular epidemiology investigations. The aim of this study was to develop and evaluate the performance of such dee…
View article: Large spatial variation of intrahepatic HDV RNA levels without association with HBV core or S RNA levels in HDV cirrhosis patients
Large spatial variation of intrahepatic HDV RNA levels without association with HBV core or S RNA levels in HDV cirrhosis patients Open
The results suggest that intrahepatic HBsAg might be a limiting factor for HDV particle secretion, but do not support the hypothesis that HDV suppresses HBV replication.
View article: Viral particles do not contribute significantly to serum levels of hepatitis B surface antigen which is produced mainly from integrated HBV DNA in most patients with chronic hepatitis B
Viral particles do not contribute significantly to serum levels of hepatitis B surface antigen which is produced mainly from integrated HBV DNA in most patients with chronic hepatitis B Open
Viral particles do not significantly contribute to HBsAg levels in serum and in HBeAg-negative patients, and the VP/SVP ratio is much lower than previously described. The contribution from cccDNA to HBsAg levels seems to be significant onl…
View article: Next-Generation Sequencing Methods for Sensitive Hepatitis B Viral Genome Analysis: A European Study
Next-Generation Sequencing Methods for Sensitive Hepatitis B Viral Genome Analysis: A European Study Open
Objectives This multicentre study investigated the utility of next-generation sequencing (NGS) to detect and generate hepatitis B virus (HBV) genomes in samples of low viral load (from 0.2 to 6207 IU/ml). Methods 23 HBV DNA positive plasma…
View article: HBV Whole-Genome Sequencing using Oxford Nanopore MinION v1
HBV Whole-Genome Sequencing using Oxford Nanopore MinION v1 Open
This protocol outlines the steps for preparing and sequencing the hepatitis B virus (HBV) whole genome using Oxford Nanopore MinION with Flongle flowcells. It details primer-based amplification, quality control using Agilent TapeStation, a…
View article: Accurate and cost-efficient whole genome sequencing of hepatitis B virus using Nanopore
Accurate and cost-efficient whole genome sequencing of hepatitis B virus using Nanopore Open
Deep sequencing of the whole hepatitis B virus genome increases the analytical resolution and has the potential to improve molecular epidemiology investigations. The aim of this work was to develop and evaluate the performance of such deep…
View article: Hepatitis B virus particles in serum contain minus strand <scp>DNA</scp> and degraded pregenomic <scp>RNA</scp> of variable and inverse lengths
Hepatitis B virus particles in serum contain minus strand <span>DNA</span> and degraded pregenomic <span>RNA</span> of variable and inverse lengths Open
This study utilized digital PCR to quantify HBV RNA and HBV DNA within three regions of the HBV genome. Analysis of 75 serum samples from patients with chronic infection showed that HBV RNA levels were higher in core than in S and X region…
View article: Enrichment Reveals Extensive Integration of Hepatitis B Virus DNA in Hepatitis Delta Virus-Infected Patients
Enrichment Reveals Extensive Integration of Hepatitis B Virus DNA in Hepatitis Delta Virus-Infected Patients Open
Background Hepatitis B virus (HBV) DNA may become integrated into the human genome of infected human hepatocytes. Expression of integrations can produce the surface antigen (HBsAg) that is required for synthesis of hepatitis D virus (HDV) …
View article: Impaired T-cell response to mRNA vaccination heralds risk of COVID-19 in long-term allogeneic hematopoietic stem cell transplantation survivors
Impaired T-cell response to mRNA vaccination heralds risk of COVID-19 in long-term allogeneic hematopoietic stem cell transplantation survivors Open
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